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Foreign trade, improving quality and making a good start.

General Secretary of the Supreme Leader stressed, "Expand foreign trade, cultivate new trade formats and new models, and promote the construction of a trade power." The outline of the 14th Five-Year Plan clearly puts forward "promoting the coordinated development of import and export", requiring "expanding the import of high-quality consumer goods, advanced technology, important equipment and energy resources", "optimizing the quality and structure of export commodities" and "guiding enterprises to deepen traditional export markets and expand emerging markets".

In the first year of the 14 th Five-Year Plan, the quality of China’s foreign trade has increased, achieving a good start.

"This is our latest CNC precision machining center, where raw materials go in and come out as finished products. The precision of holes and screws can be one percent of that of hair. " Hu Lijun, general manager of Zhejiang Cixi Boli Vehicle Co., Ltd. said that since this year, the production line has not stopped, and the order has been scheduled for April 2023.

Boli car owners want to produce high-grade bicycle brake systems, and the products are sold to Europe and South America. Affected by the COVID-19 epidemic, some countries encouraged people to travel by bike, which greatly increased the demand for bicycles. Now the company is running at full capacity, with a monthly output of 150,000 pieces, which still cannot meet the demand of foreign markets. The company’s output value last year was about 150 million yuan, and it is expected to exceed 200 million yuan this year.

"Grasping the current foreign trade business opportunities has benefited from the company’s continuous investment in product research and development and technological transformation in recent years." Hu Lijun said, "We invest more than 50% of our annual profits in research and development. Since last year, the company has invested more than 30 million yuan to transform equipment, reducing the product error rate to about one thousandth, which is at the leading level in the industry. "

According to the data released by the General Administration of Customs, in the first quarter, the total import and export value of China’s goods trade was 8.47 trillion yuan, an increase of 29.2% over the same period last year. Among them, exports were 4.61 trillion yuan, an increase of 38.7%; Imports reached 3.86 trillion yuan, up by 19.3%. In the first quarter, China’s import and export scale not only far exceeded the same period of last year, but also increased by 25.3% and 20.5% respectively compared with the same period of 2018 and 2019.

Foreign trade connects international and domestic markets and resources; The improvement of foreign trade can better smooth the domestic circulation, promote the domestic and international double circulation, and provide strong support for building a new development pattern.

Fill it up and cheer up. In the first year, the commerce, customs and other departments and localities conscientiously implemented the outline of the 14th Five-Year Plan, sought impetus from reform, sought vitality from innovation, actively responded to various unstable and uncertain factors in the international market, promoted the steady and high-quality development of foreign trade.

-expanding high-quality imports to meet domestic demand.

Hainan Duty Free Shop is popular! From February 11 to 17 this year, the sales of Hainan Island Duty Free Shop during the Spring Festival Golden Week in 7 days exceeded 1.5 billion yuan, which was fully doubled compared with the Spring Festival holiday in 2019.

In the middle of last year, the Ministry of Finance, the General Administration of Customs and the State Administration of Taxation issued an announcement to increase the duty-free shopping quota for tourists from outlying islands in Hainan to meet the demand for consumption upgrading. In 2021, all localities and departments will further reduce institutional costs, continue to expand imports of high-quality consumer goods, and promote diversification of import sources. At the same time, with the sustained and stable recovery of China’s economy, we will actively promote the import of high-tech products and energy and other basic materials. Customs data show that in the first quarter, China imported 155.27 billion integrated circuits, an increase of 33.6%; 139 million tons of crude oil, up by 9.5%; 1.436 million tons of copper, an increase of 11.7%.

-optimizing the commodity structure and increasing the added value of exports.

"We seized the consumer’s demand for home entertainment and launched new products with intelligent interaction and voice shopping functions, which suddenly became a fire in overseas markets!" The relevant person in charge of a technology company in Shenzhen said, "In the first two months of this year, the company’s exports reached 30 million US dollars. Electromechanical products such as smart speakers, vacuum cleaners, coffee machines, and electric hair clipper are highly sought after. "

This year, the Ministry of Commerce proposed to focus on the implementation of three major plans: excellent import and export, trade industry integration and smooth trade to ensure the stability and smoothness of the foreign trade industrial chain and supply chain; The General Administration of Customs has taken various measures to optimize supervision services and promote trade facilitation; The vast number of foreign trade enterprises highlight the core competitiveness of technology, brand and service, strive to optimize the quality and structure of export commodities, and cultivate new advantages in export competition. In the first quarter, China exported 2.78 trillion yuan of mechanical and electrical products, up 43%, accounting for 60.3% of the total export value, up 1.7 percentage points over the same period last year; Among them, the export of automatic data processing equipment and its parts, mobile phones and automobiles (including chassis) increased by 54.5%, 38.5% and 98.9% respectively.

-expanding emerging markets and enhancing the ability to resist risks.

Recently, 100 boxes of crisp dates with local characteristics produced and processed by Hebei Huanghua Tiantian Food Development Company were officially loaded and shipped, and sold to Brunei, a country along the Belt and Road Initiative, for the first time. "In the prevention and control of the epidemic, the relevant departments took the initiative to serve and visited the company many times to help us successfully explore new markets and stabilize foreign trade orders." The relevant person in charge of the company said.

At the beginning of this year, the Ministry of Commerce proposed the development of "Silk Road E-commerce", promoted the integration and development of new formats and new models such as cross-border e-commerce and jointly built the "Belt and Road", and added new momentum to the construction of trade corridors such as China-Europe trains and new land and sea passages. All localities, departments and related enterprises have further expanded the "friend circle" of economic and trade cooperation and continuously deepened economic and trade cooperation with countries along the "Belt and Road". In the first quarter, China imported and exported 2.5 trillion yuan to countries along the Belt and Road, an increase of 21.4%. Among them, imports and exports to Vietnam, Indonesia and Poland all achieved rapid growth.

-building an open highland and accelerating the development of new formats.

Not long ago, in Linyi Comprehensive Bonded Zone, Shandong Province, a batch of bonded R&D goods such as single-cell second-generation gel bead kits successfully entered the zone under the supervision of Linyi Customs, becoming the first bonded R&D project of genetic testing in Shandong Comprehensive Bonded Zone. "According to preliminary estimates, through bonded R&D business every year, light-related taxes can save hundreds of thousands of yuan, and our R&D motivation is stronger!" The person in charge of Shandong Kaihua Health Industry Company said.

