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How do world leaders celebrate the New Year in 2020: Trump goes to the old place again.

  Zhongxin. com, December 27 (Liu Danyi) There are only 4 days left in 2019! Many places around the world have entered the holiday mode.

  Leaders of various countries also want to take this opportunity to take a rare rest. But not everyone can get what he wants. When Trump swings freely in warm Florida, Macron is burned by the general strike … …

  How will these all-powerful political figures spend this New Year?

  Data Map: US President Trump and First Lady Melania.

  Trump: Golf is played every day, and you can’t get votes.

  The American impeachment drama has not yet ended, but President Trump has "flashed" first.

  On December 20, Trump and his family left Washington, DC, where the cold wind was blowing, and went to Haihu Manor in Florida to start their vacation.

  According to reports, Trump will stay at Haihu Manor until after the New Year’s Eve. The Daily Mail said that, not surprisingly, he would play golf every day.

  It is a well-known fact that Trump loves to play golf. Since taking office as president, as of December 22nd, Trump has played golf 245 times and spent nearly 22% of his presidency on golf courses.

  Trump plays golf.

  But during his vacation, Trump did not forget to canvass for the 2020 general election. His campaign launched a new website on Christmas Eve to help his supporters win the debate with their "liberal" relatives and friends.

  The website contains pointers to a series of political issues, including economy, medical care, border wall and impeachment. Kelly McNee, the national press spokeswoman for the Trump campaign, said in a statement that they hoped that the president’s supporters would be "prepared" when the holidays came.

  After the New Year, Trump will launch a non-stop campaign, and the first event will be held in Miami, Florida on January 3. Florida has always been a key swing state, and winning the electoral votes in this state is very important for its successful re-election.

  Johnson: Brexit is dawning, and the island holiday is in a good mood.

  British Prime Minister Johnson has been in a "good mood" recently.

  After winning the election by gambling, the British Parliament successfully passed the second reading vote of the Brexit Agreement Bill. This means that if there are no accidents, Britain can leave the EU on time on January 31, 2020.

  Johnson delivered a Christmas speech on the 24th. It seems that he is still immersed in joy. At the beginning of the video, he said happily, "Hello, I’m Boris Johnson, and I wish you a Merry Christmas first."

  He also urged people to "not have too many disputes" during Christmas, and said: "I hope you are all enjoying a wonderful holiday with your loved ones, sharing gifts and eating delicious food." The relaxed "Brexit" Prime Minister made no mention of "Brexit" in his first Christmas speech.

  According to British media reports, Johnson will take his girlfriend Kelly Simmons to the Caribbean for a holiday and usher in the new year in the warm sunshine.

  Screenshot of British media reports on Johnson’s New Year holiday.

  After the Christmas holiday, they will stay in the private island of Que Island, Masti for a few days. The couple will spend the New Year with the von Bismarck family, the descendant of the first German Prime Minister Bismarck.

  This small island, located in Saint Vincent and the Grenadines, is famous for its white sand beaches and is the favorite of the rich and famous.

  Putin: Busy! It’s a bit difficult to miss work.

  Not all heads of state can enjoy their holidays leisurely.

  Statistics from the All-Russian Social Public Opinion Research Center show that nearly half of Russians call Putin the Russian politician of the year, and 22% of Russians are willing to invite him to their home to celebrate the New Year.

  But Putin, who is busy, may decline this offer. Russian Presidential Press Secretary peskov said earlier that Putin would work as usual on December 31st. He added that even if he can rest, Putin will still spend most of his time at work.

  According to tradition, the Russian head of state will come to the government building of the Russian Federation (Moscow White House) to meet with government officials on the occasion of the New Year. Russian Prime Minister Dmitry Medvedev recently wished Putin a happy New Year and suggested that he "take a break" if possible.

  On December 31, 2018, Putin delivered a New Year message on TV in accordance with tradition, summing up the past year and determining the priorities for next year. It is expected that on the last day of this year, his New Year speech program will still be retained.

  Macron: It’s ok to go on strike. Shall we finish the festival first?

  Sending away the "yellow vest" ushered in a general strike. In 2019, France experienced an unsettled year.

  Data map: French people demonstrated in the center of Paris.

  In the past three weeks, French workers have protested against the pension reform plan proposed by the government, and the strikes have caused serious damage. During 23-24, 48% of high-speed rail and intercity railway were cancelled, and 20% of other railways stopped working.

  French President Jacques Macron has called on the transport trade unions to suspend their strikes during the Christmas and New Year holidays, so that people can go home with peace of mind and spend the holidays with their families.

  In order to quell the general strike, Macron also announced that he would give up the special pension granted by law to the president after the end of his term of office, becoming the first French president to do so in more than 50 years.

  But at present, the strikers still don’t give in. Will the strike continue during the New Year after Christmas? The answer is yes. They went on strike for more than 20 days. "The government has not given a satisfactory answer. How can it stop there?"? Brown, head of the French Railway Workers’ Union, responded.

  To make matters worse, in addition to railway and subway workers, French teachers and freelancers, including lawyers, also joined the resistance camp and will launch a strike on January 3.

  Morrison: An apology is an apology. You can’t avoid a holiday.

  In December, Australia broke the hottest record in history many times, and an unprecedented jungle fire is taking place in New South Wales.

  Australian Prime Minister Morrison also set himself on fire. When the country was scorched by high temperature and wildfire, he couldn’t wait to go on holiday with his family before Christmas.

  For this reason, Morrison had to apologize, shorten her holiday and return to Australia to inspect the disaster area.

  Despite the storm of criticism caused by this vacation, Morrison did not rule out the possibility of more vacations. He said in a TV connection program that if he decided to spend another holiday with his family before the end of 2019, he would "follow the proper procedures".

  Morrison said: "If I can spare a few days to be with my family, I will try to do it." (End)

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Enterprises send out the "big gift package" for the Spring Festival, and many measures are introduced to ensure the stability of jobs.

