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Investigation and Research | Gene Mutation Must Be a Disaster?

Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?

The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.

Harm.

What is gene suppression?

Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.

"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.

Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.

Yeast substitution experiment

"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.

But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.

"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.

Narrow the search scope of mutant genes

The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.

Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.

"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.

The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.

The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?

Jolanda:At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.

The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.

Jolanda:Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.

The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?

Jolanda:We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.

The PaperWhat do you think is the most important significance of this research?

Jolanda:The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.

(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")

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How to deal with this virus during the Spring Festival and on the way home?

Original Shanghai CDC Shanghai CDC

Recently, the Korea Disease Management Office said that "Norovirus is spreading particularly violently in South Korea, and the number of people infected in one week has reached a new high in the past five years. Uncooked fish and shellfish, contaminated vegetables and water are the main sources of infection". Seeing this news, I think there are many greetings in the hearts of eager friends who are returning home. What virus is this? What diseases are caused? Is it serious? How to prevent it?

To put it simply, we can take the strategy of "strategic contempt and tactical attention" to norovirus.

one

Understand the characteristics of the disease and strategically despise it.

Different from respiratory infectious diseases such as influenza, norovirus infection is an intestinal infectious disease, characterized by diarrhea, vomiting and other intestinal symptoms, with fecal-oral route as the main route of transmission. Main features:

one

It is seasonal and popular all year round, and the peak of incidence is in the cold season of autumn and winter.

2

There are many ways of transmission, which can be passed from person to person-inhaling aerosol produced by patients vomiting, touching patients’ feces or vomit, etc. It can also spread through food and water-ingestion of contaminated food or water, indirect contact with contaminated items and the environment, etc.

three

The course of the disease is short, and the symptoms last for 2-3 days on average. Symptoms such as fever, nausea, diarrhea, vomiting, headache, etc. can be seen. Diarrhea can reach 4-8 times within 24 hours, and the feces are mostly watery or watery.

four

It is a self-limited disease, and most of the symptoms are mild, so you can gradually recover after resting at home. A small number of infants, the elderly, people with low immunity and patients with basic diseases may have serious symptoms such as dehydration.

Although Norovirus has a short course of disease, mild symptoms and self-limitation, its attention is not low, because:

one

It is one of the main pathogens causing acute gastroenteritis, and monitoring in this city shows that norovirus accounts for more than one third of the pathogens detected in adult and child diarrhea cases.

2

The incubation period is short, and the virus can get sick in 24-48 hours after entering the human body.

three

The infection dose is low, and a small amount of virus can cause disease, which often causes cluster epidemics in collective units such as kindergartens, schools and nursing homes for the elderly.

two

Raise awareness of disease prevention and pay attention to tactics.

During the Spring Festival, family gatherings, visiting relatives and friends, taking crowded public transport, dining and eating seawater products may increase. It is suggested that everyone raise their awareness of disease prevention:

1. Strengthen the hygiene of drinking water, fully heat the food, and try not to eat cold and half-baked seafood and aquatic products.

2. Develop good personal hygiene habits and wash your hands before meals. When eating out, you can sit in a ventilated place by the window to keep the air circulating.

3. Reduce the time spent in crowded closed places, and those who have the conditions can wear masks for personal protection.

4. If you have symptoms such as vomiting and diarrhea, you should suspend gatherings, dinners and other activities, and see a doctor if necessary.

Contributed by Gong Xiaohuan and Xiao Wenjia

Draft review: Chen Jian

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How to deal with this virus during the Spring Festival and on the way home? Original Shanghai CDC Touch Read the Original Text

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Original title: "How to deal with this virus during the Spring Festival and on the way home? 》

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Han Lixuan’s barbecue buffet "Duck meat turns into beef", and the staff said that it "fooled the whole world"

[Guided by the survey of Shida University]

Friends who like to eat barbecue buffet may all know Han Lixuan barbecue buffet chain. Han Lixuan is headquartered in Beijing, with more than 200 chain stores in China and two in Changsha. In Hanlixuan Barbecue Restaurant, beef is the most popular with customers. Customers can enjoy beef rolls and beef in sauce indefinitely as long as they spend 49 yuan, which seems to be very cost-effective. However, according to a survey conducted by Shida University, the reporter recently conducted a half-month undercover operation in a Hanlixuan Barbecue Restaurant located on the third road of Fenglin in Changsha, but revealed the hidden secrets behind these buffet beef.

"Hanlixuan" barbecue buffet has more than 200 chain stores nationwide.

In this Beijing Hanlixuan buffet barbecue restaurant in Wenxuan Road, Yuelu District, Changsha, the spacious restaurant is packed. There are hundreds of kinds of dishes such as beef and mutton, and customers can enter the store to eat casually at 49 yuan. Beef is usually the first choice for guests.

In this Beijing Hanlixuan barbecue buffet, there are two kinds of beef, one is beef rolls, and the other is beef made with sauce. So, how are these beef made?

The reporter decided to go undercover into this Beijing Hanlixuan self-service barbecue restaurant to investigate. As a result, the reporter heard an amazing statement only on the third day of undercover.

Buffet beef is sought after, but employees expose themselves as "made of duck meat"

The staff told the reporter frankly that the beef in this Hanlixuan barbecue shop is made of duck breast.

As a large chain store in China, Beijing Hanlixuan barbecue buffet should be operated in good faith. How can duck be used as beef? Is the employee’s statement true? How did you turn duck meat into beef here? The reporter continued to conduct a long-term undercover investigation in Beijing Hanlixuan Barbecue Store, and finally photographed the whole process of fraud.

Behind a narrow corridor is the back kitchen of Beijing Hanlixuan self-service barbecue restaurant. Everyone is busy with their work. On the ground in the corner of the kitchen, there are peeled duck breasts, and the ground is full of dirty water. A staff member even stepped on the frozen peeled duck breasts many times with his feet.

After thawing, these peeled duck breasts were put into a meat grinder.

A worker put the peeled duck breasts into a meat grinder, broke the duck meat, and the duck meat that fell to the ground was picked up and reused.

A few minutes later, the basin was filled with minced duck breast meat, and then some minced duck meat left over from two or three days ago was mixed into this pile of raw materials.

Next, the staff added a special red sauce to these duck breasts for stirring. When the duck meat is evenly mixed with the red sauce, the duck meat becomes beef.

In this way, the skinless duck breast meat turned into beef and was put on the dining table for customers to choose. In this Han Lixuan buffet barbecue restaurant, the reporter witnessed the process of mixing frozen duck meat with duck meat a few days ago and then making fake beef.

Beijing Hanlixuan self-service barbecue restaurant is known as a large chain store. In the external publicity, it claims that it "always pays attention to the quality of dishes" and that it will become a "respected" restaurant chain brand. But it is such a store that secretly makes fake beef out of frozen duck meat, and even mixes it with duck meat that may have deteriorated a few days ago, which not only deceives consumers, but also harms consumers’ health. However, the employees of Beijing Hanlixuan barbecue restaurant are not ashamed, and even proud.

Duck meat forged beef boasted that it had "fooled the whole world"

The staff of Han Lixuan Barbecue Shop is obviously complacent about their fake beef, claiming that the diners will never see it. During the undercover period, no diners really questioned the authenticity of beef.

However, another group of reporters decided to come forward and debunk the true face of beef in Hanlixuan barbecue shop.

The reporter questioned face to face, and the staff made all kinds of excuses.

The staff’s explanation is ridiculous. On the official website of Hanlixuan Barbecue Buffet, we can see that the company claims to subvert the traditional operation mode, but their so-called subversion mode is to make fake beef out of duck meat? The concept of green diet advocated by them is to process all the spoiled duck meat, the duck meat dropped on the ground and the duck meat trampled with their feet into fake beef?

The raw materials of Beijing Hanlixuan Barbecue Restaurant are said to be purchased and distributed uniformly throughout the country, but there is no beef in these uniformly distributed raw materials, but there are quite a few peeled duck breasts.

Duck meat raw materials for counterfeiting are actually purchased and distributed in a unified way.

Subsequently, these frozen duck breasts were forged into beef and sent to the table. The staff of Hanlixuan Barbecue Store claimed that they would not eat them.

