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Special feature of 1905 film network The film is the director’s second feature film. It won two awards, namely "Best Director Honored in Fei Mu" and "Best Director Honored by Young People" at the 5th Pingyao International Film Festival, and was also nominated for the biweekly director unit of the 74th Cannes Film Festival and the rookie film competition of the 46th Hong Kong International Film Festival.

The film tells the story that the crew of the film "Yong ‘an Town Tales" stayed in the shooting location, which brought a little wave to this originally quiet town. However, after the wave, everything returned to peace. The whole film is divided into three chapters — — Waiting alone, looking beautiful, The Moment of Pluto.

01. Three seemingly ordinary stories

In terms of content, The Tales of Yong ‘an Town stirred up ripples in a quiet town with three seemingly ordinary stories. Although there are no great waves in these stories, the inner drama conflict of each character makes the whole film full of profound meaning.

The first chapter, Waiting Alone.

The proprietress (decoration) of a restaurant in Yong ‘an Town suddenly came to the film crew in the town, and her heart began to stir, eager to break the original boring life day after day. Being chosen as a fitting model by the crew made her feel that she could be the heroine, but with the arrival of the real heroine of the film, the bubble of longing was punctured and she returned to her original life.

The second chapter, "It looks beautiful"

The actress chenchen (act the role of actress) was hindered in her career progress, so she took the opportunity of filming a new film to return home. She originally wanted to go back to her hometown to find the lost past and relive the old warm time, but she found that the warm hospitality of her childhood friends or the reunion of her first love after a long separation when she was young actually had other purposes, and going back to the past was just her wishful thinking.

The actress who can’t go back to her hometown and the proprietress who can’t leave the town, two women who seem to have completely different status, also have the same predicament and sorrow.

The third chapter, The Moment of Pluto.

The filming is about to start, but the director (decoration) and the screenwriter (decoration) are still arguing over the revision of the script and the shaping of the actors. Based on artistic ideas, commercial considerations and other factors, they are constrained by each other and finally fail to get an ideal script when they start.

The collision of their creative views not only reflects the dilemma of the current creators, but also includes the conflict of the previous two stories, which are progressive and interlocking.

The three parts will connect the behind-the-scenes of the film preparation, and also turn Yong ‘an Town into a microcosm of the real society, where everyone wants to have a little "different life". But the movie doesn’t tell you what the right answer is. It just shows every choice of life. When life is dispersed by the occasional ripples, what should people do?

02. A movie about movies

In terms of creative techniques, Yong ‘an Town Tales takes "metafilm" as the creative concept and co-ordinates a three-stage narrative structure.

The concept of "meta-film" is simply to explain "movies about movies", that is, to directly quote, draw lessons from or refer to movies related to other movie texts or movies themselves. Many well-known films are of the narrative structure of "metafilm", such as director, director and director, etc.

And the ingenuity of this film is to make what we see and experience just right. The main content of the film is that a crew entered Yong ‘an Town to prepare a film "Yong ‘an Town Tales" which happened in Yong ‘an Town, and it was this "Yong ‘an Town Tales" that we watched.

Through the dialogue between the director and the screenwriter in the film, we can know that the content of Yong ‘an Town Tales, which is planned to be filmed in the film, is that a hotel proprietress who wants to change her quiet life and a pair of first loves meet again after several years, and what we see on the screen is exactly an uneasy proprietress and a pair of men and women who meet again in Yong ‘an Town after many years. In other words, Yong ‘an Town Tales are actually the same movie both on and off the screen.

There is also a very interesting time shift in this film. The last scene of the film is the launching ceremony of Yong ‘an Town Tales, and for the audience, this film has just been finished. This setting of "play in play" has brought a richer impression to the audience. A large number of directors and screenwriters’ discussions about plot creation in the film have become the creators’ interpretation of our audience’s plot, which is like watching a movie with a "sound" barrage.

In terms of content and creation, The Tales of Yong ‘an Town is not so much a literary film as an absurd comedy film. When we see the end of the Tales of Yong ‘an Town, it seems that we can appreciate the artistic charm of this kind of "if you don’t say it".

Nothing may have happened in Yong ‘an Town, but we saw the hope of future Chinese films in the Tales of Yong ‘an Town.

　 　 Special feature of 1905 film network　On March 13th, a film starring Song Hye Kyo and Jiang Dongyuan was released in the Mainland. The film tells a warm story between a young parent and a child suffering from premature senility. Recently, film directors Li Zairong and Song Hye Kyo accepted an exclusive interview with 1905 Film Network, and said that three films will be shown in mainland China one after another recently. Song Hye Kyo said that this does not mean that he will focus on China.

　

　 　 Song Hye Kyo, 33, is affectionately known as "Qiao Mei" in China. Plump, Plump, My Life is the first time that Qiao Mei plays a mother. She can play a 17-year-old high school student in the film, and the next scene will become the mother of a 16-year-old child who is plain. In this regard, Song Hye Kyo admits that it is not too difficult for her to play the role of mother, but when asked if she wants to be a mother in reality, she said that she is not ready. Song Hye Kyo also revealed that if she becomes a mother, she will make friends with her children.