CCTV News:There is a big gap in the employment of testing reagent manufacturers, especially in packaging. In addition, the Spring Festival holiday is approaching, and the demand for employment is even more scarce. For this reason, manufacturers have issued Spring Festival "big gift packages" to attract employees to stay in their posts and continue to look at them.

In order to keep employees on the spot for the New Year, a COVID-19 testing reagent manufacturer in Huzhou, Zhejiang Province issued a cash-filled red envelopes to the employees who stayed in the post for the New Year. In the first three quarters of this year, the sales of testing reagents in COVID-19 reached 7.4 billion yuan, and at present, the orders of enterprises continue to increase. Put away the red envelopes, and the workers in the workshop are full of energy and full of horsepower to make orders. Li Xiuhua is a quality inspector of reagent finished products. She has chosen to stay in the company for the New Year for two consecutive years. This year, half of the employees in the company responded to the call to celebrate the New Year on the spot like her.

It is understood that migrant workers account for more than half of the production enterprises of these Covid-19 detection reagents in Zhejiang. In order to ensure that the Covid-19 test reagents can meet the needs of customers all over the world during the Spring Festival, many enterprises do not have a holiday during the Spring Festival, and they are trying to improve their treatment as much as possible and strive for employees to stay in their posts.

In view of the problem of labor shortage, in addition to enterprises offering real money to retain employees, local government departments have also introduced employment security measures for enterprises one after another. For example, Shaoxing City, Zhejiang Province plans to put in 120 million yuan of "New Shaoxing People" coupons to promote enterprises to stay in their jobs and promote employees to stay in Shaoxing for employment.

Zhang Weiguo, Deputy Director of Employment Promotion and Unemployment Insurance Department of Shaoxing Human Resources and Social Security Bureau, Zhejiang Province:On the one hand, it is to issue a proposal to stay in Shaoxing for the New Year, to encourage employees to stay in their posts for employment, to guide enterprises to take scientific off-peak vacations, and to return to work in an orderly manner; On the other hand, we have formulated incentive measures, such as red envelopes for staying in posts, car rental subsidies, transportation subsidies, and recruitment incentives.

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A number of fine services ensure the smooth "microcirculation" of Spring Festival travel rush logistics "artery"

  CCTV News:Spring Festival travel rush opened on January 26th, 2024, and it is predicted that during the Spring Festival travel rush in 2024, the cross-regional mobility of the whole society will reach a record high. How to ensure public travel and ensure the smooth "artery" and "microcirculation" of transportation and logistics?

  The Overall Plan for Service Guarantee and Safety Production of Comprehensive Transportation in Spring Festival travel rush in 2024 (hereinafter referred to as the Plan) shows that during the period of Spring Festival travel rush in 2024, severe weather such as low temperature, rain, snow and freezing will occur frequently and widely, and the cross-regional personnel flow of the whole society will reach a record high.

  In 2024, Spring Festival travel rush will last for 40 days from January 26th to March 5th. The cross-regional flow of people in the whole society will reach a record high, with the flow of visiting relatives, students, workers and tourists superimposed at a high level, and the passenger flow in Beijing, Tianjin, Hebei, Yangtze River Delta and Guangdong-Hong Kong-Macao Greater Bay Area will be more concentrated.

  The proportion of self-driving travel will hit a record high. The public’s travel habits have undergone profound structural changes, and the factors such as the increase in the toll time of passenger cars during the Spring Festival holiday are superimposed, and the operation pressure of expressways, ordinary national and provincial trunk highways and service areas is greater. It is estimated that during the period of Spring Festival travel rush in 2024, the business passenger traffic will increase greatly compared with the same period in 2023.

  Spring Festival travel rush has a long duration, strong transportation intensity and high social concern. In addition, the severe weather such as low temperature, rain, snow and freezing during Spring Festival travel rush in 2024 is expected to increase, which makes it more arduous to comprehensively transport Spring Festival travel rush for safe production and emergency support. During the period of Spring Festival travel rush, there was a strong demand for transportation of energy materials, people’s livelihood materials, spring ploughing and other materials, and the public travel service and ensuring the smooth "artery" and "microcirculation" of transportation and logistics were under great pressure.

  The transportation department will strengthen the operation and dispatch and improve the service capacity.

  The transportation department will analyze and judge the passenger flow dynamics of comprehensive transportation in Spring Festival travel rush, strengthen the transportation capacity guarantee and transportation organization, and comprehensively improve the travel service quality.

  The "Proposal" clarifies that the transportation department should strengthen the real-time tracking of railway ticket pre-sale and standby information, closely track the passenger transportation on key routes such as Qiongzhou Strait, Hong Kong-Macao Line and "mini three links", and track the operation of popular routes at home and abroad. In particular, key passenger hub stations, tourist attractions, etc., effectively connect urban and rural passenger transport with trunk transportation by encrypting transportation capacity, operating shuttle buses, express trains at large stations, and customized buses. We will increase the security of transportation services in rural areas, open fair classes and spring ploughing classes, and carry out appointment response services.

  During the Spring Festival holiday, minibuses will be given a free pass policy, and the transportation department should reasonably open up according to the change of traffic flow, so as to improve the traffic efficiency of toll stations. Increase the supply of charging facilities and equipment in the service area, and add mobile toilets and other facilities in the service area with large traffic.

  The "Proposal" also requires the comprehensive promotion and application of online ticket purchasing, self-service ticket checking, automatic ticket checking and other services to popularize paperless travel and improve the passenger ticket purchasing service experience. Optimize and improve the standby function of railway 12306 ticket, and improve the redemption rate of standby ticket.

  In view of the flow of migrant workers and students, the transportation department will provide services such as door-to-door ticket sales, chartered cars, special trains and chartered flights for migrant workers with needs and conditions. If the travel demand is relatively concentrated and qualified, direct transportation services such as student chartered cars can be organized.