Beijing Hanlixuan Barbecue Shop is all over the country, but in Changsha, we are angry to see that the so-called beef in the shop is forged with duck meat, and even mixed with spoiled duck meat, and the duck meat used for counterfeiting is uniformly distributed. If it weren’t for the reporter’s long and hard undercover investigation, who would know the truth! Consumers will always be deceived, fraud will continue forever, and Han Lixuan will continue to "fool the world". Honesty is not only the foundation of doing business, but also the foundation of being a man. Consumers don’t welcome this so-called national chain of fraud! We expect law enforcement agencies to strike hard, not to cover up their ugliness.

(The original title is "irrefutable evidence! Uncover the inside story of Han Lixuan barbecue buffet "duck meat turns into beef")

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Fans are stopped playing for idols, and the website does not refund money! Even hardware companies are keen to set up star lists.

Both network anchors and idol stars are now supported by fans’ real money: spending money to buy virtual gifts, flowers and diamonds, and sending idols to the forefront of the list set by the platform, as evidence that idols are popular, explosive and worthy of advertisers-this is the general rule in the era of fan economy and traffic.

However, when fans exhausted their wallet labor to support their idols, they also walked into the rights trap created by the list setters and their upstream and downstream industries: virtual flowers that were not used because of changing the rules of the list were unable to get a refund; The automatic ranking software used to improve efficiency has been blocked, and who can I ask for the membership money in 2040? The list promises resources to idols. What if fans don’t fulfill their promises?

In the opinion of experts, this behavior of brushing data for idols makes the entire Internet industry sink into the carnival of crazy wallet harvesting, which is not beneficial to the long-term development of the industry.

The list was stopped and the website did not refund money.

"The star power list is the root of all evil." A Xiao, a 29-year-old white-collar worker, is a fan of H, the star who debuted in the talent show "Creation Camp 2019". In July, in order to make H rank in the top three in the "New Star List", the fan group began to spend a lot of time and money playing the list: "Reading, forwarding, commenting and posting about Weibo can get extra points, commonly known as interaction. If you don’t have time to interact, you can spend money directly. "

On the page of sending flowers in Weibo, there is only a payment button, and there is no explanation about the product.

A Xiao introduced that Weibo sells virtual flowers, one in 2 yuan, and every time a flower is sent, the idol’s admiration value increases by 2 points: "It is said that flowers are sent to idols, but in fact, they have turned around and returned to Sina’s pocket, and idols can’t get a dime."

In mid-July, Weibo was suspended from the list of July H due to the accidental exposure of the fan group through special channels.

"It is to buy a Weibo trumpet to interact. Sina usually turns a blind eye. This time we were reported by competitors, and Weibo could not pretend to be blind." A Xiao said that in this way, the fans’ early investment has hit Shui Piao. "Forget the time, shouldn’t Sina refund the flowers bought with real money?"

A Xiao said that at first, Sina just returned the flowers to its account: "The people who sent the flowers can’t make the list. What’s the use of flowers for us?" After that, fans began to call 12345 and 96315 to complain that Sina violated consumer rights.

"At that time, I realized that we were actually consumers who spent money first, and then fans." A Xiao said that after the complaint lasted for a week, the Beijing Consumers Association talked about Weibo, and Weibo gradually returned the money. "Later, I went to look at it carefully. There is no explanation on the flower purchase page, and there is no regulation on whether it can be returned."

In August, H’s qualification for the list was restored, but A Xiao no longer bought flowers: "The list is a means for the website to make money, and I won’t send money to do stupid things again."

Software blocked, membership fee wasted

On June 10th, the "Star Aid App", the behind-the-scenes promoter of 100 million reposts, was investigated. A few days later, super fans said that "Super Aid" could not be used: "From then on, it returned to the era of manual ranking."

"Star Aid App" and "Super Aid" can help users to automatically perform some operations, such as commenting on Weibo who forwarded idols, sending Weibo related to idols, and automatically searching the names of idols, thus improving the rankings of idols on Sina’s "Star Power List" and Baidu Encyclopedia’s "Star Popularity List".

"Super aid is from Sina subsidiary, and the annual membership fee for an account is 35.88 yuan. The Star Aid App is even more fierce. 20 yuan, a member for one month, can bind many trumpets with one click, and then let these trumpets automatically sign in and forward every day. " Yan Yan told reporters that the two appeared in 2018 and were very popular among fans.

Where did these members’ money go after the service was stopped?

"Can Star Aid App refund money?" On the second day after the Star Aid App was investigated, Xiao Ran asked questions on the Weibo, but so far he couldn’t find a way. "I heard that the illegal profit was more than 8 million, but the App was taken off the shelf and people were arrested. I don’t know who to ask for a refund."

After the service of "Super Aid" stopped, some fans found that they could ask for a refund from the Sina subsidiary. "Send them payment voucher screenshots, Weibo nicknames and Alipay account numbers. It doesn’t matter if you have more money or less. Remember to ask Sina for a refund. " Weibo user @ honeythurts sent this Weibo on June 17th and got 718 reposts.

Not all fans who ask for a refund can get it. "Private letter, no refund, and now I will ignore it." Fan Xiaozhen said, "There is not much money, forget it."

Forwarding for resources, promises are hard to honor.

A trend has been observed in the side dishes that have been in the powder circle for nearly 10 years-more and more companies have joined the ranks of harvesting fans with the list. "Click on the authentication information, some are still film and television companies, and some are simply trading companies selling hardware department stores. Come and share a piece of it."

WeChat applet "Idol Guardian List", fans can get 15 votes by sending Tik Tok with his name.

Dishes told reporters that the common feature of these lists is that fans can vote for idols without spending money, but they must first complete some tasks to get tickets: "What do you need? Watching a 15-second video advertisement will give you 5 votes, and sending a Tik Tok with an idol name and a small program name will give you 15 votes. To put it bluntly, it is to use fans as advertisers, as free publicity, and as a resource for other apps. "

Video advertisement viewing task of WeChat applet "Love Bean Guardian List"

And what are the benefits of idols topping the list? "It’s nothing more than putting some advertisements that can reveal the idol image in some places for fans, such as airports, high-speed railway station, squares and cafes, and opening their small programs for a day, even including sending a low-end’ reward’ such as a Weibo manuscript." Xiaocai said that new fans are often confused by these "rewards", and the old fritters can see the tricks at a glance. "Take the coffee shop advertisement as an example. The promise is 10 coffee shops, 10 Starbucks or 10 coffee shops that you can’t name. There is a big difference. This kind of commitment is simply vague. After the fans sold the coolies, they found that they were different from what they thought in advance, and they had no place to say it. "

The first prize in the weekly list of WeChat applet "Idol Guardian List"

statement

Help the stars brush the list, fans are suspected of breaking the law.

"Internet idolize has evolved into a stage full of deception and profit-seeking, which is not the same as the idolize we used to know." Zhu Wei, deputy director of the Communication Law Research Center of China University of Political Science and Law, said in an interview with Beijing Evening News that, taking the flower incident as an example, according to the provisions of the Consumer Protection Law, online shopping goods have no reason to return within 7 days, while digital goods, such as audio-visual products and software, are generally not included. "Virtual flowers belong to what goods? There is no clear stipulation in the law whether it is suitable for 7 days to push the ring without reason or similar to software. The platform should be stated in the user agreement and clearly inform consumers in advance whether they can return. "

Zhu Wei thinks it is very difficult for users to get back the prepaid membership money after the automatic ranking software stops serving: "It is illegal to brush the list, not only the operator is illegal, but also the participants are illegal. In this case, the illegal income of the operator should be collected, and it is difficult for participants to claim a refund."

As for the practice that fans use labor to exchange resources for idols, Zhu Wei bluntly said that this is no longer a normal consumption behavior, and the identity of fans is no longer a consumer, which is very risky. "This does not constitute a contract, there is no clear consideration, and it is working for others and others are not aware of it. Whether the operators have relevant abilities and qualifications is often unknown. Whether these unilateral commitments are fulfilled or not, and there is no way to measure them. Don’t do this kind of exchange under the guise of giving aid to idols. This is likely to be fraud or even fraud. "

There are many ambiguities in the list rewards promised by Aidou App.

Quick comment

Stars rely on marketing, which is a pathological condition of society.

