[US stock index]
On Wednesday, December 4, US Eastern Time, the three major US stock indexes closed higher, with the S&P 500 index rising 0.61% to 6086.49 points. The Dow Jones index rose 0.69% to 45014.04 points; The Nasdaq index rose 1.30% to 19,735.12.
American debt
On December 4, the benchmark 10-year US bond yield was 4.19%, and the 2-year US bond yield, which is most sensitive to the Fed’s policy interest rate, was 4.13%.
[Hot American stocks]
Among the popular US stocks, Apple rose 0.15%, NVIDIA rose 3.48%, Microsoft rose 1.44%, Amazon rose 2.21%, Google C rose 1.77%, Google A rose 1.77%, Meta rose 0.02%, Tesla rose 1.85%, TSMC rose 0.89% and AMD rose 1.42%.
[global index]
[China index]
On December 4th, overnight Hang Seng Technology Index futures fell by 0.59%, Nasdaq China Jinlong Index fell by 1.38%, and FTSE China A50 Index fell by 0.09%.
[China Stock Exchange]
In terms of popular Chinese stocks, Tencent Holdings (Hong Kong stocks) fell by 0.30%, Alibaba by 0.88%, Pinduoduo by 0.26%, Netease by 1.60%, Ctrip by 1.69%, Baidu by 1.51%, LI by 1.23%, Xpeng Motors by 0.75% and Weilai by 0.97%.
[foreign exchange commodities]
[Global News]
Federal Reserve Chairman Powell: Oppose the President’s suggestion on interest rate policy.
On December 4, local time, Federal Reserve Chairman Powell said in an interview on the same day that the Federal Reserve was created by Congress and acted on behalf of all Americans, regardless of politics. This is a "national law". Powell added that he was not worried that Congress would change the independence of the Fed, and opposed the suggestion that the president should express his opinion on the interest rate policy.
Regarding the US economy, Powell said that the inflation rate has dropped and the unemployment rate is relatively low, and the current situation is "very good". Powell pointed out that the US economy is stronger than expected in September, so the central bank can be more cautious when cutting interest rates. When asked about the national debt problem, Powell said that the US federal budget is on an "unsustainable track" and needs to solve this problem as soon as possible. (CCTV News)
Federal Reserve Chairman Powell: Bitcoin is used as a speculative asset; Bitcoin’s competitor is gold, not dollars.
Federal Reserve Chairman Powell: Bitcoin is used as a speculative asset; Bitcoin’s competitor is gold, not dollars.
Federal Reserve Chairman Powell: We are modeling, studying and evaluating the tariff proposal.
Federal Reserve Chairman Powell: We are modeling, studying and evaluating tariff proposals.
Powell: The Fed can be cautious when looking for neutral interest rates.
Federal Reserve Chairman Powell: As time goes by, the Fed will gradually move towards a more neutral interest rate. Although the downside risk is lower than expected, the Fed can be cautious when looking for a neutral interest rate.
Federal Reserve’s Beige Book: Economic activity in most areas has increased slightly.
Federal Reserve’s Beige Book: Economic activities in most areas have increased slightly; Prices in various regions only rose at a moderate rate; The growth of power demand is driven by the rapid expansion of data centers. It is reported that in the next few years, it is planned to meet the power demand by investing in renewable energy generation capacity.
Powell: Capitol Hill generally supports the independence of the Fed and is not worried about the risk of the Fed losing its independence.
Powell said that Capitol Hill generally supports the independence of the Fed and is not worried about the risk of the Fed losing its independence.
European Central Bank Management Committee nagel: Interest rates may be cut again next week.
Nagel, the governing board of the European Central Bank, said on Wednesday that the ECB may cut interest rates again next week, but the easing policy should be gradual and cautious. Nagel said on Wednesday, "In view of the fact that the process of falling inflation is basically in line with current expectations, at this stage, if we continue to lower the policy interest rate, I will not object." "But I will reserve my final judgment and make a decision after reviewing the new macroeconomic forecast in December and considering the risks around the baseline."
Nagel, Governing Committee of the European Central Bank: In favor of adopting a gradual and cautious interest rate cut.
Nagel, the Governing Committee of the European Central Bank: We are in favor of a gradual and prudent interest rate cut. There is no significant risk that inflation is lower than expected. Not in a hurry to adjust interest rates; I don’t object to the interest rate cut in December, but wait for the forecast result.
Google: A new dating and dating advertising policy will be launched in March 2025.
Google: A new dating and dating advertising policy will be launched in March 2025. According to the new policy, advertisers need to be certified by Google before placing dating or dating-related advertisements through Google ads.
BlackRock’s Outlook in 2025: The artificial intelligence boom continues to boost US stocks. It is expected that the Federal Reserve will not be able to lower interest rates below 4%.
BlackRock, the world’s largest asset management company, expects that the artificial intelligence boom will continue to boost US stocks and support broader economic growth next year, although the rising debt level in the United States may threaten its optimistic forecast for 2025. The agency said that the innovation of artificial intelligence technology may make US stocks benefit more than European stocks. The agency said that although the US economic growth may cool down slightly next year, the Federal Reserve may not be able to cut interest rates significantly because inflation is still sticky and higher than the central bank’s target. The agency expects that the interest rate will not fall below 4% from the current 4.5%-4.75%. Continued price pressure caused by geopolitical division and infrastructure expenditure may put pressure on the bond market.
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Opinions of Ministry of Agriculture on Promoting the Development of Water-saving Agriculture
China’s water resources are in serious shortage, and the contradiction of agricultural water use is becoming increasingly prominent. To develop modern agriculture, change the mode of agricultural development, promote disaster prevention and reduction, and achieve stable and increased agricultural production, we must vigorously develop water-saving agriculture. In order to implement this year’s central governmentoneDocumentNo. and the spirit of the instructions of the CPC Central Committee and the leading comrades of the State Council on vigorously developing water-saving agriculture, and accelerating the sound and rapid development of water-saving agriculture, this opinion is formulated.
First, fully understand the great significance of developing water-saving agriculture
Agriculture stands on soil, prospers with fertilizer and prospers with water. Water is one of the most scarce agricultural resources, and it is also a key factor restricting the sustainable development of agriculture. Agricultural departments at all levels should fully understand the significance of water-saving agriculture in ensuring national food security and changing the mode of agricultural development, earnestly enhance their sense of responsibility and urgency, seize the opportunity, and accelerate the development of water-saving agriculture.
(A) The contradiction of agricultural water shortage is becoming more and more prominent.China’s total water resources only account for the world’s.6%Per capita is less than a quarter of the world average. Agricultural water consumption is about3600Billion cubic meters, the proportion of water from1997Annual69.7%Drop to the current61.3%About, reduced200Billion cubic meters. With the population growth, especially the acceleration of industrialization and urbanization, the contradiction of water use between workers and peasants and between urban and rural areas has further increased, and the difficulty of ensuring agricultural irrigation water has been increasing. At present, the irrigation area of farmland in China9.05100 million mu, irrigation water gap300More than 100 million cubic meters. According to the national water resources development plan, the future15The annual agricultural water consumption will maintain zero growth, and the situation of agricultural water shortage is becoming increasingly severe.
(2) The threat of drought to agricultural production is increasing.With the global warming, the frequency, scope and severity of drought in China are getting higher and higher, and the threat of drought and water shortage to agricultural production is getting bigger and bigger. Drought has become the normal state that affects the development of grain and agricultural production, and the sustainable development of agriculture is facing a serious threat. near10In recent years, the average annual drought area in China has beenfourAbout 100 million mu, which is the last century.50S more than twice, the average annual disaster area.2More than 100 million mu, grain loss due to drought.600More than 100 million Jin. Therefore, we must take the development of water-saving agriculture as a revolutionary measure and explore a way to use water reasonably and efficiently.
(3) The potential of developing water-saving agriculture is increasingly apparent.At present, all over the country9.05Of the 100 million mu of irrigation area, the water-saving area of engineering facilities only accounts for.44.3%; exist23Agronomic water-saving area accounts for only 100 million mu of crop planting area.17.4%. The utilization rate of agricultural water in China is lower than that in developed countries.twentyAccording to the calculation of relevant experts, by popularizing water-saving technology in farmland, it can save water in wheat and rice production in irrigation areas.360The potential of 100 million cubic meters is equivalent to the new irrigation area.8200Ten thousand mu, increase production per mu.300Jin grain calculation can increase grain production capacity.246Billions of Jin. Improving the utilization rate of natural precipitation in dry farming areas has the following advantages.260100 million cubic meters of potential. At the same time, the grain production efficiency of irrigation water will be improved by popularizing farmland water-saving technology.0.1kilogram/Cubic meters, the grain production efficiency of precipitation per millimeter in dry areas is improved.0.1kilogram/Mu, can increase grain production capacity.1000More than 100 million Jin is equivalent to the national goal of increasing grain output by 100 billion Jin.