　

Qiao Mei is not ready to be a mother. If she is a mother, she will be friends with her children.

　 　 In My Life, Song Hye Kyo plays a mother who is pregnant at the age of 17 and has a 16-year-old son. In the film, she sometimes appears as a mother, and sometimes returns to the youthful high school student style, which surprises fans who like her. For the first time, Song Hye Kyo did not find it difficult. "In fact, there is not much difficulty in the role of mother. I personally care more about the difficulty of acting, which is the most difficult."

　 　 It is not difficult for Song Hye Kyo to play the role of mother in the play, but outside the play, she admits that she is not ready to be a mother. For getting married and having children, 33-year-old Song Hye Kyo said that she is not young. She has considered these questions. "I am not sure if I am qualified to be a mother." However, Song Hye Kyo revealed, "I think I will be the kind of mother who is like a friend with my children, and I will be strict if necessary."

　 　 1905 Movie Network: In the movie, your modeling is very simple, and your appearance is basically plain. Will you not get used to it?

　 　 Song Hye Kyo: First of all, because of the needs of the role, Merlot’s modeling was decided through discussion and screening by the director, the costume group and the makeup group. Because of the needs of the role, only such an appearance can meet the character of Merlot, and there is not much burden. I have been asked before whether there will be any burden and pressure to appear on the screen as a plain face, because the role setting is like this, so there is not much pressure in this respect. My style in the picture is plain and my hair is simple, so it is more convenient to do it. It takes only 5 minutes to prepare and it is easier to shoot at that time.

　

　 　 1905 Movie Network: Is it difficult to play Mom for the first time?

　 　 Song Hye Kyo: I discussed this role with the director before shooting. Director Li Zairong is a very careful director. Before shooting, we had a lot of time to discuss it together. Together with the director, actors and other staff, the preparatory work was very good. No matter the role or the film, I have made good preparations, so there is not much difficulty in the role of mother. In fact, I personally care more about the difficulty of acting, which is the most difficult for me, such as emotional drama. Fortunately, this drama is more relaxed than I expected. The mother I played is a mother like a friend, not a mother like a friend as everyone thinks, which makes people feel very kind.

　

　 　 1905 Movie Network: 17-year-old Milo chooses the latter between her dream and her children. What would you choose?

　 　 Song Hye Kyo: Actually, I have been asked this question many times, and I have thought about it many times. While filming, I also wondered what I would do if I really faced the same situation as Milo. I think Milo and Daxiu are a great couple and can be responsible for their children. If such a thing really happens to me, I don’t know if I can treat it as well as Milo. This is a very difficult situation. Now I’m not sure if I can break through the predicament like Milo.　

　 　 1905 Movie Network: How do you evaluate your acting skills now?

　 　 Song Hye Kyo: Actually, every actor, no matter who he is, will never be 100% satisfied with his performance in the play, and so am I. I try my best to play my role well, but I can also see my shortcomings, and I will try my best to modify my shortcomings and imperfections.

　 　 1905 Movie Network: If you become a mother in the future, will you be a "strict mother" or a mother like Milo?

　 　 Song Hye Kyo: I think I should be the kind of mother who is like friends with her children. I will be strict if necessary, but I think my children should be more obedient.

　 　 1905 Movie Network: Will you want to be a mother after this play? Do you have any plans to get married?

　 　 Song Hye Kyo: Melo in the movie is a very cheerful personality. Although the movie as a whole is a very sad story, I will be more cautious about my mother’s identity, and I will have very careful thoughts and concerns. Although I’m not young now, I’m not sure if I’m qualified to be a mother.

Song Hye Kyo said that the focus is not on China: China market is a good opportunity.

　

　 　 Li Zairong, the director who has directed movies such as,,, and, has a variety of styles. Regarding his new work, My Life, he said, "Although the theme of this movie is not the same as my previous one, I can discuss aging and death through this story, which is what I am worried about now." "My Life" is also Li Zairong’s first film released in China. He thinks that the scale of China’s film market is unimaginable in South Korea, and it is also a very good opportunity for him.

　

　 　 Recently, for China fans, there are many opportunities to see Song Hye Kyo on the big screen. In addition to The Grandmaster 3D at the end of last year, my life plopped plopped plopped, and Taiping Wheel (Part II) met with the audience one after another in the first half of this year. Previously, Song Hye Kyo had revealed that she had no intention to enter Hollywood, but she seemed to prefer the China market. However, Song Hye Kyo said in an exclusive interview that she had not shifted her focus to China, and it was a coincidence that three films were released one after another.

　 　 1905 Movie Network: I feel that now you focus on China. Why?

　 　 Song Hye Kyo: As far as I know, "I am the Queen" was supposed to be released at the end of last year, and it was delayed until the first half of this year, so it happened that three films were released this year. It seems that I shifted my focus to China, but it is not. Whether it’s China or South Korea, if there is a movie I like, I will shoot it. It’s not that I shift my focus to China or South Korea, so I will keep doing it.