"The power of Chinese idols has made many people see the huge business opportunities, and it is easy to turn business opportunities into money." Zhu Wei said that the platform corner definitely welcomes fans to hit the list. "It can not only improve the popularity of the platform, but also make a lot of money. Idols can also profit from it, because they generally have no works, and they can only increase their popularity through repeated activities. As for whether they can get the benefits of selling flowers from the platform, only fans don’t know. How many people who take the lead in crazy support are sent by idols to brainwash and circle money, and fans will not know. "

"For the fan economy, the Internet industry is actually a contradictory attitude. On the one hand, fans can increase activity and increase income for the platform; On the other hand, intentional or unintentional, active and passive list brushing, water army and public relations behavior also make the industry hate it, because a good ecology needs a fair and equitable environment, but the reality is that a mouse has broken a pot of soup. When one person starts to brush the list, everyone starts to be forced to brush the list, and the whole ecology is broken. " Liu Xingliang, president of DCCI Internet Research Institute, believes that even at the expense of reducing the activity of the platform, such ecological destruction cannot be tolerated.

Liu Xingliang introduced that in such a list-brushing game, many ash production companies in the industry earned a lot of money, such as selling trumpet, being a navy soldier and making automatic list-brushing software. "A large part of the money in the entire industrial chain has been earned by these companies, but what these companies do is meaningless or even harmful to the industry and society. The criteria for evaluating stars have also changed from works to well-done marketing and high energy of fans, which is the morbid state of the whole society. "

 

Source: Beijing Evening News reporter: White Song Illustration Wang Chen Yu

Process editor: TF021

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China has built the largest postal express network, and the rural market has become a new growth pole of the express delivery industry.

CCTV News:Today (October 9) is World Post Day, and the theme of this year’s World Post Day is "Post Guarding the Earth’s Home". In the past ten years, China’s postal industry has made historic achievements, entered a new stage with an annual express business volume of over 100 billion pieces and an annual express income of over one trillion yuan, realized direct postal service in established villages, and built the most accessible, inclusive, largest and most beneficiary postal express network in the world.

In addition, the State Post Bureau also stated that China is actively building laws, standards and policy systems that are compatible with the green concept, and accelerating the reduction, standardization and recycling of express packaging. By the end of this year, the proportion of packaging materials that meet the standards will reach 90%, the proportion of standardized packaging operations will reach 90%, the number of recyclable express boxes will reach 10 million, and 700 million corrugated boxes will be recycled.

Rural market has become a new growth pole of express delivery industry.

According to the data of the State Post Bureau, as of September this year, the coverage rate of express delivery service in established villages nationwide exceeded 80%. From the northwest Gobi to the southwest border, from wumeng mountain to the hinterland of Qinba, the express delivery network has been continuously completed and woven, which makes the circulation of parcels smoother, the rural market has become a new growth pole of the express delivery industry, and the rural consumption potential has been continuously released.

Near noon, the 205 bus carrying express parcels arrived at Gangdun Village, Cixi, Zhejiang Province. Just a few days ago, the first rural logistics express outlet in Cixi, Gangdun Zhongyou Station, was opened. In the past, the parcels of express delivery companies were only willing to be delivered to the fixed outlets at the foot of the mountain. Through the cooperation of post delivery and express delivery, the parcels of express delivery companies such as Zhongtong, Shentong and Yuantong are now taken to Gangdun Village by bus and placed at the post station.

Relying on the express network, consumer goods enter the mountains, constantly improving the quality of life of rural residents, and making agricultural products go out with better luck, and the villagers’ money bags are even more bulging.

In the past two days, the early-maturing apples in Qingyang City, Gansu Province have matured and ushered in a bumper harvest season. Kui, the king of fruit farmers in Loufangzi Village, Quzi Town, Huan County, is busy at the age of 69 while packing boxes and processing orders.

Pick up the goods at home, send them at any time, and deliver them on time, so that the sales of Wang Zhekui’s apples have expanded rapidly. Seventy percent of the annual output of more than 40,000 kilograms of apples is sold to all parts of the country through express delivery, which also drives 50 members around to get rich together.

According to the State Post Bureau, in the first three quarters, agricultural goods and e-commerce festivals were held in various places, which effectively promoted the growth of postal express delivery business through the linkage mode of "express delivery enterprise+government+merchants". In September, the online retail sales of physical goods supported by the postal express delivery industry is expected to exceed 8 trillion yuan.

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Century friendship between Zhao Puchu and Zhang Xiaoquan, a member of the Democratic Progressive Party.

one

In August 1991, Zhao Puchu took a group photo with Zhang Xiaoquan when he went to Hong Kong to attend the Shanxi Buddhist colored plastic photography exhibition.

2

An envelope sent by Zhang Xiaoquan to Zhao Puchu.


In late May, 2000, at No.1 Nanxiaoshuan Hutong, Xicheng District, Beijing, in an ordinary quadrangle, honeysuckle with a fence was full of fragrance, and a pomegranate tree in the corner was in full bloom. And the owner of the yard-Zhao Puchu can no longer enjoy these beautiful scenery. In the quadrangle, sorrow and joy are low, and the atmosphere is solemn and dignified. Among the bustling mourners in JaeHee, an old man in his late eighties wrote "zhangwenda, Hong Kong" in the guest book. Full of tears, he knelt before Zhao Puchu’s tomb. Who is zhangwenda and what is his relationship with Zhao Puchu?

Expensive: The hardest part is the old friend.

Zhangwenda, originally named Zhang Xiaoquan, was born in Changsha, Hunan Province in 1921. He graduated from the Central Political School and entered the press in 1945. After 1950, it was transferred to the Relief General Association and other units. In 1980, he settled in Hong Kong. Under the pen names of zhangwenda and Lin Xun, he wrote articles for major newspapers, served as an adviser to the president of New Newspaper and editor-in-chief of Haitian Supplement, and was quite influential in the press in Hong Kong and Macao.

Zhao Puchu and Zhang Xiaoquan met in 1945. At that time, Zhao Puchu was already a famous Buddhist and philanthropist, and Zhang Xiaoquan was a famous scholar even though he was a recruit in the press. Zhang Xiaoquan’s grandfather, Zhang Baixi, was the pioneer of modern university education in China. He founded Jingshi University, and his students were all over the world. Zhang Xiaoquan, sheltered by Tuozu’s shadow, is full of spring breeze in Shanghai, and the intersection of Zhao Puchu and Zhang Xiaoquan’s work was after the liberation of Shanghai. At the beginning of the founding of New China, Zhao Puchu was the chairman of the East China Production and Disaster Relief Committee, and Zhang Xiaoquan was the director of the office. Zhang Xiaoquan is young, energetic, quick-witted, open-minded and humorous. His professional qualities as a journalist have developed his strong communication skills and become an indispensable right-hand man for Zhao Puchu. Then Zhao Puchu was responsible for the establishment of the Shanghai Democratic Progressive Organization, and Zhang Xiaoquan was recruited as a member of the Democratic Progressive Party to continue to work together. Zhao Puchu’s gentle, meticulous and selfless nature deeply impressed Zhang Xiaoquan. Although they worked together for only three years, Zhao Puchu trusted Zhang Xiaoquan, and Zhang Xiaoquan also had a special respect for Zhao Puchu. This friendship lasted for half a century.

In the 1960s, there was a dispute about the authenticity of the author of Preface to Lanting in China literary world. At that time, someone in the domestic literary world wrote an article saying that Wang Xizhi did not write the Preface to Lanting, which caused an uproar in the north and south. Shen Yinmo, a calligrapher in Shanghai, was so angry that he wrote poems and articles to refute them. Shen Yinmo entrusted Zhang Xiaoquan to hand over the poems to Zhao Puchu. Zhao Puchu felt deeply after reading it, and thanked Shen Yinmo with a poem. "With a spoonful of Wang Yang, I can analyze the subtle theory of two kings. Wrist movement does not violate dialectics, and concentration is a health care prescription. Work deepens people’s knowledge and age, and flowers flourish in the east wind and the sun and the moon grow long. A roll of feelings is inspired by the public, and it is nothing but a sea of ink. " Zhao Puchu not only supported Shen Yinmo’s argument, but also highly praised Shen Yinmo’s achievements in calligraphy. Shen Yinmo was very moved. Although his eyes were highly nearsighted at this time, he still wrote a calligraphy work and entrusted Zhang Xiaoquan to Zhao Puchu. Zhao Puchu was very happy, and wrote "Bodhisattva Man": "Sir, I can handle things without hindrance, and I will try my best to carry the posture of keeping a good position. Zhang Cao writes Mao poems, and horizontal strokes. Li Zhu worked so hard that she did not hesitate to talk. At the same time, all the birds did not know. " Zhao Puchu asked Zhang Xiaoquan to mount Shen Yinmo’s calligraphy in Shanghai, which gave Zhang Xiaoquan a difficult problem. At this time, there were very few people engaged in mounting in Shanghai, and they either retired or changed careers. After tossing and turning, Zhang Xiaoquan finally found an old master to complete the task.

