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Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?

The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.

Harm.

What is gene suppression?

Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.

"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.

Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.

Yeast substitution experiment

"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.

But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.

"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.

Narrow the search scope of mutant genes

The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.

Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.

"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.

The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.

The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?

Jolanda：At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.

The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.

Jolanda：Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.

The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?

Jolanda：We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.

The PaperWhat do you think is the most important significance of this research?

Jolanda：The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.

(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")

Special feature of 1905 film network After 20 days of release, the box office of "Fengshen Part I" exceeded 1.7 billion, and the total box office was predicted to increase from 1.25 billion at the lowest point to 2.45 billion, nearly doubling.Maybe, directorWu ErshanFinally, I can say:"sealGodOut of the ICU.

At the same time, on the evening of August 8th, several leading actors, such as Yu Shi, Na Ran, Chen Muchi and Shan Jingyao, also made a surprise appearance in the live broadcast room of Liu Genghong. The "Proton Group" showed the war dance and joyful dancing, and the topic kept on.

"You have one vote, I have one vote to help Master Wen buy a high-speed rail ticket", "You don’t vote, I don’t vote, Yin Jiao will never have a head!" …

Never being optimistic, it is expected to compete for the second place in the summer box office. The starring role is from unknown to popular. How can "tap water" help "Fengshen" to complete the box office counterattack? How do online and offline announcements open the "road to sealing the gods" with a "two-pronged approach"?

"Tap water" helps "the road to sealing the gods"　

Different from the performance of "scheduled" explosions in summer files such as "Disappeared She", "In an octagonal cage" and "Put all your eggs in one basket", "Feng Shen I" was the one that was not optimistic until its release.The voices of "untimely blockbusters" and "Chinese magic has long been out of date" have come and gone, and only 138 million yuan was recorded in the first two days, which also lowered the total box office forecast of the film to 1.25 billion.

However, with the further release of the film, the relatively excellent quality and fascinating characters have aroused extensive discussion among netizens, and "tap water" is also constantly gathering. Stars and enthusiastic audiences from all walks of life began to spontaneously Call for the film on major social platforms, and supported the film with two brushes and three brushes.

This also allows the market to witness the mysterious power of "tap water" again after films such as The Return of the Great Sage, 22nd and The Wandering Earth.

There are still many netizens who take the initiative to undertake the heavy responsibility of film promotion, brainstorming for hot search topics and fancy whole work. Master Wen Taishi, who made a stunning appearance in the egg, was elected as the first "spokesperson" by the tap water.

"Hello, I’m Master Wen. I’m grabbing a high-speed rail ticket at 12306. Please help me to speed up my return to the DPRK." "You have one vote for me, and a surname can arrive on time!" And so on, which have a great sense of network, have gained a good communication effect.

More enthusiastic netizens thought of dozens of entries in one breath, including not only "Wen Taishi Terrier", but also related topics such as "da ji’s love brain" and "Yin Jiao Ji Fa’s brotherhood", all of which are hot spots that netizens like to see and hear. With the continuous spontaneous fermentation of "tap water", it also helped # Please seal the gods and announce that it was immediately spread to me # and boarded the hot search several times.

Different from these hot spots from the bottom up, the early official publicity of "Feng Shen" mainly focused on the cultural value of the film. There is nothing wrong with this angle itself, but it is launched when the audience still doesn’t understand the film, which means a lot of preaching, and it is not as easy to sink out of the circle as the spontaneous online topic of netizens.

Fortunately, the propagandists and creators of "Feng Shen" gradually realized this point and began to have a benign interaction with "tap water people". For example, Chen Muchi, the actor who plays Yin Jiao, was named as the uncrowned "propaganda director" by netizens because he was willing to go off to play in person.

Director Wu Ershan learned that his initials were homophonic during the road show, and immediately changed the profile "523" to "U23" (from "No Two or Three" to "There are Two or Three"), which earned a lot of goodwill. At the same time, by constantly releasing exclusive behind-the-scenes tidbits and deleting fragments, he tried his best to meet the needs of tap water, and also provided material for the continuous fermentation of the topic.

Under the overnight rescue of "tap water", "Feng Shen" also miraculously walked out of the ICU, ranking first in the box office for 13 consecutive days from the first Saturday, and set a record of 160 million yuan in a single day the next weekend, drawing a beautiful downward curve.

The box office counterattack of "Feng Shen" is undoubtedly a demonstration of the power of "tap water", and it is also worth thinking in the industry: what kind of topics and forms are loved by the audience, and what kind of propaganda points can really gain heat and flow.

　Online and offline "combination boxing"　

"ChristianRandPhillips, she is my hakimi", "Princess ChristianRandPhillips embraces Na Ran" and "Yu Shi Na Ran crosses da ji Ji Fa with each other", all of which come from the roadshow scene of "Feng Shen I".

In addition, short videos with high popularity, such as "Chen Muchi reappears in the right place to tie the gods", "Chen Muchi’s military boxing" and "Proton Group reappears famous lines", are also from roadshows. The ongoing roadshow in 24 cities across the country is like a continuous "hot search" manufacturing machine, which continuously outputs various "famous scenes".

With the rise of online platforms, the traditional road show method was once despised by many filmmakers, who thought it was strong in regionality and limited in reach. However, many summer blockbusters, including Feng Shen and Disappeared She, proved the significance of the road show through examples.