　

　 　 1905 Movie Network: You have shot many different types of movies before. Why do you want to put this story on the screen?

　 　 Li Zairong: A few years ago, the original novel of this movie was very popular in Korea. I read this novel at that time, and when I read it, I thought it might be difficult to present the story on the big screen. Later, I suggested to a producer I was familiar with, "How about making this story into a movie?" So, I read this novel again. Although the theme style of this film is not quite the same as my previous one, I can discuss the problems of getting old or dying through the story of this family, which is what I am worried about now.

　

　 　 1905 Movie Network: "Plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop, plop

　 　 Li Zairong: Actually, when I shoot this story, I feel that life can’t always be happy. Sometimes there needs to be sadness and separation. Only when it is difficult to face sadness with a smile can I feel that life really exists. It is more suitable for me to present my life through the stories of my warm family. If such a sad story is expressed in a sad way, the audience may look tired and feel dark inside, and it seems easier to express the audience in a happy way.

　

　 　 1905 Movie Network: How many box office do you expect this movie to have in China?

　 　 Li Zairong: Personally, it’s the first time for me to have my own film shown in China. On my way here, I heard that this time "My Life" was shown in China with a scale of 5,000 screen blocks. I also hope that my film will be successful in China.

　

　 　 1905 Movie Network: What do you think of China movie market? Like Song Hye Kyo, there have been many collaborations with director China in recent years. Do you have any plans in this regard?

　 　 Li Zairong: China’s films have developed very fast, and the market is also very large. Many films have been produced and shown, and some Korean directors with high quality projects are also very interested. I also have a lot of exchanges in this respect. The scale of China is unimaginable in South Korea, and the film market in China itself is a very large market, which I think is a very good opportunity.

　 　 Shin Eun kyung hasn’t appeared on the big screen since she starred four years ago, and this new film starring her also makes fans who care about her very much look forward to it. She plays the role of Shixi in the film, in order to get revenge on the usurers after the family break-up, she throws herself into this dark world and turns into a cold witch, planning to take full control of the usury company.

　　Mao Weiming, male, Han nationality, born in May 1961, is a native of Quzhou, Zhejiang Province. He joined the work in August 1982 and joined the Communist Party of China (CPC) in September 1985. He holds a bachelor’s degree in engineering and is a professor-level senior engineer.

　　Main experience:

　　From October 1978 to August 1982, he studied chemical machinery in the Department of Chemical Engineering of Zhejiang University.

　　From August 1982 to February 1987, technician and deputy director of the technical department, chief engineer’s office, technical transformation infrastructure department of Changzhou Insulating Materials General Factory, Jiangsu Province;

　　From February 1987 to August 1991, secretary of the Communist Youth League Committee, deputy director of the technical office and workshop director of Changzhou Insulating Materials General Factory in Jiangsu Province;

　　From August 1991 to March 1992, Assistant Director and Head of Sales Department of Changzhou Insulation Material General Factory in Jiangsu Province;

　　From March 1992 to April 1993, Deputy Director of Changzhou Insulating Materials General Factory, Jiangsu Province;

　　From April 1993 to December 1993, the director of Changzhou Insulation Material General Factory in Jiangsu Province;

　　From December 1993 to March 1996, the director and secretary of the Party Committee of Changzhou Insulation Material General Factory in Jiangsu Province (during the period: from June 1995 to December 1995, he participated in the economic research class for senior management talents in Jiangsu Province and went to the University of Maryland for training);

　　From March 1996 to October 1998, Director and Deputy Secretary of the Party Committee of Changzhou Foreign Economic and Trade Commission, Jiangsu Province;

　　From October 1998 to December 2000, deputy secretary and mayor of Wujin Municipal Committee of Jiangsu Province;

　　From December 2000 to September 2001, Secretary and Mayor of Wujin Municipal Committee of Jiangsu Province;

　　From September 2001 to November 2001, member of the Standing Committee of Changzhou Municipal Committee of Jiangsu Province, secretary and mayor of Wujin Municipal Committee;

　　From November 2001 to April 2003, member of the Standing Committee of Changzhou Municipal Committee of Jiangsu Province and deputy mayor (during the period: from June 2002 to September 2002, he participated in the training course for senior talents in public administration of Harvard University);

　　From April 2003 to January 2004, Deputy Secretary and Acting Mayor of Taizhou Municipal Committee of Jiangsu Province;

　　From January 2004 to December 2005, deputy secretary and mayor of Taizhou Municipal Committee of Jiangsu Province;

　　From December 2005 to November 2011, director and party secretary of Jiangsu Provincial Development and Reform Commission;

　　Secretary-General of Jiangsu Provincial People’s Government from November 2011 to January 2013;

　　Deputy Governor of Jiangsu Province from January 2013 to October 2013;

　　From October 2013 to July 2015, deputy minister and member of the party group of the Ministry of Industry and Information Technology;

　　From July 2015 to August 2015, the Standing Committee of Jiangxi Provincial Party Committee;