Since the beginning of this year, the General Administration of Customs, together with relevant departments, has continuously expanded the policy functions of the comprehensive bonded zone, supported the construction of processing and manufacturing centers, R&D and design centers and logistics distribution centers, and accelerated the construction of a new highland for opening to the outside world. The Ministry of Commerce refines service measures, promotes enterprises in the cross-border e-commerce comprehensive test zone to integrate the whole chain of import, transaction and after-sales, and develops new foreign trade models and formats. All localities take the comprehensive bonded zone and cross-border e-commerce comprehensive test zone as platforms, actively attract leading enterprises to enter the zone, and drive the surrounding areas to gather upstream and downstream supporting enterprises. In the first quarter, the import and export of comprehensive bonded zone increased by 41.1%, the import and export of free trade pilot zone increased by 28.4%, and the import of duty-free goods in Hainan Free Trade Port increased by 162.5%.

"In the first quarter, China’s foreign trade achieved a high growth rate that has not been seen for many years, showing the strong resilience and vitality of China’s foreign trade." Liang Ming, director of the Foreign Trade Research Institute of the Research Institute of the Ministry of Commerce, said that it is necessary to scientifically analyze the foreign trade situation, correctly treat the fundamentals of foreign trade, seize opportunities and meet challenges, and promote the "good start" of foreign trade to become a year-round red and sustained red, so as to make greater contributions to speeding up the construction of a new development pattern with domestic macro-cycle as the main body and domestic and international dual-cycle promoting each other.(Reporter Du Haitao, Kelly, Gu Chun, Qi Zhiming, Luo Shanshan)

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Big ranking of consistency evaluation of pharmaceutical companies: Huahai, Shiyao, Yangzijiang …

Source | Cybertron Author | Xiao Wan

The varieties of 42 enterprises passed the consistency evaluation, among which Huahai Pharmaceutical, Unacon and Yangzijiang Pharmaceutical were the top three, followed by Hengrui Pharma, Jingxin Pharmaceutical, Haosen Pharmaceutical and Zhengda Tianqing.

42 pharmaceutical companies have reviewed varieties.

Now in mid-November, the overall progress of consistency evaluation has become the most concerned topic for all pharmaceutical companies. A few days ago, according to the incomplete statistics of CyberBlue, a total of 107 product specifications passed the consistency evaluation, among which 42 enterprises passed the consistency evaluation (the number of branches passed was included in the head office).

In statistics, one product specification of 18 pharmaceutical companies passed the consistency evaluation; Two of the 10 pharmaceutical companies have passed the consistency evaluation; Three varieties of seven pharmaceutical companies have been evaluated; Four varieties of three pharmaceutical companies have been reviewed; Four pharmaceutical companies have more than five product specifications.

(Source: Cyberblue)

Among them, Zhejiang Huahai Pharmaceutical Co., Ltd. passed the consistency evaluation, while Yangzijiang Pharmaceutical Co., Ltd. and Unacon Co., Ltd. passed the consistency evaluation, and Hengrui Pharma Co., Ltd. passed the consistency evaluation. Zhejiang Jingxin Pharmaceutical, Haosen Pharmaceutical and Zhengda Tianqing all passed the consistency evaluation.

The consistency evaluation of Zhejiang Huahai Pharmaceutical, Yangzijiang Pharmaceutical and Unacon has made rapid progress.

(Source: Cyberblue)

Huahai Pharmaceutical Co., Ltd.: Consistency Evaluation of Overtaking in Curves

According to the annual report of Huahai Pharmaceutical, Huahai Pharmaceutical has invested more in the over-evaluation research and development of irbesartan tablets, fosinopril tablets, lisinopril tablets and losartan potassium tablets.

The annual report shows that in 2017, the company’s R&D expenditure was 438.2377 million yuan, a year-on-year increase of 20.38%, accounting for 8.76% of the operating income of that year. The main reason is that the company has continuously increased the declaration and conformity evaluation of domestic new products, increased the R&D investment in biopharmaceuticals, new drugs, first imitation drugs, innovative pharmaceutical preparations, and accelerated the declaration of new products and models in markets such as the United States and the European Union.

Compared with other enterprises with more varieties, Huahai Pharmaceutical is characterized by adopting the form of "overtaking in corners"

—— Its overseas drugs with quality regulations enter the domestic market through supplementary application for domestic listed varieties and direct application for four kinds of new drugs overseas, and only need to BE declared with overseas listed test data, which will greatly reduce the cost and time of declaration compared with similar products enterprises that need to do BE experiments in China.

For example, its valsartan tablet is the first oral preparation of Huahai Pharmaceutical, which has been listed in Europe and America, and it is deemed to have passed the consistency evaluation if it is declared with overseas data.

Cebolan made statistics on the disclosure announcement of Huahai Pharmaceutical. Except for its product "Voriconazole Tablets", its R&D cost is an important basis for the company’s sales pricing in the US market. The important cost data is corporate trade secrets, and the R&D investment data has not been disclosed.

The total R&D investment of the remaining 9 evaluated varieties of Huahai Pharmaceutical is 44.08 million.

Among them, valsartan tablets have the largest R&D investment of 16.6 million, followed by donepezil hydrochloride tablets with 9.25 million R&D investment.

(Source: Cyberblue)

Unacon: Both are the first enterprises that have been appraised.

According to the statistics of Cybertron, Unacon has passed 7 product specifications and 5 varieties.

Unacon’s semi-annual report shows that the company has been actively promoting consistency evaluation. At the same time, make full use of the opportunity brought by consistency evaluation, strive for greater market share for products, and establish strategic cooperation with core distributors to expand and sink the terminal market to primary medical institutions.

Unacon didn’t disclose its R&D expenses, but according to the statistics of Cybertron, all the evaluated varieties in Unacon were "enterprises that passed the conformity evaluation for the first time".

Metformin hydrochloride: According to the data, metformin, as the most widely used oral hypoglycemic agent in clinic, has been crowned as the "magic medicine". Therefore, according to the statistics of Medical Rubik’s Cube, as a 289 variety, there are as many as 130 drug approval numbers for metformin, including 116 metformin hydrochloride tablets, 8 metformin hydrochloride enteric-coated tablets, 4 metformin hydrochloride enteric-coated capsules and 2 metformin hydrochloride capsules. The consistency evaluation of metformin is bound to be a "drama".

Among them, Unacon submitted its domestic listing application on the condition of "listing in the United States". On July 24th, Unacon’s metformin hydrochloride tablets obtained the registration approval of CFDA, and were officially approved for listing, taking the lead in evaluating the consistency of metformin.

Paclitaxel for injection (albumin-bound): In July, Paclitaxel for injection (albumin-bound) produced in Unacon (trade name Ke Aili) has been included in the Catalogue of Listed Drugs in China. Ke Aili has completed the clinical BE test before applying for new drug registration, and it is deemed to have passed the consistency evaluation, so it can be used instead of the original research product. In this declaration, Unacon surpassed Hengrui, who is known as the "First Brother in R&D", and won the first imitation.