(D) The policy of developing water-saving agriculture is getting stronger and stronger.The CPC Central Committee attaches great importance to the work of water-saving agriculture, and has issued a series of supporting policies in recent years to promote the development of water-saving agriculture. In the face of the drought in southwest China the year before last, arrangements were madethree100 million yuan was used for the popularization of plastic film mulching technology, and it was arranged last year.five100 million yuan for plastic film mulching in northwest China. All localities responded positively, integrated resources, increased investment, and made overall planning and coordination to form a joint force. According to incomplete statistics, the whole society invests as much money in water-saving agriculture every year.50More than 100 million yuan. The development situation of water-saving agriculture is getting better and better, the atmosphere is getting stronger and stronger, the policies are getting stronger and stronger, and the agricultural water-saving technology modes such as full film mulching and drip irrigation under film are becoming more and more mature, which has created rare opportunities and conditions for planning large projects, building large demonstration areas and popularizing and applying new water-saving agricultural technologies in a large area.
Two, accurately grasp the guiding ideology and objectives and tasks of developing water-saving agriculture.
Agricultural departments at all levels should further clarify the working ideas of developing water-saving agriculture, clarify the objectives and tasks, highlight regional characteristics, and accelerate development.
(5) Guiding ideology.Adhere to the guidance of Scientific Outlook on Development, according to the requirements of building a resource-saving and environment-friendly society and accelerating the transformation of agricultural development mode, firmly establish the concept of "saving water and increasing production, saving water and increasing efficiency", comprehensively apply engineering, agronomy, biology, management and other measures according to the law of crop water demand and the characteristics of agricultural water resources utilization, accelerate technology integration, and demonstrate and popularize water-saving agricultural technology on a larger scale and at a higher level with the construction of demonstration areas as a platform; Establish an investment mechanism led by the government and widely participated by all sectors of society, and greatly increase the investment in farmland water saving; Further strengthen the construction of functions and means, establish and improve the national soil moisture monitoring network system, and establish and improve the grass-roots water-saving agricultural extension service system. Gradually form a water-saving agricultural policy system, technical system and working system, strengthen classified guidance, improve the optimal allocation of water resources and water production efficiency, and provide strong support for ensuring food security and changing agricultural development mode.
(6) development goals.According to the principle of optimized layout and overall promotion, during the "Twelfth Five-Year Plan" period, the National Modern Agriculture Demonstration Park was established and built nationwide.100A distinctive, large-scale water-saving agricultural core demonstration area, the new water-saving agricultural technology demonstration and promotion areaoneOne hundred million mu, irrigation water and natural precipitation production efficiency improved.10%. By vigorously developing water-saving agriculture, the overall goal of "one promotion, two alleviation and three improvement" will be realized, namely: promoting grain production and increasing farmers’ income; Alleviate the contradiction of water shortage in agricultural production and the threat of drought to agricultural production; Improve water productivity, improve agricultural drought resistance and disaster reduction capacity, and improve the comprehensive production capacity of cultivated land.
(7) Basic principles.Based on the field, comprehensive support. The key link of water-saving agriculture is in the field, and grasping farmland water-saving will grasp the foundation of water-saving agriculture. Strengthen the integrated application of engineering, equipment, agronomy, biology, chemistry and management measures in the field, and establish a comprehensive water-saving technical system of "storage-collection-protection-saving-use". Highlight key points and demonstrate. Highlight the key areas, main promotion modes, leading crops and key technologies of water-saving agriculture, strengthen integrated assembly, demonstration and radiation-driven, strive to produce scale effect, and gradually form a new pattern of water-saving agriculture with obvious benefits and unique characteristics. According to local conditions, classified guidance. According to the situation of water resources, crop distribution and farming system, the development plan and work plan of water-saving agriculture are formulated according to local conditions. According to the type of cultivated land soil, climate characteristics, water demand law of crops, etc., strengthen classification guidance and scientific management. Government-led, multi-party participation. Give full play to the leading role of the government in developing water-saving agriculture, strengthen policy support and capital investment, co-ordinate a number of resources, and give full play to the comprehensive effect of project funds. Encourage enterprises, farmers and all sectors of society to actively participate, and form a good situation of promoting the development of water-saving agriculture at multiple levels and through multiple channels.
Third, determine the regional main push technology model according to local conditions
To develop water-saving agriculture, it is necessary to integrate key technologies, make clear the main mode and achieve key breakthroughs.
(eight) the "three North" regional technology model.The northwest, north China and northeast China are seriously short of water resources, with less precipitation and large evaporation. Drought and water shortage have become the main bottleneck of agricultural development, and the annual output fluctuates greatly due to drought. These areas actively develop corn, potatoes, cotton and other staple crops mainly by popularizing and applying water-saving agricultural technologies. In areas without irrigation conditions, water storage and moisture conservation should be carried out simultaneously, and soil reservoirs should be built through conservation tillage, subsoiling and soil improvement to improve water storage and water conservation capacity; Rational development of drought-resistant small water sources, popularization of drought-resistant sowing with water, scientific application of drought-resistant agents and water-retaining agents to solve the problem of drought-resistant seedlings in spring; Vigorously promote plastic film and straw mulching technology to achieve rainwater harvesting and moisture conservation; In areas with irrigation conditions, we will vigorously develop high-efficiency water-saving technologies such as drip irrigation under film, micro-irrigation, sprinkler irrigation, rainwater harvesting and supplementary irrigation, water and fertilizer integration, and water-saving mechanization in dry farming.
(9) Technical model of main wheat producing areas in Huanghuaihai.The resource water shortage and engineering water shortage coexist in the main wheat producing areas of Huang-Huai-Hai, water shortage and waste coexist, flood irrigation is more common, groundwater is seriously over-exploited, and the contradiction of water use is increasingly prominent. The key point is to popularize soil moisture measurement and irrigation saving technology, improve irrigation system and optimize water delivery and irrigation methods. Through the monitoring of soil moisture, the irrigation scheme is scientifically formulated, and the technical modes such as "Xiaobailong" water conveyance, "Little Dilong" sprinkler irrigation and changing long border into short border are mainly popularized and applied. Focus on the production of horticultural crops such as fruits and vegetables, and vigorously promote the integration technology of micro-irrigation and fertilizer. In suitable areas, conservation tillage should be implemented, and soil moisture conservation measures such as subsoiling and suppression, hoeing and mulching should be adopted to improve soil moisture storage capacity.
(10) Technology model in southern China.The precipitation in southern China is abundant, but the spatial and temporal distribution is uneven, and the terrain is complex, and the engineering water shortage is more prominent. In recent years, the frequency of seasonal drought is getting higher and higher, and the threat of drought and water shortage to agricultural production is increasing. In seasonal arid areas, the key points are to strengthen the construction of slope to ladder, field rainwater collection, irrigation and drainage facilities, and enhance the capacity of water storage and water transfer. Around corn, potatoes and other crops, technologies such as plastic film mulching, biological mulching and rainwater harvesting and supplementary irrigation are mainly promoted. Develop efficient water-saving technology with modern micro-sprinkler irrigation and water and fertilizer integration as the core on economic horticultural crops. Popularize techniques such as shallow wet and thin sun irrigation and controlled irrigation in paddy fields to promote the coupling of water and fertilizer.
Four, earnestly do the key work of water-saving agriculture.
During the "Twelfth Five-Year Plan" period, agricultural departments at all levels should base themselves on the existing foundation and promote the development of water-saving agriculture from the aspects of facility construction, technology popularization, rational planting and scientific drought resistance.
(eleven) to strengthen infrastructure construction.Seize the favorable opportunity that the state attaches great importance to farmland water conservancy construction, integrate resources and strengthen the construction of water-saving agricultural infrastructure in the field. Combined with the construction of high-standard farmland, we will strengthen the construction of cultivated land quality, improve the guarantee conditions of farmland water sources, and form a new pattern of water-saving agriculture integrating storage, protection, collection, saving and use. In combination with the organization and implementation of projects such as the field project of adding 100 billion Jin of grain production capacity nationwide, the demonstration project of dry farming water-saving agriculture and the popularization of dry farming science and technology, we will strengthen the construction of water-saving micro-projects and supporting facilities in the field and improve the ability of farmland to store water and preserve moisture. Combined with farmland water conservancy construction and comprehensive agricultural development, we will comprehensively improve the ability of farmland to resist disasters and reduce disasters and continuously increase production of cultivated land.
(twelve) to speed up the demonstration and popularization of technology.Carry out in-depth demonstration activities of water-saving agriculture and establish a demonstration platform. Make full use of platforms such as the establishment of high yield of grain, cotton, oil and sugar and the establishment of horticultural crops standard garden, highlight superior crops according to the production conditions, resource characteristics and farming systems in different regions, strengthen the construction of farmland water-saving demonstration areas, integrate and demonstrate a number of new simple and practical water-saving technology models, and carry out the popularization and application of water-saving technology and equipment. Pay close attention to technical experiments and demonstrations, so that there are demonstrations in counties and villages, and the scale of demonstrations is constantly expanding. Strengthen the cultivation of demonstration subjects, focus on supporting, serving and guiding large grain producers, science and technology demonstration households and professional cooperatives, set an example, drive surrounding farmers, and effectively play the role of demonstration.