　　From August 2015 to September 2015, the Standing Committee of Jiangxi Provincial Party Committee and the Deputy Secretary of the Party Group of the Provincial People’s Government;

　　From September 2015 to January 2020, member of the Standing Committee of Jiangxi Provincial Party Committee, deputy secretary of the Party Group of the Provincial People’s Government and executive deputy governor;

　　From January 2020 to November 2020, Chairman and Party Secretary of State Grid Corporation;

　　From November 2020 to January 2021, Deputy Secretary of Hunan Provincial Party Committee, Party Secretary, Deputy Governor and Acting Governor of Provincial People’s Government;

　　January 2021-present Deputy Secretary of Hunan Provincial Party Committee, Party Secretary and Governor of Provincial People’s Government.

　　Alternate member of the 19th Central Committee.

　　(Resume source: Hunan Provincial People’s Government Network)

　 　　Zhang Jiajia’s original work/screenwriter, directed by Zhang Yibai, starring Deng Chao, starring Bai Baihe, starring Yang Yang, Crystal, Yun-peng Yue, Du Fu and Ada, and the film with the strongest IP and the strongest cast will be released on September 29th. A few days ago, Faye Wong, the queen of heaven, contributed to the film by singing the ending song "You Wait for me at the Terminal", and told the audience a delicate and gentle love story with an ethereal and tactful "voice of nature".

The Chinese music world’s top lineup devoted itself to Chen Xiaoxia’s composition and Yao Ruolong’s lyrics.Zhang YadongAs a producer

　　　　After the theme song "Don’t Say" of "Passing Through Your World" was released, the movie "Passing Through Your World" made another heavy attack and released the ending song — — "You Wait for me at the Terminal" sung by Tianhou Faye Wong. This time, Faye Wong narrated the meeting, passing by and the end point in the movie with a heavenly "girlish voice", telling the story that people who are intoxicated with love are willing to pay for love, and even take the initiative to fulfill each other, only to find that their lover is waiting at the end point. The creative lineup of this song is very luxurious, composed by Chen Xiaoxia, the composer of classic hot songs such as Ten Years, Agreement and He doesn’t Love Me, and written by Yao Ruolong, ci writers of Taiwan Province, known as the "lover singer" who won the best lyricist award in the 6th and 7th Taiwan Golden Melody Awards in succession. The cooperative relationship between them for more than 20 years and Zhang Yadong, the "master of music", as the producer, made the super lineup of the music world create golden songs again.

　　　In this exposed MV, with Faye Wong’s ethereal and clear singing, the stories of the protagonists also change with the ups and downs of the songs, which is memorable. "You gave me an umbrella", the piano and strings were gently brought in, and the sweet songs sounded slowly. The heavy rain in the picture poured down like the loneliness in Chen’s heart and Mo’s heart. In the chorus, "I’ve been following the footsteps of your mood", the mood slowly warmed up. Chen and Yao Ji looked at each other on the rooftop, litchi and Mao Shiba slowly walked to the church in the snowy grassland, and pig heads and swallows strolled around the campus, as if their love began to sprout with the song, and then gradually strengthened. "You are waiting for me at the end, and live in your heart", the first chorus ends, the piano, strings and drums suddenly get excited, and the light rail in Chongqing, a "mountain city", shuttles through the city. The pictures of the leading actors running and embracing each other and the more intense dramatic conflict paragraphs flash one after another, and the song gradually enters the next climax, and the mood is also blazing. "Those twists and turns and sentimentality are all wings, all to fly to your shoulders", which seems to symbolize that their love is about to usher in a happy ending after going through countless difficulties and "passing by". "Passing through your world, I am Chen Mo". Finally, in the monologue of Deng Chao and others, the song comes to an end.The lingering sound is unforgettable.

Faye Wong sang the theme song of Zhang Yibai movies for three times, and the annual emotional giant broke the ice for the film market.　

　　　　This song "You Wait for me at the Terminal", the ending song of the film "Passing Through Your World", is the third collaboration between Wang Fei and director Zhang Yibai after singing the theme song "Because of Love" with Eason Chan and the theme song "In a hurry that year" with the same name. This time, Faye Wong performed with a girl’s voice of "reverse growth", which made the audience feel extremely surprised. Every time they cooperate, they will attract the attention of the film and music circles and get extraordinary achievements, which will become a hot topic of public discussion and add a lot of color to the film. With the joint efforts of the strongest IP and the strongest cast, and the blessing of the ending song "You Wait for me at the Terminal" sung by Faye Wong, I believe the film will definitely make the audience shine.

　　　　This year’s film market was cold after the Spring Festival, and the trend of box office was worrying. In this regard, the original/screenwriter Zhang Jiajia and director Zhang Yibai expressed great confidence in the performance of the film Passing Through Your World in the National Day. They not only thought that the film was "the best romantic film in the past decade", but also believed that the film could break the ice for the film market in 2016, drive a new wave of watching movies, and make everyone expect more from this annual emotional giant.