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Latest recall! Involving these vehicles

According to the State Administration of Markets, BYD Auto Co., Ltd. and Aston Martin Laganda (China) Automobile Sales Co., Ltd. recalled some vehicles. See ↓

BYD Auto Co., Ltd. recalled some seagull electric vehicles.

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A few days ago, BYD Auto Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Measures for the Implementation of the Regulations on the Management of Defective Automobile Product Recall. Since May 20, 2024, a total of 16,666 seagull electric vehicles produced between April 7, 2023 and May 31, 2023 have been recalled.

Knock on the blackboard and outline the reasons for the recall.

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Due to the camera driver software problems in the multimedia display assembly, some vehicles in this recall area may not display the reversing picture, which may affect the driver’s vision when reversing, increase the risk of vehicle collision, and have potential safety hazards.

Don’t panic if there is a problem. See here for the solution.

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BYD Auto Co., Ltd. will upgrade the software for vehicles within the scope of recall free of charge through OTA technology to ensure the normal display of reversing images. For vehicles that cannot be recalled through OTA technology, BYD Auto Co., Ltd. will take the initiative to contact relevant users and upgrade the software for vehicles free of charge to eliminate potential safety hazards.

BYD Auto Co., Ltd. will notify the relevant car owners by registered mail, WeChat and telephone. Users can call the customer service hotline of BYD Auto Co., Ltd.: 4008-303-666 to learn more about the recall.

Aston Martin Laguna (China)

Automobile sales co., ltd.

Recall some imported cars

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A few days ago, Aston Martin Laguna (China) Automobile Sales Co., Ltd. filed a recall plan with the State Administration of Market Supervision according to the requirements of the Regulations on the Management of Defective Automobile Product Recall and the Implementation Measures of the Regulations on the Management of Defective Automobile Product Recall. From now on, the following vehicles will be recalled.

1. Recall 11 DBX I6 vehicles produced from May 17, 2022 to August 9, 2022.

2. Recall 26 DBX707 cars produced from September 30, 2022 to July 19, 2023.

3. Recall 1,088 DBX vehicles produced from May 7, 2020 to September 28, 2022; A total of 96 DBX707 cars were produced from January 27, 2022 to September 30, 2023; A total of 710 DBX I6 vehicles were produced from September 7, 2021 to August 31, 2023.

4. Recall one DBX vehicle with the production date of November 10, 2020.

Knock on the blackboard and outline the reasons for the recall.

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For some vehicles within the scope of this recall (1), the fixing nuts of the 48V battery cable of the fuse box after connection are not properly tightened. Loose nuts may cause the fuse box to be damaged by heat or the vehicle to lose power, resulting in engine flameout, loss of headlights, electric power assisted steering and other functions, increasing the risk of accidents of the vehicle and posing potential safety hazards.

For some vehicles within the scope of this recall (II), pits and nail marks may be formed on the inner wall of the hose of the oil cooler due to the manufacturing process. In extreme cases, the hose may crack, resulting in the instantaneous loss of oil and oil pressure, causing the engine to stall, increasing the risk of accidents or fires in the vehicle, and posing potential safety hazards.

For some vehicles within the scope of this recall (3), the fixing nut of the cable in the fuse box of 12V battery may be loose, which may cause the fuse box to be damaged by heat or the vehicle to lose power, resulting in engine flameout, loss of headlights, electric power assisted steering and other functions, increasing the risk of accidents of vehicles and posing potential safety hazards.

The bolts of the vehicles, front transmission shaft and front differential within the recall scope (4) do not reach the specified tightening torque, and the bolts may loosen during the driving of the vehicles, which may lead to the loss of the front wheel driving function in extreme cases, posing a safety hazard.

Don’t panic if there is a problem. See here for the solution.

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For the vehicles within the scope of recall (1), Aston Martin Laguna (China) Automobile Sales Co., Ltd. will tighten the 48V battery cable fixing nuts for the vehicles within the scope of recall free of charge through authorized dealers, and replace the rear fuse box and 48V battery cable if they are damaged, so as to eliminate potential safety hazards.

For the vehicles within the recall scope (2), Aston Martin Laguna (China) Automobile Sales Co., Ltd. will replace the oil cooler hoses for the vehicles within the recall scope free of charge through authorized dealers to eliminate potential safety hazards.

For the vehicles within the recall range (3), Aston Martin Laguna (China) Automobile Sales Co., Ltd. will install new cable fixing elements for the vehicles within the recall range through authorized dealers and tighten them as required to eliminate potential safety hazards.

For the vehicles within the scope of recall (4), Aston Martin Laguna (China) Automobile Sales Co., Ltd. will check the bolt torques of the front drive shaft and the front differential for the recalled vehicles through authorized dealers, and tighten them as required to eliminate potential safety hazards.

Aston Martin Laguna (China) Automobile Sales Co., Ltd. will notify the relevant owners by registered mail or telephone. Users can call the customer service hotline of Aston Martin Laguna (China) Automobile Sales Co., Ltd. at 400-1780-007 to get relevant information about this recall.

Photo: Issued by the State Administration of Market Supervision in Shanghai

Original title: "The latest recall! Involving these vehicles "

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Prevention and control of "hard core" epidemic situation in rural areas of Shanxi Province: disinfection on pesticide spraying vehicles

On February 1 ST, a pesticide spraying vehicle turned into a "disinfection vehicle" in the streets and alleys of villages and towns in Tunliu District, Changzhi City, Shanxi Province, spraying 84 disinfectant. Photo courtesy of the Agricultural Economics Center in Tunliu District

On February 1 ST, a pesticide spraying vehicle turned into a "disinfection vehicle" in the streets and alleys of villages and towns in Tunliu District, Changzhi City, Shanxi Province, spraying 84 disinfectant. Photo courtesy of the Agricultural Economics Center in Tunliu District

  Zhongxin. com Changzhi, February 1 (Li Tingyao) On February 1, in the streets and alleys of villages and towns in Tunliu District, Changzhi City, Shanxi Province, a pesticide spraying vehicle turned into a "disinfection vehicle", spraying 84 disinfectant, and hardcore prevention and control of pneumonia infected by novel coronavirus.