(thirteen) the implementation of adaptive planting methods.According to the situation of water resources in different regions, make overall planning, rationally arrange crop planting structure because of water layout, and promote the sustainable utilization of water resources. Adjust and optimize the structure of planting crops and varieties, make full use of natural rainfall, synchronize the water demand period of crop growth with the rainy season, and change passive drought resistance into active drought avoidance. Cultivate and popularize high-yield and drought-tolerant varieties, improve farming and cultivation systems, improve crop water use efficiency, and achieve the goals of saving water, increasing production and increasing efficiency.
(fourteen) do a good job in scientific drought relief.Make overall plans, plan ahead for a rainy day, study and formulate emergency plans for drought relief, actively prepare for drought-resistant technology, materials, work organization and operation mechanism, and improve the ability to cope with drought. Establish and improve the network system of soil moisture monitoring, make full use of modern information technology, optimize monitoring methods, and improve the timeliness, pertinence and scientificity of soil moisture monitoring. Improve the information release mechanism and provide scientific basis for agricultural production and drought relief in time.
Five, constantly strengthen the safeguard measures for the development of water-saving agriculture
(15) Strengthen organizational leadership.Agricultural departments at all levels should fully understand the great significance of developing water-saving agriculture in safeguarding national food security and transforming agricultural development mode, earnestly strengthen organizational leadership, conscientiously perform the responsibility of "developing water-saving agriculture by using engineering facilities, agronomy, agricultural machinery, biology and other measures", develop and expand the professional team, promote the construction of water-saving agriculture system, and provide organizational and institutional guarantee for accelerating the development of water-saving agriculture.
(16) Increase investment.Strengthen communication and cooperation with relevant departments, integrate resources, form a joint force, and establish an investment mechanism with government as the leading factor and social participation. Make full use of project funds such as irrigation and water conservancy construction, water-saving in dry farming, plastic film mulching, national plan for increasing grain production capacity by 100 billion Jin, demonstration project of water-saving agriculture in dry farming, special financial project for popularization of dry farming science and technology and conservation tillage, actively guide local governments and all sectors of society to increase investment in water-saving agriculture, strengthen the construction of water-saving projects and supporting facilities in the field, and improve the level of technology and equipment of water-saving agriculture.
(seventeen) to strengthen the foundation support.Strengthen the construction of water-saving agricultural technology system, improve service means and improve service capacity. Formulate the "Twelfth Five-Year Plan" for the development of water-saving agriculture, clarify the development ideas, objectives and tasks, regional layout and main promotion mode, and scientifically guide the development of water-saving agriculture. Strengthen the docking of teaching, scientific research and popularization, accelerate the application of modern high-tech, develop and popularize simple, economical and practical new technologies and products, and provide scientific and technological support for the development of water-saving agriculture. Actively learn from foreign water-saving agricultural technology, experience and management methods, and combine production practice to guide the development of water-saving agriculture.
(eighteen) extensive publicity and training.All localities should take various forms to publicize water-saving agriculture through various media, strive for leadership attention and departmental support, and form a good atmosphere for the whole society to care, support and participate in the development of water-saving agriculture. Through going to the countryside through science and technology, demonstrating and observing, printing and distributing materials and on-site training, we will publicize and popularize water-saving agricultural technology, raise farmers’ awareness of water-saving and promote the sustainable development of water-saving agriculture.
The Ministry of Agriculture of the People’s Republic of China
two0January 31, 1921
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Investigation and Research ｜ Gene Mutation Must Be a Disaster？
Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?
The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.
Harm.
What is gene suppression?
Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.
"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.
Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.
Yeast substitution experiment
"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.
But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.
"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.
Narrow the search scope of mutant genes
The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.
Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.
"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.
The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.
The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?
Jolanda：At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.
The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.
Jolanda：Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.
The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?
Jolanda：We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.
The PaperWhat do you think is the most important significance of this research?
Jolanda：The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.
(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")
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How to deal with this virus during the Spring Festival and on the way home？
Original Shanghai CDC Shanghai CDC
Recently, the Korea Disease Management Office said that "Norovirus is spreading particularly violently in South Korea, and the number of people infected in one week has reached a new high in the past five years. Uncooked fish and shellfish, contaminated vegetables and water are the main sources of infection". Seeing this news, I think there are many greetings in the hearts of eager friends who are returning home. What virus is this? What diseases are caused? Is it serious? How to prevent it?
To put it simply, we can take the strategy of "strategic contempt and tactical attention" to norovirus.
one
Understand the characteristics of the disease and strategically despise it.
Different from respiratory infectious diseases such as influenza, norovirus infection is an intestinal infectious disease, characterized by diarrhea, vomiting and other intestinal symptoms, with fecal-oral route as the main route of transmission. Main features:
one
It is seasonal and popular all year round, and the peak of incidence is in the cold season of autumn and winter.
2
There are many ways of transmission, which can be passed from person to person-inhaling aerosol produced by patients vomiting, touching patients’ feces or vomit, etc. It can also spread through food and water-ingestion of contaminated food or water, indirect contact with contaminated items and the environment, etc.
three
The course of the disease is short, and the symptoms last for 2-3 days on average. Symptoms such as fever, nausea, diarrhea, vomiting, headache, etc. can be seen. Diarrhea can reach 4-8 times within 24 hours, and the feces are mostly watery or watery.
four
It is a self-limited disease, and most of the symptoms are mild, so you can gradually recover after resting at home. A small number of infants, the elderly, people with low immunity and patients with basic diseases may have serious symptoms such as dehydration.
Although Norovirus has a short course of disease, mild symptoms and self-limitation, its attention is not low, because:
one
It is one of the main pathogens causing acute gastroenteritis, and monitoring in this city shows that norovirus accounts for more than one third of the pathogens detected in adult and child diarrhea cases.
2
The incubation period is short, and the virus can get sick in 24-48 hours after entering the human body.
three
The infection dose is low, and a small amount of virus can cause disease, which often causes cluster epidemics in collective units such as kindergartens, schools and nursing homes for the elderly.
two
Raise awareness of disease prevention and pay attention to tactics.
During the Spring Festival, family gatherings, visiting relatives and friends, taking crowded public transport, dining and eating seawater products may increase. It is suggested that everyone raise their awareness of disease prevention:
1. Strengthen the hygiene of drinking water, fully heat the food, and try not to eat cold and half-baked seafood and aquatic products.
2. Develop good personal hygiene habits and wash your hands before meals. When eating out, you can sit in a ventilated place by the window to keep the air circulating.
3. Reduce the time spent in crowded closed places, and those who have the conditions can wear masks for personal protection.
4. If you have symptoms such as vomiting and diarrhea, you should suspend gatherings, dinners and other activities, and see a doctor if necessary.
Contributed by Gong Xiaohuan and Xiao Wenjia
Draft review: Chen Jian
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How to deal with this virus during the Spring Festival and on the way home? Original Shanghai CDC Touch Read the Original Text
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Original title: "How to deal with this virus during the Spring Festival and on the way home? 》
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Hong Kong Morning Post ｜ Significantly abolish employees over 35 years old？ Xiaomi rumors!
[Review last week]
Hong Kong stocks performed strongly in early trading last Friday, but the bulls failed to hold their advantage in the afternoon. The Hang Seng Index closed down 0.59, and the Hang Seng Science and Technology Index rose nearly 2% in early trading, and the closing increase narrowed to 0.29%.
On the disk, JD.COM Q1′ s performance was bright, and its share price rose over 7%, leading the strength of weighted technology stocks; Film and television entertainment stocks, power stocks and mobile game stocks rose.
On the other hand, the price of gold fell at a high level, and the non-ferrous metal plate fell; Collective adjustment of the concept stocks of China Special Appraisal Company.
[capital flow]
Last Friday, southbound funds sold a net of HK$ 235 million. SMIC ranked first in net purchases and first in net sales.
Short-selling data are as follows:
[breaking news]
90% of employees over the age of 35 are laid off? Xiaomi responded: rumors
Recently, some netizens posted on social media: "The second headquarters of a certain meter in Wuhan officially announced that 90% of employees over the age of 35 will be laid off." This statement quickly fermented on the Internet, and some netizens speculated that it was Xiaomi Group.
In response to the above rumors, Wang Hua, general manager of the public relations department of Xiaomi Group, responded in Weibo on May 14th. "Last night, there were reports on social media platforms that employees over 35 years old in our Wuhan headquarters only kept 10% of the information, which were all rumors after investigation. Now the legal department of the company has obtained evidence for relevant information and reported it to relevant departments. "
Xu Jiayin became the executor.