　　Cctv newsOn July 21, the State Council held a press conference to optimize the birth policy and promote the long-term balanced development of the population.

　　At the meeting, Yu Xuejun, deputy director of the National Health and Wellness Commission, said that the population problem is the biggest problem in the country. The CPC Central Committee and the State Council have always attached great importance to it, always adhered to the comprehensive decision on population and development, constantly improved the birth policy based on the basic national conditions of the population, and embarked on a road with China characteristics to solve the population problem. Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has focused on the overall situation of economic and social development and the new changes in population development, made a strategic plan to gradually improve the birth policy and promote the long-term balanced development of the population, and successively implemented the two-child policy and the the universal two-child policy, and achieved positive results.

　　In recent years, new changes have taken place in the population situation of our country. The fertility level is declining year by year, and the population growth rate continues to slow down. The people have encountered practical difficulties in fertility, parenting and education, especially affected by the COVID-19 epidemic, and the population situation is more complicated. General Secretary of the Supreme Leader has given important instructions for many times, stressing that population development is a major issue related to the development of the Chinese nation, and demanding that the research on the birth policy and population development trend be deepened, the population development strategy be improved, and the birth policy be gradually improved according to the changing situation of China’s population development. The Fifth Plenary Session of the 19th CPC Central Committee proposed to implement the national strategy of actively responding to the aging population, optimize the birth policy and enhance the inclusiveness of the birth policy, and made a series of arrangements in the 14th Five-Year Plan.

　　In accordance with the requirements of the central government’s deployment, the National Health and Wellness Commission, the National Development and Reform Commission and other relevant departments set up special work classes, organized a number of scientific research institutions and experts in various fields, comprehensively utilized various data to conduct in-depth research, carried out multi-scheme comparison and demonstration, widely listened to opinions and suggestions from all walks of life, and gathered consensus from all parties. In particular, the data of the seventh national census provided timely, comprehensive and scientific data support for the central scientific decision-making.

　　"Look, how beautiful our carefully designed math tabloid is."

　　Nanjing Daily News (Reporter He Jie) "What is mathematics? Is it a boring number, symbol or formula? " "Mathematics is a wonderful and vivid story." In the morning meeting on Thursday, the students in Xianlinhu Campus of Jinling Primary School spoke freely and described the interesting mathematics in their hearts. Last week was the fourth "Mathematics Story Collection" activity week in Xianlinhu Campus of Jinling Primary School. During the activity week, children were active in colorful mathematics activities and deeply understood the fun of mathematics.

　　The children in the lower grades are lively and active, and their attention is hard to last. They mainly play, use a matchstick to start a jigsaw puzzle, easily master "addition and subtraction" and fall in love with mathematics; Middle-grade students already have the ability to think deeply. They make mathematical tabloids and write and perform stage plays. In the problem-solving contest, children are clear-headed and calm, and overcome one math problem after another. Senior students, on the other hand, take the class as the unit, unite and cooperate in the math literacy contest to win glory for the class. "The Mathematics Literacy Competition not only tests everyone’s observation and thinking ability, but also requires us to master mathematics knowledge in an all-round way." Meng Chun, a sixth-grade student in the school, said that the "Math Story Collection" activity week turned him into a complete "math fan" who had always been uninterested in mathematics.

　　Why do children love math so much? As the planning organizer of the "Mathematics Story Collection" project, Hua Qin, the vice president of the school, told reporters that in order to cultivate students’ interest in mathematics, the school launched the "Mathematics Story Collection" project as early as 2015, including classroom reading, lesson discussion, Hujiang online class, reading sharing, activity week and school magazine publicity, and insisted on taking "stories" as the carrier, with the help of reading, performance, discussion and discussion. In this way, children are more and more interested in mathematics. The fourth "Math Story Collection" activity week is also a platform for children to show their elegance and improve their self-confidence.

Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?

The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.

Harm.

What is gene suppression?

Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.

"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.

Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.

Yeast substitution experiment

"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.

But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.

"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.

Narrow the search scope of mutant genes

The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.

Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.

"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.

The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.

The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?

Jolanda：At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.

The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.

Jolanda：Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.

The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?

Jolanda：We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.

The PaperWhat do you think is the most important significance of this research?

Jolanda：The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.

(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")

Special feature of 1905 film network After 20 days of release, the box office of "Fengshen Part I" exceeded 1.7 billion, and the total box office was predicted to increase from 1.25 billion at the lowest point to 2.45 billion, nearly doubling.Maybe, directorWu ErshanFinally, I can say:"sealGodOut of the ICU.

At the same time, on the evening of August 8th, several leading actors, such as Yu Shi, Na Ran, Chen Muchi and Shan Jingyao, also made a surprise appearance in the live broadcast room of Liu Genghong. The "Proton Group" showed the war dance and joyful dancing, and the topic kept on.

"You have one vote, I have one vote to help Master Wen buy a high-speed rail ticket", "You don’t vote, I don’t vote, Yin Jiao will never have a head!" …

Never being optimistic, it is expected to compete for the second place in the summer box office. The starring role is from unknown to popular. How can "tap water" help "Fengshen" to complete the box office counterattack? How do online and offline announcements open the "road to sealing the gods" with a "two-pronged approach"?