Captopril Tablets: On July 3rd, Captopril Tablets (25mg) produced by Unacon Ouyi Pharmaceutical Company passed the evaluation of the consistency of generic drug quality and efficacy. Unacon Ouyi Pharmaceutical Co., Ltd. became the first enterprise to pass the consistency evaluation of Captopril tablets.

Tramadol Hydrochloride Tablets: On May 21st, Unacon announced that the group’s "Chimet" (tramadol Hydrochloride Tablets (50mg)) has been approved by china food and drug administration to pass the consistency evaluation of generic drug quality and efficacy, becoming the first enterprise in China to pass the consistency evaluation of this variety. It is reported that tramadol Hydrochloride Tablets are one of the key products of the group’s analgesic drugs.

Azithromycin tablets: On April 12th, Unacon announced that the group "Weihong" (azithromycin tablets (0.25g and 0.5g)) had passed the consistency evaluation of generic drugs, becoming the first enterprise in China to pass the consistency evaluation. It is reported that azithromycin tablets are one of the key products of the group’s anti-infective drugs.

Yangzijiang Pharmaceutical: Sustained efforts in mid-2018

Up to now, according to the statistics of Cybertron, seven specifications and five varieties of Yangzijiang Pharmaceutical have passed the consistency evaluation, among which five varieties of amlodipine besylate tablets, montmorillonite powder, glimepiride tablets, enalapril maleate tablets and dexmedetomidine hydrochloride injection have been evaluated.

In the carding process, Ceibaran found that all the remaining varieties passed the consistency evaluation from June to September 2018 except Enalapril Maleate Tablets which were reviewed in September 2017, and Yangzijiang Pharmaceutical continued to exert its strength and continuously reviewed in mid-2018.

(Source: Cyberblue)

From this, it can be seen that the style of Yangzijiang Pharmaceutical Co., Ltd. is to accumulate wealth and make thin hair. At a certain stage, it will exert its strength and continuously evaluate many varieties. When the 289 deadline is coming, Yangzijiang may be accumulating strength and making a big move, which is worth looking forward to.

To sum up, 42 enterprises have varieties that have passed the consistency evaluation, among which Huahai Pharmaceutical, Unacon Pharmaceutical and Yangzijiang Pharmaceutical are the top three, followed by Hengrui Pharma Pharmaceutical, Jingxin Pharmaceutical, Haosen Pharmaceutical and Zhengda Tianqing, and the deadline of 289 is coming soon. All pharmaceutical companies should pay close attention to it.

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Announcement of Bid Winning Results of Security Outsourcing Service Project of Financial Network of Tongchuan Branch

Publicity of the bid-winning result of security outsourcing service project in financial outlets of Tongchuan Branch

(TenderNo.: SY2025-37/XBMH2025-076)

 

 

 

A, the winning bidder information:

Bid (package) [001] Security outsourcing service project of financial outlets of Tongchuan Branch:

中标人: 陕西京武保安服务有限公司(主供应商)?xa0;?xa0;  其他类型中标价:单价报价

中标人: 陕西汇丰保安服务有限公司(备选供应商)  其他类型中标价:单价报价

二、其他:

(一)陕西京武保安服务有限公司(主供应商)投标单价报价:8.4 元/工时,服务期:2 年。 (二)陕西汇丰保安服务有限公司(备选供应商)投标单价报价:8.43 元/工时,服务期:2 年.

三、监督部门

本招标项目的监督部门为中国邮政集团有限公司陕西省分公司纪委办公室

四、联系方式

招 标 人:中国邮政集团有限公司陕西省分公司

?xa0;  址:陕西省西安市高新区唐延路 5 陕西省邮政大厦 系 人:文琰童

?xa0;  话:029-88602048 电子邮件:/

 

招标代理机构:陕西西北民航工程咨询有限公司

?xa0;  址: 西安市唐延路 3 号唐延国际中心 AB 8/9

联 系 人: 佘冰霞、张恒

?xa0;  话: 029-88347987-8046

电子邮件: 745496892@qq.com

 

 

 

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Hit your face hot? Chloe Bennet, a shock wave woman, was selected as the seven goddesses of Marvel Comics in the year.

Stills of Chloe Bennet’s "Aegis Secret Service"


1905 movie network news Recently, some netizens found that Chloe Bennet’s MV "Tonight" starring in the popular group BIGBANG accidentally bumped into Dilraba, and many netizens said that "both of them have exquisite facial features and are indeed somewhat similar".

Chloe Bennet and Dilraba were both born in 1992. One is of mixed blood between China and the United States, and the other is of Uygur nationality. The same exotic customs make them have certain similarities in appearance.Chloe Bennet is a typical actress of European and American models, while Dilraba is a small flower of the new generation in China. In essence, their routes and development directions are different.


Comparison between Chloe Bennet and Dilraba


Chloe Bennet, a post-90s Chinese actress, won high popularity and attention for her role as the heroine "Shockwave Girl" Skye. Recently, some netizens launched the "Seven Goddess of Marvel Comics of the Year" selection campaign, and Skye, the "Shockwave Woman" played by Chloe Bennet, was on the list. Some netizens commented: "This super-powerful heroine that was missed has finally been discovered, and her strength really does not lose the black widow!" .

In the play, Chloe Bennet’s "Shobo Girl" is Nick Frey’s right-hand man. At the age of 18, she has the tenth security clearance of SHIELD. She is the only agent with this clearance except Frey and the Black Widow, and she is also the youngest agent in the history of SHIELD. Although in Marvel comics, Shobo Girl is a member of the reunion, but in the drama, Shobo Girl played by Chloe Bennet has become a substitute for the reunion.

Chloe Bennet’s Stills of S.H.I.E.L.D. Agents


After six auditions, Chloe Bennet finally got the chance to play in the sci-fi action drama "Agents of S.H.I.E.L.D.", in which she played the beautiful female agent "Shobo Girl", who was very lovable because of her independent and confident personality and super skills, and was nominated as "the best TV actress in the world" by virtue of this role in the 15th Huading Award.

In addition to her superpowers, "Shobo Girl" is proficient in fighting and sniper, and is good at performing undercover tasks. In order to play the role of "Shock Girl", fitness has become an indispensable part of Chloe Bennet’s daily life.

With the discussion of Chloe Bennet bumping into Dilraba increasing, Chloe Bennet recently took photos on social media, saying that she will come to Beijing in the future. Some netizens speculated that the Chinese actress born in the 1990s will return to China for development in the near future. Let’s wait and see!

