标签归档 武汉红灯一条街

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How long is the course of influenza? What if you have a fever? Fourteen questions about influenza are answered authoritatively by Beijing Children’s Hospital.

There are many respiratory diseases in children in winter, among which influenza virus is one of the common pathogens. On the questions that parents and friends are concerned about, the National Children’s Medical Center Beijing Children’s Hospital answered authoritatively.

1. What are the typical symptoms of influenza?

Children infected with influenza virus can show fever, chills, headache, myalgia and general malaise, often accompanied by respiratory diseases such as cough, sore throat and runny nose. The degree of fever in young children may be heavier, and some children may also have febrile convulsions; In addition, they will have more gastrointestinal symptoms, such as nausea, vomiting, diarrhea and poor appetite. Very few children infected with influenza may develop into severe influenza, causing laryngitis, pneumonia, encephalopathy, myocarditis and so on.

2. How does the flu spread and how long is the incubation period?

Influenza virus can spread from person to person through respiratory droplets (such as sneezing, coughing and talking) or after polluting the surface of objects. Influenza viruses can also spread through small air particles released by influenza patients when they breathe. Influenza patients are the main source of infection. The incubation period of influenza is generally 1-7 days, and most of them are 2-4 days.

3. How long is the general course of influenza and what is the change of the course?

For children without basic diseases, the course of influenza virus infection is acute and self-limited, and most symptoms disappear in about 2-3 days after onset. Some children’s fever lasts for 5 days, and most patients recover within 1 week, but cough may last for a long time, and fatigue and fatigue of a few elderly children (over seven or eight years old) may last for several weeks.

4. How to distinguish the flu from the common cold?

The full name of the flu is called "influenza", and you may think it is similar to the common cold, but the flu and the common cold cannot be confused.

The common cold can be caused by many pathogens, among which viruses are the most common, including rhinovirus, adenovirus, metapneumovirus, bocavirus, etc. Bacteria and mycoplasma can also cause the common cold. The symptoms of the common cold are mild, usually low-to-moderate fever, which lasts for 1-2 days, and may be accompanied by other catarrhal symptoms such as sneezing, runny nose, stuffy nose and slight cough, while the systemic symptoms such as chills, headache and joint muscle pain are very mild. Generally, there are no serious complications.

Influenza is mainly caused by influenza A and B virus infection, with high fever, severe systemic symptoms such as chills, headache and joint muscle pain. A few influenza patients may have complications such as rhabdomyolysis, pneumonia, encephalitis and encephalopathy.

In the flu season, children with flu-like symptoms, especially those with a history of contact with influenza patients, should first consider influenza virus infection, which can be diagnosed by influenza virus antigen detection or influenza virus nucleic acid detection.

5. How is the flu generally treated?

After being infected with influenza virus, the treatment measures include antiviral and symptomatic treatment.

Anti-influenza drugs: At present, the oral antiviral drugs for influenza virus are mainly neuraminidase inhibitors, commonly used drugs include oseltamivir and mabaloxavir, and intravenous drugs include paramivir. Once you have the flu, the sooner you use anti-influenza drugs, the better, especially within 48 hours of onset. However, even if the course of the disease exceeds 48 hours, once the flu is confirmed, you should actively use drugs.

Symptomatic treatment measures: mainly to reduce fever and relieve discomfort. You can choose antipyretics scientifically, and you can also use some drugs to relieve symptoms such as cough and stuffy nose. It should be noted that the pharmaceutical ingredients of some compound preparations may overlap with other therapeutic drugs, and the combined use may cause an excessive amount of one ingredient and cause adverse reactions in children.

6. Is there any specific medicine for influenza and can it be prevented by drugs?

Oseltamivir is an antiviral drug specifically for influenza virus, which can shorten the duration of clinical symptoms. However, it is not recommended that children take anti-influenza drugs as soon as they have a fever, because there are many respiratory pathogens that cause fever, and oseltamivir is only effective for influenza.

The best way to prevent influenza virus is to actively vaccinate. If there is no contraindication, people over 6 months are advised to actively vaccinate against influenza. For children with high risk of severe influenza or influenza complications, who are contraindicated by influenza vaccine or have not been vaccinated (or within 2 weeks after vaccination), drug prevention should be considered. Drug prevention can reduce but not eliminate the risk of influenza, and the susceptibility to influenza will be restored after drug withdrawal. Therefore, routine drug prevention for children is not recommended.

7. Are azithromycin and other antibacterial drugs useful for influenza?

Antibacterials, including azithromycin, are ineffective against viral infection. However, if there is a mixed infection of influenza virus and bacteria or mycoplasma, doctors will also consider the use of anti-influenza drugs combined with antibacterial drugs.

8. Fever is one of the typical symptoms of children. What misunderstandings should be avoided in home care?

The main purpose of taking antipyretics for children is not to reduce the body temperature to normal, but to increase the comfort of children and let them spend the fever period comfortably and safely.

First of all, you can’t take two antipyretics at the same time, which will increase the burden on your child’s liver and kidney and cause adverse reactions; It is also not recommended to use the two antipyretics alternately, because it can not increase the antipyretic effect, but may mistake the time and even lead to overdose.

Secondly, when parents choose antipyretics for their children, they should not only choose drugs suitable for their age, but also read the instructions carefully, and give them to their children in strict accordance with the instructions, paying attention to the dosage and time interval. Remember not to increase the dosage or frequency at will because the child’s body temperature has not dropped to normal.

Finally, if you give your child a compound cold preparation at the same time, you must read the drug ingredient list to avoid duplication with other drugs being used, such as antipyretics. If there is duplication, please use it with caution to avoid overdose.

In daily life, children should be kept in a regular routine to ensure adequate sleep; In terms of diet, we should pay attention to nutrition, have a balanced diet, eat more fruits and vegetables and drink more water. At the same time, avoid the family environment being too dry and ensure the humidity, which is conducive to the recovery of children. Parents should also pay attention to the fact that children should neither cover up their fever nor let them catch cold again. Parents should maintain a peaceful attitude, pay attention to their children’s fever, and don’t be overly anxious, carefully observe their children’s situation and help them recover as soon as possible.

9. I am particularly worried about my child’s febrile convulsion. What should I do if there is febrile convulsion?

If the child has a febrile convulsion, parents must keep calm and don’t panic: (1) Let the child lie on his side or tilt his head to one side, and clean up things with sharp corners around him to ensure that the child will not be hurt when the convulsion occurs. (2) When convulsions occur, don’t stuff anything into the child’s mouth, and don’t feed anything, and don’t try to stop twitching by pressing the limbs. (3) Record the duration and seizure characteristics of convulsions. If the duration of convulsions exceeds 5 minutes or the status quo of convulsions has occurred in the past, call an ambulance. In most cases, febrile convulsions will stop within 5 minutes.

10. What happens that requires timely medical treatment?

Most children with influenza are mild patients, so they can take care of them at home. However, if the following situations occur, they should seek medical attention in time: children who have been diagnosed with influenza have high fever or fever for more than three days, poor mental health or even consciousness disorder, shortness of breath/dyspnea, chest pain, blue skin on the lips, frequent vomiting or diarrhea, convulsions, refusal to eat, scanty urine or urine turning red, and obvious muscle pain; Or if the symptoms are repeated, such as fever again after the flu symptoms are relieved, you need to seek medical advice in time to avoid aggravation and even danger.

