标签归档 武汉红灯一条街

通过admin

Hit your face hot? Chloe Bennet, a shock wave woman, was selected as the seven goddesses of Marvel Comics in the year.

Stills of Chloe Bennet’s "Aegis Secret Service"


1905 movie network news Recently, some netizens found that Chloe Bennet’s MV "Tonight" starring in the popular group BIGBANG accidentally bumped into Dilraba, and many netizens said that "both of them have exquisite facial features and are indeed somewhat similar".

Chloe Bennet and Dilraba were both born in 1992. One is of mixed blood between China and the United States, and the other is of Uygur nationality. The same exotic customs make them have certain similarities in appearance.Chloe Bennet is a typical actress of European and American models, while Dilraba is a small flower of the new generation in China. In essence, their routes and development directions are different.


Comparison between Chloe Bennet and Dilraba


Chloe Bennet, a post-90s Chinese actress, won high popularity and attention for her role as the heroine "Shockwave Girl" Skye. Recently, some netizens launched the "Seven Goddess of Marvel Comics of the Year" selection campaign, and Skye, the "Shockwave Woman" played by Chloe Bennet, was on the list. Some netizens commented: "This super-powerful heroine that was missed has finally been discovered, and her strength really does not lose the black widow!" .

In the play, Chloe Bennet’s "Shobo Girl" is Nick Frey’s right-hand man. At the age of 18, she has the tenth security clearance of SHIELD. She is the only agent with this clearance except Frey and the Black Widow, and she is also the youngest agent in the history of SHIELD. Although in Marvel comics, Shobo Girl is a member of the reunion, but in the drama, Shobo Girl played by Chloe Bennet has become a substitute for the reunion.

Chloe Bennet’s Stills of S.H.I.E.L.D. Agents


After six auditions, Chloe Bennet finally got the chance to play in the sci-fi action drama "Agents of S.H.I.E.L.D.", in which she played the beautiful female agent "Shobo Girl", who was very lovable because of her independent and confident personality and super skills, and was nominated as "the best TV actress in the world" by virtue of this role in the 15th Huading Award.

In addition to her superpowers, "Shobo Girl" is proficient in fighting and sniper, and is good at performing undercover tasks. In order to play the role of "Shock Girl", fitness has become an indispensable part of Chloe Bennet’s daily life.

With the discussion of Chloe Bennet bumping into Dilraba increasing, Chloe Bennet recently took photos on social media, saying that she will come to Beijing in the future. Some netizens speculated that the Chinese actress born in the 1990s will return to China for development in the near future. Let’s wait and see!

通过admin

Prevention and control of "hard core" epidemic situation in rural areas of Shanxi Province: disinfection on pesticide spraying vehicles

On February 1 ST, a pesticide spraying vehicle turned into a "disinfection vehicle" in the streets and alleys of villages and towns in Tunliu District, Changzhi City, Shanxi Province, spraying 84 disinfectant. Photo courtesy of the Agricultural Economics Center in Tunliu District

On February 1 ST, a pesticide spraying vehicle turned into a "disinfection vehicle" in the streets and alleys of villages and towns in Tunliu District, Changzhi City, Shanxi Province, spraying 84 disinfectant. Photo courtesy of the Agricultural Economics Center in Tunliu District

  Zhongxin. com Changzhi, February 1 (Li Tingyao) On February 1, in the streets and alleys of villages and towns in Tunliu District, Changzhi City, Shanxi Province, a pesticide spraying vehicle turned into a "disinfection vehicle", spraying 84 disinfectant, and hardcore prevention and control of pneumonia infected by novel coronavirus.

  Tunliu District has 21 agricultural production hosting service subjects and a large number of large-scale agricultural machinery, and the comprehensive level of agricultural mechanization in the whole region reaches 86%. Hou Xuezeng, director of the Agricultural Economics Center in Tunliu District, said that after the outbreak of pneumonia in novel coronavirus, people in the WeChat group, the main body of agricultural production custody service in Tunliu District, paid attention to the development of the epidemic every day. During the chat, everyone came up with the idea of contributing to the prevention and control of the epidemic.