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Faye Wong sang heavily at the end of "Passing Through Your World"

    Zhang Jiajia’s original work/screenwriter, directed by Zhang Yibai, starring Deng Chao, starring Bai Baihe, starring Yang Yang, Crystal, Yun-peng Yue, Du Fu and Ada, and the film with the strongest IP and the strongest cast will be released on September 29th. A few days ago, Faye Wong, the queen of heaven, contributed to the film by singing the ending song "You Wait for me at the Terminal", and told the audience a delicate and gentle love story with an ethereal and tactful "voice of nature".

The Chinese music world’s top lineup devoted itself to Chen Xiaoxia’s composition and Yao Ruolong’s lyrics.Zhang YadongAs a producer

    After the theme song "Don’t Say" of "Passing Through Your World" was released, the movie "Passing Through Your World" made another heavy attack and released the ending song — — "You Wait for me at the Terminal" sung by Tianhou Faye Wong. This time, Faye Wong narrated the meeting, passing by and the end point in the movie with a heavenly "girlish voice", telling the story that people who are intoxicated with love are willing to pay for love, and even take the initiative to fulfill each other, only to find that their lover is waiting at the end point. The creative lineup of this song is very luxurious, composed by Chen Xiaoxia, the composer of classic hot songs such as Ten Years, Agreement and He doesn’t Love Me, and written by Yao Ruolong, ci writers of Taiwan Province, known as the "lover singer" who won the best lyricist award in the 6th and 7th Taiwan Golden Melody Awards in succession. The cooperative relationship between them for more than 20 years and Zhang Yadong, the "master of music", as the producer, made the super lineup of the music world create golden songs again.

   In this exposed MV, with Faye Wong’s ethereal and clear singing, the stories of the protagonists also change with the ups and downs of the songs, which is memorable. "You gave me an umbrella", the piano and strings were gently brought in, and the sweet songs sounded slowly. The heavy rain in the picture poured down like the loneliness in Chen’s heart and Mo’s heart. In the chorus, "I’ve been following the footsteps of your mood", the mood slowly warmed up. Chen and Yao Ji looked at each other on the rooftop, litchi and Mao Shiba slowly walked to the church in the snowy grassland, and pig heads and swallows strolled around the campus, as if their love began to sprout with the song, and then gradually strengthened. "You are waiting for me at the end, and live in your heart", the first chorus ends, the piano, strings and drums suddenly get excited, and the light rail in Chongqing, a "mountain city", shuttles through the city. The pictures of the leading actors running and embracing each other and the more intense dramatic conflict paragraphs flash one after another, and the song gradually enters the next climax, and the mood is also blazing. "Those twists and turns and sentimentality are all wings, all to fly to your shoulders", which seems to symbolize that their love is about to usher in a happy ending after going through countless difficulties and "passing by". "Passing through your world, I am Chen Mo". Finally, in the monologue of Deng Chao and others, the song comes to an end.The lingering sound is unforgettable.

Faye Wong sang the theme song of Zhang Yibai movies for three times, and the annual emotional giant broke the ice for the film market. 

    This song "You Wait for me at the Terminal", the ending song of the film "Passing Through Your World", is the third collaboration between Wang Fei and director Zhang Yibai after singing the theme song "Because of Love" with Eason Chan and the theme song "In a hurry that year" with the same name. This time, Faye Wong performed with a girl’s voice of "reverse growth", which made the audience feel extremely surprised. Every time they cooperate, they will attract the attention of the film and music circles and get extraordinary achievements, which will become a hot topic of public discussion and add a lot of color to the film. With the joint efforts of the strongest IP and the strongest cast, and the blessing of the ending song "You Wait for me at the Terminal" sung by Faye Wong, I believe the film will definitely make the audience shine.

    This year’s film market was cold after the Spring Festival, and the trend of box office was worrying. In this regard, the original/screenwriter Zhang Jiajia and director Zhang Yibai expressed great confidence in the performance of the film Passing Through Your World in the National Day. They not only thought that the film was "the best romantic film in the past decade", but also believed that the film could break the ice for the film market in 2016, drive a new wave of watching movies, and make everyone expect more from this annual emotional giant.

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On Children’s Day, these films are worth watching with parents and children.

Today’s "Children’s Day" is the day when the "God beast" comes out! In the hot summer, parents who are not only afraid of their children suffering from heatstroke outdoors, but also want to go out to play with their children, if they are still in distress, might as well take them to the cinema for a fantasy adventure of mind and vision! Even if there is no time for "moving bricks" during the day, it is also a good choice to accompany the "beasts" at home after work, blowing air conditioning together and watching a parent-child movie clearly.

What parent-child movies are shown in this "June 1" and what classics are worth revisiting?

#1

Classic parent-child movies

The enlightenment of life is not limited to children.

1. "Journey to the Dream Ring"

Introduction to the film

On the way to pursue his musical dream, the little boy met his grandfather who had died for many years, and thus entered the world of the undead.

Ghosts in the undead world are not scary at all. On the contrary, they are cute and interesting, very pleasing to children, and they also bring their own brave buff.

Recommended reason

Death was originally a topic that adults are very shy about, but death is the end point that everyone can’t avoid. This is a film suitable for enlightening children with the concept of life and death, and we can tell them that death is not the end of life, but forgetting.

2. Ne Zha

Introduction to the film

The world always says that good and evil are at odds, the good is always good, and the bad is always bad, but The Magic Boy’s Coming to the World just breaks the rules. Whoever is unfair by fate is qualified to fight it to the end and change his life! The affection in the film is even more touching.

Recommended reason

It is reasonable to abandon the traditional image, but it is subversive. Compared with the end of the old story, the Magic Child focuses on writing juvenile rebellion and family affection, which deserves people’s aftertaste and deep thought.

3. Zootopia

Introduction to the film

The story constructs an animal utopia, where animals coexist peacefully without killing and injury. However, animal city has strict rules, and the relationship between races is not as good as expected.

The protagonist Judy, a weak herbivorous rabbit, dreams of being a policeman who punishes evil and promotes good. You know, it has always been the territory of large carnivorous animals.

Everyone thinks Judy is dreaming, but with unremitting efforts, she graduated from the police school with the first place. After many tests, she finally got a foothold in Animal City. ……

The relationship between different races in Animal City has also changed from the initial tit-for-tat to the handshake.

Recommended reason

If you don’t know how to describe the adult world to your children, this film may help you.

This film shows children a real world that is easy to understand and recognize by way of fable, so that they can gradually get in touch with the rules of the adult world while maintaining their innocence.