On the evening of May 12th, China Evergrande announced that it had received an enforcement notice from the Guangzhou Intermediate People’s Court on the arbitration award of Shenzhen International Arbitration Court. The Company, its subsidiary "Guangzhou Kailong Real Estate" and the executive director Xu Jiayin are the executors of the enforcement notice. According to the execution notice, the items to be executed are:
(1) Guangzhou Kailong and Mr. Xu paid the balance of dividends of Evergrande Real Estate in 2020 to make up about RMB 204 million, and assumed the liquidated damages of about RMB 51.53 million;
(2) Mr. Xu and the company bought back the equity of Evergrande Real Estate held by the arbitration applicant for RMB 5 billion;
(3) The compensation paid by the company to the arbitration applicant from February 1, 2021 to the completion of the repurchase is about RMB 770 million;
(4) The Company, Guangzhou Kailong and Mr. Xu paid about RMB 35.53 million in legal fees, arbitration fees and execution fees.
The total valuation of 47 projects of Evergrande Auto 2 yuan "Sale" exceeds 60 billion.
On May 12th, Evergrande announced that the shareholders’ meeting had agreed to sell its 47 real estate projects to China Evergrande and its subsidiaries. This means that Evergrande has completed the divestiture of real estate business and focused on the new energy vehicle business. Evergrande Automobile will concentrate resources to fully guarantee the R&D and production of Hengchi.
According to the announcement, the two parties signed an agreement to transfer all the issued shares of Huibao and Flaming Ace under Evergrande Automobile, covering 47 existing health space projects of Evergrande Automobile Group, including 21 Evergrande Health Valley projects, 5 Evergrande Health City projects and 21 various property development projects.
After the completion of the sale, Evergrande no longer holds any rights and interests of the above two companies, and it is estimated that it will record a sale income of about 24.789 billion yuan.
According to the unaudited data provided by Evergrande Automobile, as of December 31, 2022, the net liabilities of projects such as Health Valley to be sold were 24.789 billion yuan, and the project valuation was about 60.1 billion yuan. In 2022, its income was only about 1.5 billion yuan, and its net loss after tax reached 8.824 billion yuan.
Large shareholder clearance and evacuation? Vida International Emergency Response
Recently, there is market news that the Swedish company Essity, the controlling shareholder of Vida International, announced that it is considering selling the shares of Vida International; Fuan International, controlled by Li Chaowang, the second largest shareholder and chairman of the board of directors of Vida International, intends to acquire Essity.
On May 14th, Vader International published a voluntary announcement, saying that the Board of Directors had not received any latest information about the review of Essity strategy.
[Company News]
1. (): In the first four months, the accumulated original premium income was 108.343 billion yuan and 71.543 billion yuan respectively through Taiping Life Insurance and Pacific Property Insurance, which decreased by 2.9% and increased by 16.0% respectively.
2. Ping An in China: In the first four months, the premium income of the original insurance contract was about 100.459 billion yuan, 208.185 billion yuan, 8.214 billion yuan and 5.849 billion yuan respectively through Ping An Property Insurance, Ping An Life Insurance Company of China, Ping An Endowment Insurance and Ping An Health Insurance, totaling about 322.707 billion yuan, up 5.93% year-on-year.
3. Baekje Shenzhou: The revenue in the first quarter was 3.066 billion yuan, a year-on-year increase of 57.4%; During the period, the total product revenue was about 2.808 billion yuan, a year-on-year increase of 69%; The net loss attributable to shareholders was about 2,446.6 million yuan, a year-on-year decrease of 14.64%. Mainly due to the sales growth of self-developed products and authorized products.
4. (): The subsidiary plans to invest 2.5 billion yuan to build a new energy lithium battery production research and development project in Xiangyang.
5. (): It is planned to invest in a new battery-grade lithium hydroxide production base project with an annual output of 30,000 tons in Zhangjiagang Free Trade Zone, with an estimated annual income of not less than 2 billion yuan.
6. R&F Property: In the first four months, the accumulated contracted sales were 9.02 billion yuan, down 49.18% year-on-year, of which the contracted sales in April were 1.66 billion yuan, down 61.12% year-on-year.
7. Hejing Taifu Group: The contracted sales in April was 3.231 billion yuan, a year-on-year decrease of 25.8%; The sales area was 144,000 square meters, a year-on-year decrease of 29.8%.
8. Good Boy International: Revenue in the first quarter decreased by 17.5% year-on-year to about HK$ 1.842 billion, and decreased by 14% year-on-year in terms of constant currency.
9. CGNPC New Energy: The subsidiary intends to sell all the shares of Nantong Meiya, and the initial public bidding price is about 420 million yuan.
[repurchase dynamics]
1. AIA: It spent about HK$ 132 million to buy back 1.652 million shares at a repurchase price of HK$ 79.55-81.3.
2. HSBC Holdings: It spent about HK$ 147 million to repurchase 2.5 million shares at a repurchase price of HK$ 58.40-58.95.
3. (): Chongqing Water Investment Group increased its holdings of 35.0092 million A shares, with a total shareholding ratio of 7.013%.
4. (): It is planned to buy back 1.5 billion to 3 billion yuan of A shares for the implementation of the company’s employee stock ownership plan.
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Global information ｜ Cat is expected to bring a huge loss of $71 million.
Global information group new culture business
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A quick look at information
1. Ne Zha box office finally broke 5 billion.
2. Zhang Yongchang, Vice President of Himalaya: The cash flow is quite good, and there is not such a strong demand for listing and fundraising.
3. Tencent Video: The number of paid members has exceeded 100 million.
4. "Gunshot of the Whole People" was sentenced to plagiarize the map of "Crossing the Fire Line", and Tencent was awarded more than 45 million yuan.
5.12 Departments jointly issued a document: Focus on checking online games, live broadcasts, short videos and educational applications.
6. Today’s headline responded to Baidu’s lawsuit: Headline search has always supported brand protection.
7. The domestic animation "Mr. Miao" announced an emergency withdrawal.
8. The annual tragedy "Cat" is expected to bring a huge loss of $71 million.
9. Frozen II ranks among the top three in the global annual box office.
10. Tesla CEO Musk: Disney+ is about to enter Tesla Cinema.
Domestic information
1. Ne Zha box office finally broke 5 billion.
On December 28th, after the re-recording at the box office, the domestic animated film Ne Zha finally broke 5 billion, making it the second domestic film to break 5 billion after Wolf Warriors 2. At present, the film ranks second in the box office list of China film history. This film is the highest-grossing animation in China, and it is also the film that China Mainland declared as the "Best International Film" for next year’s Oscar.
Due to some studios’ behavior of concealing data or intercepting box office, a few days ago, the National Film Bureau issued a notice asking all studios in the country to check with third-party e-commerce whether the box office data of e-commerce sales in 2019 is consistent with the data reported by the state. If there is a difference, you need to make up the box office difference. This has also caused some films to increase at the box office after re-recording.
2. Tencent Video: The number of paid members has exceeded 100 million.
Tencent Video released the 2019 annual index report, showing that the average daily coverage of Tencent Video has exceeded 200 million, and the number of paid members has exceeded 100 million; This year, there are 149 domestic dramas on Tencent Video, which is 10 fewer than that in 2018. At the same time, the single-day broadcast volume of TV drama channels has set a record, with the peak exceeding 1.5 billion. The proportion of male and female drama chasers has gradually increased: 54.3% are male drama chasers, which holds up half the sky of TV drama users. (36Kr)
3.12 Departments jointly issued a document: Focus on checking online games, live broadcasts, short videos and educational applications.
Twelve departments, including the National Health and Wellness Commission, Publicity Department of the Communist Party of China, State Administration of Radio, Film and Television, and the Central Network Information Office, issued the "Healthy China Action-Action Plan for Children and Adolescents’ Mental Health (2019-2022)", which mentioned that management departments should strengthen supervision over online content, timely discover and clean up illegal and harmful publications and information related to children and adolescents on the Internet, and focus on checking online games, webcasts, short videos, educational apps, etc. with more problems, and crack down on online gambling and education. (澎湃)
4. Today’s headline responded to Baidu’s lawsuit: Headline search has always supported brand protection.
Today’s headline released an explanation about "brand protection" through the official WeChat WeChat official account. Today’s headline said in the explanation that it has received a lawsuit from Baidu about unfair search ranking. Since its launch, headline search has always supported brand protection; No matter whether the brand buys the advertising service of headline search or not, it will be protected by this principle. At present, headline search is constantly broadening the coverage of brand protection.
On December 19, 2019, Haidian Court Network issued a case report. Express shows that Baidu sued today’s headlines on the grounds of unfair competition. Baidu said that its copyrighted video products were used by today’s headlines as keywords to trigger search advertisements in "headline search" and interfered with search results. Specifically, in today’s headline mobile phone client, the headline search service is used to search for "good-looking video" and "Baidu video", and the search results show that the headline product is "watermelon video".