11. Which children are at high risk of severe influenza?

High-risk children with severe influenza include: children under 5 years old, especially children under 2 years old; There are basic diseases, such as asthma, tumor, kidney disease, immunodeficiency, taking immunosuppressive drugs, etc.; Obese children are also high-risk groups. When high-risk people have fever during the influenza epidemic season, they should attach great importance to it and seek medical treatment as soon as possible. Once influenza virus infection is considered, antiviral treatment should be started as soon as possible. If there are no contraindications, people at high risk of severe influenza should be actively vaccinated before the flu season begins.

12. Will you get the flu if you are infected with mycoplasma pneumonia recently?

I will. Because the body’s resistance will decrease when it is infected, it may be easy to be infected with other pathogens. Measures to prevent cross-infection include paying attention to self-protection, trying not to take children to crowded places, especially places with poor air circulation, during the high incidence season of respiratory diseases; Pay attention to open the window regularly for ventilation indoors, and isolate it from the sick family if possible; Pay attention to hand hygiene and remind children not to touch their eyes, nose and mouth with unclean hands.

13. Will children have sequelae after the flu?

Most children will not leave sequelae after being infected with the flu. However, after the flu temperature is normal, cough and runny nose may last for a week or even longer. The treatment is mainly symptomatic, keeping the air moist and promoting airway recovery. If cough seriously affects rest, you can take some antitussive drugs under the guidance of a doctor. Some children may have chronic cough due to airway hyperresponsiveness, especially those with eczema and wheezing history, and can be given medication under the guidance of a doctor.

14. How to prevent the spread of influenza in schools and families?

Schools should organize and mobilize students and faculty to get flu vaccine before the flu season begins; It is necessary to strengthen health education for students and their families, help and urge students to develop good hygiene habits, such as washing hands frequently and maintaining environmental hygiene; The classroom should be ventilated regularly; The school monitors students’ body temperature to find sick children in time; Once students are infected with influenza virus, they should rest at home and not go to school with illness; Attach importance to students’ physical exercise and enhance their physique and disease resistance.

Children suffering from influenza should ensure adequate rest, balanced nutrition, drink plenty of water and eat easily digestible food at home; Family members should maintain good hygienic living habits, pay attention to environmental hygiene and cough etiquette. If possible, we should try our best to isolate ourselves from sick family members; If you can’t isolate, you should wear a mask for protection. In addition, the indoor window should be ventilated regularly, but we should pay attention to keep warm in winter to avoid catching cold.

Authors: Zhao Guangyuan, the attending physician of emergency medicine in Beijing Children’s Hospital.

Audit: Wang Quan, Director of Department of Critical Care Medicine, Beijing Children’s Hospital

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Beijing property market regulates the full moon: the transaction cools down, and the official force purchases rents simultaneously.

  BEIJING, Beijing, April 17 (Zhongqing) After the introduction of the "3.17" overweight control policy in Beijing’s property market, Beijing has made more than ten moves in succession in the past month, blocking the loopholes in real estate speculation in an all-round way, and at the same time, focusing on building a housing system with both purchase and rent based on the fundamental demand of "living and living"; At the same time, strictly investigate the school district housing speculation, aisle rooms, garage, etc. that do not meet the actual living conditions, are not allowed as admission qualifications.

  Punch 12 times a month

  According to the incomplete statistics of Zhongxin. com, within one month from March 17 to April 16, Beijing issued 12 highly targeted property market regulation policies, all of which were "zero transition" on the same day or the next day. The determination to regulate is self-evident.

  In addition to opening the mode of "recognizing houses and loans", Beijing’s regulatory heavy punches also include reducing the first home loan discount, modifying the tax standard for non-Beijing-born houses, making it clear that the houses in the corridor school district are not registered, restricting the purchase of commercial projects, and piloting public rental housing with "New Beijingers". The industry believes that this has blocked any possibility of real estate speculation in Beijing.

  Now, what changes have taken place in the Beijing property market? Data from the Central Plains Real Estate Research Center show that from March 18th to April 10th, all properties in Beijing signed 5,817 contracts, which was 19% lower than that before the chain regulation. From the data point of view, due to the lag of online signing data, the actual market transaction or cooling is more obvious.

  A number of real estate agents also told the reporter of Zhongxin. com that "there are obviously fewer customers who come to see the house, and those who have the willingness to buy a house before have turned to wait and see." Recently, the reporter found in a number of chain intermediary stores in Fangshan District, Beijing that there were very few customers in the store, and the staff either chatted or looked at their computers.

  "It is estimated that in the second half of April, the transaction volume of second-hand houses may decline by about 50%." Zhang Dawei, chief analyst of Zhongyuan Real Estate, said that a few months ago, the second-hand housing prices in Beijing increased significantly faster than those of new houses. Therefore, the second-hand housing market was the most affected after the regulation and overweight.

  Commercial market cooling

  On the evening of March 26th, commercial houses in Beijing were officially restricted. When individuals can’t buy houses that are not built, under construction or under sale, they also need to meet two "harsh" conditions when buying second-hand commercial houses. At the same time, commercial banks suspend personal housing loans for individuals to buy commercial projects.

  Restricted purchases, stopped loans, and strictly investigated illegal sales, and the commercial market cooled down overnight.

  According to the data of Zhongyuan Real Estate, from March 27 to April 10, in half a month, the total number of commercial contracts in Beijing was 303, which was more than 90% lower than the previous transaction volume. Not only that, the contracted projects are concentrated in Tongzhou area, such as Tongzhou Everbright New Beijing Center and World Overseas Chinese Business Center, which have been restricted before. From a certain perspective, the commercial market is close to freezing.

  According to the reporter’s investigation, many buyers who are stuck in the purchase restriction policy and have not completed the online signing are eager to repent. "I am afraid of hitting my hands in the future" is what they are most worried about.

  Strictly check the corridor school district

  As the vanguard of the property market, the school district housing has also become the focus of Beijing’s crackdown on speculation. On March 23, the Beijing Municipal Education Commission, the Municipal Planning and Land Commission, the Municipal Public Security Bureau and other departments joined hands to refuse to register, settle down or enroll in schools nearby.

  The next day, 10 intermediary stores of Chain Home, I Love My Family and Zhongyuan Intermediary Company near four communities, such as Fenghuiyuan in Xicheng District, were ordered to suspend business for one month for rectification due to illegal acts such as tax payment, illegal agency, and bid up housing prices.

  In response to the speculation of the Beijing school district, the Beijing Municipal Education Commission has also repeatedly shot. First, it is clearly stated that "the corridor school district room" cannot be used as a qualification condition for admission; Then, in the opinions on enrollment in the compulsory education stage in 2017 released on April 16th, it is proposed to explore the enrollment mode of combining single-school scribing with multi-school scribing.

  In Zhang Dawei’s view, the above policies are real, whether in real estate regulation or in education coordination. The policy is very strong, and the structural adjustment of the school district is still steady and progressive.

  Make great efforts to purchase and rent at the same time

  If you want to "have a place to live", it is not the only way to buy a house. A multi-level, market-oriented, equal and orderly rental market can also solve this problem.