  Tunliu District has 21 agricultural production hosting service subjects and a large number of large-scale agricultural machinery, and the comprehensive level of agricultural mechanization in the whole region reaches 86%. Hou Xuezeng, director of the Agricultural Economics Center in Tunliu District, said that after the outbreak of pneumonia in novel coronavirus, people in the WeChat group, the main body of agricultural production custody service in Tunliu District, paid attention to the development of the epidemic every day. During the chat, everyone came up with the idea of contributing to the prevention and control of the epidemic.

  Hou Xuezeng introduced that a total of 15 agricultural production custody service entities voluntarily signed up to participate in epidemic prevention and control, and can provide 21 large, medium and small pesticide spraying vehicles. On the evening of January 30th, the Agricultural Economics Center of Tunliu District asked the district party committee and district government for instructions, and it was agreed that all the registered service subjects were arranged by the leading group for prevention and control of pneumonia infected by novel coronavirus in Tunliu District.

  On the second day of approval, pesticide spraying vehicles from various agricultural production custody service subjects went to six townships (districts) in Tunliu District, including Fengyi Town, Heshenmiao Township, Xijia Township, Lucun Township, Yuwu Town and Kangzhuang Park, to carry out disinfection operations in streets, Little Square and vegetable markets.

  At 13: 00 on January 31, Shi Shuanghu’s agricultural production hosting service provider sent two medium-sized pesticide spraying vehicles to disinfect the streets and lanes of Fengyi Town. It was near 24: 00 that they finished their homework that day. For the 11-hour continuous disinfection operation, Shi Shuanghu said that he did not feel hard or tired. In the face of the epidemic, if he can contribute, he must contribute.

  As of 24: 00 on January 31st, Changzhi has reported 3 confirmed cases of pneumonia infected by novel coronavirus, including 1 case in Luzhou District and 2 cases in Zhangzi County, which are adjacent to Tunliu District.

  At about 9: 00 on February 1, Li Lin started to disinfect the streets and public places in Lucun Township with a pesticide spraying truck. He said that it is expected that he will finish his homework in Lucun Township in another day or two. "After all, I have the equipment and the ability, so I must actively participate."

  "The main body of agricultural production custody service in Tunliu District is highly conscious and responsible. We are deeply moved by taking the initiative to participate in epidemic prevention and control, and we have also been well received by the people." Hou Xuezeng said that the disinfection operation itself is also a kind of propaganda, which can make people further realize the importance of epidemic prevention and control.

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Chang’ an hit hard! Brand-new super hybrid, plug-in and extended range, cheap B-class car, only 66,600! What a good deal!

Chang’ an hits hard! The new super hybrid A05,666,600, subverting the B-class car market!

Friends, the auto market is frying again!

Changan Automobile is really have no martial ethics this time, and directly put a bombshell.

The brand-new Qiyuan A05 they just released is simply a sword to stir up the whole B-class car market.

This car not only hasSuper hybrid system, still canPlug-in hybridandExtended rangeThe key is that the price is so low that people doubt life-Only 66,600 cases.!

Yes, you are not mistaken, it is 66,600!

Market background

In the current automobile market, new energy vehicles are a red sea. The major manufacturers, you can sing and I will appear, but they are often high-priced and low-priced, which makes ordinary consumers flinch. But Chang’ an is going to take a drastic measure this time! Breaking into the B-class car market with ultra-low price is going to set off a blood shed!

appearance design

The design of Qiyuan A05 can be said to be quite amazing.

The front face is adoptedSharp split headlightsDesign, cooperatePenetrating LED daytime running lampIt looks both fashionable and full of technology.

The side lines are smooth,Waist line risingIt gives people a feeling of being dynamic.

The rear taillight group is also used.Penetration designIt is simply a beautiful landscape after lighting up at night.

Interior configuration

Open the car door, you can be at first sight.Double screenDesign attraction.

The one on the center console12.3-inch touch screenDon’t be too cool, it’s also a flowing operation.

The steering wheel is adoptedMultifunctional key design, all kinds of functions can be reached at one finger.

It is worth mentioning that A05 is also equipped withPanoramic sunroofIt makes the whole interior space look particularly spacious and bright.

power system

When it comes to power system, this is A05′ s biggest killer.

It adoptsSuper hybrid system, can be automatically switched according to different scenes.Plug-in hybridandExtended range mode.

What does this mean?

It means that you can drive with pure electricity in the city, and you don’t have to worry about battery life when you go far away.

it is saidPure battery life can reach more than 100 kilometers.This is more than enough for daily commuting.

Price advantage

Now let’s talk about the most exciting part-the price!

The starting price of is only66,600 yuan!

Yes, this is the incredible price.

You know, the same level of B-class cars, other brands will start at 150,000.

Changan can be said to be this timeDiscount the price directly.Ah!

This is simply to use the price butcher knife to wash the whole market!

Cost performance analysis

From the configuration alone, A05 can definitely compete with more than 100,000 models.

However, the price of others is only 66,600, which is simply off the charts!

You know, the new energy vehicles on the market now cost tens of thousands of batteries alone.

How did Chang ‘an do it?

Are they making Guinness World Records at a loss?

Personal point of view

To tell the truth, when I first saw the price of A05, my expression was like seeing a ghost. This is too cheap! But think about it carefully, this may be Chang ‘an’s.market strategy. Quickly occupy the market with ultra-low prices, and then slowly enhance the brand image. This move can be said to be quite clever.

Interactive appeal

Friends, what do you think of Changan’s operation this time? Will A05 really become the showstopper of the B-class car market? Welcome to leave a message in the comment area for discussion!

tag

Changan Qiyuan A05 was born, which undoubtedly injected a shot in the arm into the B-class car market.

It is not only a new car, but also a ticket to the future.Enjoy high-end configuration at ultra-low price.This may become a new trend in the future automobile market.