The film has been emphasizing one sentence: everyone can do anything.

4. My Neighbor Totoro

Introduction to the film

Miyazaki Hayao, a famous Japanese cartoonist, is one of his representative works, with colorful pictures and touching stories. The feelings between the two little heroes and the love between their father and mother are naturally expressed. The big dragon cat is cute and warm, and the children will love it very much.

Recommended reason

It views, interprets and explores the world from the perspective of childlike innocence, regardless of whether the audience is children, teenagers or naive adults.

There is a big foundation of loneliness, fear and suffering in My Neighbor Totoro’s story, and the core of this film is to dissolve and rebuild-to dissolve loneliness with warmth, to dissolve fear with magic, to dissolve suffering with happiness, and to build up independent courage on this basis!

5. Charlotte’s Web

Introduction to the film

The film is adapted from the novel Charlotte’s Web by American writer E·B· White, and tells the story of a cute little pig Wilbur who tries to avoid being made into a big meal with his animal friends.

Recommended reason

This film tells children to be honest and trustworthy and bravely say no with the help of cute animals around them.

Xiao Mao, who translated the original novel of this film, once said that Charlotte’s Web just wrote a story that happened in a year. The four seasons on the farm are like the four stages of life: the joys and sorrows are all in it, which changes with the opening and closing of the plot. Finally, the prosperity and noise finally come to an end, and the tragedy and comedy are all over, leaving only a dull and endless life.

6. Travel Notes of Flying House Ring

Introduction to the film

The animated film "Travels around the Flying House" tells the story of an old man who once agreed with his wife to travel to a waterfall in remote South America, but failed to make it because of the rush of life. It was not until the government forced the demolition of his old house that he decided to fly to the waterfall with his house and take risks with Russell, the little fat man he met.

Recommended reason

There are children and old people in the film, there is a generation gap and integration, and there are dreams and losses. Love and dreams, courage and hope will always go with you.

7. Inside Out

Introduction to the film

Riley, a little girl, grew up under the care of her parents and lived a happy and fulfilling life every day.

Until one day, her parents took her away from her hometown. The empty apartment, strange school and lost friendship all made Riley’s negative emotions begin to accumulate. She didn’t know what was wrong with her.

In fact, all this is related to the five little people who live in Riley’s brain. They are Lele, Anger, Worry, Disgust and Fear, which control the five emotions of human beings.

In order to make Molly happy, Lele, who is in charge of happiness, began to guard against other emotional worries and others, but the result was not satisfactory. Molly’s inner world was not happy again, and the original good memories gradually collapsed.

Recommended reason

I recommend this movie because we adults and children always subconsciously reject, control and suppress negative emotions.

But in fact, Inside Out personified the five emotions in his brain with his imagination, telling you that happiness is not the only theme of life.

There is no difference between high and low emotions. What we have to do is not to destroy them, but to learn to live in peace with them.

8. "Wrestle! Dad

Introduction to the film

Indian national wrestling champion Singh gave up wrestling because of life. He hoped to have a son to help him fulfill his wish, but he had no choice but to give birth to four daughters. Singer, who thought her dream was broken, unexpectedly found her daughter’s amazing talent for wrestling, so she decided to let her daughters: change their skirts, cut off their long hair, practice wrestling and win one championship after another …

Recommended reason

"Your father is fighting against the whole world for your future", and behind the painful training is actually a love encouragement and education.

After reviewing the classics, let’s take a look at the cinema parent-child movies that have been released or will be released soon!

#2

Cinema parent-child film

Science fiction and adventure ignite the dream of innocence.

Doraemon: Daxiong and the Ideal Country of the Sky

Type: Animation Adventure

Release time: 2023-06-01 09:00

Synopsis:

Sky adventure, let’s go! Doraemon Doraemon and Nobita are driving the "Led Zeppelin of Time" with the function of time jumping. In order to find the dreamland that everyone once imagined, such as Atlantis and Miyagi, which many adventurers have dreamed of since ancient times, they launched an adventure in the air. ……

Castle in the Sky

Type: animation adventure family fantasy

Release time: 2023-06-01 08:00

Synopsis:

Baru, an apprentice mechanic, accidentally met Hida, a girl who fell from the sky. Her life is mysterious and she holds a flying stone that can open Laputa, the city of the sky. In the pursuit of the dual forces of the military and pirates, Baru and Hida finally found the legendary city of the sky, which also revealed the secret of the decline of this ancient empire that once had advanced technology and great wealth.

God and daddy

Type: children’s inspirational

Release time: June 1, 2023

Synopsis:

In April, 2020, Shendoudou children’s clothing store was forced to close its business. A Luo, who wanted to go back to his hometown for fun, saw his daughter going to kindergarten for a while, but the kindergarten was temporarily closed, so he chose to take her four-year-old daughter for a ride to Lhasa.

Adventures of Qiaohu Fantasy Stage

Type: adventure

Release time: June 1, 2023

Synopsis:

It was a little white tiger girl named Mary who starred in the hat captain of the magic show group. Unfortunately, the tent of the magic show group was messed up by naughty Xiao Bu and his friends. When the head of the orangutan was about to cancel the show, Qiaohu took his little friends and invited big friends and children from Qiaohu Island to help. On the other hand, Mary, who plays the captain of the hat, has no confidence in her performance. Qiaohu takes on the responsibility of encouraging Mary, but he and Mary are accidentally sucked into the magic bag. They found that there was a hole in the magic bag.

The little mermaid

Type: love

Release time: May 31, 2023

Synopsis:

Inspired by the well-known fairy tales of Andersen, the film features Ai Lier (Halle Bailey), a naive, brave and rebellious mermaid. Eager to explore the world beyond the sea, she falls in love with human prince Alec (Jonah Hauer-King). Ai Lier follows his inner voice, goes against tradition, and makes a deal with the evil undersea witch Ursula (Melissa McCarthy Melissa McCarthy) in exchange for the opportunity to experience human life, only to find that he and his father are in extreme danger.

Spider-Man: The Universe.

Genre: comedy/science fiction/animation/adventure

Release time: June 2, 2023

Synopsis:

The film tells the story of Spider-Man Myers (voiced by Shameik Moore Shameik Moore) and Gwen Spider (voiced by Hailee Steinfeld Hailee Steinfeld), a new generation, crossing the multiverse and embarking on a more grand adventure journey. Facing the fate that every Spider-Man will lose his loved ones, Myers vowed to break the curse of fate and find his own heroic road. This decision is in great conflict with the Spider Alliance led by Spider-Man 2099 (voiced by Oscar Is aac in oscar isaac), and a civil war in Spider-Man with one enemy and one hundred enemies is about to start!