  It is precisely based on the "big goal" of paying equal attention to both rent and purchase that the Beijing Municipal Commission of Housing and Urban-Rural Development officially launched a pilot project of special allocation for new Beijingers (non-Beijing families with stable employment) in public rental housing and self-occupied housing this month. On April 12th, the first batch of 120 sets of public rental housing participating in the pilot project has been registered. According to the introduction of the Beijing Municipal Commission of Housing and Urban-Rural Development, about 1,000 suites of two public rental housing projects, namely, Changyang Lingfeng Four Seasons Garden and Yancun Lehuo Yayuan, will be taken out later, and special rent allocation will be piloted again.

  On the other hand, Beijing also actively expands the multi-level development of the leasing market, and encourages housing enterprises to use self-sustaining houses as rental houses through the land transfer method of "controlling land prices and limiting house prices". On April 14, the Beijing Municipal Commission of Housing and Urban-Rural Development issued the Notice on Relevant Issues Concerning the Management of Self-sustaining Commercial Housing Leases of Enterprises in this Municipality, prohibiting the housing enterprises that have obtained the held rental land from selling in disguised form through grey channels; At the same time, it provides a guarantee for enterprises and individuals to rent self-sustaining commercial houses of developers.

  With decoration, long lease period and negotiable rent, isn’t it great to rent a first-hand house directly with the developer? According to the regulations, the tenant is not limited to a specific enterprise or individual; The rental price shall be determined by both parties through consultation according to the market level; Before renting a self-sustaining commodity house, the house should be fully renovated; The term of the lease contract shall not exceed 10 years. (End)

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Affordable and healthy anti-cancer vegetables with two parity

  Some studies have found that cruciferous vegetables have certain benefits in preventing lung cancer, breast cancer, gastric cancer and intestinal cancer.

  Which vegetables belong to Cruciferae?

  In addition to the familiar purple cabbage, cabbage, broccoli and cauliflower, in fact, many green leafy vegetables belong to Cruciferae, even including Chinese cabbage, Chinese cabbage, white radish, Chinese kale, rape, water bamboo and so on.

  Today, I recommend two cheap anti-cancer dishes to my friends, purple cabbage and Chinese cabbage. They are cheap, especially Chinese cabbage. When they are on the market in large quantities, one yuan can buy several kilograms. Buy these two kinds of vegetables, 5 yuan can fill the vegetable basket, which is very affordable.

  First, purple cabbage

  Among all kinds of substances that play an anti-cancer role, there is a very important component called isothiocyanate.

  Purple cabbage itself does not contain isothiocyanate, but it contains glucose isothiocyanate. When eating purple cabbage, you should chew. In the process of chewing, glucose isothiocyanate is released and becomes isothiocyanate after human metabolism.

  In the whole metabolic process, isothiocyanate produces indole and thioglycoside. In vitro experiments showed that indole and glucosinolates had certain inhibitory effects on some cancer cells.

  In addition, purple cabbage is rich in flavonoids because of its purple color. Flavonoids are a very powerful group of antioxidants, and their antioxidant effects are better than those of β -Carotene, vitamin C and vitamin E should all be high.

  Second, Chinese cabbage

  Chinese cabbage is sweet and fragrant, crisp and juicy. Although the price is cheap, it definitely does not lose other vegetables in nutrition.

  Chinese cabbage is low in calories and suitable for people who want to lose weight. Chinese cabbage also contains dietary fiber, vitamin C, B vitamins, potassium, calcium, magnesium and other nutrients, which have the effects of relaxing bowels and resisting aging. In addition, the stewed cabbage is helpful for digestion and is also very suitable for people with low gastrointestinal function.

  Some researchers have found that the incidence of breast cancer in women who eat a lot of cabbage has decreased.

  However, when the components we detected in Chinese cabbage were extracted and made into medicines for people to take, the same effect did not appear. Increasing the dose, or taking several ingredients at the same time, has no effect.

  This has greatly inspired people, and it is more scientific and reasonable to ingest nutrients in the form of whole food than to ingest purified substances alone.

  In terms of the total amount of vegetables, the average adult can basically meet the demand by eating vegetables weighing about a catty every day.

  In fact, there are not many vegetables that weigh a catty. According to the amount after cooking, it is a plate at noon and a plate at night. The "Jin" mentioned here includes all kinds of vegetables. You can eat cruciferous vegetables 3-4 times a week, and you should also eat some other vegetables interspersed.

  For people with thyroid-related diseases, whether they can eat cruciferous vegetables depends on the specific situation, including whether they smoke, whether they take too much iodine or lack iodine, and the current treatment. It is recommended to follow the doctor’s advice.

  Text/Yu Kang (Professor of Clinical Nutrition, Peking Union Medical College Hospital)

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Kang Zhensheng: Determined to make China’s agricultural scientific research achievements "go abroad" after more than 30 years of wheat disease research.

CCTV News:In Yangling, Shaanxi, the birthplace of Chinese farming civilization, there is such a scientific researcher: he has been rooted in the northwest for more than 30 years and stuck to the yellow land. He is not a farmer, but better than a farmer.

He carried out research on the occurrence law and comprehensive control of wheat stripe rust, revealed the pathogenic variation path and mechanism of wheat stripe rust, made clear the causes of the prone areas of wheat stripe rust in summer in China, improved the understanding of the epidemic system of wheat stripe rust, and provided theoretical basis for comprehensive control of wheat stripe rust in China. The comprehensive control technology system of stripe rust in the prone areas in summer in China was constructed, and remarkable results were achieved through demonstration and application promotion, which effectively controlled stripe rust in China. The infection route and pathogenic mechanism of wheat scab were revealed, and the key period of disease prevention and control was determined, which provided theoretical basis and technical support for the prevention and control of wheat scab.

(Academician Kang Zhensheng introduced wheat stripe rust and its prevention to reporters. CCTV reporter Di Chenchen/photo)

(Academician Kang Zhensheng introduced wheat stripe rust and its prevention to reporters. CCTV reporter Di Chenchen/photo)

"Wheat stripe rust and scab are major biological disasters that affect China’s food security and food safety. I came out of a wheat field, and my career is in a wheat field. " He is Kang Zhensheng, an academician of China Academy of Engineering, distinguished professor, a Changjiang scholar of the Ministry of Education, a doctoral supervisor, and the director of the State Key Laboratory of Crop Stress Biology in Arid Areas. In the research building of Northwest A&F University, CCTV reporter met Professor Kang Zhensheng and listened to him tell his own research story.

Germinate the long-cherished wish of "relying on science to help agriculture increase production and income"

Kang Zhensheng was born in Anyue, Sichuan in 1957. He was a famous "good student" from primary school to high school. In 1981, Kang Zhensheng became the first graduate student of the school after the reform of the enrollment system with excellent results and the first place in the graduation thesis grade. Kang Zhensheng, who was born in a farmer’s family, witnessed the huge losses caused by stripe rust to wheat production. His character of not being afraid of difficulties and being brave in exploration also made Kang Zhensheng sprout his long-cherished wish of relying on science to help agriculture increase production and income in the vast fields.

He began his research career under the guidance of Professor Li Zhenqi, a famous plant pathologist in China. Under the leadership of Li Zhenqi, Kang Zhensheng visited the key areas where wheat stripe rust occurred in Longnan, Longdong and Guanzhong of Shaanxi Province for many times.