5. The domestic animation "Mr. Miao" announced an emergency withdrawal.
The domestic animation "Mr Miao", originally scheduled to be released on December 31st, has been withdrawn, and the new schedule has not been announced yet. Mr. Miao is produced by the light striped house film industry, and both of them are derived from the original worldview of not thinking about everything, which "has the ultimate national style of ink painting and profound ideological connotation". Guangcai intends to create a "Guo Man Diablo Series". It is reported that "Mr. Miao" has a total of 1600+ shots, which was polished by the first-line animation production team for four years.
6. Didi launched a variety show: "Let’s go, master! 》
Recently, Didi launched a variety show called "Let’s go, Master! 》。 The program was jointly produced by Didi’s film and television company Beijing Granula Orange Media Co., Ltd. and Canxing Production, jointly produced by iQiyi and exclusively broadcast on this platform. At present, a program registration entrance and a viewing entrance are set in the taxi interface of Didi App. The first issue of this program was updated on December 25th, lasting about one hour, and the form of the program is similar to China’s Got Talent.
Didi established Beijing Granular Orange Media Co., Ltd. on November 12 this year with RMB 10 million from Hidesuke. Sky Eye Survey shows that the company’s business scope includes TV drama production, audio-visual product production, electronic publication production, film distribution, etc. It is wholly owned by Beijing Xiaoju Technology Co., Ltd..
7. "Gunshot of the Whole People" was sentenced to plagiarize the map of "Crossing the Line of Fire", and Tencent was awarded more than 45 million yuan.
Recently, the Shenzhen Intermediate People’s Court made a first-instance judgment on the case that Tencent sued seven companies, including Changyou Yunyun and Heroes Entertainment, for copyright infringement, and found that six game maps of the mobile game Gunfight for the Whole People released by Heroes Entertainment infringed the copyright of the online game Crossing the Line of Fire, and ruled that the seven defendants immediately stopped the infringement and jointly compensated Tencent for economic losses and reasonable rights protection expenses exceeding 45.24 million yuan. Tencent has the exclusive agency operation right of Crossfire in Chinese mainland from 2012 to 2021. (21st century business herald)
8. Zhang Yongchang, Vice President of Himalaya: The cash flow is quite good, and there is not such a strong demand for listing and fundraising.
Zhang Yongchang, vice president of Himalaya, said that the problem we have always wanted to solve is the sinking of users, because it is still relatively high-tech and concentrated in first-and second-tier cities. He said that we have been rumored (listed) and have not admitted it. In fact, our cash flow is quite good, and there is no such strong demand for listing and fundraising. At this stage, we don’t care much about whether it is profitable, because even if it is profitable, we have to invest in our content layout again. Our industry is still small, and the speed is still not fast enough, but faster.
Foreign information
1. The annual tragedy "Cat" is expected to bring a huge loss of $71 million.
Ten days after the release of Cats, a musical visual masterpiece produced by Universal, the film based on the classic musical of the same name only received US$ 17.82 million in North America, which did not reach one-fifth of the cost line. The fantastic visual effect style of the film has attracted bad comments from audiences and film critics. The global box office of the film is nearly $37 million, including over $16 million in the United States and $20 million overseas. According to industry estimates, the film disaster will cause huge losses of about $71 million to the producers.
2. Frozen II ranks among the top three in the global annual box office.
The cumulative box office of Frozen II in North America has reached $421 million, easily surpassing the final score of the first Frozen ($401 million). "Frozen II" has also become Disney’s fifth box office-breaking work this year. At present, Mickey Mouse has swept the top five in the annual box office.
After the film landed in the last batch of overseas markets, the cumulative overseas box office has reached 796 million US dollars, and it will easily break through the 800 million mark. Its global cumulative box office has reached 1.218 billion US dollars, successfully surpassing Spider-Man: Heroic Expedition (1.132 billion) and Captain Surprise (1.128 billion), ranking among the top three box offices in the world. According to the current momentum, the final box office of the film will hit more than $1.3 billion.
In 2020, American media and technology companies will face a severe regulatory environment in Russia.
American media and technology giants may face more pressure in Russia next year because various laws are being tightened. New protectionist legislation is aimed at Apple, Facebook, Twitter and Netflix, and more measures are being formulated.
At the same time, the operation prospect of global streaming media services such as Netflix and Apple TV+ in Russia is still unclear. Before the launch of Apple TV+, the Russian government indicated that it would prepare legislation to restrict the operation of foreign video services to protect domestic companies from the impact of foreign competitors, especially Apple.
4. Comcast buys free streaming service Xumo
According to the Wall Street Journal, people familiar with the matter said that Comcast was in deep talks to acquire Xumo, an advertising-supported video streaming company. Xumo, located in Irvine, California, provides a free advertising-supported streaming service. As Comcast’s nbc Universal prepares to launch Peacock, a streaming service, the financial terms of the potential deal are unclear.
5. Tesla CEO Musk: Disney+ is about to enter Tesla Cinema.
According to foreign media reports, Elon Musk, CEO of Tesla, said Disney+ will soon enter the Tesla cinema. Now, Tesla Cinema includes streaming media services Netflix and Hulu, as well as oil pipes, Twitch and a Tesla Tutorials channel.
Previously, Musk had pointed out that when the regulator approved autonomous driving, Tesla would allow passengers to watch videos while the car was driving.
6. The director of Mysterious Sea quits again.
According to foreign media reports, Taravis Knight, the director of Bumblebee and Magic String Legend, withdrew from directing the game adaptation film Mystic Sea starring Tom Hollander, the Little Spider. According to public reports only, he is the sixth director to quit.
Previously, directors who have quit include: David O. Russell (american hustle), neil burger (Out of Reach), seth gordon (Beach Ranger), Sean Levi (Fantastic Night at the Museum) and Dan Trachtenberg (No.10 Clover Road).
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Original title: Global Information | Cat is expected to bring a huge loss of $71 million.
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Closed five department stores in six years, and Tianhe City’s transformation suffered setbacks.
Original Li Xinting Times Weekly
Guangdong Yuehai Tianhe City (hereinafter referred to as "Tianhe City"), which once opened the first year of China Shopping Center by Guangzhou Tianhe City Shopping Center, failed to survive the industry cycle.
Recently, according to the notice issued by WeChat official account, the official commercial WeChat of Tianhe City in Guangdong Province, due to the expiration of the lease contract of the shopping mall, Dongpu Store of Tianhe City Department Store in Guangzhou will be closed on December 31, 2023.
This is the second store that Tianhe City Department Store has closed in Guangzhou this year. As of the end of 2017, Tianhe City Department Store had 9 stores, but since then, Tianhe City Department Store has closed many department stores. After the closure of Dongpu Store, Tianhe City Department Store has only four stores in Yingmen Store, creating a new low in the number of stores in Tianhe City Department Store in recent years.
The continuous contraction of Tianhe City’s department store format is the epitome of the current offline consumption format iteration.
Under the impact of e-commerce, in recent years, traditional department store brands with old space design and poor consumption experience have successively withdrawn from public view. At the same time, new shopping centers that focus more on catering, tide play and other experience formats continue to attack. Between advance and retreat, Tianhe City is also striving to update its own format.
On December 7th, regarding the business operation of Tianhe City Department Store and Shopping Center, Time Weekly reporter called and sent a letter to Tianhe City’s parent company, Yuehai Investment (00270.HK), but no reply was received as of press time.
△ Tianhe City Department Store Dongpu Store Times Weekly reporter photo
Close 5 stores in 6 years.
Tianhecheng Department Store Dongpu Store, which recently issued a notice of suspension, has been in business for nearly 12 years, but in terms of "qualifications", it is still slightly inferior to Tianhecheng Department Store Beijing Road Store, which closed at the beginning of the year.
On March 26th, Tianhe City Department Store Beijing Road Store closed due to the need of strategic adjustment. The store opened on September 26th, 2008, and has been in business for nearly 15 years by the time it closed.
In addition, in recent years, the size of Tianhe City department stores has continued to shrink. As of December 31, 2017, the number of Tianhe City department stores was 9. Since then, including the two stores closed this year, Yuehai Yangzhonghui Store, Dongguan Store and Foshan Nanhai Store have also been closed.
The continuous closing action is directly reflected in the weak performance of Tianhe City Department Store in recent years.
Yuehai Investment Financial Report shows that from 2015 to 2019, the annual revenue of Tianhe City Department Store declined as a whole. In 2019, Tianhe City Department Store’s annual revenue was 665 million Hong Kong dollars, down 7.2% year-on-year, and its pre-tax profit was 230 million yuan, down 2.3% year-on-year.
The latest financial report shows that in the first three quarters of 2023, the revenue of Tianhe City Department Store was 592 million yuan, down 0.7% year-on-year; Affected by the fair value loss of investment properties during this period and the gains from shortening the lease period of department stores, the pre-tax profit decreased by 84.8% to HK$ 23.787 million.
△ Tianhe City Department Store Dongpu Store Times Weekly reporter photo
The decline of Tianhe City Department Store is the embodiment of the dilemma of the current traditional department store format.