Comprehensive cover news editor Cai Yuting

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North American box office: "Star Wars 8" won six new films in a row, and the "brave" won.


1905 movie network news Last weekend (12.22-12.24), the box office revenue in North America totaled $169 million, down 38.9% from the previous week. Disney’s strong trump card "Star Wars 8: The Last Jedi Knight" continued to win the weekend box office list with $68.64 million, but compared with the previous week, it suddenly dropped by 68.8%, which was a bit surprising. Fortunately, its own box office base is, and now the local box office has reached 365 million US dollars, and the global box office has reached 745 million US dollars. It is expected that there will be another good-looking "soaring" after the subsequent opening of paintings in mainland China.

 

In terms of new films, Dwayne Douglas Johnson starred in the highest box office, earning $50.6 million in 3,765 cinemas in five days. There are emotional blessings in word of mouth, but it is also very stable, and it is considered to be entertaining, so it is good to grasp the balance between comedy and action. As the final part, it can’t compare with the brilliance of the second part. It only got $20.45 million in 3,447 cinemas in three days over the weekend, and it was evaluated as "out of tune"! The box office of Hugh Jackman’s musical films is weak, with a total box office of $13.19 million in five days. The evaluation is seriously polarized. Those who like it think it is "full of sincerity" and "perfect and passionate", while those who don’t love it accuse it of being empty. Directed by alexander payne and starring Matt Damon, they also failed to make a difference, earning $4.6 million at the box office in three days, and receiving a moderate evaluation: "I don’t feel the fullness of the story itself". Small-scale screening won $495,000 in nine theaters in three days, with an average box office of 55,000 in a single theater, which was relatively mediocre, but the media evaluation was well maintained. From the short comments, most American media expressed their preference for Steven Allan Spielberg’s brand and basically praised its "practical significance".

ranking

film

Weekend box office

(USD)

Cumulative box office

(USD)

Number of release weeks

this week

last week

one

one

Star Wars: The Last Jedi

6864ten thousand

3.65a hundred million

2

2

new

Jumanji: Welcome to the Jungle

3400ten thousand

5060ten thousand

one

three

new

perfectTone 3

2045ten thousand

2045ten thousand

one

four

new

circusKing of kings

860ten thousand

1319ten thousand

one

five

2

Bulladventures

705ten thousand

2653ten thousand

2

six

three

Coco

5.2 million

1.613a hundred million

five

seven

new

shrinklife

4.6 million

460ten thousand

one

eight

16

Darkest Hour

4.1 million

695ten thousand

five

nine

new

Father image

320ten thousand

320ten thousand

one

10

twelve

Water substancelanguage

305ten thousand

761ten thousand

four

11

four

Miracleboy

2 million

1.149a hundred million

six

twelve

11

Saintbe bornStar

137ten thousand

3846ten thousand

six

Data source:boxofficemojo


Stills of "Brave Game"

"The Brave Game" is full of emotional skills. "Perfect Tone 3" is out of tune.

 

Recommended star rating for Brave Game: ★★★

"Perfect Tone 3" recommended interstellar: ★★★

"Father Image" recommended Star: ★★★

 

Sony Colombia "played" 34 million dollars in 3,765 cinemas for three days on the weekend, and the total box office for five days (the film opened last Wednesday) was 50.6 million dollars. Dwayne Douglas Johnson came out of the gloom of its earlier fiasco, which can be compared with the same period in 2007 (the first week’s box office was 44.78 million US dollars, and the final domestic box office was 219 million US dollars). At present, the word-of-mouth is very strong. If this trend continues, the final domestic box office of Game of the Brave: Battle of the Jungle is expected to reach 175 million US dollars. The film is a sequel to robin williams’s classic The Brave Game in 1995. The production cost is 90 million US dollars, and now the global box office has exceeded 100 million US dollars. It is likely to become Sony’s highest-grossing film in China except 007 and Spider-Man series, and the global box office will also become a rare "highlight" after 2015.

 

The movie Game of the Brave: Battle of the Jungle scored 7.2 in IMDb, 58 in MTC, 77% in freshness of rotten tomatoes, and 89% in audience. "International Screen" commented: "It is entertaining, fascinating, bright in color, ingenious in action and adventure rhythm, and well-arranged in comedy effect." Hollywood Reporter: "The most attractive thing about this film is that you can watch familiar actors pretend to be ordinary children and try to adapt to this new self." Vanity Fair holds that: "Movies can strike a balance between action and comedy. Action design serves the plot, and it is not too flashy. The special effects have also distanced themselves from the previously shoddy monkeys. The comedy elements are cleverly rooted in the characters themselves, and they are not cheap to imitate and follow fixed patterns." Some media that don’t like it, such as Variety, spit out: "This is like watching the worst, except that there is no Indiana Jones."

 

Universal’s Perfect Tone 3 earned $20.45 million in 3,447 theaters in three days on the weekend, which is completely inferior to the $69 million in the first week. If it can be suppressed first and then promoted like that ($75 million in the first six days and $270 million in the final box office), the final box office is expected to reach $150 million. If it’s really the last movie, it’s still a good ending. From the word of mouth, the media and fans also hope that "Perfect Tone 4 or 5" will not disturb people’s peace again. The movie Perfect Tone 3 now has an IMDb score of 6.1, an MTC score of 40, and the freshness of rotten tomatoes is 29%. "Empire" magazine thinks: "Compared with the jokes in the first two films, it is much weaker, so it drags on to a warm-hearted ending. But it’s all right to end the trilogy like this. After all, it has already started to be framed in fantasy. "International Screen" thinks: "This film finally realizes how ridiculous it is. All the cheerful and stupid plot settings are mostly to make them smoothly transition to the next song or dance. It is hard not to feel the hardship of this film." Hollywood Reporter: "No matter how charming the first two movies are (mainly because of the charm of the leading role), they have lost their charm in this soulless sequel." Chicago Sun: "In a nutshell, Perfect Tone 3 is like a comeback show that no one calls encore."Seattle Times: "It’s just the same movie going back and forth. Is it going to be over until everyone dies?" The Los Angeles Daily directly said: "Out of tune!"

 

Warner Bros., this year’s big winner, released another film "Father’s Image" near the end of the year, which earned 3.2 million dollars in 2,902 cinemas in three days on weekends. At present, the IMDb score of Father Image is 5.4, the MTC score is 23, and the freshness of rotten tomatoes is 22%. "Hollywood Reporter" thinks: "The whole narrative is from one encounter to the next. In fact, the image of the father doesn’t need to exist at all. If it has to appear, it can actually be developed into a Netflix series by a more comic star, and each suspicious father will talk for half an hour." San Francisco Chronicle: "Such a flawed film is simply not worth two hours." In fact, a lot of bad word-of-mouth has flowed out before the release. It can only be said that Warner’s market is doing too well, and many ordinary fans are still "laughing" with joy.