In the era of short video, the role of roadshows is not only to effectively incite regional resources and ferment word of mouth, but also to generate a large number of short video-oriented materials through the interaction between the main creators and local audiences. These grassroots and creative pictures are often easier to spread and spread.

From offline to online, unlike other blockbusters selling tickets live in the early stage of the release, "Fengshen" chose to go to the online head live broadcast room after the actors accumulated a certain degree of heat and popularity.

On August 5th, the cast of "Feng Shen" parachuted into the "Brother Xiao Yang" live room for the first time to sell tickets, and 200,000 movie tickets were sold out in seconds, with over 150 million praises in one minute. Choosing to link with the anchor of the short video platform with grounding gas like "Xiao Yang Ge", the film obviously expects the film to further incite the sinking market.

On August 8th, with the long-awaited fans, the representative of "Proton Group" finally merged with Liu Genghong in the live broadcast room, with a high degree of matching between people and audience, which is expected to produce better communication effect.

Coupled with the live broadcast of a popular game on August 10, and the live broadcast of various actors, from offline to online, from the road show site to the live broadcast room, the "combination boxing" of "Feng Shen" is exerting its power.

Why is "Feng Shen I"?　

Before the screening, I wanted to see why "Feng Shen", which was not favored by the market, attracted so much "tap water" to complete the box office counterattack.

On the one hand, it is naturally because of the excellent quality of the film. Douban scored 7.8 points, Cat’s Eye scored 9.4 points, and Taobao Film scored 9.2 points, which were outstanding in both magic films and movies of the same file, and also gave Amway the confidence of "tap water".

On the other hand, the film is well-made, the old opera bones are superb, and the strength of the new actors is all important points.

With the release of documentaries and behind-the-scenes specials, the ubiquitous cultural details, craftsman spirit and the six-month training camp for worshipping gods have gained the recognition of netizens, making "worshipping gods" a recognized work of "grinding a sword in ten years".

Not only that, although the genre of "Feng Shen" is a magical epic action blockbuster, it "accidentally" captured the "heart" of female audiences. According to a ticketing platform, 52.8% of users who want to see the portraits of Fengshen are women, and the score of women is as high as 9.8, which is much higher than that of men.

The brotherhood of Yin Jiao and Ji Fa’s "well-connected suburbs" combination, the sunny and strong appearance of the members of the "Proton Group" and ChristianRandPhillips, who is more attractive as he gets older, have aroused extensive discussions among the female audience, and also invisibly led a new aesthetic direction. As netizens commented, it is suggested that domestic ancient costumes be rolled up according to this standard.

At the same time, through hard training, the members of Proton Group have completed the all-round transformation from body, will to acting skills, and such "nurturing" actors are more likely to arouse the recognition and resonance of the audience.

The box office counterattack of "Feng Shen" is the victory of "tap water", which also proves that gold always shines. However, "the fragrance of wine is also afraid of the depth of the alley". While looking forward to "Feng Shen II", we might as well sum up our experience and prevent the excellent works from being buried again.

The following article comes from China, the author of Science Popularization, Xue Qingxin.

Cop China.

Public science popularization and scientific communication

Why does barbecue smell good?

The origin of barbecue is very early, and it has been started since our primate ancestors. The love for barbecue can be said to go deep into the soul. Few people can control their desire for the smell of barbecue food. The smell of barbecue coming from the streets is really tempting, not to mention the lively atmosphere of barbecue all over the city!

Then why does the barbecue smell so good?

The most common barbecue is charcoal barbecue, which can give food a unique aroma mainly for two reasons.

1. Maillard reaction

During the barbecue of food, the amino acids decomposed by protein will have Maillard reaction with the reducing sugar in food or marinade, which can give food a unique aroma and attractive color.

2. Flavor droplets

Flavor droplets are the key to the flavor formation of barbecue food. After burning, food droplets will emit many aromatic compounds to cover the food.

For example, the drippings of fruit juice contain sugar, protein and oil, and the drippings of meat contain a lot of fat, which will be burnt at the high temperature of charcoal and excited into aromatic molecules to return to the smoke, giving food an aromatic taste.

The combination of these two flavors makes people drool over barbecue.

Why advise you to eat less barbecue?

Barbecue is delicious, but you should not eat it often. In order to persuade you to eat less barbecue, I have properly sorted out many reasons.

Step 1 get fat

Fat and thin kebabs especially capture people’s hearts, such as pork belly, soy sauce tendons, fat and thin, and even cooked tendons, skin and fat intestines … You may brush oil over and over again during the barbecue. The reason why these kebabs are delicious is that they are high in fat, so they taste good, and the calories are naturally not low. Eating them often will inevitably increase the risk of obesity, which is not conducive to cardiovascular and cerebrovascular health.

2. It is not conducive to controlling blood pressure

The salt content of pickled kebabs and the dipping sauce is not low, so eating them often is not conducive to controlling blood pressure.

3. It is not conducive to controlling blood uric acid.

Barbecues, especially those in coastal areas, have more meat and seafood, and often drink beer at the same time, which will make us consume more purine, which may lead to an increase in blood uric acid. Patients with hyperuricemia and gout should pay special attention to eating moderately.

4. There are carcinogens

Barbecue belongs to high-temperature cooking, and the highest temperature can reach 370℃. At this high temperature, meat will produce heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are carcinogens, and the content of carcinogens will gradually increase with the increase of temperature and time.