  Hou Xuezeng introduced that a total of 15 agricultural production custody service entities voluntarily signed up to participate in epidemic prevention and control, and can provide 21 large, medium and small pesticide spraying vehicles. On the evening of January 30th, the Agricultural Economics Center of Tunliu District asked the district party committee and district government for instructions, and it was agreed that all the registered service subjects were arranged by the leading group for prevention and control of pneumonia infected by novel coronavirus in Tunliu District.

  On the second day of approval, pesticide spraying vehicles from various agricultural production custody service subjects went to six townships (districts) in Tunliu District, including Fengyi Town, Heshenmiao Township, Xijia Township, Lucun Township, Yuwu Town and Kangzhuang Park, to carry out disinfection operations in streets, Little Square and vegetable markets.

  At 13: 00 on January 31, Shi Shuanghu’s agricultural production hosting service provider sent two medium-sized pesticide spraying vehicles to disinfect the streets and lanes of Fengyi Town. It was near 24: 00 that they finished their homework that day. For the 11-hour continuous disinfection operation, Shi Shuanghu said that he did not feel hard or tired. In the face of the epidemic, if he can contribute, he must contribute.

  As of 24: 00 on January 31st, Changzhi has reported 3 confirmed cases of pneumonia infected by novel coronavirus, including 1 case in Luzhou District and 2 cases in Zhangzi County, which are adjacent to Tunliu District.

  At about 9: 00 on February 1, Li Lin started to disinfect the streets and public places in Lucun Township with a pesticide spraying truck. He said that it is expected that he will finish his homework in Lucun Township in another day or two. "After all, I have the equipment and the ability, so I must actively participate."

  "The main body of agricultural production custody service in Tunliu District is highly conscious and responsible. We are deeply moved by taking the initiative to participate in epidemic prevention and control, and we have also been well received by the people." Hou Xuezeng said that the disinfection operation itself is also a kind of propaganda, which can make people further realize the importance of epidemic prevention and control.

通过admin

Notice of Beijing Municipal Bureau of Commerce on Issuing the Guiding Opinions of Beijing Municipality on Promoting the High-quality Development of Commercial Pedestrian Streets

Jing Shang Gui Zi [2022] No.11

Bureau of Commerce of each district and Bureau of Commerce and Finance of Beijing Economic and Technological Development Zone:

  In order to implement the requirement of "Beijing’s Implementation Plan for Cultivating and Building an International Consumer Center City (2021-2025)" that "by 2025, there will be at least one commercial pedestrian street in each district" and create a commercial pedestrian street with characteristics, quality, digitalization and cultural heritage, the Municipal Bureau of Commerce has studied and formulated the Guiding Opinions on Promoting the High-quality Development of Commercial Pedestrian Street in Beijing, which is hereby printed and distributed to you. Please conscientiously implement it in light of the actual situation.

  I hereby inform you.

Beijing Municipal Bureau of Commerce              

November 30, 2022      

Guiding Opinions of Beijing Municipality on Promoting the High-quality Development of Commercial Pedestrian Street

  In accordance with the decision-making arrangements of the Municipal Party Committee and the Municipal Government, in order to implement the Implementation Plan for Cultivating and Building an International Consumer Center City in Beijing (2021-2025) and accelerate the high-quality development of commercial pedestrian streets, the following opinions are put forward.

  I. General requirements

  (A) the definition of commercial pedestrian street

  Commercial pedestrian street is an open commercial activity space with street architectural form as the main body, motor vehicles are prohibited or restricted on the ground, and commercial and service facilities are highly concentrated, which meets people’s comprehensive or professional consumption demand for commerce and fully embodies pedestrians’ priority, including strip commercial pedestrian street and block commercial pedestrian street. According to the vehicle ban, it can be divided into full-time and time-sharing commercial pedestrian streets. According to the functional orientation, it can be divided into comprehensive and characteristic commercial pedestrian streets.

  (2) Basic principles

  1. Government guidance and market dominance. On the basis of strictly implementing the general rules and zoning planning, and extensively listening to the opinions of market participants and all sectors of society, the municipal and district governments should do a good job in planning and guiding, clarify the development orientation of commercial pedestrian streets, provide policy support in terms of renovation, business upgrading, project approval, and provide service guarantee in terms of market supervision, traffic organization, environmental improvement, and intelligent construction. It is necessary to fully understand that market players are the main force in the transformation and upgrading of commercial pedestrian streets, and support them to participate in planning, construction, management and operation in improving overall quality, introducing commercial brands, creating consumption atmosphere and improving service quality.