(Northwest A&F University Artificial Climate Room CCTV reporter Di Chenchen/photo)

(Northwest A&F University Artificial Climate Room CCTV reporter Di Chenchen/photo)

Through intensive investigation and repeated demonstration, they first discovered a new pathogenic strain of stripe rust, which seriously harmed the main wheat varieties in China, from thousands of analysis materials and infected wheat plants through a large number of analysis experiments and field inoculation, and made an accurate prediction on the development trend and harm of this strain. The prevention and control strategies and solutions put forward were adopted by agricultural production departments, which played an important guiding role in preventing and reducing the harm of wheat stripe rust. This achievement won the third prize of scientific and technological progress in Shaanxi Province in 1987.

Become a conqueror of "wheat cancer"

Wheat stripe rust, known as "wheat cancer", is a low-temperature fungal disease spread through the air, and it is one of the main public enemies of wheat production in the world, which often reduces wheat production by 10% to 30%, and even leads to wheat failure in serious cases.

For many years, Kang Zhensheng led the team to focus on the interaction between pathogenic fungi and host wheat, and to find out what caused the frequent changes of wheat stripe rust from the aspects of histology, cytology, molecular cytology and molecular biology.

(Wheat stripe rust in Academician Kang Zhensheng's office and its parasitic Berberis CCTV reporter Di Chenchen/photo)

(Wheat stripe rust in Academician Kang Zhensheng’s office and its parasitic Berberis CCTV reporter Di Chenchen/photo)

In order to find out the species of Berberis in the over-summer area of wheat stripe rust, Kang Zhensheng led his team members to travel all over the ravines of Gansu, Shaanxi, Sichuan and Yunnan provinces, and insisted on investigating the occurrence of wheat stripe rust. After a lot of field follow-up research, he sought the evidence that wheat stripe rust camped on Berberis in natural conditions and carried out experiments by using advanced scientific and technological means, and finally obtained a major discovery: sexual reproduction is the main pathogenic variation of wheat stripe rust in China. Wheat stripe rust is widely distributed in shrub leaves in northwest mountainous areas — — "Having children" on wild Berberis makes a new generation of germs become the "killer" of wheat varieties. On August 26, 2017, the research results were published in the top international academic journal Annual Review of Plant Pathology, which attracted wide attention at home and abroad.

Kang Zhensheng’s team established a technical system for forecasting wheat stripe rust in different places, and the accuracy of disease prediction was over 90%. The control technology system of "over-summer variable area" was established by taking measures such as crop structure adjustment, distribution of disease-resistant varieties, seed dressing with chemicals, winter spore isolation and Berberis treatment, which reduced the initial bacterial source of "over-summer variable area" by 40%, reduced the frequency of new races by 50% and extended the service life of disease-resistant varieties by 3-5 years, which played a key role in the effective control of stripe rust in China.

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

The research results benefit many countries and regions in the Belt and Road Initiative.

Wheat stripe rust is a serious biological disaster that affects the global wheat production safety for a long time. As the main academic leader of plant pathology in China, Kang Zhensheng led his team to make outstanding contributions to the research on the occurrence regularity, pathogenic mechanism and control technology of major diseases such as wheat stripe rust and scab. Kang Zhensheng promoted the establishment of "China Wheat Stripe Rust Germ Base Comprehensive Control Technology System", which was applied in 12 provinces, autonomous regions and municipalities in China, reducing the occurrence area of stripe rust by 50%, recovering more than 2 billion kilograms of grain losses every year, and increasing income and reducing expenditure by 4 billion yuan annually.

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

(Northwest A&F University Wheat-Stripe Rust Interaction Room CCTV reporter Di Chenchen/photo)

Since the "Belt and Road Initiative" was put forward, Kang Zhensheng’s team has successively cooperated with more than 10 countries and regions, including Kazakstan, Turkish and Ethiopian, collected and studied more than 1,300 standard samples of wheat stripe rust pathogens, and made China’s agricultural scientific research achievements with high quality and high yield of wheat "go abroad".

Today, Kang Zhensheng is still busy, but what he considers most now is to train young people, let them stand on their shoulders and grow up as soon as possible. "The work of revealing the genetic and molecular mechanism of virulence variation of Puccinia striiformis has just begun. In the future, while engaging in scientific research, we should train the young people behind us so that our agricultural science and technology can really run from the past to the leading stage." (Part of the data comes from Northwest A&F University)

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Is the "Today’s Headline" brought to court "Today’s Fried Bread" an infringement? Lawyer’s detailed explanation

  With today’s headlines, can there be "today’s fried dough sticks" and "today’s noodles"? Recently, this issue has caused netizens to watch. Today’s fried dough sticks company in Henan has designed a storefront that is highly similar to today’s headline LOGO and its APP interface, and a slogan similar to today’s headline "You care about the headline": "You care about you is a good fried dough sticks", and the business looks good.

  However, the announcement of Guangzhou Intellectual Property Court recently showed that Beijing ByteDance Technology Co., Ltd., to which today’s headline belongs, took "Today’s fried dough sticks" to court.

  Does today’s fried dough sticks constitute infringement? What is trademark infringement? What punishment will "today’s fried dough sticks" face once they are convicted of infringement? Please see the lawyer for a detailed explanation.

  Can "Today’s Headline" Trademark be Cross-protected?

  According to the enterprise survey data, today’s fried dough sticks catering management Co., Ltd. was established on May 13 this year with a registered capital of 1 million yuan. In addition to the "Today’s fried dough sticks" signboard, today’s fried dough sticks company applied for 16 trademarks such as today’s noodles, many cakes, instant cakes and tomorrow’s fried dough sticks in the categories of food, catering accommodation and convenience food. However, the above trademark applications are in a state of "waiting for substantive examination" and have not been successfully registered at present.

  China’s trademark law stipulates that using a trademark similar to its registered trademark on the same commodity or using a trademark identical to or similar to its registered trademark on similar commodities without the permission of the trademark registrant is likely to lead to confusion, which is an infringement of the exclusive right to use a registered trademark.

  The reporter noted that although ByteDance Company also registered the "Today’s Headline" trademark in the international classification "Class 43", the sub-item is "Day Nursery (babysitting); Animal foster care; Blankets for rent. " The trademark "Today’s Headline" registered in such sub-projects as "restaurants, teahouses and cafes" has passed the preliminary examination under the name of "Xia Rong (Shanghai) Catering Management Co., Ltd.". Therefore, "Today’s Headline" does not actually have the prior right of the trademark of the restaurant category, and whether the "Today’s Headline" trademark of the information technology category can be protected to the catering category will become the key.

  Huang Hui, an intellectual property partner of Wanhuida, believes that now is the era of attention economy, and today’s deep-fried dough-strips company is still applying for quick cakes and lots of cakes. In fact, they all want to take a shortcut and hitchhike and should not be encouraged. "This is obviously a free ride by taking advantage of other people’s market reputation." Huang Hui believes that the word "today’s headline" itself is relatively weak, because "today" and "headline" are the daily language of news media, but combined with the special graphic expression, according to the judicial interpretation of protecting well-known trademarks in China, today’s headlines may still be protected by well-known trademarks.