As we all know, 3,4- benzopyrene is the highest class 1 carcinogen, which is definitely carcinogenic to human beings. It belongs to one kind of polycyclic aromatic hydrocarbons, which is the most toxic and accounts for a large proportion, so it is the most representative polycyclic aromatic hydrocarbons with strong carcinogenicity. In the way of ingesting polycyclic aromatic hydrocarbons through diet, fried and grilled foods account for 88%~98%. [1]

In addition, foods with high carbohydrate content, such as steamed bread, bread, potato chips, etc., will produce acrylamide during barbecue, which belongs to category 2A carcinogen. It has been confirmed that it will cause cancer in animals, but the evidence of carcinogenicity in humans is limited.

5. Air pollution

The burning and incomplete burning of charcoal for barbecue will produce carbon dioxide and carbon monoxide. The former is a kind of greenhouse gas, while the latter is a toxic gas. The smoke from barbecue contains toxic and harmful substances such as dioxins, nitrosamines and heterocyclic amines, among which dioxins not only cause cancer, but also have reproductive toxicity and genetic toxicity. The smoke contains particles such as PM2.5 and PM10, and the concentration is off the charts! Relevant tests by environmental NGOs show that the concentration of PM2.5 in barbecue intensive areas is 1 meter, 10 meters and 100 meters away from the oven, which is far higher than that in non-barbecue areas, and PM10 can also cause haze weather, which seriously harms the health of respiratory system. [2]

How to reduce injuries?

Since there are health risks while eating barbecue, how can people who like to eat barbecue eat relatively healthily? In order to let everyone enjoy the food happily, the following eight points are best arranged.

Step 1 don’t burn

The higher the barbecue temperature and time, the higher the carcinogen content. It is best to remove the burnt place and not eat it, because the more burnt the place, the higher the carcinogen content. After baking, you should wipe the head of the barbecue label before eating.

For example, it is reasonable to have a small stove on each table of Zibo BBQ, and the degree to which the meat is roasted can be completely in your own hands. It is suggested that the meat can be eaten when it is completely cooked, and don’t wait for it to dry and paste.

2. Choose more lean meat

Lean meat is low in fat, which is helpful for weight control. Moreover, if the fat content is high, it will further promote the formation of carcinogens, and polycyclic aromatic hydrocarbons are most likely to be produced at high temperature. Lean meat may have lower carcinogen content than fat and thin kebabs, and it can also reduce the intake of saturated fatty acids.

3. Don’t just eat meat

Many people eat kebabs all over the table, which will lead to high meat intake, which is not conducive to cardiovascular health. If you eat so much meat often, you will increase the risk of developing diseases such as type 2 diabetes, colorectal cancer and obesity. [3] Therefore, it is best to mix some staple foods, vegetables and bean products, which will help to enhance satiety and control meat intake.

Zibo barbecue, for example, is very good. Burritos are the staple food, and shallots are vegetables, but the taste is spicy.

Step 4 match fresh fruits and vegetables

Fresh fruits and vegetables are rich in dietary fiber and antioxidant components, such as lycopene, carotene and anthocyanin. Tomatoes, Chinese cabbage, cherry tomatoes, leeks, oil-wheat vegetables, sweet peppers, colored peppers, etc., when eaten with barbecue, can reduce the harm of carcinogens in barbecue to the body.

5. Microwave before baking

Microwave pretreatment can significantly reduce the production of heterocyclic amines in meat, because microwave can reduce the water content in food, so that the "raw materials" that form carcinogens can not seep out to the surface of meat to participate in the reaction with water, thus significantly reducing the production of heterocyclic amines.

The results showed that the total amount of heterocyclic amines in half-cooked chicken and beef pretreated by microwave decreased by 24% and 21% respectively, while the total amount of heterocyclic amines in fully cooked samples decreased by 35% and 42% respectively. [1]

In addition, microwave pretreatment can significantly reduce the production of polycyclic aromatic hydrocarbons in barbecue products, which may be due to shortening the barbecue time.

Therefore, if you barbecue food at home by yourself, you can microwave the meat until it is 67% cooked or fully cooked before roasting.

Step 6 marinate with spices

Pretreatment of food with spices can significantly inhibit the formation of harmful substances such as heterocyclic amines, acrylamide and polycyclic aromatic hydrocarbons in food. This may be because spices generally have strong free radical scavenging ability, which can significantly inhibit the free radical reaction of meat products during high temperature processing. [1]

You can marinate the meat with garlic juice, onion, red pepper, Chili powder, ginger, black pepper, thirteen spices and so on before baking.

7. Put less or no soy sauce

Soy sauce can promote the formation of heterocyclic amines, and it is best to put less or not.

8. Barbecue style

Compared with charcoal roasting, electric roasting is more recommended, and the amount of harmful substances generated by electric roasting is lower. It was found that the content of polycyclic aromatic hydrocarbons (PAHs) was 24 μg/kg when sausages were roasted by electric roasting, and it increased to 51 μg/kg when sausages were roasted by charcoal, which was nearly 2 times higher than that by electric roasting. [4]

In addition, gas barbecue and stone barbecue can also effectively reduce the content of carcinogens in barbecue meat products.

summary

Let’s be realistic. No matter where the barbecue is, it’s not healthy food. Here, it’s good to remind everyone to relieve their cravings occasionally. Maybe it’s just right to have a barbecue once in a while. Remember to drink less wine and drink less sweet drinks when eating barbecue ~

Original title: "Barbecue is delicious, but healthy skewers should do these 8 points! 》

Read the original text

According to the arrangement of Announcement on the Recruitment of Civil Servants for the 2023 Examination in Yunnan Province, the written examination and interview work have ended. Now, the comprehensive scores and follow-up work arrangements of candidates applying for the General Office of Yunnan Provincial People’s Government, the Office Automation Technology Center of the General Office of Yunnan Provincial People’s Government, the Bulletin Office of Yunnan Provincial People’s Government and the Office of Yunnan Local Records Compilation Committee (referring to the staff of the management unit) are announced as follows:

I. Comprehensive achievements

According to the proportion of 50% written test scores and 50% interview scores, the written test scores and interview scores are rounded to two decimal places, and the comprehensive scores are rounded to three decimal places. See the annex for specific comprehensive achievements.