"Tap water" helps "the road to sealing the gods"　

Different from the performance of "scheduled" explosions in summer files such as "Disappeared She", "In an octagonal cage" and "Put all your eggs in one basket", "Feng Shen I" was the one that was not optimistic until its release.The voices of "untimely blockbusters" and "Chinese magic has long been out of date" have come and gone, and only 138 million yuan was recorded in the first two days, which also lowered the total box office forecast of the film to 1.25 billion.

However, with the further release of the film, the relatively excellent quality and fascinating characters have aroused extensive discussion among netizens, and "tap water" is also constantly gathering. Stars and enthusiastic audiences from all walks of life began to spontaneously Call for the film on major social platforms, and supported the film with two brushes and three brushes.

This also allows the market to witness the mysterious power of "tap water" again after films such as The Return of the Great Sage, 22nd and The Wandering Earth.

There are still many netizens who take the initiative to undertake the heavy responsibility of film promotion, brainstorming for hot search topics and fancy whole work. Master Wen Taishi, who made a stunning appearance in the egg, was elected as the first "spokesperson" by the tap water.

"Hello, I’m Master Wen. I’m grabbing a high-speed rail ticket at 12306. Please help me to speed up my return to the DPRK." "You have one vote for me, and a surname can arrive on time!" And so on, which have a great sense of network, have gained a good communication effect.

More enthusiastic netizens thought of dozens of entries in one breath, including not only "Wen Taishi Terrier", but also related topics such as "da ji’s love brain" and "Yin Jiao Ji Fa’s brotherhood", all of which are hot spots that netizens like to see and hear. With the continuous spontaneous fermentation of "tap water", it also helped # Please seal the gods and announce that it was immediately spread to me # and boarded the hot search several times.

Different from these hot spots from the bottom up, the early official publicity of "Feng Shen" mainly focused on the cultural value of the film. There is nothing wrong with this angle itself, but it is launched when the audience still doesn’t understand the film, which means a lot of preaching, and it is not as easy to sink out of the circle as the spontaneous online topic of netizens.

Fortunately, the propagandists and creators of "Feng Shen" gradually realized this point and began to have a benign interaction with "tap water people". For example, Chen Muchi, the actor who plays Yin Jiao, was named as the uncrowned "propaganda director" by netizens because he was willing to go off to play in person.

Director Wu Ershan learned that his initials were homophonic during the road show, and immediately changed the profile "523" to "U23" (from "No Two or Three" to "There are Two or Three"), which earned a lot of goodwill. At the same time, by constantly releasing exclusive behind-the-scenes tidbits and deleting fragments, he tried his best to meet the needs of tap water, and also provided material for the continuous fermentation of the topic.

Under the overnight rescue of "tap water", "Feng Shen" also miraculously walked out of the ICU, ranking first in the box office for 13 consecutive days from the first Saturday, and set a record of 160 million yuan in a single day the next weekend, drawing a beautiful downward curve.

The box office counterattack of "Feng Shen" is undoubtedly a demonstration of the power of "tap water", and it is also worth thinking in the industry: what kind of topics and forms are loved by the audience, and what kind of propaganda points can really gain heat and flow.

　Online and offline "combination boxing"　

"ChristianRandPhillips, she is my hakimi", "Princess ChristianRandPhillips embraces Na Ran" and "Yu Shi Na Ran crosses da ji Ji Fa with each other", all of which come from the roadshow scene of "Feng Shen I".

In addition, short videos with high popularity, such as "Chen Muchi reappears in the right place to tie the gods", "Chen Muchi’s military boxing" and "Proton Group reappears famous lines", are also from roadshows. The ongoing roadshow in 24 cities across the country is like a continuous "hot search" manufacturing machine, which continuously outputs various "famous scenes".

With the rise of online platforms, the traditional road show method was once despised by many filmmakers, who thought it was strong in regionality and limited in reach. However, many summer blockbusters, including Feng Shen and Disappeared She, proved the significance of the road show through examples.

In the era of short video, the role of roadshows is not only to effectively incite regional resources and ferment word of mouth, but also to generate a large number of short video-oriented materials through the interaction between the main creators and local audiences. These grassroots and creative pictures are often easier to spread and spread.

From offline to online, unlike other blockbusters selling tickets live in the early stage of the release, "Fengshen" chose to go to the online head live broadcast room after the actors accumulated a certain degree of heat and popularity.

On August 5th, the cast of "Feng Shen" parachuted into the "Brother Xiao Yang" live room for the first time to sell tickets, and 200,000 movie tickets were sold out in seconds, with over 150 million praises in one minute. Choosing to link with the anchor of the short video platform with grounding gas like "Xiao Yang Ge", the film obviously expects the film to further incite the sinking market.

On August 8th, with the long-awaited fans, the representative of "Proton Group" finally merged with Liu Genghong in the live broadcast room, with a high degree of matching between people and audience, which is expected to produce better communication effect.