  Wu Xinhua, a senior partner of Beijing Weiheng Law Firm and director of the intellectual property department, also said that "Today’s Headline" itself is a word combination with weak distinctiveness, but it has gained high popularity and is well known by the relevant public after being widely used and publicized by ByteDance Company in recent years. However, whether it can be protected as a well-known trademark depends on the trial of Guangzhou Intellectual Property Court.

  Main identification elements of trademark infringement

  The cross-border imitation of "today’s fried dough sticks" is not unusual. Around well-known enterprises, "trademark imitation show" is often staged. Then, in judicial practice, how to identify trademark infringement? As long as the names are close, is it infringement?

  The reporter noticed that there is a ready-made case that is very close to today’s fried dough sticks, which can be used to illustrate.

  Pinduoduo, a well-known e-commerce platform, has been ridiculed by many people as "fighting for the evening". In November 2017, Shanghai Shita Information Technology Co., Ltd. registered the trademark "Pinxixi", and launched the website "Pinxixi Mall", WeChat WeChat official account and the mobile phone software "Pinxixi". On the "Pinxi Shopping Mall", there are also columns such as time-limited spike, quality fruit, half-day arrival, spelling love, 9 yuan and 9 special sales, and even imitating Pinduoduo’s advertising slogan: "Shopping APP that 100 million people are fighting for".

  In 2018, Pinduoduo’s Shanghai Dream Search Technology Co., Ltd. sued Shanghai Shita Information Technology Co., Ltd. to the court on the grounds of trademark infringement and unfair competition.

  The court’s first-instance judgment clearly stated that the central part of the two trademarks is Chinese "spelling". Observing the trademarks of the two brands with the general attention of the relevant public, the overall structure is similar, and it is easier for the relevant public to use Chinese "spelling" as the calling keyword when identifying the two brands. In addition, Pinduoduo’s trademarks are well-known and prominent. When the relevant public identifies the accused logo in isolation, it is easy to misunderstand the service source. Therefore, the court ruled that the two trademarks constitute similar trademarks, and the use of the accused logo by Shita Company infringed the exclusive right to use the trademark enjoyed by Dream Search Company.

  It can be seen from the court’s judgment that the key to trademark infringement lies in whether the main identification elements will cause misidentification.

  "Specific to this case, the design of the scarlet letter in today’s headline box is its unique logo, and its popularity is high. Today, the attempt to imitate the use of fritters is obvious." Huang Hui analyzed, "When the court identifies a well-known trademark, it should combine the specific pattern to identify it."

  In other words, whether today’s fried dough sticks or today’s noodles are suspected of hitchhiking on today’s headlines, as for today’s fried dough sticks, highlighting the word "fried dough sticks" in the form of oblique red frame and white background in the trademark, highly imitating the trademark and propaganda slogan of today’s headlines, and the intention of creating associations is very obvious, which is likely to infringe on the exclusive right to use trademarks enjoyed by ByteDance.

  "China’s trademark law stipulates that applying for trademark registration shall not damage the existing prior rights of others, nor shall it preemptively register trademarks that others have used and have certain influence by unfair means. In addition, for well-known trademarks registered by others, the trademark law gives cross-class protection under certain conditions. " Wu Xinhua said, "ByteDance can object to the trademark of today’s fried dough sticks in accordance with the law during the announcement period of preliminary examination. If it is a registered trademark, you can file an application for invalidation. "

  "Bangda Brand" can be fined up to 5 million yuan.

  Regarding his trademark registration, the person in charge of today’s fried dough sticks company explained: "I brush today’s headline APP every day, and I am a loyal user, ‘ Next to the big name ’ Just for fun. " The company also issued an "open letter", saying that it should take headlines as an example and be a favorite breakfast brand for ordinary people.

  "If the report is true, the words of the person in charge of today’s fried dough sticks company just show his subjective intention, which will be unfavorable to the enterprise in determining the facts of the case." Wu Xinhua believes.

  According to the trademark law, the infringer usually has to bear the responsibility of stopping the infringement, and the perpetrator who knows or should know that it is an infringement also has to bear the responsibility of compensation. If the circumstances are serious, they shall also bear criminal responsibility.

  In recent years, China’s protection of intellectual property rights, including trademarks, has been increasing. In April 2019, the National People’s Congress Standing Committee (NPCSC) revised the Trademark Law to increase the punishment for infringement of the exclusive right to use a trademark. The revised terms increased the amount of compensation for malicious infringement of the exclusive right to use a trademark from more than one time to less than three times to more than one time to less than five times, and raised the upper limit of legal compensation from 3 million yuan to 5 million yuan. The revised terms came into effect on November 1, 2019.

  "Operators must enhance their awareness of intellectual property rights and respect the prior trademark rights and interests of others, ‘ Next to the big name ’ It’ s cool for a while, and there are two lines of tears after the calculation. Malicious infringement of the exclusive right to use registered trademarks of others will be severely punished by law. " Wu Xinhua reminded, "In addition, the Anti-Unfair Competition Law stipulates that it is forbidden to use the same or similar marks such as commodity names, packaging and decoration that have certain influence on others without authorization. Today, the font pattern used by the fritters company on the storefront signboard is very similar to today’s headline trademark, and it is also suspected of violating the Anti-Unfair Competition Law. "

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Investigation and Research | Gene Mutation Must Be a Disaster?

Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?

The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.

Harm.

What is gene suppression?

Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.

"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.

Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.

Yeast substitution experiment

"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.

But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.

"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.

Narrow the search scope of mutant genes

The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.

Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.

"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.

The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.

The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?

Jolanda:At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.

The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.

Jolanda:Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.

The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?

Jolanda:We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.

The PaperWhat do you think is the most important significance of this research?

Jolanda:The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.

(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")

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Implementing new regulations, optimizing services, and comprehensively returning to work to stimulate demand, China’s high-quality economic development has steadily advanced.

  Cctv newsOn March 1st, News Network reported that the restoration and reconstruction of flood control and water damage projects will be completed before the main flood season this year, and the annual water transfer will be started for the north extension emergency water supply project of the east route of South-to-North Water Transfer Project. At the same time, a number of new regulations will be implemented on March 1st, and the China manufacturing purchasing managers index will be released in February … … A number of economic and social development progress shows that in March,Full resumption of work and productionDriven the centralized release of the demand of related industries, a number of new regulations were implemented to improve the service level, and the high-quality economic development of China was steadily advanced.

  More than 80% of the key water damage repair projects after the State Council’s press conference have been repaired.

  On March 1st, the State Council Information Office held a press conference, and the relevant persons in charge of the Ministry of Water Resources and the National Development and Reform Commission introduced that the post-disaster water conservancy infrastructure construction was progressing smoothly.Key water damage restoration projectsOver 80% of the projects have been repaired.

  In 2023, river floods in China occurred frequently. Up to now, 4,558 key water damage restoration projects have been repaired, ensuring that the restoration and reconstruction of water damage projects undertaking flood control tasks are completed with high standards before the main flood season this year. At the same time, the central government issued additional treasury bonds to speed up the construction of post-disaster water conservancy projects. Up to now, 1,488 treasury bonds water conservancy projects have been implemented with an investment of 29.31 billion yuan, and the overall progress is smooth.