Zhao Puchu’s calligraphy works are Mo Bao that the world is scrambling to collect. Whenever Zhang Xiaoquan is entrusted, he is always responsive. In 1991, Zhang Xiaoquan wrote that Wang Danfeng’s husband Liu Heqing had settled in Hong Kong and opened a vegetarian restaurant near his apartment. Liu wanted to ask Zhao Puchu to write the words "Vegetarian in Kutokuhayashi and Shanghai". Generally speaking, Zhao Puchu doesn’t write an inscription for business easily, but because Zhang Xiaoquan entrusted him, he not only met his requirements, but also wrote in person and sent it by air. Soon after, Zhang Xiaoquan wrote to ask for two more words. One was to Chen Naiqiang, the former Hong Kong Secretary for Lands and Civil Service, who was an engineer, a consultant on Hong Kong affairs and the chairman of the former Hong Kong Senior Civil Servants Association. The other is Anthony Pun, former deputy editor of Sanlian Bookstore. In addition, I plan to write the word "Meihuazhuang" for myself, saying that "Meihuazhuang" is his former residence outside the north gate of Changsha, and I want to make a small plaque as a souvenir. Zhao Puchu met his requirements one by one.

The Letter is a prestigious newspaper in Hong Kong, and its directors are Lin Mushan and Luo Youmei. Zhang Xiaoquan has been writing for Xinbao for more than ten years. In order to reward them, Zhang Xiaoquan specially wrote a book and begged Zhao Puchu for a calligraphy. After receiving the book, Zhao Puchu immediately wrote two calligraphy pieces in calligraphy and sent them by letter.

Odd: Rhyme exists in the "bank"

Zhao Puchu is also a famous writer and poet. In 1960s and 1970s, due to the lack of information, Zhao Puchu’s works were spread by copying.

On the anniversary of Premier Zhou’s death in 1977, Zhang Xiaoquan was on his way home. When he passed by Shanghai No.2 Middle School, he saw that on the opposite wall, the Shanghai Painting Academy copied Zhao Puchu’s recent work "Golden Melody-A Sense of the Anniversary of Premier’s Death", and drew red boxes and horizontal lines with white newspapers. Each wall wrote a sentence, and the audience was crowded. Zhang Xiaoquan was very excited. When he got home, he immediately wrote to Zhao Puchu about this exciting scene.

In fact, every new work by Zhao Puchu is often shared by Zhang Xiaoquan and Chen Bangyan. Chen Bangyan, Zhao Puchu’s brother-in-law, has a deep research on ancient poetry. Zhang and Chen used to work in the Shanghai Municipal Committee of the Democratic Progressive Party, and then together they decentralized Fengxian coastal labor, which can be described as he is my brother. Zhao Puchu once joked in a letter: "In the future, poetry should be copied and sent to two companies, such as depositing money in the bank, so as not to lose your ears." In a letter, Zhao Puchu attached two papers to the letter: "I didn’t send the letter yesterday, but now I have another one in your bank." Zhang Xiaoquan also likes poetry, and every time he has a new work, he always sends it to Zhao Puchu to beg for correction. In 1976, Zhang Xiaoquan learned that Wen Wei Po published Zhao Puchu’s poem "Never Forget" in memory of Chairman Mao, and immediately wrote to Fan Chen, asking him to send a copy of Wen Wei Po and forward it to Zhao Puchu for filing. Fan Chen is the founder and editor-in-chief of Hong Kong’s Yilin Conglu. Zhang Xiaoquan met Fan Chen through Yang Dongchun’s introduction. Zhang Xiaoquan is congenial to Fan Chen, and he handled a large number of Shanghai manuscripts contained in Yilin.

Zhao Puchu’s deposit of his poems in the "bank" proved to be a wise move. Zhao Puchu is well educated and quick-witted, and he is ready to write. A large number of works created in his life are scattered everywhere. Without these backups, there would be no later magnificent Collection of Zhao Puchu Rhymes, which was published by Shanghai Ancient Books Publishing House and compiled by Chen Bangyan.

In his later years, Zhang Xiaoquan wrote to Zhao Puchu about the loss of traditional Chinese studies in mainland China, which was worrying. He said that when he was a child, he studied in a private school, and the enlightenment was Tang poetry and Song poetry, so he memorized many poems. And my own pair of children have no interest in poetry. At the end of the letter, Zhang Xiaoquan said with emotion, it seems that my children and grandchildren have no chance of literature. After reading the letter, Zhao Puchu felt the same way. To this end, he specially organized a joint proposal to establish a classical poetry school for children at the CPPCC meeting.

Jane: There is always love in one branch and one leaf.

From 1950s to 1970s, materials were scarce. Every holiday, Zhang Xiaoquan will receive hawthorn cakes, preserved eggs, bamboo shoots and dried vegetables from Nanxiaoshuan Hutong from time to time. Besides food, there are calendars or calendars. At that time, these beautifully printed calendars and calendars were rare.

Come and go. One day, Zhang Xiaoquan saw "Evergreen" soda cookies on sale in the street. He thought that Zhao Puchu was a vegetarian all the year round and was prone to hunger. He wanted to buy some and take them to Beijing. As a result, he stood in line for an hour, but when he got to him, it was sold out. He had to buy more than a catty of sweet biscuits in the sales department of Yimin No.3 Factory, seal them in plastic bags and send them to someone. On New Year’s Day in 1977, Shanghai issued a meat coupon to the citizens, and each person received a monthly 2 yuan. On New Year’s Day of National Day, 1 yuan was added. Zhang Xiaoquan wrote to Zhao Puchu to report this situation and was concerned about Beijing’s policy. And charged Zhao Puchu vegetarian meat is not necessary, but milk is absolutely indispensable.

In 1976, the Tangshan earthquake, with strong earthquake waves, hit Beijing, and the traffic on the Beijing-Shanghai line was cut off. There are many legends in Shanghai. Zhang Xiaoquan was very anxious after learning the news. He was busy making a long-distance call to Zhao Puchu’s home in Nanxiaoshuan Hutong to inquire about the situation. However, the Shanghai post office was crowded and could not get forward, so he had to send an airmail letter for inquiry. That night, the postman sent a telegram. Before opening it, Zhang Xiaoquan was scared to death. When he saw the word "peace", his long-hanging heart was put down. It turned out that Zhao Puchu was afraid that he was in a hurry and the telegram was safe.

After Zhang Xiaoquan went to Hongkong, Zhao Puchu did not forget to ask someone to take a calendar every New Year’s Day. Upon learning that Zhang Xiaoquan was physically weak due to hard work in writing, Zhao Puchu specially called Hong Kong Hongxun Master to send four boxes of Niuhuang Qingxin Pills, which made Zhang Xiaoquan grateful. On the Dragon Boat Festival in 1991, Zhao Puchu specially sent Zhang Xiaoquan two boxes of dumplings. Zhang Xiaoquan felt that he should not enjoy this gift exclusively. He distributed zongzi to the teachers and students of Huaren Primary School, a famous school in Hong Kong, so that Huaren teachers and students could feel the deep affection of this venerable person from the mainland of China. Zhang Xiaoquan also gave his beloved little grandson a nickname "Xiaozongzi".

Sometimes I can’t hear from Zhao Puchu for a long time when I’m far away from Hong Kong, and Zhang Xiaoquan always misses it. Every time I see photos of Zhao Puchu running around from newspapers, my spirit is good, and Zhang Xiaoquan is a little relieved. Zhao Puchu was deaf and deaf in his later years, so Zhang Xiaoquan specially bought the best hearing AIDS from abroad. Zhao Puchu likes to use ballpoint pens in his work, especially the imported ballpoint pens sent by Zhang Xiaoquan. His writing is fluent and of good quality. In 1995, Zhang Xiaoquan, as the head of the delegation, led a "Hong Kong cultural delegation" to Hebei for an interview. When passing through Beijing, he visited Nanxiaoshuan Hutong, and brought him 100 pens and hair cream that Zhao Puchu liked at a time. Although it was a hasty meeting, Zhang Xiaoquan was overjoyed to see that Zhao Puchu was as healthy as ever. Zhao Puchu returned Zhang Xiaoquan’s watch and American ginseng. Naturally, whenever the refill on hand runs out, Zhao Puchu will write a note to his secretary, "Bring some pens from zhangwenda".