Second, the follow-up work arrangements

(1) About physical examination.

1. Schedule: April 25th, 2023 (Tuesday) at 8: 30am.

2. Physical examination location: Affiliated Hospital of Yunnan University (formerly Red Cross Hospital of Yunnan Province, No.176 Qingnian Road, Kunming).

3. Precautions: First, please ask the relevant candidates to pay at the No.1 window on the third floor of the outpatient department of the Affiliated Hospital of Yunnan University (formerly Yunnan Red Cross Hospital) at 8:00 am on Tuesday, April 25, 2023 (the standard medical examination for civil servants costs about 500 yuan/person), and the medical examination expenses shall be borne by the candidates themselves; At 8:30, fill in the form in the physical examination center (12th floor of Medical Technology Building). Second, please ask the relevant candidates to bring their original ID card, a recent 1-inch bareheaded color photo, black carbon pen and double-sided tape (for posting photos). Third, please eat light food one day before the physical examination, and fast gas-producing foods such as melon beans and milk, and fast after 9:00 pm. Please be present on an empty stomach in the early morning of the physical examination day.

(2) About the inspection work.

In accordance with the relevant requirements of the Measures for the Investigation of Civil Servants’ Employment (Trial) and the Implementation Measures for the Investigation of Civil Servants’ Employment in Yunnan Province (Trial), the follow-up will be notified by the telephone reserved by the candidates when they register. Please be sure to keep the communication open. If you can’t contact, the candidates will bear the consequences themselves.

Tel: 0871-63631608

Attachment: Comprehensive Scorecard of Civil Servants Employed in the 2023 Examination of the General Office of Yunnan Provincial People’s Government. docx

General Office of Yunnan Provincial People’s Government

April 18, 2023

　　As long as you keep moving forward, the eggs of life will appear inadvertently. This sentence is especially suitable for Liu Yuanjie.

　　Last summer, Liu Yuanjie was questioned by netizens in a live broadcast that his oil-painting background was post-processed. In order to prove himself, he threw a bucket into the river behind him and asked the netizen, "Really?"? As a result, this clip became popular on the Internet and was re-created by many netizens. Liu Yuanjie was thus called "the background is too fake", and the whole network rose by about 10 million.

　　Liu Yuanjie, who suddenly became angry, worked, created a business, studied graphic design and wrote online novels. Born in the rural areas of Guizhou, he had poor family conditions when he was a child, and his parents who worked with him lived in Jiangsu since childhood. Although he is only 25 years old, the experience of "Brother with too fake background" is very rich, and he has suffered so many setbacks that he doesn’t want to say it. His appearance looks much older than his actual age.

　　In the summer of 2020, Liu Yuanjie, who failed to start his business again, came to Xinjiang from Jiangsu to help farmers sell goods live in Korla. By the way, he was distracted and adjusted, but he didn’t expect to become popular overnight. Netizens like Liu Yuanjie’s hard work, frankness, sincerity and open-mindedness. This unexpected red-hot is an egg of life.

　　Life is the best screenwriter, writing a script for everyone. As long as you persist in your efforts and sincerity, you will bury eggs for you. Sweat and tears interweave, nourishing growth. All the twists and turns and setbacks that Liu Yuanjie experienced finally became nutrients and accumulated energy.

　　In Yili, Xinjiang, there is also a online celebrity named "Brother of Xinjiang", who also dug up the eggs of life. The real name of "Brother of Xinjiang" is Xu Jiezhi. Since 2019, short videos have been released on the online platform to promote the landscape of Yili and Damei Xinjiang. Last year, he planned and released a series of video works entitled "Traveling in Ili by Singing", which was well received by netizens.

　　If you want to be "arrogant" online, you must work hard offline. In recent years, Xu Jiezhi has traveled all over his hometown and accumulated a lot of short video materials. He used the way of "music+beautiful scenery" to let colorful Ili ride on the line with songs. Now, the active "Brother of Xinjiang" has gained more and more traffic and attention by reading classic articles, promoting special scenic spots, promoting high-quality products, or introducing travel strategies.

　　The greater the flow, the greater the responsibility; The more you pay attention, the better you will do. Thanks to the efforts of young anchor groups represented by Liu Yuanjie and Xu Jiezhi, Xinjiang, as a rich mine of short video material resources, is realizing the transformation from fun to charm, from face value to output value, and huge positive energy is surging out of large traffic.

　　Today, Liu Yuanjie is a member of the Yuli County Political Consultative Conference, the president of the Yuli County Bee Industry Association and the vice president of the Bayinguoleng Mongolian Autonomous Prefecture Media Association. He is busier than before. Visit farmers, select products, engage in training, and find a shooting location … … "The background is too fake." Just go and do it. When it comes to short videos and live broadcasts, he feels that there is no secret, just three words: work hard. Because he is too busy, Liu Yuanjie often only sleeps for three or four hours at night.