  Multi-measures to optimize payment service and improve payment convenience

  On March 1,The the State Council Information Office held a regular briefing. The relevant person in charge of the People’s Bank of China and other departments said that in order to further optimize payment services and improve payment convenience, it is necessary to promote key places and key merchants to accept overseas bank cards; Do a good job in service arrangements such as aging and internationalization; Business districts and tourist attractions above designated size must support diversified payment methods such as mobile payment, bank card and cash.

  Annual water transfer is started for the emergency water supply project in the north extension of the east route of South-to-North Water Transfer Project.

  On March 1,The north extension emergency water supply project of the first phase of the East Route of South-to-North Water Transfer Project started the annual water transfer, and it is planned to transfer 221 million cubic meters of water to Hebei and Tianjin. Since 2019, the project has transferred a total of 588 million cubic meters of water, effectively helping special actions such as comprehensive management of groundwater overexploitation in North China and water replenishment for the entire Beijing-Hangzhou Grand Canal.

  MarchFull resumption of work and production Drive the centralized release of related industry demand.

  On March 1st, the China Federation of Logistics and Purchasing and the Service Industry Survey Center of the National Bureau of Statistics announced that the purchasing managers’ index of China’s manufacturing industry was 49.1% in February. Due to the influence of the Spring Festival holiday, the activity of the manufacturing market generally declined, but the market demand of the manufacturing industry was relatively stable, while the demand of high-tech manufacturing industry and consumer goods manufacturing industry increased significantly, with new order indexes of 51.3% and 52.3% respectively.

  In February, China’s non-manufacturing business activity index was 51.4%, up 0.7 percentage points from the previous month, rising for three consecutive months, and the increase was larger than that of the previous month.

  In March, the comprehensive resumption of work and production will drive the centralized release of demand for construction and production-related service industries, and the demand for non-manufacturing industries is expected to pick up further.

  From March 1 ST, the new regulations shall not be thrown or trampled on express mail.

  The newly revised "Measures for the Administration of Express Delivery Market" will be implemented on March 1 to ensure the safety of express mail, and it is not allowed to throw or trample on express mail; Without the user’s consent, it is not allowed to confirm the receipt of the express mail, and it is not allowed to deliver the express mail to the express terminal service facilities such as intelligent express box and express service station without authorization.

  In any of the above circumstances, the postal administration department shall order it to make corrections, give a warning or informed criticism, and may impose a fine of less than 10,000 yuan; If the circumstances are serious, a fine of not less than 10 thousand yuan but not more than 30 thousand yuan shall be imposed.

  From March 1, the new regulations will be implemented. Electronic invoices have the same legal effect as paper invoices.

  The decision on amending the Detailed Rules for the Implementation of the Measures for the Administration of Invoices in People’s Republic of China (PRC) shall come into force on March 1, and it shall be clear that electronic invoices and paper invoices have the same legal effect, and no unit or individual may refuse to accept them; Units and individuals shall bear the obligation to protect the invoice data in accordance with the law, and shall not store the invoice data in excess of the specified amount, and shall not use, illegally sell or illegally provide the invoice data to others in violation of the regulations.

  From March 1 ST, the new regulations will not be implemented by using the default check on the webpage to sell insurance.

  The Measures for the Administration of Insurance Sales Behavior came into effect on March 1st, which divided the insurance sales behavior into three stages: pre-insurance sales behavior, in-insurance sales behavior and post-insurance sales behavior, and regulated them respectively.

  The "Measures" propose that insurance companies, insurance intermediaries and their insurance sales personnel shall not enter into insurance contracts with policyholders by means of compulsory tying, default check on information systems or web pages.

  In 2023, the annual settlement of personal income tax began to be processed.

  On March 1, 2023, the annual settlement of personal income tax began, and the processing time was as of June 30 this year. The annual settlement of personal income tax means that taxpayers need to summarize the four comprehensive incomes of the previous year, such as wages and salaries, labor remuneration, royalties, etc., and apply to the tax authorities for final settlement and tax refund or supplementary tax.

  In case of any of the following circumstances, the taxpayer shall handle the settlement:

  (a) the prepaid tax amount is greater than the final tax payable and applies for tax refund;

  (2) The comprehensive income obtained in 2023 exceeds 120,000 yuan, and the amount of tax payment required for final settlement exceeds that of 400 yuan.

  Taxpayers who have paid personal income tax in advance according to law in 2023 and meet one of the following circumstances do not need to apply for settlement:

  (1) Final calculationneedPay taxes, but the comprehensive income does not exceed 120 thousand yuan for the whole year;

  (2) Final calculationneedThe amount of overdue tax does not exceed that of 400 yuan;

  (3) The prepaid tax amount is consistent with the final taxable amount;

  (4) Those who meet the conditions for final tax refund but do not apply for tax refund.

  276 cities have established urban financing coordination mechanisms.

  It is reported that as of February 28, 276 cities in 31 provinces have established urban financing coordination mechanisms, and about 6,000 real estate projects have been proposed. Commercial banks have quickly screened projects and approved loans exceeding 200 billion yuan.

  The 7 th China International Import Expo(CIIE) signing exhibition covers an area of over 240,000 square meters.

  The 7th China International Import Expo(CIIE) will be held in Shanghai from November 5 to 10 this year, consisting of national exhibition, enterprise exhibition, Hongqiao Forum, professional supporting activities and cultural exchange activities.

  It is understood that the preparations for the 7th China International Import Expo(CIIE) are progressing steadily. Among them, the contracted exhibition area of the Enterprise Exhibition exceeds 240,000 square meters, which is faster than the same period in 2023, and nearly 200 Fortune 500 and leading enterprises in the industry have been signed.

  China-Thailand mutual visa exemption agreement for ordinary passport holders came into effect.

  On March 1st, the agreement between China and Thailand on mutual visa exemption for ordinary passport holders came into effect. According to the agreement, Chinese passport holders, ordinary passport holders and Thai passport holders can stay in the other country for no more than 30 days without a visa (Every 180 days, the cumulative stay shall not exceed 90 days.)。

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Hong Kong Morning Post | Significantly abolish employees over 35 years old? Xiaomi rumors!

  [Review last week]

  Hong Kong stocks performed strongly in early trading last Friday, but the bulls failed to hold their advantage in the afternoon. The Hang Seng Index closed down 0.59, and the Hang Seng Science and Technology Index rose nearly 2% in early trading, and the closing increase narrowed to 0.29%.

  On the disk, JD.COM Q1′ s performance was bright, and its share price rose over 7%, leading the strength of weighted technology stocks; Film and television entertainment stocks, power stocks and mobile game stocks rose.

  On the other hand, the price of gold fell at a high level, and the non-ferrous metal plate fell; Collective adjustment of the concept stocks of China Special Appraisal Company.

  [capital flow]

  Last Friday, southbound funds sold a net of HK$ 235 million. SMIC ranked first in net purchases and first in net sales.

  Short-selling data are as follows:

  [breaking news]

  90% of employees over the age of 35 are laid off? Xiaomi responded: rumors

  Recently, some netizens posted on social media: "The second headquarters of a certain meter in Wuhan officially announced that 90% of employees over the age of 35 will be laid off." This statement quickly fermented on the Internet, and some netizens speculated that it was Xiaomi Group.