Ya: Shuxiang accompanied the world of mortals all the way.

Zhang Xiaoquan loves books, especially books. At one time, Zhang Xiaoquan entrusted a friend to buy a copy of the Great Battle of the Second World War, which was a treasure. Chen Bangyan borrowed a book from him and accidentally stained it with wine. Zhang Xiaoquan was deeply saddened and repeatedly blamed it, which made Chen Bangyan very embarrassed. It happened that Chen Bangzhi bought a copy for Chen Bangyan at this time. Chen Bangyan gave Zhang Xiaoquan the old and new books at the same time in order to make up for it. Zhang Xiaoquan turned his anger into a smile. Zhang Xiaoquan once said that the first thing he did after he set foot in Hong Kong was to plunge into the bookstore. Once he learned that there was a translation of a book called "The Decline of the West", he quickly wrote to Nanxiaoshuan Hutong, asking Chen Bangzhi to find it for him, and he went to several bookstores to buy it.

In the early 1990s, Bai Yang’s A Mirror of Vernacular Information was very popular in Hong Kong and Taiwan. When Zhao Puchu wanted to buy a set, he entrusted Zhang Xiaoquan to do it for him. The book is magnificent, and has been published in 61 issues one after another. Zhang Xiaoquan commissioned all of them to be taken to Beijing in batches. Later, every time there was a new issue, it was always sent in the first place.

Every time he comes to Hong Kong, Zhao Puchu always meets Zhang Xiaoquan, either by letter or in person. Zhao Puchu joked that Zhang Xiaoquan had "a house like a boat, a desk like a mountain". In 1996, Taiwan Province published Zhang Xiaoquan’s "Vertical Pen". After the book was completed, Zhang Xiaoquan sent it to Zhao Puchu, and Zhao Puchu read it carefully, and corrected or marked the typos, punctuation and doubts in the book one by one with red pen. Zhang Xiaoquan is also a volunteer information officer in Zhao Puchu. As long as the news and comments published by major newspapers in Hong Kong, both at home and abroad, feel valuable, Zhang Xiaoquan will carefully cut them out and send them to Zhao Puchu. In July 1994, Zhao Puchu wrote a poem entitled "A Brief Report from Hongkong", in which "rumors started behind Duke Zhou, hoping to climb to heaven. A rumor can hurt the sun and the moon, and the flames shine on the rivers and mountains. " This Hong Kong briefing was sent from Zhang Xiaoquan.

Fun: the cat will clean the bowl.

Zhang Xiaoquan has a loose personality, unrestrained and unrestrained. In the early 1950s, Zhao Puchu went to Beijing to preside over the work of the Chinese Buddhist Association, and invited him to go north with him because he appreciated Zhang Xiaoquan’s talent. At that time, it coincided with the cancellation of the East China Bureau, and there was no doubt that going to Beijing with Zhao Puchu had a better future, but Zhang Xiaoquan declined. What he wanted more was a free life in Shanghai.

In 1979, Mr. and Mrs. Zhao Puchu went to Shanghai for a holiday, especially to catch up with Zhang Xiaoquan. Zhao Puchu jokingly said as soon as he entered the door, Xiao Quan, I will have lunch at your house today. But don’t entertain guests with the bowl that the cat added. A group of people here couldn’t help laughing. It turns out that there is a story in it.

During the "Cultural Revolution", Zhang Xiaoquan was first sent to Fengxian seaside countryside with Chen Bangyan, and then returned to Shanghai to become a worker, knocking cinder bricks every day. Zhang Xiaoquan didn’t feel bitter, but he felt that he was far more at leisure in the factory than in the office. Chatting with Chen Bangyan and his wife after work every day, and being with kittens at home is quite enjoyable. One day, Zhang Xiaoquan’s nanny returned home, and he wanted to cook for himself, which was miserable for him, so he ran to Chen Bangyan to learn from him. Although Zhang Xiaoquan is not good at cooking, he thinks of a wonderful way to wash dishes, that is, ask his kitten to lick the greasy bowl clean, and then take it to the tap for a flush, as bright as new. Do the same thing every day, and it really saves trouble. Zhang Xiaoquan wrote to Zhao Puchu about it, and this is the origin of the cat licking the bowl.

After dinner, Zhao Puchu invited Zhang Xiaoquan to travel with him to Yangzhou, which is the place where Zhang Xiaoquan studied. Zhang Xiaoquan gladly went there. Considering Zhang Xiaoquan’s financial difficulties, Zhao Puchu paid the round-trip ticket and other expenses for him.

At the end of May of the following year, Zhang Xiaoquan crossed Shenzhen Luohu Port and arrived in Hong Kong. After living in Hong Kong, Zhang Xiaoquan, as a freelance writer, kept soliciting manuscripts. Every time Zhang Xiaoquan got something, he always wrote or telegraphed Zhao Puchu. Therefore, in 1990, Zhao Puchu came to Hong Kong to praise him. "It took 36 years for Xi Jun to be more graceful."

In front of Zhang Xiaoquan, Zhao Puchu also revealed his frankness. One day, 87-year-old Zhao Puchu sent a poem by Zhang Xiaoquan, entitled "Walking in front of the court suddenly fell without injury", "I was shocked by the Yushan Mountain, and I got up to see the sky." Don’t lie in the mountains, don’t lie in the fields, and the old man stays at home with ninety sticks. "The poems are humorous and vivid.

(Hu Wenfei, author: Zhao Puchu Cultural Park Management Office)


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Box office 1.7 billion, jump into the live room! How to counterattack "Feng Shen I"


Special feature of 1905 film network After 20 days of release, the box office of "Fengshen Part I" exceeded 1.7 billion, and the total box office was predicted to increase from 1.25 billion at the lowest point to 2.45 billion, nearly doubling.Maybe, directorWu ErshanFinally, I can say:"sealGodOut of the ICU.



At the same time, on the evening of August 8th, several leading actors, such as Yu Shi, Na Ran, Chen Muchi and Shan Jingyao, also made a surprise appearance in the live broadcast room of Liu Genghong. The "Proton Group" showed the war dance and joyful dancing, and the topic kept on.



"You have one vote, I have one vote to help Master Wen buy a high-speed rail ticket", "You don’t vote, I don’t vote, Yin Jiao will never have a head!" …


Never being optimistic, it is expected to compete for the second place in the summer box office. The starring role is from unknown to popular. How can "tap water" help "Fengshen" to complete the box office counterattack? How do online and offline announcements open the "road to sealing the gods" with a "two-pronged approach"?


"Tap water" helps "the road to sealing the gods" 


Different from the performance of "scheduled" explosions in summer files such as "Disappeared She", "In an octagonal cage" and "Put all your eggs in one basket", "Feng Shen I" was the one that was not optimistic until its release.The voices of "untimely blockbusters" and "Chinese magic has long been out of date" have come and gone, and only 138 million yuan was recorded in the first two days, which also lowered the total box office forecast of the film to 1.25 billion.



However, with the further release of the film, the relatively excellent quality and fascinating characters have aroused extensive discussion among netizens, and "tap water" is also constantly gathering. Stars and enthusiastic audiences from all walks of life began to spontaneously Call for the film on major social platforms, and supported the film with two brushes and three brushes.


This also allows the market to witness the mysterious power of "tap water" again after films such as The Return of the Great Sage, 22nd and The Wandering Earth.



There are still many netizens who take the initiative to undertake the heavy responsibility of film promotion, brainstorming for hot search topics and fancy whole work. Master Wen Taishi, who made a stunning appearance in the egg, was elected as the first "spokesperson" by the tap water.


"Hello, I’m Master Wen. I’m grabbing a high-speed rail ticket at 12306. Please help me to speed up my return to the DPRK." "You have one vote for me, and a surname can arrive on time!" And so on, which have a great sense of network, have gained a good communication effect.