Whether you are a car fan or not, A05 is worth knowing.

Who doesn’t want to buy a B-class car comparable to 150,000 for 66,600?

disclaimerThe opinions in this article only represent personal opinions. Please refer to the actual car model and price for specific car purchase.

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On Children’s Day, these films are worth watching with parents and children.

Today’s "Children’s Day" is the day when the "God beast" comes out! In the hot summer, parents who are not only afraid of their children suffering from heatstroke outdoors, but also want to go out to play with their children, if they are still in distress, might as well take them to the cinema for a fantasy adventure of mind and vision! Even if there is no time for "moving bricks" during the day, it is also a good choice to accompany the "beasts" at home after work, blowing air conditioning together and watching a parent-child movie clearly.

What parent-child movies are shown in this "June 1" and what classics are worth revisiting?

#1

Classic parent-child movies

The enlightenment of life is not limited to children.

1. "Journey to the Dream Ring"

Introduction to the film

On the way to pursue his musical dream, the little boy met his grandfather who had died for many years, and thus entered the world of the undead.

Ghosts in the undead world are not scary at all. On the contrary, they are cute and interesting, very pleasing to children, and they also bring their own brave buff.

Recommended reason

Death was originally a topic that adults are very shy about, but death is the end point that everyone can’t avoid. This is a film suitable for enlightening children with the concept of life and death, and we can tell them that death is not the end of life, but forgetting.

2. Ne Zha

Introduction to the film

The world always says that good and evil are at odds, the good is always good, and the bad is always bad, but The Magic Boy’s Coming to the World just breaks the rules. Whoever is unfair by fate is qualified to fight it to the end and change his life! The affection in the film is even more touching.

Recommended reason

It is reasonable to abandon the traditional image, but it is subversive. Compared with the end of the old story, the Magic Child focuses on writing juvenile rebellion and family affection, which deserves people’s aftertaste and deep thought.

3. Zootopia

Introduction to the film

The story constructs an animal utopia, where animals coexist peacefully without killing and injury. However, animal city has strict rules, and the relationship between races is not as good as expected.

The protagonist Judy, a weak herbivorous rabbit, dreams of being a policeman who punishes evil and promotes good. You know, it has always been the territory of large carnivorous animals.

Everyone thinks Judy is dreaming, but with unremitting efforts, she graduated from the police school with the first place. After many tests, she finally got a foothold in Animal City. ……

The relationship between different races in Animal City has also changed from the initial tit-for-tat to the handshake.

Recommended reason

If you don’t know how to describe the adult world to your children, this film may help you.

This film shows children a real world that is easy to understand and recognize by way of fable, so that they can gradually get in touch with the rules of the adult world while maintaining their innocence.

The film has been emphasizing one sentence: everyone can do anything.

4. My Neighbor Totoro

Introduction to the film

Miyazaki Hayao, a famous Japanese cartoonist, is one of his representative works, with colorful pictures and touching stories. The feelings between the two little heroes and the love between their father and mother are naturally expressed. The big dragon cat is cute and warm, and the children will love it very much.

Recommended reason

It views, interprets and explores the world from the perspective of childlike innocence, regardless of whether the audience is children, teenagers or naive adults.

There is a big foundation of loneliness, fear and suffering in My Neighbor Totoro’s story, and the core of this film is to dissolve and rebuild-to dissolve loneliness with warmth, to dissolve fear with magic, to dissolve suffering with happiness, and to build up independent courage on this basis!

5. Charlotte’s Web

Introduction to the film

The film is adapted from the novel Charlotte’s Web by American writer E·B· White, and tells the story of a cute little pig Wilbur who tries to avoid being made into a big meal with his animal friends.

Recommended reason

This film tells children to be honest and trustworthy and bravely say no with the help of cute animals around them.

Xiao Mao, who translated the original novel of this film, once said that Charlotte’s Web just wrote a story that happened in a year. The four seasons on the farm are like the four stages of life: the joys and sorrows are all in it, which changes with the opening and closing of the plot. Finally, the prosperity and noise finally come to an end, and the tragedy and comedy are all over, leaving only a dull and endless life.

6. Travel Notes of Flying House Ring

Introduction to the film

The animated film "Travels around the Flying House" tells the story of an old man who once agreed with his wife to travel to a waterfall in remote South America, but failed to make it because of the rush of life. It was not until the government forced the demolition of his old house that he decided to fly to the waterfall with his house and take risks with Russell, the little fat man he met.

Recommended reason

There are children and old people in the film, there is a generation gap and integration, and there are dreams and losses. Love and dreams, courage and hope will always go with you.

7. Inside Out

Introduction to the film

Riley, a little girl, grew up under the care of her parents and lived a happy and fulfilling life every day.

Until one day, her parents took her away from her hometown. The empty apartment, strange school and lost friendship all made Riley’s negative emotions begin to accumulate. She didn’t know what was wrong with her.

In fact, all this is related to the five little people who live in Riley’s brain. They are Lele, Anger, Worry, Disgust and Fear, which control the five emotions of human beings.

In order to make Molly happy, Lele, who is in charge of happiness, began to guard against other emotional worries and others, but the result was not satisfactory. Molly’s inner world was not happy again, and the original good memories gradually collapsed.

Recommended reason

I recommend this movie because we adults and children always subconsciously reject, control and suppress negative emotions.

But in fact, Inside Out personified the five emotions in his brain with his imagination, telling you that happiness is not the only theme of life.

There is no difference between high and low emotions. What we have to do is not to destroy them, but to learn to live in peace with them.

8. "Wrestle! Dad

Introduction to the film

Indian national wrestling champion Singh gave up wrestling because of life. He hoped to have a son to help him fulfill his wish, but he had no choice but to give birth to four daughters. Singer, who thought her dream was broken, unexpectedly found her daughter’s amazing talent for wrestling, so she decided to let her daughters: change their skirts, cut off their long hair, practice wrestling and win one championship after another …

Recommended reason

"Your father is fighting against the whole world for your future", and behind the painful training is actually a love encouragement and education.