Coupled with the live broadcast of a popular game on August 10, and the live broadcast of various actors, from offline to online, from the road show site to the live broadcast room, the "combination boxing" of "Feng Shen" is exerting its power.

Why is "Feng Shen I"?　

Before the screening, I wanted to see why "Feng Shen", which was not favored by the market, attracted so much "tap water" to complete the box office counterattack.

On the one hand, it is naturally because of the excellent quality of the film. Douban scored 7.8 points, Cat’s Eye scored 9.4 points, and Taobao Film scored 9.2 points, which were outstanding in both magic films and movies of the same file, and also gave Amway the confidence of "tap water".

On the other hand, the film is well-made, the old opera bones are superb, and the strength of the new actors is all important points.

With the release of documentaries and behind-the-scenes specials, the ubiquitous cultural details, craftsman spirit and the six-month training camp for worshipping gods have gained the recognition of netizens, making "worshipping gods" a recognized work of "grinding a sword in ten years".

Not only that, although the genre of "Feng Shen" is a magical epic action blockbuster, it "accidentally" captured the "heart" of female audiences. According to a ticketing platform, 52.8% of users who want to see the portraits of Fengshen are women, and the score of women is as high as 9.8, which is much higher than that of men.

The brotherhood of Yin Jiao and Ji Fa’s "well-connected suburbs" combination, the sunny and strong appearance of the members of the "Proton Group" and ChristianRandPhillips, who is more attractive as he gets older, have aroused extensive discussions among the female audience, and also invisibly led a new aesthetic direction. As netizens commented, it is suggested that domestic ancient costumes be rolled up according to this standard.

At the same time, through hard training, the members of Proton Group have completed the all-round transformation from body, will to acting skills, and such "nurturing" actors are more likely to arouse the recognition and resonance of the audience.

The box office counterattack of "Feng Shen" is the victory of "tap water", which also proves that gold always shines. However, "the fragrance of wine is also afraid of the depth of the alley". While looking forward to "Feng Shen II", we might as well sum up our experience and prevent the excellent works from being buried again.

The following article comes from China, the author of Science Popularization, Xue Qingxin.

Cop China.

Public science popularization and scientific communication

Why does barbecue smell good?

The origin of barbecue is very early, and it has been started since our primate ancestors. The love for barbecue can be said to go deep into the soul. Few people can control their desire for the smell of barbecue food. The smell of barbecue coming from the streets is really tempting, not to mention the lively atmosphere of barbecue all over the city!

Then why does the barbecue smell so good?

The most common barbecue is charcoal barbecue, which can give food a unique aroma mainly for two reasons.

1. Maillard reaction

During the barbecue of food, the amino acids decomposed by protein will have Maillard reaction with the reducing sugar in food or marinade, which can give food a unique aroma and attractive color.

2. Flavor droplets

Flavor droplets are the key to the flavor formation of barbecue food. After burning, food droplets will emit many aromatic compounds to cover the food.

For example, the drippings of fruit juice contain sugar, protein and oil, and the drippings of meat contain a lot of fat, which will be burnt at the high temperature of charcoal and excited into aromatic molecules to return to the smoke, giving food an aromatic taste.

The combination of these two flavors makes people drool over barbecue.

Why advise you to eat less barbecue?

Barbecue is delicious, but you should not eat it often. In order to persuade you to eat less barbecue, I have properly sorted out many reasons.

Step 1 get fat

Fat and thin kebabs especially capture people’s hearts, such as pork belly, soy sauce tendons, fat and thin, and even cooked tendons, skin and fat intestines … You may brush oil over and over again during the barbecue. The reason why these kebabs are delicious is that they are high in fat, so they taste good, and the calories are naturally not low. Eating them often will inevitably increase the risk of obesity, which is not conducive to cardiovascular and cerebrovascular health.

2. It is not conducive to controlling blood pressure

The salt content of pickled kebabs and the dipping sauce is not low, so eating them often is not conducive to controlling blood pressure.

3. It is not conducive to controlling blood uric acid.

Barbecues, especially those in coastal areas, have more meat and seafood, and often drink beer at the same time, which will make us consume more purine, which may lead to an increase in blood uric acid. Patients with hyperuricemia and gout should pay special attention to eating moderately.

4. There are carcinogens

Barbecue belongs to high-temperature cooking, and the highest temperature can reach 370℃. At this high temperature, meat will produce heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are carcinogens, and the content of carcinogens will gradually increase with the increase of temperature and time.

As we all know, 3,4- benzopyrene is the highest class 1 carcinogen, which is definitely carcinogenic to human beings. It belongs to one kind of polycyclic aromatic hydrocarbons, which is the most toxic and accounts for a large proportion, so it is the most representative polycyclic aromatic hydrocarbons with strong carcinogenicity. In the way of ingesting polycyclic aromatic hydrocarbons through diet, fried and grilled foods account for 88%~98%. [1]

In addition, foods with high carbohydrate content, such as steamed bread, bread, potato chips, etc., will produce acrylamide during barbecue, which belongs to category 2A carcinogen. It has been confirmed that it will cause cancer in animals, but the evidence of carcinogenicity in humans is limited.