More enthusiastic netizens thought of dozens of entries in one breath, including not only "Wen Taishi Terrier", but also related topics such as "da ji’s love brain" and "Yin Jiao Ji Fa’s brotherhood", all of which are hot spots that netizens like to see and hear. With the continuous spontaneous fermentation of "tap water", it also helped # Please seal the gods and announce that it was immediately spread to me # and boarded the hot search several times.



Different from these hot spots from the bottom up, the early official publicity of "Feng Shen" mainly focused on the cultural value of the film. There is nothing wrong with this angle itself, but it is launched when the audience still doesn’t understand the film, which means a lot of preaching, and it is not as easy to sink out of the circle as the spontaneous online topic of netizens.


Fortunately, the propagandists and creators of "Feng Shen" gradually realized this point and began to have a benign interaction with "tap water people". For example, Chen Muchi, the actor who plays Yin Jiao, was named as the uncrowned "propaganda director" by netizens because he was willing to go off to play in person.



Director Wu Ershan learned that his initials were homophonic during the road show, and immediately changed the profile "523" to "U23" (from "No Two or Three" to "There are Two or Three"), which earned a lot of goodwill. At the same time, by constantly releasing exclusive behind-the-scenes tidbits and deleting fragments, he tried his best to meet the needs of tap water, and also provided material for the continuous fermentation of the topic.



Under the overnight rescue of "tap water", "Feng Shen" also miraculously walked out of the ICU, ranking first in the box office for 13 consecutive days from the first Saturday, and set a record of 160 million yuan in a single day the next weekend, drawing a beautiful downward curve.


The box office counterattack of "Feng Shen" is undoubtedly a demonstration of the power of "tap water", and it is also worth thinking in the industry: what kind of topics and forms are loved by the audience, and what kind of propaganda points can really gain heat and flow.



 Online and offline "combination boxing" 


"ChristianRandPhillips, she is my hakimi", "Princess ChristianRandPhillips embraces Na Ran" and "Yu Shi Na Ran crosses da ji Ji Fa with each other", all of which come from the roadshow scene of "Feng Shen I".


In addition, short videos with high popularity, such as "Chen Muchi reappears in the right place to tie the gods", "Chen Muchi’s military boxing" and "Proton Group reappears famous lines", are also from roadshows. The ongoing roadshow in 24 cities across the country is like a continuous "hot search" manufacturing machine, which continuously outputs various "famous scenes".



With the rise of online platforms, the traditional road show method was once despised by many filmmakers, who thought it was strong in regionality and limited in reach. However, many summer blockbusters, including Feng Shen and Disappeared She, proved the significance of the road show through examples.


In the era of short video, the role of roadshows is not only to effectively incite regional resources and ferment word of mouth, but also to generate a large number of short video-oriented materials through the interaction between the main creators and local audiences. These grassroots and creative pictures are often easier to spread and spread.



From offline to online, unlike other blockbusters selling tickets live in the early stage of the release, "Fengshen" chose to go to the online head live broadcast room after the actors accumulated a certain degree of heat and popularity.


On August 5th, the cast of "Feng Shen" parachuted into the "Brother Xiao Yang" live room for the first time to sell tickets, and 200,000 movie tickets were sold out in seconds, with over 150 million praises in one minute. Choosing to link with the anchor of the short video platform with grounding gas like "Xiao Yang Ge", the film obviously expects the film to further incite the sinking market.



On August 8th, with the long-awaited fans, the representative of "Proton Group" finally merged with Liu Genghong in the live broadcast room, with a high degree of matching between people and audience, which is expected to produce better communication effect.


Coupled with the live broadcast of a popular game on August 10, and the live broadcast of various actors, from offline to online, from the road show site to the live broadcast room, the "combination boxing" of "Feng Shen" is exerting its power.



Why is "Feng Shen I"? 


Before the screening, I wanted to see why "Feng Shen", which was not favored by the market, attracted so much "tap water" to complete the box office counterattack.


On the one hand, it is naturally because of the excellent quality of the film. Douban scored 7.8 points, Cat’s Eye scored 9.4 points, and Taobao Film scored 9.2 points, which were outstanding in both magic films and movies of the same file, and also gave Amway the confidence of "tap water".



On the other hand, the film is well-made, the old opera bones are superb, and the strength of the new actors is all important points.


With the release of documentaries and behind-the-scenes specials, the ubiquitous cultural details, craftsman spirit and the six-month training camp for worshipping gods have gained the recognition of netizens, making "worshipping gods" a recognized work of "grinding a sword in ten years".



Not only that, although the genre of "Feng Shen" is a magical epic action blockbuster, it "accidentally" captured the "heart" of female audiences. According to a ticketing platform, 52.8% of users who want to see the portraits of Fengshen are women, and the score of women is as high as 9.8, which is much higher than that of men.



The brotherhood of Yin Jiao and Ji Fa’s "well-connected suburbs" combination, the sunny and strong appearance of the members of the "Proton Group" and ChristianRandPhillips, who is more attractive as he gets older, have aroused extensive discussions among the female audience, and also invisibly led a new aesthetic direction. As netizens commented, it is suggested that domestic ancient costumes be rolled up according to this standard.


At the same time, through hard training, the members of Proton Group have completed the all-round transformation from body, will to acting skills, and such "nurturing" actors are more likely to arouse the recognition and resonance of the audience.



The box office counterattack of "Feng Shen" is the victory of "tap water", which also proves that gold always shines. However, "the fragrance of wine is also afraid of the depth of the alley". While looking forward to "Feng Shen II", we might as well sum up our experience and prevent the excellent works from being buried again.


通过admin

Barbecue is delicious, but you must do these eight points for health!

The following article comes from China, the author of Science Popularization, Xue Qingxin.

Cop China.

Public science popularization and scientific communication

Why does barbecue smell good?

The origin of barbecue is very early, and it has been started since our primate ancestors. The love for barbecue can be said to go deep into the soul. Few people can control their desire for the smell of barbecue food. The smell of barbecue coming from the streets is really tempting, not to mention the lively atmosphere of barbecue all over the city!

Then why does the barbecue smell so good?

The most common barbecue is charcoal barbecue, which can give food a unique aroma mainly for two reasons.

1. Maillard reaction

During the barbecue of food, the amino acids decomposed by protein will have Maillard reaction with the reducing sugar in food or marinade, which can give food a unique aroma and attractive color.

2. Flavor droplets

Flavor droplets are the key to the flavor formation of barbecue food. After burning, food droplets will emit many aromatic compounds to cover the food.

For example, the drippings of fruit juice contain sugar, protein and oil, and the drippings of meat contain a lot of fat, which will be burnt at the high temperature of charcoal and excited into aromatic molecules to return to the smoke, giving food an aromatic taste.

The combination of these two flavors makes people drool over barbecue.

Why advise you to eat less barbecue?

Barbecue is delicious, but you should not eat it often. In order to persuade you to eat less barbecue, I have properly sorted out many reasons.

Step 1 get fat

Fat and thin kebabs especially capture people’s hearts, such as pork belly, soy sauce tendons, fat and thin, and even cooked tendons, skin and fat intestines … You may brush oil over and over again during the barbecue. The reason why these kebabs are delicious is that they are high in fat, so they taste good, and the calories are naturally not low. Eating them often will inevitably increase the risk of obesity, which is not conducive to cardiovascular and cerebrovascular health.

2. It is not conducive to controlling blood pressure

The salt content of pickled kebabs and the dipping sauce is not low, so eating them often is not conducive to controlling blood pressure.

3. It is not conducive to controlling blood uric acid.

Barbecues, especially those in coastal areas, have more meat and seafood, and often drink beer at the same time, which will make us consume more purine, which may lead to an increase in blood uric acid. Patients with hyperuricemia and gout should pay special attention to eating moderately.

4. There are carcinogens

Barbecue belongs to high-temperature cooking, and the highest temperature can reach 370℃. At this high temperature, meat will produce heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are carcinogens, and the content of carcinogens will gradually increase with the increase of temperature and time.

As we all know, 3,4- benzopyrene is the highest class 1 carcinogen, which is definitely carcinogenic to human beings. It belongs to one kind of polycyclic aromatic hydrocarbons, which is the most toxic and accounts for a large proportion, so it is the most representative polycyclic aromatic hydrocarbons with strong carcinogenicity. In the way of ingesting polycyclic aromatic hydrocarbons through diet, fried and grilled foods account for 88%~98%. [1]

In addition, foods with high carbohydrate content, such as steamed bread, bread, potato chips, etc., will produce acrylamide during barbecue, which belongs to category 2A carcinogen. It has been confirmed that it will cause cancer in animals, but the evidence of carcinogenicity in humans is limited.