Next page:The King of Circus and Narrowing Life are mediocre, and Washington post has strong practical significance.

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Ministry of Natural Resources: Resolutely prevent the phenomenon of changing the planning of a party committee and government.

  CCTV News (Reporter Liu Liang):On May 27th, the State Council Office held a press conference on "Several Opinions of the Central Committee of the Communist Party of China and the State Council on Establishing Land Spatial Planning System and Supervising its Implementation" (hereinafter referred to as "Several Opinions"). Zhao Long, Vice Minister of the Ministry of Natural Resources, Zhuang Shaoqin, Chief Planner of the Ministry of Natural Resources, and Zhang Bing, Deputy Director of the Land and Space Planning Bureau of the Ministry of Natural Resources, introduced the relevant situation of the Opinions and answered questions from reporters.

  Zhao Long said at the meeting that the national land spatial planning is a guide for national spatial development, a spatial blueprint for sustainable development, and a basic basis for all kinds of development, protection and construction activities, and the CPC Central Committee and the State Council attached great importance to it. On January 23 this year, the Sixth Meeting of the Central Committee for Comprehensively Deepening Reform deliberated and adopted "Several Opinions on Establishing a Land Spatial Planning System and Supervising its Implementation", which was officially issued. Zhao Long emphasized the four main contents of Several Opinions at the meeting.

  First, implement the major decision-making arrangements of the CPC Central Committee and unswervingly promote the "integration of multiple regulations"

  Since the founding of New China, especially since the reform and opening-up, all kinds of spatial planning at all levels have played an active role in supporting the rapid development of urbanization and promoting the rational utilization and effective protection of land space. However, there are also problems such as too many types of planning, overlapping and conflicting contents, complicated approval process, too long cycle, and frequent changes in local planning. In order to solve these problems from the system and mechanism, according to the deployment of the CPC Central Committee, the National Development and Reform Commission, the former Ministry of Land and Resources, the former Ministry of Environmental Protection, and the Ministry of Housing and Urban-Rural Development jointly carried out the pilot work of "multi-regulation integration" at the provincial and municipal levels, and accumulated valuable experience. On this basis, the CPC Central Committee made a major decision to set up the Ministry of Natural Resources, realize "multi-regulation integration", establish a land and space planning system and supervise its implementation. The Ministry of Natural Resources will continue to adhere to the Party’s leadership in planning, unswervingly promote and implement "multi-regulation integration" according to the set goals, form "one plan, one blueprint", establish a unified examination and approval system, implementation supervision system, laws and regulations policy system and technical standard system, build a unified basic information platform, form a "one map" of national land space development and protection, and implement various arrangements of "Several Opinions" to achieve higher quality of land space development and protection.

  Two, adhere to the scientific preparation, strict supervision.

  It is necessary to improve the scientific nature of planning. Implement the new development concept, adhere to the people-centered principle, promote high-quality development, scientifically and orderly plan the ecological, agricultural and urban space on the basis of the evaluation of the carrying capacity of resources and environment and the suitability of land space development, delimit the red line of ecological protection, permanent basic farmland, urban development boundary and other control boundaries, optimize the layout of land space structure, protect ecological barriers, carry out ecological protection and restoration, improve infrastructure and public service facilities, continue the historical context, and highlight regional characteristics. It is necessary to strengthen the authority of planning and implementation supervision. Once the plan is approved, it will have legal effect. No department or individual may modify it at will or change it in violation of regulations, and resolutely prevent the phenomenon of changing the plan for a new party committee and government. Insist on planning first, then implementing, and prohibit illegal construction; Adhere to the statutory procedures to modify the plan, strict examination and approval. For violations of laws and regulations in the process of the preparation and implementation of land and space planning, we must seriously investigate the responsibility.

  Third, adhere to the "streamline administration, delegate power, strengthen regulation and improve services" reform and strive to improve administrative efficiency

  Actively implement the requirements of the CPC Central Committee and the State Council to promote the transformation of government functions and deepen the "streamline administration, delegate power, strengthen regulation and improve services" reform. In the process of planning approval, we should reduce the number of cities submitted to the State Council for approval, and at the same time, streamline the content of planning approval according to the principle of "approving whatever is in charge", focusing on controlling review from the aspects of target positioning, bottom line constraint, controlling indicators and neighboring relations, greatly reducing the approval time and improving administrative efficiency; It is necessary to combine the "multi-regulation integration", promote the "multi-examination integration" and "multi-certification integration" of land use approval and planning permission, effectively optimize the business environment, and reflect the reform effect of "multi-regulation integration".

  Four, adhere to the linkage from top to bottom, multi-party cooperation, for a long time, a blueprint to the end.

  The release of "Several Opinions" marks the basic formation of the top-level design and "four beams and eight columns" of the national land spatial planning system. It is a systematic project to establish a national unified, clear-cut, scientific and efficient national spatial planning system, which cannot be achieved overnight. It is necessary for all localities and departments to follow the arrangements of the CPC Central Committee and the State Council, clarify the objectives and requirements, implement the main responsibility, and form a joint force with the spirit of nailing for a long time, and work out a blueprint to the end.

  Finally, Zhao Long said, the Ministry of Natural Resources will strengthen overall planning and coordination, earnestly take responsibility, work with relevant departments to plan the overall layout in accordance with the overall framework of the land and space planning system, constantly improve the system design, step up the establishment of the land and space planning system and supervise the implementation, plan every inch of land clearly and clearly, and form a land and space pattern with intensive and efficient production space, moderate living space, beautiful ecological space, safety, harmony, competitiveness and sustainable development, which will make the CPC Central Committee and the State Council’s major.

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Investigation and Research | Gene Mutation Must Be a Disaster?

Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?

The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.

Harm.

What is gene suppression?

Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.

"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.

Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.

Yeast substitution experiment

"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.

But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.

"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.

Narrow the search scope of mutant genes

The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.

Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.

"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.

The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.

The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?

Jolanda:At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.

The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.

Jolanda:Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.

The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?

Jolanda:We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.

The PaperWhat do you think is the most important significance of this research?

Jolanda:The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.

(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")

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Hong Kong Morning Post | Significantly abolish employees over 35 years old? Xiaomi rumors!

  [Review last week]

  Hong Kong stocks performed strongly in early trading last Friday, but the bulls failed to hold their advantage in the afternoon. The Hang Seng Index closed down 0.59, and the Hang Seng Science and Technology Index rose nearly 2% in early trading, and the closing increase narrowed to 0.29%.