　　Under the blue sky, in the blazing sun, in the boundless grassland and in the snow, with the blessing of the magnificent mountains and rivers in Xinjiang, "Brother Tai Fake" was broadcast live to bring goods and help farmers sell. He was full of energy and vitality in front of the camera, even if he was stung by bees, he didn’t care. Special products such as fragrant pears, honey and medlar, together with the beautiful scenery of Xinjiang behind him, are constantly climbing to new heights of traffic. Liu Yuanjie has set a "small goal" for 2023: bringing 100 million goods.

　　Xu Jiezhi, who is also busy, takes "Ili Tourism Recommender" as his responsibility, and plans to launch a series of videos such as "Traveling to Ili with Food", "Traveling to Ili with Folk Customs" and "Traveling to Ili with Stories", trying to tell the stories of Ili and Xinjiang well, and helping rural revitalization with short videos, so that more people can enter this vast and colorful land.

　　Unique food and beautiful scenery, rich folk customs and customs, hidden secret territory and secret path make Xinjiang bring its own traffic. Short videos and webcasts are excellent "windows" to know, observe and understand Xinjiang. How to show this vast and colorful region through these methods and make good use of this "rich mine" in Xinjiang, different people have different perspectives, but quality, thought and significance are the password to obtain traffic. The experience of "Liu Yuanjie" looking for passwords is the process of growing from a "rookie" to an excellent anchor with feelings, ability and responsibility, and it is also a journey of digging out eggs with patience, hard work and tenacity. (Author: Qiao Wenhui Source: Economic Daily)

　　"At present, the company’s soda production has started at full capacity, with tight balance between production and sales, sufficient orders, strong demand from downstream customers, relatively low inventory and tight spot market." Recently,Relevant person in charge of ShanghaiThe reporter said.

　　Affected by factors such as spot shortage, soda ash futures rose sharply on November 27,The contract rose more than 8%, and the price has approached the 2500 yuan/ton mark, hitting a new high in nearly 9 months. In the spot market, the domestic soda ash market has also continued to rise. According to the data of Baichuan Yingfu, as of November 27th, domestic light soda ash and heavy soda ash both rose by more than 500 yuan/ton in a month. Among them, the average market price of light soda ash was 2509 yuan/ton, up by 80 yuan/ton from the previous working day; The average market price of heavy soda ash was 2722 yuan/ton, up by 57 yuan/ton from the previous working day. At the same time, the profit of domestic soda ash industry continues to rise. At present, the average gross profit of the industry is about 626.8 yuan/ton, with an obvious increase.

　　Many insiders said that the uncertainty of soda ash supply will continue to support the strong state of the market, and it is expected that the prosperity of soda ash industry will be maintained until the end of this year.

　　Industrial chain companies have sufficient orders.

　　According to the statistics of Baichuan Yingfu, the spot inventory of soda ash manufacturers has shown a downward trend recently. As of November 23rd, the total inventory of domestic soda enterprises is estimated to be about 365,000 tons, down 12.01% from the previous week. A-share listed companies producing soda ash mainly include、、、、、、Wait. The reporter learned that at present, the production capacity of each company is almost running at full capacity, and the inventory is at a low level. Most manufacturers’ orders in November were saturated, and some manufacturers’ orders in December were full, and there was basically no spot in the near future.

　　It is worth mentioning that the shortage of supply is the main reason for the rise of soda ash market. A person in charge of a listed company producing soda ash told reporters that the shipment of soda ash industry has exceeded the output recently, the inventory of soda ash manufacturers has further declined, the downstream customers’ willingness to take goods is high, and the relationship between supply and demand is in a tight balance.

　　"Some enterprises in the industry failed to put into production as scheduled for some reasons. At the same time, some soda plants are still running at reduced load, and the first batch of central eco-environmental protection inspectors in the third round nationwide have been fully launched, including some soda producing areas, which will further aggravate the tightening of the supply side. " The person in charge said.

　　Photovoltaic glass becomes the source of increasing demand.

　　From the supply side, at present, the new capacity of soda industry mainly comes from natural soda faucet. It is understood that the company has four production lines in the first phase of Alashan natural alkali project, with a planned production capacity of 5 million tons of soda ash and 400,000 tons of baking soda. The first production line has been put into trial operation at the end of June this year, the second production line has been put into trial operation at the end of September, and the third and fourth production lines will be put into trial operation one after another. By then, the company will have a soda production capacity of 6.8 million tons/year, ranking first in the industry.

　　Many people in the industry said that they are optimistic about the trend of soda ash in the near future. On the whole, the uncertainty of soda supply will continue to support the strong market. At present, the incremental change of downstream demand in the market is limited. Although the willingness of downstream replenishment has increased recently, the supply and demand structure of soda ash has changed relatively rapidly, and the market changes in the later period need further observation.

　　Relevant data show that from January to October this year, the apparent consumption of soda ash in China totaled 23.54 million tons, up 8.63% year-on-year. From the demand of industrial chain, the glass industry is still the biggest demand in the downstream of soda ash. "From the perspective of demand, the demand for float glass is the largest, which is mainly affected by real estate; In terms of increment, it is mainly on photovoltaic glass. " A person in charge of a soda production enterprise told the reporter.