The emerging e-commerce format in recent years has a huge impact on physical commerce. On December 6, Lai Yang, member of the Expert Committee of China Business Federation and executive vice president of Beijing Business Economics Association, told the Times Weekly reporter that in the era of cloud consumption, it has become a general trend for consumption to break the restrictions of time and space. Traditional department stores sell goods in stores, and labor costs, rental costs, offline channel costs, inventory costs, etc. need to be converted into product pricing, so commodity prices are on the high side.
"In contrast, online shop products have low cost, diverse choices and convenient delivery. Therefore, the opportunity for consumers to go to traditional department stores for rigid shopping needs is now tending to zero. " Lai Yang analyzed.
On the same day, a commercial real estate operator told Times Weekly that the biggest problem of traditional department stores is that the format is single and the space design has fallen behind the times.
"Traditional department stores are highly focused on retail, with limited supporting facilities and catering formats. There are almost no categories with particularly novel experiences, which are out of the current consumption hotspots, and the catering formats are often limited to street shops, lacking quality and special catering categories. At the same time, because there is no atrium in traditional department stores, customers will feel limited in terms of on-site activities, beauty and customer service. " The operator said.
Performance fluctuation of shopping center plate
While the traditional department store format has declined rapidly, the offline consumption format has also ushered in a breakthrough.
Laiyang told Times Weekly that people’s offline consumption behavior has shifted from meeting rigid demand to experiential consumption. Nowadays, consumers’ main demand for offline business has turned to socializing or discovering some novel and interesting products.
"The sense of existence in the offline retail format has been greatly reduced, and catering, leisure, culture and entertainment have become the key to stimulating offline consumption. The performance of offline businesses that have made breakthroughs and innovations in this regard is good, and they are still based on the traditional model, and the difficulty of survival will become more and more serious. " Lai Yang said.
Therefore, in recent years, new shopping centers that pay more attention to providing "experience" are constantly rising, and Yuehai Investment has also widely distributed shopping malls across the country.
In 2017, 2020 and 2022, Tianhe City Shopping Mall operated by Yuehai Investment in Tianjin, Panyu, Guangzhou and Shenzhen opened one after another. At the beginning of 2022, Tianhe City Shopping Center Beijing Road Store also reported that its business area continued to expand.
In the operation of shopping malls, Yuehai Tianhe City is struggling to catch up with the consumption trend.
△ In July this year, Guangzhou Tianhe City Shopping Center, located in Sports West, held a theme exhibition of Baokemeng. Source: Guangzhou Tianhe City official Weibo.
Tianjin Tianhe City Shopping Center, which opened in 2017, is positioned as a one-stop "city enjoyment home", which not only introduces diversified formats such as fashion clothes, cultural travel experience and indoor entertainment, but also increases the proportion of catering formats to 30%; Panyu Tianhe City, which opened in 2020, introduced brands covering retail, catering, entertainment, education and other formats, providing a variety of experiences such as home aesthetics, trendy skin care and beauty, and trendy play.
Tianhe City, Shenzhen, which opened at the end of 2022, organically integrated with the Golden Beer House transformed from the site of Jinwei Brewery, and introduced the chain pub brand Tiaohai Tavern, which was popular among young people in recent years, and KUDDO COFFEE, a local coffee brand in Shenzhen.
Despite considerable efforts in operation, the performance of Yuehai Tianhe City has not improved significantly. In the first three quarters of this year, the total revenue of Yuehai Tianhe City Shopping Center also declined.
More importantly, Tianhe City Shopping Center, as the core pillar of Yuehai Tianhe City’s business, has also seen a decline in average occupancy rate in recent years. From 2019 to 2021, the average occupancy rate of Tianhe Shopping Center was 99.9%. However, in the first three quarters of 2022 and 2023, the index was 99.4% and 99.3% respectively.
The offline consumption environment is changing with each passing day. Can Tianhe City update its format in time to catch up with the trend? The result remains to be seen.
Reporter Li Xinting
Editor Liu Ting
Yi ke on duty
Original title: "Closing five old department stores in six years, Tianhe City’s transformation suffered setbacks"
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Box office 1.7 billion, jump into the live room! How to counterattack ＂Feng Shen I＂
Special feature of 1905 film network After 20 days of release, the box office of "Fengshen Part I" exceeded 1.7 billion, and the total box office was predicted to increase from 1.25 billion at the lowest point to 2.45 billion, nearly doubling.Maybe, directorWu ErshanFinally, I can say:"sealGodOut of the ICU.
At the same time, on the evening of August 8th, several leading actors, such as Yu Shi, Na Ran, Chen Muchi and Shan Jingyao, also made a surprise appearance in the live broadcast room of Liu Genghong. The "Proton Group" showed the war dance and joyful dancing, and the topic kept on.
"You have one vote, I have one vote to help Master Wen buy a high-speed rail ticket", "You don’t vote, I don’t vote, Yin Jiao will never have a head!" …
Never being optimistic, it is expected to compete for the second place in the summer box office. The starring role is from unknown to popular. How can "tap water" help "Fengshen" to complete the box office counterattack? How do online and offline announcements open the "road to sealing the gods" with a "two-pronged approach"?
"Tap water" helps "the road to sealing the gods"
Different from the performance of "scheduled" explosions in summer files such as "Disappeared She", "In an octagonal cage" and "Put all your eggs in one basket", "Feng Shen I" was the one that was not optimistic until its release.The voices of "untimely blockbusters" and "Chinese magic has long been out of date" have come and gone, and only 138 million yuan was recorded in the first two days, which also lowered the total box office forecast of the film to 1.25 billion.
However, with the further release of the film, the relatively excellent quality and fascinating characters have aroused extensive discussion among netizens, and "tap water" is also constantly gathering. Stars and enthusiastic audiences from all walks of life began to spontaneously Call for the film on major social platforms, and supported the film with two brushes and three brushes.
This also allows the market to witness the mysterious power of "tap water" again after films such as The Return of the Great Sage, 22nd and The Wandering Earth.
There are still many netizens who take the initiative to undertake the heavy responsibility of film promotion, brainstorming for hot search topics and fancy whole work. Master Wen Taishi, who made a stunning appearance in the egg, was elected as the first "spokesperson" by the tap water.
"Hello, I’m Master Wen. I’m grabbing a high-speed rail ticket at 12306. Please help me to speed up my return to the DPRK." "You have one vote for me, and a surname can arrive on time!" And so on, which have a great sense of network, have gained a good communication effect.
More enthusiastic netizens thought of dozens of entries in one breath, including not only "Wen Taishi Terrier", but also related topics such as "da ji’s love brain" and "Yin Jiao Ji Fa’s brotherhood", all of which are hot spots that netizens like to see and hear. With the continuous spontaneous fermentation of "tap water", it also helped # Please seal the gods and announce that it was immediately spread to me # and boarded the hot search several times.
Different from these hot spots from the bottom up, the early official publicity of "Feng Shen" mainly focused on the cultural value of the film. There is nothing wrong with this angle itself, but it is launched when the audience still doesn’t understand the film, which means a lot of preaching, and it is not as easy to sink out of the circle as the spontaneous online topic of netizens.
Fortunately, the propagandists and creators of "Feng Shen" gradually realized this point and began to have a benign interaction with "tap water people". For example, Chen Muchi, the actor who plays Yin Jiao, was named as the uncrowned "propaganda director" by netizens because he was willing to go off to play in person.
Director Wu Ershan learned that his initials were homophonic during the road show, and immediately changed the profile "523" to "U23" (from "No Two or Three" to "There are Two or Three"), which earned a lot of goodwill. At the same time, by constantly releasing exclusive behind-the-scenes tidbits and deleting fragments, he tried his best to meet the needs of tap water, and also provided material for the continuous fermentation of the topic.
Under the overnight rescue of "tap water", "Feng Shen" also miraculously walked out of the ICU, ranking first in the box office for 13 consecutive days from the first Saturday, and set a record of 160 million yuan in a single day the next weekend, drawing a beautiful downward curve.
The box office counterattack of "Feng Shen" is undoubtedly a demonstration of the power of "tap water", and it is also worth thinking in the industry: what kind of topics and forms are loved by the audience, and what kind of propaganda points can really gain heat and flow.
Online and offline "combination boxing"
"ChristianRandPhillips, she is my hakimi", "Princess ChristianRandPhillips embraces Na Ran" and "Yu Shi Na Ran crosses da ji Ji Fa with each other", all of which come from the roadshow scene of "Feng Shen I".
In addition, short videos with high popularity, such as "Chen Muchi reappears in the right place to tie the gods", "Chen Muchi’s military boxing" and "Proton Group reappears famous lines", are also from roadshows. The ongoing roadshow in 24 cities across the country is like a continuous "hot search" manufacturing machine, which continuously outputs various "famous scenes".
With the rise of online platforms, the traditional road show method was once despised by many filmmakers, who thought it was strong in regionality and limited in reach. However, many summer blockbusters, including Feng Shen and Disappeared She, proved the significance of the road show through examples.