After reviewing the classics, let’s take a look at the cinema parent-child movies that have been released or will be released soon!

#2

Cinema parent-child film

Science fiction and adventure ignite the dream of innocence.

Doraemon: Daxiong and the Ideal Country of the Sky

Type: Animation Adventure

Release time: 2023-06-01 09:00

Synopsis:

Sky adventure, let’s go! Doraemon Doraemon and Nobita are driving the "Led Zeppelin of Time" with the function of time jumping. In order to find the dreamland that everyone once imagined, such as Atlantis and Miyagi, which many adventurers have dreamed of since ancient times, they launched an adventure in the air. ……

Castle in the Sky

Type: animation adventure family fantasy

Release time: 2023-06-01 08:00

Synopsis:

Baru, an apprentice mechanic, accidentally met Hida, a girl who fell from the sky. Her life is mysterious and she holds a flying stone that can open Laputa, the city of the sky. In the pursuit of the dual forces of the military and pirates, Baru and Hida finally found the legendary city of the sky, which also revealed the secret of the decline of this ancient empire that once had advanced technology and great wealth.

God and daddy

Type: children’s inspirational

Release time: June 1, 2023

Synopsis:

In April, 2020, Shendoudou children’s clothing store was forced to close its business. A Luo, who wanted to go back to his hometown for fun, saw his daughter going to kindergarten for a while, but the kindergarten was temporarily closed, so he chose to take her four-year-old daughter for a ride to Lhasa.

Adventures of Qiaohu Fantasy Stage

Type: adventure

Release time: June 1, 2023

Synopsis:

It was a little white tiger girl named Mary who starred in the hat captain of the magic show group. Unfortunately, the tent of the magic show group was messed up by naughty Xiao Bu and his friends. When the head of the orangutan was about to cancel the show, Qiaohu took his little friends and invited big friends and children from Qiaohu Island to help. On the other hand, Mary, who plays the captain of the hat, has no confidence in her performance. Qiaohu takes on the responsibility of encouraging Mary, but he and Mary are accidentally sucked into the magic bag. They found that there was a hole in the magic bag.

The little mermaid

Type: love

Release time: May 31, 2023

Synopsis:

Inspired by the well-known fairy tales of Andersen, the film features Ai Lier (Halle Bailey), a naive, brave and rebellious mermaid. Eager to explore the world beyond the sea, she falls in love with human prince Alec (Jonah Hauer-King). Ai Lier follows his inner voice, goes against tradition, and makes a deal with the evil undersea witch Ursula (Melissa McCarthy Melissa McCarthy) in exchange for the opportunity to experience human life, only to find that he and his father are in extreme danger.

Spider-Man: The Universe.

Genre: comedy/science fiction/animation/adventure

Release time: June 2, 2023

Synopsis:

The film tells the story of Spider-Man Myers (voiced by Shameik Moore Shameik Moore) and Gwen Spider (voiced by Hailee Steinfeld Hailee Steinfeld), a new generation, crossing the multiverse and embarking on a more grand adventure journey. Facing the fate that every Spider-Man will lose his loved ones, Myers vowed to break the curse of fate and find his own heroic road. This decision is in great conflict with the Spider Alliance led by Spider-Man 2099 (voiced by Oscar Is aac in oscar isaac), and a civil war in Spider-Man with one enemy and one hundred enemies is about to start!

Comprehensive cover news editor Cai Yuting

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North American box office: "Star Wars 8" won six new films in a row, and the "brave" won.


1905 movie network news Last weekend (12.22-12.24), the box office revenue in North America totaled $169 million, down 38.9% from the previous week. Disney’s strong trump card "Star Wars 8: The Last Jedi Knight" continued to win the weekend box office list with $68.64 million, but compared with the previous week, it suddenly dropped by 68.8%, which was a bit surprising. Fortunately, its own box office base is, and now the local box office has reached 365 million US dollars, and the global box office has reached 745 million US dollars. It is expected that there will be another good-looking "soaring" after the subsequent opening of paintings in mainland China.

 

In terms of new films, Dwayne Douglas Johnson starred in the highest box office, earning $50.6 million in 3,765 cinemas in five days. There are emotional blessings in word of mouth, but it is also very stable, and it is considered to be entertaining, so it is good to grasp the balance between comedy and action. As the final part, it can’t compare with the brilliance of the second part. It only got $20.45 million in 3,447 cinemas in three days over the weekend, and it was evaluated as "out of tune"! The box office of Hugh Jackman’s musical films is weak, with a total box office of $13.19 million in five days. The evaluation is seriously polarized. Those who like it think it is "full of sincerity" and "perfect and passionate", while those who don’t love it accuse it of being empty. Directed by alexander payne and starring Matt Damon, they also failed to make a difference, earning $4.6 million at the box office in three days, and receiving a moderate evaluation: "I don’t feel the fullness of the story itself". Small-scale screening won $495,000 in nine theaters in three days, with an average box office of 55,000 in a single theater, which was relatively mediocre, but the media evaluation was well maintained. From the short comments, most American media expressed their preference for Steven Allan Spielberg’s brand and basically praised its "practical significance".

ranking

film

Weekend box office

(USD)

Cumulative box office

(USD)

Number of release weeks

this week

last week

one

one

Star Wars: The Last Jedi

6864ten thousand

3.65a hundred million

2

2

new

Jumanji: Welcome to the Jungle

3400ten thousand

5060ten thousand

one

three

new

perfectTone 3

2045ten thousand

2045ten thousand

one

four

new

circusKing of kings

860ten thousand

1319ten thousand

one

five

2

Bulladventures

705ten thousand

2653ten thousand

2

six

three

Coco

5.2 million

1.613a hundred million

five

seven

new

shrinklife

4.6 million

460ten thousand

one

eight

16

Darkest Hour

4.1 million

695ten thousand

five

nine

new

Father image

320ten thousand

320ten thousand

one

10

twelve

Water substancelanguage

305ten thousand

761ten thousand

four

11

four

Miracleboy

2 million

1.149a hundred million

six

twelve

11

Saintbe bornStar

137ten thousand

3846ten thousand

six

Data source:boxofficemojo


Stills of "Brave Game"

"The Brave Game" is full of emotional skills. "Perfect Tone 3" is out of tune.