　　It is understood that each ton of glass consumes about 0.2 tons of soda ash, accounting for 20% to 30% of the cost. In addition to traditional float glass, soda ash is indispensable. With the rapid development of photovoltaic industry, the demand for soda ash for photovoltaic glass is also growing rapidly. At the same time, high-end soda ash products can also be applied to lithium carbonate and so on.Industry, it takes about 2 tons of soda ash to produce 1 ton of lithium carbonate.

　　From the application classification, light soda ash is used for daily glass, sodium pyrosulfite, sodium silicate, metallurgy, printing and dyeing, water treatment and lithium carbonate, while heavy soda ash is used for flat glass and photovoltaic glass. The capacity distribution of manufacturers in light and heavy alkali is adjusted according to the downstream market demand and price quotation.

　　A number of interviewed production enterprise leaders said that at present, heavy soda ash accounts for a larger proportion in the products. Lithium carbonate, a popular downstream product, has seen a large price drop since this year. Although the related large enterprises started working normally, the overall operating rate of the industry is not high, and its contribution to the increment of light soda ash is limited.

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车系eπ008采用了流线型的前脸设计，前脸部分呈现出锋利的线条，营造出强烈的视觉冲击力。进气格栅采用了封闭式设计，凸显了其电动车型的身份。整体风格方面，eπ008呈现出未来感和科技感，外观线条简洁流畅，车身比例协调，令人眼前一亮。

eπ008的车身尺寸为5002*1972*1732mm，轴距为3025mm，前后轮距均为1650mm，这样的设计为车内提供了宽敞舒适的乘坐空间。车侧线条流畅动感，搭配265/45 R21的轮胎规格和时尚的轮圈风格，使整车更具运动气息。

eπ008的内饰设计以豪华与科技感并重，车内采用了大量的皮质材料，提升了整体的质感和舒适度。方向盘材质为皮质，支持手动上下和前后调节，提供良好的操控体验。中控台配备了15.6英寸的超大屏幕，内置先进的多媒体系统、导航、电话和空调控制功能，支持语音识别，提升了操作便捷性。前排配备了手机无线充电功能，方便日常使用。座椅采用仿皮材质，主副驾驶座椅均支持多种调节方式，包括前后调节、靠背调节、高低调节和腰部支撑调节，同时具备加热和通风功能，为驾驶者和乘客提供了舒适和健康的乘坐环境。前排座椅还配备了头枕扬声器，进一步提升了车内的娱乐体验。第二排座椅同样支持前后调节、靠背调节和腿托调节，增加了乘坐舒适度。后排座椅可以按比例放倒，为储物提供更大的空间。

eπ008搭载了一台1.5T 147马力的L4发动机，最大功率可达108kW，峰值扭矩为210N·m，配合电动车单速变速箱，为车辆提供了强劲的动力输出。

汽车之家车主对eπ008的外观赞不绝口，她表示：“外形很大气！前脸很帅！颜值高！开出去回头率很高！车标也简洁！”这些积极的评价无疑为eπ008增添了更多的魅力和吸引力。

　　Xinhua News Agency reporter Xie Rong

　　Russia is undoubtedly one of the most important players in the international political and military arena in 2016. Under the multiple unfavorable circumstances of poor domestic economy, persistent western sanctions and NATO’s military squeeze, Russia did not retreat but advanced, took the offensive as the defense, flexibly used its military power, and launched a fierce game with the United States and Europe in Europe and the Middle East, which improved its strategic environment to a certain extent.

　　Strategic breakthrough in circuitous Middle East

　　Russia put its main strategic breakthrough in Syria. In the autumn of 2015, Russia made a high-profile intervention in the Syrian war and gradually became a major participant in the Syrian war. In 2016, Russia invested more military forces, continued to send combat aircraft to Syria, deployed advanced air defense missile systems, and sent aircraft carrier combat formations to the Mediterranean, which greatly strengthened the air and sea strike force in Syria and helped the Bashar government to crack down on the Syrian opposition armed forces and extremist organization "Islamic State".

　　Russia’s unexpected military attack in Syria helped the Syrian government forces win the initiative on the battlefield. Before the end of this year, the Syrian government forces regained control of Aleppo, a strategic town long occupied by anti-government forces. The transfer of the dominance of the Syrian battlefield to the hands of the Russian and Bashar governments has greatly weakened the influence of the United States in leading the situation in Syria and the Middle East, while Russia’s voice and influence in the Middle East have greatly improved.

　　The symbolic significance of Russia’s strong involvement in the Syrian war is that it is the first time that Russia has deployed its military forces outside the former Soviet Union after the end of the Cold War. This strategic adjustment has opened up a new battlefield for the military and political game between Russia and the West.

　　Another significance lies in that Russia has keenly captured fighter planes, grasped the situation in Syria, gained Russian military strategic interests in the Middle East and the Mediterranean through limited military intervention, and countered the pressure exerted by the United States and Europe on Russia on the Ukrainian issue.

　　Against NATO, tit for tat

　　In the direction of Europe, the wrestling between Russia and NATO countries such as the United States became more intense in 2016. The conventional military forces of NATO countries are advancing near the western border of Russia, and they are also actively promoting the deployment of missile defense systems in Romania and Poland. In this regard, Russia did not show weakness, and tit for tat announced the formation of three divisions in the west, the deployment of S-400 air defense missile system and "iskander-M" missile in Kaliningrad, an enclave bordering Poland and Lithuania, and the deployment of "redoubt" shore-based anti-ship system and other weapons and equipment in the Baltic Fleet.