In the era of short video, the role of roadshows is not only to effectively incite regional resources and ferment word of mouth, but also to generate a large number of short video-oriented materials through the interaction between the main creators and local audiences. These grassroots and creative pictures are often easier to spread and spread.
From offline to online, unlike other blockbusters selling tickets live in the early stage of the release, "Fengshen" chose to go to the online head live broadcast room after the actors accumulated a certain degree of heat and popularity.
On August 5th, the cast of "Feng Shen" parachuted into the "Brother Xiao Yang" live room for the first time to sell tickets, and 200,000 movie tickets were sold out in seconds, with over 150 million praises in one minute. Choosing to link with the anchor of the short video platform with grounding gas like "Xiao Yang Ge", the film obviously expects the film to further incite the sinking market.
On August 8th, with the long-awaited fans, the representative of "Proton Group" finally merged with Liu Genghong in the live broadcast room, with a high degree of matching between people and audience, which is expected to produce better communication effect.
Coupled with the live broadcast of a popular game on August 10, and the live broadcast of various actors, from offline to online, from the road show site to the live broadcast room, the "combination boxing" of "Feng Shen" is exerting its power.
Why is "Feng Shen I"?
Before the screening, I wanted to see why "Feng Shen", which was not favored by the market, attracted so much "tap water" to complete the box office counterattack.
On the one hand, it is naturally because of the excellent quality of the film. Douban scored 7.8 points, Cat’s Eye scored 9.4 points, and Taobao Film scored 9.2 points, which were outstanding in both magic films and movies of the same file, and also gave Amway the confidence of "tap water".
On the other hand, the film is well-made, the old opera bones are superb, and the strength of the new actors is all important points.
With the release of documentaries and behind-the-scenes specials, the ubiquitous cultural details, craftsman spirit and the six-month training camp for worshipping gods have gained the recognition of netizens, making "worshipping gods" a recognized work of "grinding a sword in ten years".
Not only that, although the genre of "Feng Shen" is a magical epic action blockbuster, it "accidentally" captured the "heart" of female audiences. According to a ticketing platform, 52.8% of users who want to see the portraits of Fengshen are women, and the score of women is as high as 9.8, which is much higher than that of men.
The brotherhood of Yin Jiao and Ji Fa’s "well-connected suburbs" combination, the sunny and strong appearance of the members of the "Proton Group" and ChristianRandPhillips, who is more attractive as he gets older, have aroused extensive discussions among the female audience, and also invisibly led a new aesthetic direction. As netizens commented, it is suggested that domestic ancient costumes be rolled up according to this standard.
At the same time, through hard training, the members of Proton Group have completed the all-round transformation from body, will to acting skills, and such "nurturing" actors are more likely to arouse the recognition and resonance of the audience.
The box office counterattack of "Feng Shen" is the victory of "tap water", which also proves that gold always shines. However, "the fragrance of wine is also afraid of the depth of the alley". While looking forward to "Feng Shen II", we might as well sum up our experience and prevent the excellent works from being buried again.
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Barbecue is delicious, but you must do these eight points for health!
The following article comes from China, the author of Science Popularization, Xue Qingxin.
Cop China.
Public science popularization and scientific communication
Why does barbecue smell good?
The origin of barbecue is very early, and it has been started since our primate ancestors. The love for barbecue can be said to go deep into the soul. Few people can control their desire for the smell of barbecue food. The smell of barbecue coming from the streets is really tempting, not to mention the lively atmosphere of barbecue all over the city!
Then why does the barbecue smell so good?
The most common barbecue is charcoal barbecue, which can give food a unique aroma mainly for two reasons.
1. Maillard reaction
During the barbecue of food, the amino acids decomposed by protein will have Maillard reaction with the reducing sugar in food or marinade, which can give food a unique aroma and attractive color.
2. Flavor droplets
Flavor droplets are the key to the flavor formation of barbecue food. After burning, food droplets will emit many aromatic compounds to cover the food.
For example, the drippings of fruit juice contain sugar, protein and oil, and the drippings of meat contain a lot of fat, which will be burnt at the high temperature of charcoal and excited into aromatic molecules to return to the smoke, giving food an aromatic taste.
The combination of these two flavors makes people drool over barbecue.
Why advise you to eat less barbecue?
Barbecue is delicious, but you should not eat it often. In order to persuade you to eat less barbecue, I have properly sorted out many reasons.
Step 1 get fat
Fat and thin kebabs especially capture people’s hearts, such as pork belly, soy sauce tendons, fat and thin, and even cooked tendons, skin and fat intestines … You may brush oil over and over again during the barbecue. The reason why these kebabs are delicious is that they are high in fat, so they taste good, and the calories are naturally not low. Eating them often will inevitably increase the risk of obesity, which is not conducive to cardiovascular and cerebrovascular health.
2. It is not conducive to controlling blood pressure
The salt content of pickled kebabs and the dipping sauce is not low, so eating them often is not conducive to controlling blood pressure.
3. It is not conducive to controlling blood uric acid.
Barbecues, especially those in coastal areas, have more meat and seafood, and often drink beer at the same time, which will make us consume more purine, which may lead to an increase in blood uric acid. Patients with hyperuricemia and gout should pay special attention to eating moderately.
4. There are carcinogens
Barbecue belongs to high-temperature cooking, and the highest temperature can reach 370℃. At this high temperature, meat will produce heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are carcinogens, and the content of carcinogens will gradually increase with the increase of temperature and time.
As we all know, 3,4- benzopyrene is the highest class 1 carcinogen, which is definitely carcinogenic to human beings. It belongs to one kind of polycyclic aromatic hydrocarbons, which is the most toxic and accounts for a large proportion, so it is the most representative polycyclic aromatic hydrocarbons with strong carcinogenicity. In the way of ingesting polycyclic aromatic hydrocarbons through diet, fried and grilled foods account for 88%~98%. [1]
In addition, foods with high carbohydrate content, such as steamed bread, bread, potato chips, etc., will produce acrylamide during barbecue, which belongs to category 2A carcinogen. It has been confirmed that it will cause cancer in animals, but the evidence of carcinogenicity in humans is limited.
5. Air pollution
The burning and incomplete burning of charcoal for barbecue will produce carbon dioxide and carbon monoxide. The former is a kind of greenhouse gas, while the latter is a toxic gas. The smoke from barbecue contains toxic and harmful substances such as dioxins, nitrosamines and heterocyclic amines, among which dioxins not only cause cancer, but also have reproductive toxicity and genetic toxicity. The smoke contains particles such as PM2.5 and PM10, and the concentration is off the charts! Relevant tests by environmental NGOs show that the concentration of PM2.5 in barbecue intensive areas is 1 meter, 10 meters and 100 meters away from the oven, which is far higher than that in non-barbecue areas, and PM10 can also cause haze weather, which seriously harms the health of respiratory system. [2]
How to reduce injuries?
Since there are health risks while eating barbecue, how can people who like to eat barbecue eat relatively healthily? In order to let everyone enjoy the food happily, the following eight points are best arranged.
Step 1 don’t burn
The higher the barbecue temperature and time, the higher the carcinogen content. It is best to remove the burnt place and not eat it, because the more burnt the place, the higher the carcinogen content. After baking, you should wipe the head of the barbecue label before eating.
For example, it is reasonable to have a small stove on each table of Zibo BBQ, and the degree to which the meat is roasted can be completely in your own hands. It is suggested that the meat can be eaten when it is completely cooked, and don’t wait for it to dry and paste.
2. Choose more lean meat
Lean meat is low in fat, which is helpful for weight control. Moreover, if the fat content is high, it will further promote the formation of carcinogens, and polycyclic aromatic hydrocarbons are most likely to be produced at high temperature. Lean meat may have lower carcinogen content than fat and thin kebabs, and it can also reduce the intake of saturated fatty acids.
3. Don’t just eat meat
Many people eat kebabs all over the table, which will lead to high meat intake, which is not conducive to cardiovascular health. If you eat so much meat often, you will increase the risk of developing diseases such as type 2 diabetes, colorectal cancer and obesity. [3] Therefore, it is best to mix some staple foods, vegetables and bean products, which will help to enhance satiety and control meat intake.
Zibo barbecue, for example, is very good. Burritos are the staple food, and shallots are vegetables, but the taste is spicy.
Step 4 match fresh fruits and vegetables
Fresh fruits and vegetables are rich in dietary fiber and antioxidant components, such as lycopene, carotene and anthocyanin. Tomatoes, Chinese cabbage, cherry tomatoes, leeks, oil-wheat vegetables, sweet peppers, colored peppers, etc., when eaten with barbecue, can reduce the harm of carcinogens in barbecue to the body.
5. Microwave before baking
Microwave pretreatment can significantly reduce the production of heterocyclic amines in meat, because microwave can reduce the water content in food, so that the "raw materials" that form carcinogens can not seep out to the surface of meat to participate in the reaction with water, thus significantly reducing the production of heterocyclic amines.