 

Recommended star rating for Brave Game: ★★★

"Perfect Tone 3" recommended interstellar: ★★★

"Father Image" recommended Star: ★★★

 

Sony Colombia "played" 34 million dollars in 3,765 cinemas for three days on the weekend, and the total box office for five days (the film opened last Wednesday) was 50.6 million dollars. Dwayne Douglas Johnson came out of the gloom of its earlier fiasco, which can be compared with the same period in 2007 (the first week’s box office was 44.78 million US dollars, and the final domestic box office was 219 million US dollars). At present, the word-of-mouth is very strong. If this trend continues, the final domestic box office of Game of the Brave: Battle of the Jungle is expected to reach 175 million US dollars. The film is a sequel to robin williams’s classic The Brave Game in 1995. The production cost is 90 million US dollars, and now the global box office has exceeded 100 million US dollars. It is likely to become Sony’s highest-grossing film in China except 007 and Spider-Man series, and the global box office will also become a rare "highlight" after 2015.

 

The movie Game of the Brave: Battle of the Jungle scored 7.2 in IMDb, 58 in MTC, 77% in freshness of rotten tomatoes, and 89% in audience. "International Screen" commented: "It is entertaining, fascinating, bright in color, ingenious in action and adventure rhythm, and well-arranged in comedy effect." Hollywood Reporter: "The most attractive thing about this film is that you can watch familiar actors pretend to be ordinary children and try to adapt to this new self." Vanity Fair holds that: "Movies can strike a balance between action and comedy. Action design serves the plot, and it is not too flashy. The special effects have also distanced themselves from the previously shoddy monkeys. The comedy elements are cleverly rooted in the characters themselves, and they are not cheap to imitate and follow fixed patterns." Some media that don’t like it, such as Variety, spit out: "This is like watching the worst, except that there is no Indiana Jones."

 

Universal’s Perfect Tone 3 earned $20.45 million in 3,447 theaters in three days on the weekend, which is completely inferior to the $69 million in the first week. If it can be suppressed first and then promoted like that ($75 million in the first six days and $270 million in the final box office), the final box office is expected to reach $150 million. If it’s really the last movie, it’s still a good ending. From the word of mouth, the media and fans also hope that "Perfect Tone 4 or 5" will not disturb people’s peace again. The movie Perfect Tone 3 now has an IMDb score of 6.1, an MTC score of 40, and the freshness of rotten tomatoes is 29%. "Empire" magazine thinks: "Compared with the jokes in the first two films, it is much weaker, so it drags on to a warm-hearted ending. But it’s all right to end the trilogy like this. After all, it has already started to be framed in fantasy. "International Screen" thinks: "This film finally realizes how ridiculous it is. All the cheerful and stupid plot settings are mostly to make them smoothly transition to the next song or dance. It is hard not to feel the hardship of this film." Hollywood Reporter: "No matter how charming the first two movies are (mainly because of the charm of the leading role), they have lost their charm in this soulless sequel." Chicago Sun: "In a nutshell, Perfect Tone 3 is like a comeback show that no one calls encore."Seattle Times: "It’s just the same movie going back and forth. Is it going to be over until everyone dies?" The Los Angeles Daily directly said: "Out of tune!"

 

Warner Bros., this year’s big winner, released another film "Father’s Image" near the end of the year, which earned 3.2 million dollars in 2,902 cinemas in three days on weekends. At present, the IMDb score of Father Image is 5.4, the MTC score is 23, and the freshness of rotten tomatoes is 22%. "Hollywood Reporter" thinks: "The whole narrative is from one encounter to the next. In fact, the image of the father doesn’t need to exist at all. If it has to appear, it can actually be developed into a Netflix series by a more comic star, and each suspicious father will talk for half an hour." San Francisco Chronicle: "Such a flawed film is simply not worth two hours." In fact, a lot of bad word-of-mouth has flowed out before the release. It can only be said that Warner’s market is doing too well, and many ordinary fans are still "laughing" with joy.

Next page:The King of Circus and Narrowing Life are mediocre, and Washington post has strong practical significance.

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Kang Zhensheng: Determined to make China’s agricultural scientific research achievements "go abroad" after more than 30 years of wheat disease research.

CCTV News:In Yangling, Shaanxi, the birthplace of Chinese farming civilization, there is such a scientific researcher: he has been rooted in the northwest for more than 30 years and stuck to the yellow land. He is not a farmer, but better than a farmer.

He carried out research on the occurrence law and comprehensive control of wheat stripe rust, revealed the pathogenic variation path and mechanism of wheat stripe rust, made clear the causes of the prone areas of wheat stripe rust in summer in China, improved the understanding of the epidemic system of wheat stripe rust, and provided theoretical basis for comprehensive control of wheat stripe rust in China. The comprehensive control technology system of stripe rust in the prone areas in summer in China was constructed, and remarkable results were achieved through demonstration and application promotion, which effectively controlled stripe rust in China. The infection route and pathogenic mechanism of wheat scab were revealed, and the key period of disease prevention and control was determined, which provided theoretical basis and technical support for the prevention and control of wheat scab.

(Academician Kang Zhensheng introduced wheat stripe rust and its prevention to reporters. CCTV reporter Di Chenchen/photo)

(Academician Kang Zhensheng introduced wheat stripe rust and its prevention to reporters. CCTV reporter Di Chenchen/photo)

"Wheat stripe rust and scab are major biological disasters that affect China’s food security and food safety. I came out of a wheat field, and my career is in a wheat field. " He is Kang Zhensheng, an academician of China Academy of Engineering, distinguished professor, a Changjiang scholar of the Ministry of Education, a doctoral supervisor, and the director of the State Key Laboratory of Crop Stress Biology in Arid Areas. In the research building of Northwest A&F University, CCTV reporter met Professor Kang Zhensheng and listened to him tell his own research story.