  In response to the above rumors, Wang Hua, general manager of the public relations department of Xiaomi Group, responded in Weibo on May 14th. "Last night, there were reports on social media platforms that employees over 35 years old in our Wuhan headquarters only kept 10% of the information, which were all rumors after investigation. Now the legal department of the company has obtained evidence for relevant information and reported it to relevant departments. "

  Xu Jiayin became the executor.

  On the evening of May 12th, China Evergrande announced that it had received an enforcement notice from the Guangzhou Intermediate People’s Court on the arbitration award of Shenzhen International Arbitration Court. The Company, its subsidiary "Guangzhou Kailong Real Estate" and the executive director Xu Jiayin are the executors of the enforcement notice. According to the execution notice, the items to be executed are:

  (1) Guangzhou Kailong and Mr. Xu paid the balance of dividends of Evergrande Real Estate in 2020 to make up about RMB 204 million, and assumed the liquidated damages of about RMB 51.53 million;

  (2) Mr. Xu and the company bought back the equity of Evergrande Real Estate held by the arbitration applicant for RMB 5 billion;

  (3) The compensation paid by the company to the arbitration applicant from February 1, 2021 to the completion of the repurchase is about RMB 770 million;

  (4) The Company, Guangzhou Kailong and Mr. Xu paid about RMB 35.53 million in legal fees, arbitration fees and execution fees.

  The total valuation of 47 projects of Evergrande Auto 2 yuan "Sale" exceeds 60 billion.

  On May 12th, Evergrande announced that the shareholders’ meeting had agreed to sell its 47 real estate projects to China Evergrande and its subsidiaries. This means that Evergrande has completed the divestiture of real estate business and focused on the new energy vehicle business. Evergrande Automobile will concentrate resources to fully guarantee the R&D and production of Hengchi.

  According to the announcement, the two parties signed an agreement to transfer all the issued shares of Huibao and Flaming Ace under Evergrande Automobile, covering 47 existing health space projects of Evergrande Automobile Group, including 21 Evergrande Health Valley projects, 5 Evergrande Health City projects and 21 various property development projects.

  After the completion of the sale, Evergrande no longer holds any rights and interests of the above two companies, and it is estimated that it will record a sale income of about 24.789 billion yuan.

  According to the unaudited data provided by Evergrande Automobile, as of December 31, 2022, the net liabilities of projects such as Health Valley to be sold were 24.789 billion yuan, and the project valuation was about 60.1 billion yuan. In 2022, its income was only about 1.5 billion yuan, and its net loss after tax reached 8.824 billion yuan.

  Large shareholder clearance and evacuation? Vida International Emergency Response

  Recently, there is market news that the Swedish company Essity, the controlling shareholder of Vida International, announced that it is considering selling the shares of Vida International; Fuan International, controlled by Li Chaowang, the second largest shareholder and chairman of the board of directors of Vida International, intends to acquire Essity.

  On May 14th, Vader International published a voluntary announcement, saying that the Board of Directors had not received any latest information about the review of Essity strategy.

  [Company News]

  1. (): In the first four months, the accumulated original premium income was 108.343 billion yuan and 71.543 billion yuan respectively through Taiping Life Insurance and Pacific Property Insurance, which decreased by 2.9% and increased by 16.0% respectively.

  2. Ping An in China: In the first four months, the premium income of the original insurance contract was about 100.459 billion yuan, 208.185 billion yuan, 8.214 billion yuan and 5.849 billion yuan respectively through Ping An Property Insurance, Ping An Life Insurance Company of China, Ping An Endowment Insurance and Ping An Health Insurance, totaling about 322.707 billion yuan, up 5.93% year-on-year.

  3. Baekje Shenzhou: The revenue in the first quarter was 3.066 billion yuan, a year-on-year increase of 57.4%; During the period, the total product revenue was about 2.808 billion yuan, a year-on-year increase of 69%; The net loss attributable to shareholders was about 2,446.6 million yuan, a year-on-year decrease of 14.64%. Mainly due to the sales growth of self-developed products and authorized products.

  4. (): The subsidiary plans to invest 2.5 billion yuan to build a new energy lithium battery production research and development project in Xiangyang.

  5. (): It is planned to invest in a new battery-grade lithium hydroxide production base project with an annual output of 30,000 tons in Zhangjiagang Free Trade Zone, with an estimated annual income of not less than 2 billion yuan.

  6. R&F Property: In the first four months, the accumulated contracted sales were 9.02 billion yuan, down 49.18% year-on-year, of which the contracted sales in April were 1.66 billion yuan, down 61.12% year-on-year.

  7. Hejing Taifu Group: The contracted sales in April was 3.231 billion yuan, a year-on-year decrease of 25.8%; The sales area was 144,000 square meters, a year-on-year decrease of 29.8%.

  8. Good Boy International: Revenue in the first quarter decreased by 17.5% year-on-year to about HK$ 1.842 billion, and decreased by 14% year-on-year in terms of constant currency.

  9. CGNPC New Energy: The subsidiary intends to sell all the shares of Nantong Meiya, and the initial public bidding price is about 420 million yuan.

  [repurchase dynamics]

  1. AIA: It spent about HK$ 132 million to buy back 1.652 million shares at a repurchase price of HK$ 79.55-81.3.

  2. HSBC Holdings: It spent about HK$ 147 million to repurchase 2.5 million shares at a repurchase price of HK$ 58.40-58.95.

  3. (): Chongqing Water Investment Group increased its holdings of 35.0092 million A shares, with a total shareholding ratio of 7.013%.

  4. (): It is planned to buy back 1.5 billion to 3 billion yuan of A shares for the implementation of the company’s employee stock ownership plan.

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Tank 300 of bicycle analysis in the measured cross-country season

[car home] I don’t know if everyone has seen it just now. Six mainstream hard-core off-road vehicles with different prices on the market competed in several projects, showing their off-road strength and different characteristics. Well, I’ve seen them competing in the same field. The graphic content focuses on the comprehensive performance of each bicycle in all events. If you happen to want to buy a hard-core off-road vehicle recently, I believe the following contents will help you choose to buy it. The protagonist of this article is (|). In addition, we have also produced a detailed analysis article of tank 300 four-wheel drive, and interested friends can click to watch it.

Home of the car

Home of the car

Tank 300 2.0T Conqueror is a mid-equipped model in the whole department. In the original factory state, the approach angle is 33, the departure angle is 34, the longitudinal passing angle is 23.1, the minimum ground clearance is 224mm and the maximum wading depth is 700mm, so the congenital conditions are good. The 2.0T engine has a maximum power of 227Ps and a maximum torque of 387N·m, matching the 8AT gearbox.

Home of the car

Home of the car

Tank 300 2.0T Conqueror adopts part-time 4wd structure, and also has two differential locks at the front and rear. The torque of low-speed four-wheel drive mode can be enlarged by 2.48 times, and it has its own tank turning and crawling mode. It is also one of the only two cars with front locks in this cross-evaluation, and it should be said that it is relatively strong in hardware.

Home of the car

K&C is called Kinematics and Compliancs in English, where K stands for geometric kinematics characteristics of suspension, and C stands for elastic kinematics characteristics of suspension. K&C characteristics jointly determine the posture and position of the wheel when it jumps, as well as the driving performance of the vehicle. K&C experiment is an important link to ensure the handling, stability and driving experience of the vehicle in the process of vehicle development.