  On the disk, JD.COM Q1′ s performance was bright, and its share price rose over 7%, leading the strength of weighted technology stocks; Film and television entertainment stocks, power stocks and mobile game stocks rose.

  On the other hand, the price of gold fell at a high level, and the non-ferrous metal plate fell; Collective adjustment of the concept stocks of China Special Appraisal Company.

  [capital flow]

  Last Friday, southbound funds sold a net of HK$ 235 million. SMIC ranked first in net purchases and first in net sales.

  Short-selling data are as follows:

  [breaking news]

  90% of employees over the age of 35 are laid off? Xiaomi responded: rumors

  Recently, some netizens posted on social media: "The second headquarters of a certain meter in Wuhan officially announced that 90% of employees over the age of 35 will be laid off." This statement quickly fermented on the Internet, and some netizens speculated that it was Xiaomi Group.

  In response to the above rumors, Wang Hua, general manager of the public relations department of Xiaomi Group, responded in Weibo on May 14th. "Last night, there were reports on social media platforms that employees over 35 years old in our Wuhan headquarters only kept 10% of the information, which were all rumors after investigation. Now the legal department of the company has obtained evidence for relevant information and reported it to relevant departments. "

  Xu Jiayin became the executor.

  On the evening of May 12th, China Evergrande announced that it had received an enforcement notice from the Guangzhou Intermediate People’s Court on the arbitration award of Shenzhen International Arbitration Court. The Company, its subsidiary "Guangzhou Kailong Real Estate" and the executive director Xu Jiayin are the executors of the enforcement notice. According to the execution notice, the items to be executed are:

  (1) Guangzhou Kailong and Mr. Xu paid the balance of dividends of Evergrande Real Estate in 2020 to make up about RMB 204 million, and assumed the liquidated damages of about RMB 51.53 million;

  (2) Mr. Xu and the company bought back the equity of Evergrande Real Estate held by the arbitration applicant for RMB 5 billion;

  (3) The compensation paid by the company to the arbitration applicant from February 1, 2021 to the completion of the repurchase is about RMB 770 million;

  (4) The Company, Guangzhou Kailong and Mr. Xu paid about RMB 35.53 million in legal fees, arbitration fees and execution fees.

  The total valuation of 47 projects of Evergrande Auto 2 yuan "Sale" exceeds 60 billion.

  On May 12th, Evergrande announced that the shareholders’ meeting had agreed to sell its 47 real estate projects to China Evergrande and its subsidiaries. This means that Evergrande has completed the divestiture of real estate business and focused on the new energy vehicle business. Evergrande Automobile will concentrate resources to fully guarantee the R&D and production of Hengchi.

  According to the announcement, the two parties signed an agreement to transfer all the issued shares of Huibao and Flaming Ace under Evergrande Automobile, covering 47 existing health space projects of Evergrande Automobile Group, including 21 Evergrande Health Valley projects, 5 Evergrande Health City projects and 21 various property development projects.

  After the completion of the sale, Evergrande no longer holds any rights and interests of the above two companies, and it is estimated that it will record a sale income of about 24.789 billion yuan.

  According to the unaudited data provided by Evergrande Automobile, as of December 31, 2022, the net liabilities of projects such as Health Valley to be sold were 24.789 billion yuan, and the project valuation was about 60.1 billion yuan. In 2022, its income was only about 1.5 billion yuan, and its net loss after tax reached 8.824 billion yuan.

  Large shareholder clearance and evacuation? Vida International Emergency Response

  Recently, there is market news that the Swedish company Essity, the controlling shareholder of Vida International, announced that it is considering selling the shares of Vida International; Fuan International, controlled by Li Chaowang, the second largest shareholder and chairman of the board of directors of Vida International, intends to acquire Essity.

  On May 14th, Vader International published a voluntary announcement, saying that the Board of Directors had not received any latest information about the review of Essity strategy.

  [Company News]

  1. (): In the first four months, the accumulated original premium income was 108.343 billion yuan and 71.543 billion yuan respectively through Taiping Life Insurance and Pacific Property Insurance, which decreased by 2.9% and increased by 16.0% respectively.

  2. Ping An in China: In the first four months, the premium income of the original insurance contract was about 100.459 billion yuan, 208.185 billion yuan, 8.214 billion yuan and 5.849 billion yuan respectively through Ping An Property Insurance, Ping An Life Insurance Company of China, Ping An Endowment Insurance and Ping An Health Insurance, totaling about 322.707 billion yuan, up 5.93% year-on-year.

  3. Baekje Shenzhou: The revenue in the first quarter was 3.066 billion yuan, a year-on-year increase of 57.4%; During the period, the total product revenue was about 2.808 billion yuan, a year-on-year increase of 69%; The net loss attributable to shareholders was about 2,446.6 million yuan, a year-on-year decrease of 14.64%. Mainly due to the sales growth of self-developed products and authorized products.

  4. (): The subsidiary plans to invest 2.5 billion yuan to build a new energy lithium battery production research and development project in Xiangyang.

  5. (): It is planned to invest in a new battery-grade lithium hydroxide production base project with an annual output of 30,000 tons in Zhangjiagang Free Trade Zone, with an estimated annual income of not less than 2 billion yuan.

  6. R&F Property: In the first four months, the accumulated contracted sales were 9.02 billion yuan, down 49.18% year-on-year, of which the contracted sales in April were 1.66 billion yuan, down 61.12% year-on-year.

  7. Hejing Taifu Group: The contracted sales in April was 3.231 billion yuan, a year-on-year decrease of 25.8%; The sales area was 144,000 square meters, a year-on-year decrease of 29.8%.

  8. Good Boy International: Revenue in the first quarter decreased by 17.5% year-on-year to about HK$ 1.842 billion, and decreased by 14% year-on-year in terms of constant currency.

  9. CGNPC New Energy: The subsidiary intends to sell all the shares of Nantong Meiya, and the initial public bidding price is about 420 million yuan.

  [repurchase dynamics]

  1. AIA: It spent about HK$ 132 million to buy back 1.652 million shares at a repurchase price of HK$ 79.55-81.3.

  2. HSBC Holdings: It spent about HK$ 147 million to repurchase 2.5 million shares at a repurchase price of HK$ 58.40-58.95.

  3. (): Chongqing Water Investment Group increased its holdings of 35.0092 million A shares, with a total shareholding ratio of 7.013%.

  4. (): It is planned to buy back 1.5 billion to 3 billion yuan of A shares for the implementation of the company’s employee stock ownership plan.