5. Air pollution

The burning and incomplete burning of charcoal for barbecue will produce carbon dioxide and carbon monoxide. The former is a kind of greenhouse gas, while the latter is a toxic gas. The smoke from barbecue contains toxic and harmful substances such as dioxins, nitrosamines and heterocyclic amines, among which dioxins not only cause cancer, but also have reproductive toxicity and genetic toxicity. The smoke contains particles such as PM2.5 and PM10, and the concentration is off the charts! Relevant tests by environmental NGOs show that the concentration of PM2.5 in barbecue intensive areas is 1 meter, 10 meters and 100 meters away from the oven, which is far higher than that in non-barbecue areas, and PM10 can also cause haze weather, which seriously harms the health of respiratory system. [2]

How to reduce injuries?

Since there are health risks while eating barbecue, how can people who like to eat barbecue eat relatively healthily? In order to let everyone enjoy the food happily, the following eight points are best arranged.

Step 1 don’t burn

The higher the barbecue temperature and time, the higher the carcinogen content. It is best to remove the burnt place and not eat it, because the more burnt the place, the higher the carcinogen content. After baking, you should wipe the head of the barbecue label before eating.

For example, it is reasonable to have a small stove on each table of Zibo BBQ, and the degree to which the meat is roasted can be completely in your own hands. It is suggested that the meat can be eaten when it is completely cooked, and don’t wait for it to dry and paste.

2. Choose more lean meat

Lean meat is low in fat, which is helpful for weight control. Moreover, if the fat content is high, it will further promote the formation of carcinogens, and polycyclic aromatic hydrocarbons are most likely to be produced at high temperature. Lean meat may have lower carcinogen content than fat and thin kebabs, and it can also reduce the intake of saturated fatty acids.

3. Don’t just eat meat

Many people eat kebabs all over the table, which will lead to high meat intake, which is not conducive to cardiovascular health. If you eat so much meat often, you will increase the risk of developing diseases such as type 2 diabetes, colorectal cancer and obesity. [3] Therefore, it is best to mix some staple foods, vegetables and bean products, which will help to enhance satiety and control meat intake.

Zibo barbecue, for example, is very good. Burritos are the staple food, and shallots are vegetables, but the taste is spicy.

Step 4 match fresh fruits and vegetables

Fresh fruits and vegetables are rich in dietary fiber and antioxidant components, such as lycopene, carotene and anthocyanin. Tomatoes, Chinese cabbage, cherry tomatoes, leeks, oil-wheat vegetables, sweet peppers, colored peppers, etc., when eaten with barbecue, can reduce the harm of carcinogens in barbecue to the body.

5. Microwave before baking

Microwave pretreatment can significantly reduce the production of heterocyclic amines in meat, because microwave can reduce the water content in food, so that the "raw materials" that form carcinogens can not seep out to the surface of meat to participate in the reaction with water, thus significantly reducing the production of heterocyclic amines.

The results showed that the total amount of heterocyclic amines in half-cooked chicken and beef pretreated by microwave decreased by 24% and 21% respectively, while the total amount of heterocyclic amines in fully cooked samples decreased by 35% and 42% respectively. [1]

In addition, microwave pretreatment can significantly reduce the production of polycyclic aromatic hydrocarbons in barbecue products, which may be due to shortening the barbecue time.

Therefore, if you barbecue food at home by yourself, you can microwave the meat until it is 67% cooked or fully cooked before roasting.

Step 6 marinate with spices

Pretreatment of food with spices can significantly inhibit the formation of harmful substances such as heterocyclic amines, acrylamide and polycyclic aromatic hydrocarbons in food. This may be because spices generally have strong free radical scavenging ability, which can significantly inhibit the free radical reaction of meat products during high temperature processing. [1]

You can marinate the meat with garlic juice, onion, red pepper, Chili powder, ginger, black pepper, thirteen spices and so on before baking.

7. Put less or no soy sauce

Soy sauce can promote the formation of heterocyclic amines, and it is best to put less or not.

8. Barbecue style

Compared with charcoal roasting, electric roasting is more recommended, and the amount of harmful substances generated by electric roasting is lower. It was found that the content of polycyclic aromatic hydrocarbons (PAHs) was 24 μg/kg when sausages were roasted by electric roasting, and it increased to 51 μg/kg when sausages were roasted by charcoal, which was nearly 2 times higher than that by electric roasting. [4]

In addition, gas barbecue and stone barbecue can also effectively reduce the content of carcinogens in barbecue meat products.

summary

Let’s be realistic. No matter where the barbecue is, it’s not healthy food. Here, it’s good to remind everyone to relieve their cravings occasionally. Maybe it’s just right to have a barbecue once in a while. Remember to drink less wine and drink less sweet drinks when eating barbecue ~

Original title: "Barbecue is delicious, but healthy skewers should do these 8 points! 》

Read the original text

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Announcement of the General Office of the People’s Government of Yunnan Province on the announcement of the comprehensive results of civil servants employed in the 2023 annual examination and the foll

According to the arrangement of Announcement on the Recruitment of Civil Servants for the 2023 Examination in Yunnan Province, the written examination and interview work have ended. Now, the comprehensive scores and follow-up work arrangements of candidates applying for the General Office of Yunnan Provincial People’s Government, the Office Automation Technology Center of the General Office of Yunnan Provincial People’s Government, the Bulletin Office of Yunnan Provincial People’s Government and the Office of Yunnan Local Records Compilation Committee (referring to the staff of the management unit) are announced as follows:

I. Comprehensive achievements

According to the proportion of 50% written test scores and 50% interview scores, the written test scores and interview scores are rounded to two decimal places, and the comprehensive scores are rounded to three decimal places. See the annex for specific comprehensive achievements.

Second, the follow-up work arrangements

(1) About physical examination.

1. Schedule: April 25th, 2023 (Tuesday) at 8: 30am.

2. Physical examination location: Affiliated Hospital of Yunnan University (formerly Red Cross Hospital of Yunnan Province, No.176 Qingnian Road, Kunming).

3. Precautions: First, please ask the relevant candidates to pay at the No.1 window on the third floor of the outpatient department of the Affiliated Hospital of Yunnan University (formerly Yunnan Red Cross Hospital) at 8:00 am on Tuesday, April 25, 2023 (the standard medical examination for civil servants costs about 500 yuan/person), and the medical examination expenses shall be borne by the candidates themselves; At 8:30, fill in the form in the physical examination center (12th floor of Medical Technology Building). Second, please ask the relevant candidates to bring their original ID card, a recent 1-inch bareheaded color photo, black carbon pen and double-sided tape (for posting photos). Third, please eat light food one day before the physical examination, and fast gas-producing foods such as melon beans and milk, and fast after 9:00 pm. Please be present on an empty stomach in the early morning of the physical examination day.

(2) About the inspection work.

In accordance with the relevant requirements of the Measures for the Investigation of Civil Servants’ Employment (Trial) and the Implementation Measures for the Investigation of Civil Servants’ Employment in Yunnan Province (Trial), the follow-up will be notified by the telephone reserved by the candidates when they register. Please be sure to keep the communication open. If you can’t contact, the candidates will bear the consequences themselves.

Tel: 0871-63631608


Attachment: Comprehensive Scorecard of Civil Servants Employed in the 2023 Examination of the General Office of Yunnan Provincial People’s Government. docx


General Office of Yunnan Provincial People’s Government

April 18, 2023


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Street shooting is risky. Experts: Internet platforms can’t ignore infringement.

  A lady in a floral dress walked through Sanlitun Square in Beijing, attracting many photographers to follow.

  □ Our reporter Pu Xiaolei

  □ Intern of this newspaper Rollin Wang Wen/map

  Recently, Taikooli in Chengdu, known as the "Holy Land of Street Shooting", suddenly lost a lot of street shooters.

  It turns out that in order to protect the public’s right to portrait, Taikooli erected a signboard of "improving the awareness of prevention and protecting the right to personal portrait", and the civilized code also stated that it is forbidden to take pictures or shoot without permission. At the same time, street shooters here must apply for a "shooting license".

  The street shooting in Taikooli, Chengdu has cooled down, while the street shooting in Sanlitun, Beijing is still hot.