5. Air pollution

The burning and incomplete burning of charcoal for barbecue will produce carbon dioxide and carbon monoxide. The former is a kind of greenhouse gas, while the latter is a toxic gas. The smoke from barbecue contains toxic and harmful substances such as dioxins, nitrosamines and heterocyclic amines, among which dioxins not only cause cancer, but also have reproductive toxicity and genetic toxicity. The smoke contains particles such as PM2.5 and PM10, and the concentration is off the charts! Relevant tests by environmental NGOs show that the concentration of PM2.5 in barbecue intensive areas is 1 meter, 10 meters and 100 meters away from the oven, which is far higher than that in non-barbecue areas, and PM10 can also cause haze weather, which seriously harms the health of respiratory system. [2]

How to reduce injuries?

Since there are health risks while eating barbecue, how can people who like to eat barbecue eat relatively healthily? In order to let everyone enjoy the food happily, the following eight points are best arranged.

Step 1 don’t burn

The higher the barbecue temperature and time, the higher the carcinogen content. It is best to remove the burnt place and not eat it, because the more burnt the place, the higher the carcinogen content. After baking, you should wipe the head of the barbecue label before eating.

For example, it is reasonable to have a small stove on each table of Zibo BBQ, and the degree to which the meat is roasted can be completely in your own hands. It is suggested that the meat can be eaten when it is completely cooked, and don’t wait for it to dry and paste.

2. Choose more lean meat

Lean meat is low in fat, which is helpful for weight control. Moreover, if the fat content is high, it will further promote the formation of carcinogens, and polycyclic aromatic hydrocarbons are most likely to be produced at high temperature. Lean meat may have lower carcinogen content than fat and thin kebabs, and it can also reduce the intake of saturated fatty acids.

3. Don’t just eat meat

Many people eat kebabs all over the table, which will lead to high meat intake, which is not conducive to cardiovascular health. If you eat so much meat often, you will increase the risk of developing diseases such as type 2 diabetes, colorectal cancer and obesity. [3] Therefore, it is best to mix some staple foods, vegetables and bean products, which will help to enhance satiety and control meat intake.

Zibo barbecue, for example, is very good. Burritos are the staple food, and shallots are vegetables, but the taste is spicy.

Step 4 match fresh fruits and vegetables

Fresh fruits and vegetables are rich in dietary fiber and antioxidant components, such as lycopene, carotene and anthocyanin. Tomatoes, Chinese cabbage, cherry tomatoes, leeks, oil-wheat vegetables, sweet peppers, colored peppers, etc., when eaten with barbecue, can reduce the harm of carcinogens in barbecue to the body.

5. Microwave before baking

Microwave pretreatment can significantly reduce the production of heterocyclic amines in meat, because microwave can reduce the water content in food, so that the "raw materials" that form carcinogens can not seep out to the surface of meat to participate in the reaction with water, thus significantly reducing the production of heterocyclic amines.

The results showed that the total amount of heterocyclic amines in half-cooked chicken and beef pretreated by microwave decreased by 24% and 21% respectively, while the total amount of heterocyclic amines in fully cooked samples decreased by 35% and 42% respectively. [1]

In addition, microwave pretreatment can significantly reduce the production of polycyclic aromatic hydrocarbons in barbecue products, which may be due to shortening the barbecue time.

Therefore, if you barbecue food at home by yourself, you can microwave the meat until it is 67% cooked or fully cooked before roasting.

Step 6 marinate with spices

Pretreatment of food with spices can significantly inhibit the formation of harmful substances such as heterocyclic amines, acrylamide and polycyclic aromatic hydrocarbons in food. This may be because spices generally have strong free radical scavenging ability, which can significantly inhibit the free radical reaction of meat products during high temperature processing. [1]

You can marinate the meat with garlic juice, onion, red pepper, Chili powder, ginger, black pepper, thirteen spices and so on before baking.

7. Put less or no soy sauce

Soy sauce can promote the formation of heterocyclic amines, and it is best to put less or not.

8. Barbecue style

Compared with charcoal roasting, electric roasting is more recommended, and the amount of harmful substances generated by electric roasting is lower. It was found that the content of polycyclic aromatic hydrocarbons (PAHs) was 24 μg/kg when sausages were roasted by electric roasting, and it increased to 51 μg/kg when sausages were roasted by charcoal, which was nearly 2 times higher than that by electric roasting. [4]

In addition, gas barbecue and stone barbecue can also effectively reduce the content of carcinogens in barbecue meat products.

summary

Let’s be realistic. No matter where the barbecue is, it’s not healthy food. Here, it’s good to remind everyone to relieve their cravings occasionally. Maybe it’s just right to have a barbecue once in a while. Remember to drink less wine and drink less sweet drinks when eating barbecue ~

Original title: "Barbecue is delicious, but healthy skewers should do these 8 points! 》

Read the original text