The results showed that the total amount of heterocyclic amines in half-cooked chicken and beef pretreated by microwave decreased by 24% and 21% respectively, while the total amount of heterocyclic amines in fully cooked samples decreased by 35% and 42% respectively. [1]
In addition, microwave pretreatment can significantly reduce the production of polycyclic aromatic hydrocarbons in barbecue products, which may be due to shortening the barbecue time.
Therefore, if you barbecue food at home by yourself, you can microwave the meat until it is 67% cooked or fully cooked before roasting.
Step 6 marinate with spices
Pretreatment of food with spices can significantly inhibit the formation of harmful substances such as heterocyclic amines, acrylamide and polycyclic aromatic hydrocarbons in food. This may be because spices generally have strong free radical scavenging ability, which can significantly inhibit the free radical reaction of meat products during high temperature processing. [1]
You can marinate the meat with garlic juice, onion, red pepper, Chili powder, ginger, black pepper, thirteen spices and so on before baking.
7. Put less or no soy sauce
Soy sauce can promote the formation of heterocyclic amines, and it is best to put less or not.
8. Barbecue style
Compared with charcoal roasting, electric roasting is more recommended, and the amount of harmful substances generated by electric roasting is lower. It was found that the content of polycyclic aromatic hydrocarbons (PAHs) was 24 μg/kg when sausages were roasted by electric roasting, and it increased to 51 μg/kg when sausages were roasted by charcoal, which was nearly 2 times higher than that by electric roasting. [4]
In addition, gas barbecue and stone barbecue can also effectively reduce the content of carcinogens in barbecue meat products.
summary
Let’s be realistic. No matter where the barbecue is, it’s not healthy food. Here, it’s good to remind everyone to relieve their cravings occasionally. Maybe it’s just right to have a barbecue once in a while. Remember to drink less wine and drink less sweet drinks when eating barbecue ~
Original title: "Barbecue is delicious, but healthy skewers should do these 8 points! 》
Read the original text
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Tank 300 of bicycle analysis in the measured cross-country season
[car home] I don’t know if everyone has seen it just now. Six mainstream hard-core off-road vehicles with different prices on the market competed in several projects, showing their off-road strength and different characteristics. Well, I’ve seen them competing in the same field. The graphic content focuses on the comprehensive performance of each bicycle in all events. If you happen to want to buy a hard-core off-road vehicle recently, I believe the following contents will help you choose to buy it. The protagonist of this article is (|). In addition, we have also produced a detailed analysis article of tank 300 four-wheel drive, and interested friends can click to watch it.
Tank 300 2.0T Conqueror is a mid-equipped model in the whole department. In the original factory state, the approach angle is 33, the departure angle is 34, the longitudinal passing angle is 23.1, the minimum ground clearance is 224mm and the maximum wading depth is 700mm, so the congenital conditions are good. The 2.0T engine has a maximum power of 227Ps and a maximum torque of 387N·m, matching the 8AT gearbox.
Tank 300 2.0T Conqueror adopts part-time 4wd structure, and also has two differential locks at the front and rear. The torque of low-speed four-wheel drive mode can be enlarged by 2.48 times, and it has its own tank turning and crawling mode. It is also one of the only two cars with front locks in this cross-evaluation, and it should be said that it is relatively strong in hardware.
K&C is called Kinematics and Compliancs in English, where K stands for geometric kinematics characteristics of suspension, and C stands for elastic kinematics characteristics of suspension. K&C characteristics jointly determine the posture and position of the wheel when it jumps, as well as the driving performance of the vehicle. K&C experiment is an important link to ensure the handling, stability and driving experience of the vehicle in the process of vehicle development.
Five kinds of sensors are used in this experiment, including front and rear seat cushion sensors, sound pressure sensors of front and rear seat cushions, and multiple unidirectional and three-directional acceleration sensors installed on the steering wheel and the guide rail under the seat respectively, in order to avoid the interference of the seat cushion and simply look at the chassis performance.
We will simulate three different bumpy road conditions, A, B and C, in which A road condition is equivalent to an asphalt road that has been in disrepair for a long time, B road condition can be regarded as a vehicle passing through cobblestone roads, and C road condition is basically a bad unpaved road that is often encountered during long-distance crossing.
Let’s draw a conclusion directly. After several rounds of tests and calculations, in the interior noise test, the performance of Tank 300 can be ranked second among the six models, second only to Beijing BJ40. In the ride comfort test to measure the human vibration evaluation index, from the data obtained by the sensors on the front and rear seats and the seat guide rail, several cars did not open the obvious gap, which was far below the safety threshold. From the vibration data measured at the steering wheel position, the performance of Tank 300 can rank fourth among the six cars.
In the tension test, we can see the tension values obtained by four wheels, two wheels or even a single wheel in different four-wheel drive modes through the data. In the actual off-road situation, if a wheel loses its grip, you can also know more clearly what mode can make it easier for you to get out of trouble.
When the full-wheel tension of tank 300 in 4H mode is 2362kg, the tire will break through the grip and slip, resulting in data decline. Using the 4L mode with greater torque will only make the tire break through the grip limit earlier, and the performance has not improved again. In the front axle tension test, the difference between 4H and 4L modes is very small, which is 1281kg and 1284kg respectively. The difference is that 4L mode is more likely to break through the tire grip limit. In the rear axle tension test, the tension in 4L mode is slightly higher than that in 4H, which is 1398kg and 1326kg respectively, which is slightly higher than that in the front axle as a whole.
In the cross-axle test, the power output will be limited when using the 4-hour mode, and the rotation speed will be limited to 1100rpm, and the tension will be 864kg； when the rotation speed limit is lifted after the rear lock. The effect of using 4L mode is obvious, and the tension value increases to 1052kg. However, if the rear differential lock is locked at this time, although the power output is more direct, the wheel will instantly break through the grip, so the measured data will be lower, which is 824kg. The mode that can get the maximum pulling force in the cross axle test is 4L+ front and rear locks, at which time the vehicle can get the pulling force of 1285kg.
In the single-wheel tension test, there is no doubt that the tension when the single rear wheel has adhesion is greater than that when the single front wheel has adhesion. Whether in 4H or 4L mode, the tension of the single front wheel is 250kg, while that of the single rear wheel is basically 400-500kg. After locking the differential lock, the situation has been greatly improved. In the mode of 4L+ front and rear lock, the pulling force of the single front wheel can reach 816kg, which can basically reach the same level as that of the single rear wheel 4H padlock, while the single rear wheel has the largest data of 895kg when it is 4L padlocked.
Field cross-country is the best way to test the comprehensive quality of a hard-core SUV. We still came to the Kaiser cross-country venue to see their performance.
The 80% ramp is just an appetizer for the tank 300. Under the condition that the tires have adhesion, it can be easily climbed to the top only by using the 4H standard mode, and the engine speed is only 2000rpm in the whole process. There was no accident in the performance of 66% side slope, and there was no sign of downward sliding of the vehicle during the whole process.
In the Big Butterfly Valley project, the standard mode is still 4H, and the vehicle can easily pass through with the throttle stabilized. During the whole process, the electronic limited slip intervention is quick after the wheel loses adhesion, and there is not too much invalid idling, and the vehicle is relatively stable when the center of gravity shifts. However, because the suspension setting of the tank 300 is soft, some "seesaw" effects are easy to appear when the vehicle reaches the top.
The height of each steamed bread bag crossing the shaft on the difficult level is 45cm, which not only examines the slip-limiting ability of vehicles, but also puts forward certain requirements for passing. In this link, the tank 300 directly uses the low-speed four-wheel drive+rock mode. At this time, the vehicle will close the ESC and lock the rear differential. In this case, the tank 300 has no difficulty in passing, and the basic idle crawling state can pass the test.
The most difficult project this time is the 80% uphill cross axle, which is a comprehensive test of the off-road ability of vehicles. Power, passability, four-wheel drive distribution ability and even vehicle weight will affect the passing effect of vehicles. The tank 300 still uses the 4L+ rock mode. In addition to hanging the rear lock, the driver manually locked the front differential this time. In the whole climbing process, the challenge can be completed only by stepping on the accelerator deeply when crossing the shaft. However, when climbing to the top, the side pedal of the vehicle will rub against the ground. On the whole, the performance of the tank 300 in this field cross-country can be said to be excellent.
It’s not unreasonable for Tank 300 to be the best-selling hard-core SUV in the market at the level of 200,000 yuan at present. In addition to its pleasing retro square box appearance, its four-wheel drive performance can stand the test. Excluding the influence of vehicle configuration on off-road performance, the approach angle and departure angle of the tank 300 ensure its passability, and the calibration of the electronic system is also very mature, which are its advantages. In addition, many mature modification cases and parts on the market provide great convenience for the owner’s later upgrade, which is also related to its huge user base, so it is basically still one of the most worthwhile off-road vehicles at this price. (Text/photo/photo by car home Wang Zeshi)