　　Russia’s new military deployment in Europe has formed a combination of land, air and coastal defense, which has turned the airspace around Russia, such as Central and Eastern Europe and Baltic countries, into a de facto "no-fly zone" and at the same time deterred the core areas of Europe and the US military bases in Europe.

　　The tough confrontation between Russia and NATO in Europe has caused observers to exclaim and warn of the "new cold war" from time to time. But on the other hand, there are differences and cracks in Europe on how to deal with Russia.

　　Strategic game for initiative

　　In the Far East Pacific, Russia is also strengthening its military deployment, including setting up a heavy bomber aviation division in the Far East and studying the deployment of a Pacific fleet base in the South Kuril Islands. Russia also decided to deploy a shore-based anti-ship missile system and a shore-based anti-ship missile system on the island after the country and the island of Chosun in the South Kuril Islands (called the four northern islands in Japan) to strengthen the overall defense capability of the Kuril Islands. Analysts pointed out that this is not only to meet the needs of the United States to increase its military deployment in the Asia-Pacific region, but also to guard against Japanese and put in order armaments.

　　In the direction of South Asia and Southeast Asia, Russia continues to maintain its strategic presence by deepening cooperation with India, Vietnam and other countries in the military and security fields.

　　The adjustment of Russia’s military strategy this year and its demonstrated actual combat capability have made western countries see Russia’s determination and strength to safeguard its own security strategic interests, and also made some political leaders in Europe and America realize the importance of dialogue with Russia. After winning the US presidential election, Trump showed his willingness to ease Russia-US relations. Russian President Vladimir Putin also expressed his willingness to improve relations with the United States and Europe in his latest State of the Union address.

　　Whether and to what extent Russia-US relations can be improved in the new year needs further observation. Undoubtedly, the adjustment and evolution of Russia’s military strategy will profoundly affect the development of relations between Russia and western countries, and will also have an important impact on the changes and reshaping of the international structure in the future.

Under the bombardment of domestic new energy vehicles round after round of "price war", is the once-popular joint-venture sedan ok now? Looking at the recent domestic car sales rankings, Nissan and Volkswagen, which had long dominated the list, have given up the top position, but thanks to the current substantial terminal concessions, their monthly sales have remained above 20,000, ranking third and fourth. It seems that consumers are still enthusiastic about them.

Let’s compare the entry models of these two cars and see what level the joint venture sedan with a terminal price of 70 thousand yuan is now.

Price comparison:

Nissan sylphy classic 1.6XE CVT comfort edition????

Manufacturer’s guide price: 108,600 yuan; market reference price: 71,600 yuan.

Volkswagen LaVida cutting-edge 1.5L automatic outstanding Xinyi Edition

Manufacturer’s guide price: 79,900 yuan; market reference price: 74,000 yuan.

Appearance contrast

The reason why Sylphy Classic is named "Classic" is because it is completely the previous generation model. After all, it was designed many years ago, and now it does look a little old. Fortunately, the family design of Nissan’s previous generation highlights the sense of luxury. The iconic middle net at the front of the car is somewhat smart with the rising headlights. The body lines are elegant and elegant, and the rear of the car is thick and steady. The whole car does not look cheap, and even many people think it is more atmospheric and durable than the new Sylphy.

LaVida Xinrui is a younger and more entry-level model divided from LaVida, and its prototype is actually a sedan previously launched by Volkswagen in India, Mexico and other markets. The model follows the popular family-style design and adds the latest design elements of the brand. The front of the car adopts the same starry front face with a low body posture, which adds some sports atmosphere to the whole car. It is worth mentioning that LaVida Xinrui offers five beautiful car colors, including turquoise and coral red, which are younger than Sylphy classics in appearance. There is also a small detail. LaVida is equipped with daytime running lights, while Sylphy Classic is also equipped with.

Interior contrast

Sylphy’s classic interior is also "classic" enough, and even a color screen can’t be found on this entry-level model. The traditional pointer instrument panel is simple and easy to read, and the multimedia in the central control is still like a knob radio, which can only realize the most basic "entertainment" function. The workmanship and materials are quite satisfactory. The top of the center console is wrapped in a large area of soft material. The entry model only has a plastic steering wheel, which feels ordinary.

LaVida’s cutting-edge interior design also adopts the popular family design language, matching various accessories from the popular unified mold, and there is not much new idea. In the configuration part, LaVida is obviously more sincere. The entry model is equipped with a dual-screen combination of an 8-inch full LCD dashboard and an 8-inch central control screen. The system supports mainstream multimedia functions and mobile phone interconnection functions such as Apple CarPlay. Although the steering wheel is also made of plastic, the overall practicability has been improved by adding multi-function buttons.

Spatial contrast

Space and ride comfort are the traditional advantages of Sylphy classics. Its length, width and height are 4631 mm, 1760 mm and 1503mm respectively, and its wheelbase reaches 2700 mm. Thanks to the larger body size and longer wheelbase, the head and leg space are excellent. In the comfort part, the label of "Japanese big sofa" is by no means a hollow reputation. The seat filling material is thick and soft, and the classic "sinking feeling" makes people who have sat there impressed. The fabric seat on the entry model looks ordinary, but the permeability and friction are actually better than ordinary leather materials. It is also worth mentioning that in the rear configuration, Sylphy Classic has more air conditioning outlets than LaVida, which is more friendly to the rear passengers.