Germinate the long-cherished wish of "relying on science to help agriculture increase production and income"

Kang Zhensheng was born in Anyue, Sichuan in 1957. He was a famous "good student" from primary school to high school. In 1981, Kang Zhensheng became the first graduate student of the school after the reform of the enrollment system with excellent results and the first place in the graduation thesis grade. Kang Zhensheng, who was born in a farmer’s family, witnessed the huge losses caused by stripe rust to wheat production. His character of not being afraid of difficulties and being brave in exploration also made Kang Zhensheng sprout his long-cherished wish of relying on science to help agriculture increase production and income in the vast fields.

He began his research career under the guidance of Professor Li Zhenqi, a famous plant pathologist in China. Under the leadership of Li Zhenqi, Kang Zhensheng visited the key areas where wheat stripe rust occurred in Longnan, Longdong and Guanzhong of Shaanxi Province for many times.

(Northwest A&F University Artificial Climate Room CCTV reporter Di Chenchen/photo)

(Northwest A&F University Artificial Climate Room CCTV reporter Di Chenchen/photo)

Through intensive investigation and repeated demonstration, they first discovered a new pathogenic strain of stripe rust, which seriously harmed the main wheat varieties in China, from thousands of analysis materials and infected wheat plants through a large number of analysis experiments and field inoculation, and made an accurate prediction on the development trend and harm of this strain. The prevention and control strategies and solutions put forward were adopted by agricultural production departments, which played an important guiding role in preventing and reducing the harm of wheat stripe rust. This achievement won the third prize of scientific and technological progress in Shaanxi Province in 1987.

Become a conqueror of "wheat cancer"

Wheat stripe rust, known as "wheat cancer", is a low-temperature fungal disease spread through the air, and it is one of the main public enemies of wheat production in the world, which often reduces wheat production by 10% to 30%, and even leads to wheat failure in serious cases.

For many years, Kang Zhensheng led the team to focus on the interaction between pathogenic fungi and host wheat, and to find out what caused the frequent changes of wheat stripe rust from the aspects of histology, cytology, molecular cytology and molecular biology.

(Wheat stripe rust in Academician Kang Zhensheng's office and its parasitic Berberis CCTV reporter Di Chenchen/photo)

(Wheat stripe rust in Academician Kang Zhensheng’s office and its parasitic Berberis CCTV reporter Di Chenchen/photo)

In order to find out the species of Berberis in the over-summer area of wheat stripe rust, Kang Zhensheng led his team members to travel all over the ravines of Gansu, Shaanxi, Sichuan and Yunnan provinces, and insisted on investigating the occurrence of wheat stripe rust. After a lot of field follow-up research, he sought the evidence that wheat stripe rust camped on Berberis in natural conditions and carried out experiments by using advanced scientific and technological means, and finally obtained a major discovery: sexual reproduction is the main pathogenic variation of wheat stripe rust in China. Wheat stripe rust is widely distributed in shrub leaves in northwest mountainous areas — — "Having children" on wild Berberis makes a new generation of germs become the "killer" of wheat varieties. On August 26, 2017, the research results were published in the top international academic journal Annual Review of Plant Pathology, which attracted wide attention at home and abroad.

Kang Zhensheng’s team established a technical system for forecasting wheat stripe rust in different places, and the accuracy of disease prediction was over 90%. The control technology system of "over-summer variable area" was established by taking measures such as crop structure adjustment, distribution of disease-resistant varieties, seed dressing with chemicals, winter spore isolation and Berberis treatment, which reduced the initial bacterial source of "over-summer variable area" by 40%, reduced the frequency of new races by 50% and extended the service life of disease-resistant varieties by 3-5 years, which played a key role in the effective control of stripe rust in China.

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

The research results benefit many countries and regions in the Belt and Road Initiative.

Wheat stripe rust is a serious biological disaster that affects the global wheat production safety for a long time. As the main academic leader of plant pathology in China, Kang Zhensheng led his team to make outstanding contributions to the research on the occurrence regularity, pathogenic mechanism and control technology of major diseases such as wheat stripe rust and scab. Kang Zhensheng promoted the establishment of "China Wheat Stripe Rust Germ Base Comprehensive Control Technology System", which was applied in 12 provinces, autonomous regions and municipalities in China, reducing the occurrence area of stripe rust by 50%, recovering more than 2 billion kilograms of grain losses every year, and increasing income and reducing expenditure by 4 billion yuan annually.

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

(Northwest A&F University Wheat-Stripe Rust Interaction Room CCTV reporter Di Chenchen/photo)

Since the "Belt and Road Initiative" was put forward, Kang Zhensheng’s team has successively cooperated with more than 10 countries and regions, including Kazakstan, Turkish and Ethiopian, collected and studied more than 1,300 standard samples of wheat stripe rust pathogens, and made China’s agricultural scientific research achievements with high quality and high yield of wheat "go abroad".

Today, Kang Zhensheng is still busy, but what he considers most now is to train young people, let them stand on their shoulders and grow up as soon as possible. "The work of revealing the genetic and molecular mechanism of virulence variation of Puccinia striiformis has just begun. In the future, while engaging in scientific research, we should train the young people behind us so that our agricultural science and technology can really run from the past to the leading stage." (Part of the data comes from Northwest A&F University)

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Investigation and Research | Gene Mutation Must Be a Disaster?

Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?

The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.

Harm.

What is gene suppression?

Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.

"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.

Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.

Yeast substitution experiment

"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.

But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.

"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.

Narrow the search scope of mutant genes

The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.

Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.

"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.

The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.

The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?

Jolanda:At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.

The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.

Jolanda:Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.

The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?

Jolanda:We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.

The PaperWhat do you think is the most important significance of this research?

Jolanda:The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.

(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")