Five kinds of sensors are used in this experiment, including front and rear seat cushion sensors, sound pressure sensors of front and rear seat cushions, and multiple unidirectional and three-directional acceleration sensors installed on the steering wheel and the guide rail under the seat respectively, in order to avoid the interference of the seat cushion and simply look at the chassis performance.

We will simulate three different bumpy road conditions, A, B and C, in which A road condition is equivalent to an asphalt road that has been in disrepair for a long time, B road condition can be regarded as a vehicle passing through cobblestone roads, and C road condition is basically a bad unpaved road that is often encountered during long-distance crossing.

Home of the car

Let’s draw a conclusion directly. After several rounds of tests and calculations, in the interior noise test, the performance of Tank 300 can be ranked second among the six models, second only to Beijing BJ40. In the ride comfort test to measure the human vibration evaluation index, from the data obtained by the sensors on the front and rear seats and the seat guide rail, several cars did not open the obvious gap, which was far below the safety threshold. From the vibration data measured at the steering wheel position, the performance of Tank 300 can rank fourth among the six cars.

Home of the car

In the tension test, we can see the tension values obtained by four wheels, two wheels or even a single wheel in different four-wheel drive modes through the data. In the actual off-road situation, if a wheel loses its grip, you can also know more clearly what mode can make it easier for you to get out of trouble.

Home of the car

When the full-wheel tension of tank 300 in 4H mode is 2362kg, the tire will break through the grip and slip, resulting in data decline. Using the 4L mode with greater torque will only make the tire break through the grip limit earlier, and the performance has not improved again. In the front axle tension test, the difference between 4H and 4L modes is very small, which is 1281kg and 1284kg respectively. The difference is that 4L mode is more likely to break through the tire grip limit. In the rear axle tension test, the tension in 4L mode is slightly higher than that in 4H, which is 1398kg and 1326kg respectively, which is slightly higher than that in the front axle as a whole.

In the cross-axle test, the power output will be limited when using the 4-hour mode, and the rotation speed will be limited to 1100rpm, and the tension will be 864kg; when the rotation speed limit is lifted after the rear lock. The effect of using 4L mode is obvious, and the tension value increases to 1052kg. However, if the rear differential lock is locked at this time, although the power output is more direct, the wheel will instantly break through the grip, so the measured data will be lower, which is 824kg. The mode that can get the maximum pulling force in the cross axle test is 4L+ front and rear locks, at which time the vehicle can get the pulling force of 1285kg.

In the single-wheel tension test, there is no doubt that the tension when the single rear wheel has adhesion is greater than that when the single front wheel has adhesion. Whether in 4H or 4L mode, the tension of the single front wheel is 250kg, while that of the single rear wheel is basically 400-500kg. After locking the differential lock, the situation has been greatly improved. In the mode of 4L+ front and rear lock, the pulling force of the single front wheel can reach 816kg, which can basically reach the same level as that of the single rear wheel 4H padlock, while the single rear wheel has the largest data of 895kg when it is 4L padlocked.

Field cross-country is the best way to test the comprehensive quality of a hard-core SUV. We still came to the Kaiser cross-country venue to see their performance.

Home of the car

Home of the car

The 80% ramp is just an appetizer for the tank 300. Under the condition that the tires have adhesion, it can be easily climbed to the top only by using the 4H standard mode, and the engine speed is only 2000rpm in the whole process. There was no accident in the performance of 66% side slope, and there was no sign of downward sliding of the vehicle during the whole process.

Home of the car

In the Big Butterfly Valley project, the standard mode is still 4H, and the vehicle can easily pass through with the throttle stabilized. During the whole process, the electronic limited slip intervention is quick after the wheel loses adhesion, and there is not too much invalid idling, and the vehicle is relatively stable when the center of gravity shifts. However, because the suspension setting of the tank 300 is soft, some "seesaw" effects are easy to appear when the vehicle reaches the top.

Home of the car

The height of each steamed bread bag crossing the shaft on the difficult level is 45cm, which not only examines the slip-limiting ability of vehicles, but also puts forward certain requirements for passing. In this link, the tank 300 directly uses the low-speed four-wheel drive+rock mode. At this time, the vehicle will close the ESC and lock the rear differential. In this case, the tank 300 has no difficulty in passing, and the basic idle crawling state can pass the test.

Home of the car

The most difficult project this time is the 80% uphill cross axle, which is a comprehensive test of the off-road ability of vehicles. Power, passability, four-wheel drive distribution ability and even vehicle weight will affect the passing effect of vehicles. The tank 300 still uses the 4L+ rock mode. In addition to hanging the rear lock, the driver manually locked the front differential this time. In the whole climbing process, the challenge can be completed only by stepping on the accelerator deeply when crossing the shaft. However, when climbing to the top, the side pedal of the vehicle will rub against the ground. On the whole, the performance of the tank 300 in this field cross-country can be said to be excellent.

It’s not unreasonable for Tank 300 to be the best-selling hard-core SUV in the market at the level of 200,000 yuan at present. In addition to its pleasing retro square box appearance, its four-wheel drive performance can stand the test. Excluding the influence of vehicle configuration on off-road performance, the approach angle and departure angle of the tank 300 ensure its passability, and the calibration of the electronic system is also very mature, which are its advantages. In addition, many mature modification cases and parts on the market provide great convenience for the owner’s later upgrade, which is also related to its huge user base, so it is basically still one of the most worthwhile off-road vehicles at this price. (Text/photo/photo by car home Wang Zeshi)

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Sea lion seal? Stupid can’t tell clearly.

seal

Land activities: walking

Appearance characteristics: 1. The forelimbs are long and the neck is long, which can lift the body; 2. claws are like fins

sea lion

Land activities: peristalsis

Appearance characteristics: 1. Round and fat, with short hands and short neck, and can only move with the belly sticking to the ground; 2. claws are like cat claws

1 with or without ears

Sea lions have a pair of lovely ears, that is, external ears, while seal ears become extremely small or degenerate into only two holes, with no ear contour, and can be opened and closed freely when swimming.

The marine animal show that we often watch, is the seal performing? Or a sea lion? Can you tell them apart?

2 claws are different

Comparing the feet of sea lions and seals, you will find that the claws of sea lions are more like fins, which are smooth and long. Seal claws have small hooks and short front feet. Most kinds of claws are furry, like cat claws.

3 Neck length

Sea lions have long necks and can hold their heads high, while seals are round and fat, and their necks are super short. Sea lions can proudly hold their heads high, while seals can only sell cute on their knees. In terms of height, sea lions kill seals perfectly.

4 can you lift yourself?

Sea lions have long forelegs, so they can lift their upper bodies, that is, lift their bellies away from the ground. It is difficult for seals to do this, and most of them can only move with their bellies on the ground and drag their bodies forward.

5 Can you perform?

Sea lions have sharp heads and long forelimbs, so they can lift their bodies. Therefore, sea lions are often used in aquariums to perform overhead performances, but seals can’t do this. Seals can only appear in "posters".

6 presence of spots

Sea lions are slippery and have almost no other colors. Seals have blue-black spots.

7 different strokes

Sea lions lift their bodies gracefully to swim; The seal is "crawling forward", which is also the essential difference between the two. Sea lions swim more beautifully, and seals are more cute.

Xiaohui arrangement

Now, can you tell a sea lion from a seal?