The body length, width and height dimensions of LaVida are 4561, 1740 and 1494mm, respectively, and the wheelbase is 2651mm, which is slightly smaller than that of Sylphy Classic, but the actual interior space level is similar. The integrated front seat is more sporty, but the filling material is relatively thin and the sitting feeling is slightly harder. The same is true for the rear seats, and the statement of high emotional intelligence is "providing better support". As for the loading capacity of the trunk, both models performed well. Sylphy’s classic trunk has a larger space, reaching 510L, while LaVida’s new one is 498L, but it supports the whole back-laying function and has better expansibility.

Performance comparison

In the power part, Sylphy is equipped with a 1.6L naturally aspirated engine and matched with CVT transmission. The maximum power is 90kW and the maximum torque is 155 N m. The comprehensive fuel consumption of WLTC is 5.94L/100km, and only 92 # gasoline is needed. This powertrain is quite mature, and its performance can also meet the needs of daily transportation. Its excellent reliability, ride comfort and fuel economy contributed to Nissan’s dominance in the domestic family car market that year.

LaVida Xinrui is equipped with Volkswagen EA211-DRZ 1.5L naturally aspirated engine, matched with 6-speed automatic manual transmission, with a maximum power of 81kW and a maximum torque of 141N·m, and a comprehensive fuel consumption of WLTC of 5.98L/100km, and only 92 # gasoline is needed. LaVida’s new powertrain is also focused on reliability and economy. From the power parameters, it is slightly lower than Sylphy’s classic, which actually shows that it is between the real and the real.

In the chassis part, Sylphy classic adopts front McPherson independent suspension and rear trailing arm torsion beam independent suspension, and the overall adjustment is soft and comfortable. LaVida Xinrui also uses the former McPherson independent suspension and the rear trailing arm torsion beam independent suspension, but the overall adjustment is a little tougher. In addition, Sylphy Classic is equipped with 16-inch rims and rear wheel disc brakes, while LaVida Xinrui is only equipped with 15-inch rims, and the rear wheel is only equipped with drum brakes.

Safety comparison

In the security configuration part, LaVida has obvious advantages. Taking two entry-level models as examples, the front collision warning and active braking system that comes standard in LaVida’s new system is not common in the same class. At the same time, it has more practical driving assistance configurations such as reversing radar, uphill assist and cruise control than Sylphy’s classic, which can improve the daily car experience.

Purchase suggestion

Nowadays, although the parameters of these two models are not as good as those of domestic new energy rivals at the same level in terms of power performance and intelligent configuration, they can still occupy a place in the market with their high-quality reputation accumulated over the years, excellent reliability and affordable price.

Specific to these two entry-level models, LaVida Xinrui maintains the driving texture of German cars, with a solid and stable chassis, and at the same time has advantages in technology configuration and safety configuration, plus more fashionable design and color matching, which will be more attractive to young consumers. Sylphy Classic continues its advantages in comfort and economy. Although it is limited by the cost, the configuration is really not available, but overall, it is still a qualified and comfortable family car.

Have you found that the frequency of the recent listing of Link is very high and intensive? Following the release of a lot of product information from the first pure electric car, the 2025 Lexus 08 EM-P was officially launched on August 8, which not only added 245 long-life Pro version to the model version, but also ushered in the synchronous launch of OTA 1.6.0, adding 10+ functions and 80+ experience optimization. The increase will not increase the price, but how to choose the new six models this time? If you haven’t made up your mind, please read on!

As an annual redesigned model, the 2025 LECK 08 EM-P has not changed much in appearance compared with the old model. Between different versions, the main differences are pure electric endurance, driving form (two-wheel drive or four-wheel drive), intelligent configuration and so on.

Let’s talk about pure electric endurance. The top 220 four-wheel drive performance version adopts a plug-in hybrid system consisting of a 1.5T engine and dual motors, with a comprehensive power of 436kW, a system peak torque of 905nm, and an acceleration of 4.6s at 0-100km/h. With a capacity of 39.6kW, the CLTC has a pure electric endurance of 245km, a comprehensive endurance of 1,400km and a fuel consumption of 5.5l/100. Other versions, such as the 120-long-life Plus version and the 120-long-life Pro version, are configured with the front single motor, 280 kW, respectively matching the ternary lithium/21.2 kWh, and the pure battery life of CLTC is 120 km.

In addition, the 2025 LECK 08 EM-P also added the color scheme of "Dawn Blue" and upgraded the intelligent configuration, such as adding the functions of "sentry mode", water inlet monitoring, NFC key of mobile phone and so on. However, the top version will have four driving mode selection systems, one more off-road driving option, and other versions will be enough for daily use. Moreover, the 245 long battery life Halo and the 220 four-wheel drive performance Halo can be equipped with automatic parking, automatic lane change assistance, automatic driving assistance and other systems.

In addition to the entry-level version, the interior seat materials are all wrapped in leather. The whole system comes standard with electric adjustment of the main and auxiliary drivers, and the front seat is heated as standard. In addition to the entry-level version, other models also come standard with front seat ventilation and massage. The second row of some models also provides seat heating/ventilation/massage functions.

On the whole, on the basis of maintaining the consistency of the overall design language, each version of the 2025 Lectra 08 EM-P meets the needs of different users through different configurations and performance. Every consumer can buy a car according to his own needs, and it is recommended to go to a physical store for a test drive, so that he can better understand the model and better buy his favorite car ~