  According to a survey conducted by the reporter of Legal Daily, after 3 pm every day, the number of street shooters in Sanlitun will gradually increase. From occupying favorable terrain to finding targets, from capturing photos to following photos, street shooters are extremely skilled in their business.

  Zhu Wei, deputy director of the Communication Law Research Center of China University of Political Science and Law, pointed out in an interview recently that street shooting can be seen everywhere in the streets of major cities, but this common behavior has brought troubles to the photographers, and citizens’ right to privacy, portrait and reputation has been repeatedly violated.

  "In the Internet age, street photos often spread on the Internet, causing great troubles to the parties. To solve this problem, the responsibility of relevant network platforms is the key. It is suggested that in the personal information protection law, the duty of care of relevant network platforms should be further strengthened, and it is required to take necessary anti-infringement measures to reduce the occurrence of infringement. " Xu Hao, a lawyer at Beijing Jingshi Law Firm, said.

  Street photos of beautiful women can get more traffic.

  In Sanlitun, the enthusiasm of street shooters is as hot as the temperature in summer of beijing.

  After 3 pm on July 27th, the number of street shooters in Sanlitun, Beijing increased one after another. They were carrying "long guns and short guns", squatting at the intersections of the square, debugging their equipment and carefully selecting the shooting targets among the crowd.

  The reporter found that the subjects were basically fashionable ladies, among whom ladies wearing suspenders, tube tops, hot pants and mini skirts were more popular. Once there is a beautiful woman dressed in fashionable and cool clothes, these street shooters will not only press the shutter in the distance, but also many people will run forward to shoot at close range.

  Some women have no idea that they have been photographed, some women look dumbfounded when they see such a scene, some women cover their faces with their hands and leave quickly when they find that they have been photographed, and some women clearly wave their hands to express their refusal … … But no matter how the ladies react, the photographer will "persevere" to catch up and shoot.

  Just as the reporter was observing the shooting scene of street shooters, suddenly there was a commotion around him.

  It turned out that a lady in a floral dress attracted many photographers to trot and shoot when she crossed Sanlitun Square. The lady kept walking, and these photographers followed her. Until she walked out of the square, photographers still came forward to talk to her.

  "I have a large number of fans in Weibo, which is one of the big V’s, and the pictures of street beauty are particularly concerned. Just looking for a beautiful woman and a WeChat friend, I want to have long-term cooperation in the future. " A photographer "teaches experience" to reporters like this.

  Under the influence of flow economy, it is not uncommon to make profits by infringement.

  In the Internet age, with the help of technology and new media, street shooting has been regarded as a profit-making tool — — Street shooters publish photos on Weibo, WeChat WeChat official account, Tik Tok, Aauto Quicker, Hupu and other online platforms, so as to improve the click-through rate and attention, and achieve profit-making purposes by attracting traffic.

  In the eyes of street photographers, it is not so important whether the photographed lady is infringed when taking and publishing photos.

  Zhu Wei pointed out that the photographer has the right to shoot, and the parties have the right to refuse. When the photographer explicitly refuses, this shooting behavior should stop immediately. The act of uploading the photos to the Internet platform, whether it is used for profit or not, does not affect the establishment of infringement of personal portrait rights.

  "In the Internet age, those who get traffic get the world. In most cases, with traffic, they can be realized. Therefore, street shooters who post photos online to pursue traffic, whether they cash out at that time or not, can be regarded as a profit-making behavior. " Xu Hao said.

  Although infringement is ignored by online platforms.

  In recent years, short videos represented by Tik Tok, Aauto Quicker, etc. have become popular, and all major platforms encourage the public to become photographers, taking pictures of people and things they meet in their lives. As everyone knows, there are many legal risks in the act of street shooting.

  In 2016, a photographer happened to encounter a contradiction between a man and a woman on the street. The photographer raised his mobile phone, filmed the process of the man beating the woman, and uploaded the video to the Internet, which caused widespread concern. The man and woman in conflict are a couple, and the wide spread of this video has brought great trouble to their lives. Therefore, they took the photographer to court and demanded that the photographer bear the tort liability. After the trial, the court held that the auctioneer did not conceal the appearance and image of the parties, which infringed on the personal dignity rights of the parties, and the auctioneer was sentenced to bear the responsibility.

  Zhu Wei pointed out that without the consent of the portrait owner, the portrait of the portrait owner may not be made, used or made public. If the photographer happens to be shooting a model, and this photo is used for commercial publicity, it will also involve the infringement of commercial personality rights.

  "There are also some short video bloggers who harass, chat up and trick passers-by in the form of outdoor live broadcast, which clearly violates the Public Security Administration Punishment Law." Zhu Wei said.

  For the photographer, because the shooting places are mostly in public places such as subways and streets, many photographers don’t know that they have entered the lens of street shooters, so it is impossible to determine whether the shooting behavior of street shooters is illegal or not. Even if you know that you have been infringed, you still have to face the dilemma of high cost of rights protection.

  "on the one hand, the cost of safeguarding rights is high, it is difficult to prove, and it takes time and money. On the other hand, even if you win, the amount of compensation is very low. Therefore, it is difficult for the general public to have the energy and financial resources to defend their rights. " Xu Hao said.

  "It is easy for photographers to get money, and the cost of defending their rights is high. Most online platforms are left unchecked. This is an important reason why street shooting is so rampant and repeated." Zhu Wei said.

  The platform should be held responsible for not taking necessary measures.

  When a reporter searched for "street shooting" in a short video App, he found that many bloggers would publish a large number of short videos with the theme of fashion wear, and some short videos would also use words such as "meeting their ex-girlfriend" and "my first love" to attract attention.

  "No organization or individual may infringe upon the portrait rights of others by uglifying, defacing or forging by means of information technology. Some photographers PS the photos they take, deliberately uglify and spoof them, and match them with some suggestive words, which is obviously an infringement on the reputation of the parties. " Zhu Wei said.

  Isn’t there a better way to face the infringement of street shooting?

  "In the Internet age, online platforms should shoulder their due responsibilities in protecting citizens’ portrait rights. For example, smooth reporting and complaint channels, so as to better safeguard the legitimate rights and interests of portrait rights holders. " Xu Hao said.

  After investigation, the reporter found that the complaint reporting channels of most short video platforms are extremely hidden, and there are no obvious icons on the page menu. Only by clicking the share button on the short video playing interface, the report button will be seen in the drop-down menu. After clicking in, there will be requirements for submitting the complainant’s personal identity information and uploading the proof of rights, and the procedure is extremely cumbersome.

  In this regard, experts pointed out that the personal information protection law is in the process of being formulated, and it is suggested to standardize the behavior of street shooting and clarify the duty of care of the network platform.

  Xu Hao pointed out that the reporting function in short video applications should be clearly regulated. It can be clearly stipulated in legislation that the application platform should put the report button in a prominent position and handle the report information in time after receiving the report.

  "In recent years, the development of artificial intelligence has made face recognition no longer difficult. For the identity information, life photos and other evidence provided by portrait owners, the online platform should be able to easily complete the comparison with street photos and videos. For the protection of the legitimate rights and interests of portrait owners, this practice is undoubtedly the lowest cost and the fastest effect. " Xu Hao said.

  Zhu Wei also believes that the network platform that stands at the cusp of traffic in the 5G era should bear more responsibilities while benefiting.

  "The platform should make efforts to improve the audit system, smooth feedback and complaint channels, and strengthen punishment measures. Now all major platforms are using artificial intelligence to review videos and photos. These platforms should focus on the infringement of street shooting, and reflect their attitude in the algorithm to prevent problems before they happen. " Zhu Wei said.

  Zhu Wei believes that in terms of specific practices, we can refer to the relevant provisions of the e-commerce law.

  Article 45 of the E-commerce Law stipulates that if the operators of e-commerce platforms know or should know that the operators in the platforms infringe intellectual property rights, they should take necessary measures such as deleting, shielding, disconnecting links, terminating transactions and services; If necessary measures are not taken, they shall be jointly and severally liable with the infringer.

  "For videos and photos that violate the rules, the platform should take necessary measures such as deleting, shielding and disconnecting links. For bloggers who have been reported many times, they should take the title disposal. If the platform fails to take necessary measures, it shall be jointly and severally liable with the infringer. " Zhu Wei said.

  Cartography/Li Xiaojun