  2. Scientific planning and overall development. Guide the high-quality development of commercial pedestrian street with high-standard planning, and avoid blind development and longer construction of commercial pedestrian street. Identify their own advantages, optimize the neighborhood environment, improve the quality of business, build smart neighborhoods, standardize management and operation, focus on improving the level of convenience and comfort, form a distinctive development pattern, and effectively improve people’s sense of acquisition and happiness.

  3. Based on the stock, transform and upgrade. Adhere to the economic development stage and objective reality, combined with the development status of commercial pedestrian streets, each district chooses the existing commercial pedestrian streets with good foundation and great potential for transformation and upgrading, or based on the current commercial streets, upgrade them into commercial pedestrian streets through transformation, further supplement the shortcomings and strengths, and do not engage in large-scale demolition and construction, and do not engage in image projects.

  4. Respect for culture and distinctive features. Dig deep into cultural connotation, highlight regional characteristics, pay attention to civilization inheritance and cultural continuity, and persist in protective development and utilization of historical and cultural resources. Integrate the development of commercial pedestrian street with the protection of historical and cultural heritage, and promote the integration of traditional culture into modern life.

  5. Clear responsibilities and form a joint force. Establish a cross-departmental coordination mechanism with horizontal cooperation and vertical linkage, and all relevant departments at the municipal level systematically plan policy innovation and give policy support. Each district is the leading body of the quality improvement of commercial pedestrian street, responsible for the upgrading of commercial pedestrian street and the landing of new cultivation tasks.

  (3) Development goals

  By 2025, at least one high-quality commercial pedestrian street will be built in each district, and a number of high-quality commercial pedestrian streets with prosperous business, strong culture, distinctive features, beautiful environment and standardized governance will be built in the city.

  Second, the key tasks

  (A) to strengthen the planning and layout

  Combined with the development status and future planning guidance requirements of the city’s commercial pedestrian streets, the city’s commercial pedestrian streets are divided into updated and upgraded types and newly cultivated types. Renewal and upgrading should focus on stock renewal, and transform and upgrade the business, environment and operation of the block; The new cultivation type should combine regional development resources and spatial structure, pay attention to the combination of planning guidance and market leadership, and cultivate commercial pedestrian streets through traffic optimization, space upgrading, business upgrading and operation upgrading.

  Each district should work out a work plan for improving the quality of commercial pedestrian streets, which should be linked with the overall urban planning, zoning planning, urban renewal action and the spatial layout planning of commercial service facilities. It is necessary to highlight the main street, link auxiliary streets and coordinate development, clarify the scope, target positioning and functional layout of commercial pedestrian streets, and determine key tasks, timetables and road maps to ensure that they can land and be effective.

  (2) Optimize the allocation of business formats

  According to the development orientation of the block, the dynamic adjustment mechanism of the business format is established, the commercial pedestrian street and its surrounding commercial carriers are upgraded, the main street and the auxiliary street are organically connected, the commercial brands are misplaced, and the advantages are complementary, so as to build a diversified business ecosystem with high-end and public, outstanding themes and characteristics, and both fashion and trend. Comprehensive commercial pedestrian street should gather shopping, catering, culture, tourism, art, hotels and other diversified formats for integrated development, with retail and catering formats accounting for more than 50%; Characteristic commercial pedestrian street should reflect the advantages of high specialization, clustering, scale and branding, and can meet people’s specific consumption and life service needs. The scale of specialty shops with main formats accounts for more than 50% of the total operating area.

  Encourage the combination of block commerce with culture, tourism, leisure, entertainment and sports consumption, and develop local specialties, handicrafts, time-honored brands and intangible cultural heritage. Support conditional neighborhoods to activate and utilize historical buildings, and introduce creative fairs, immersive performances, and historical theme exhibitions. Encourage time-honored brands to focus on traditional culture and local characteristics, develop products and services that meet the needs of modern consumption, and launch characteristic cultural and creative products with limited amount and high amount.

  (3) Optimize traffic organization

  When planning a commercial pedestrian street, each district should strengthen the organization and guidance of various traffic elements in and around the block, make overall consideration of vehicle access and transit needs, and scientifically design bypass schemes and road traffic rules to ensure the normal traffic of vehicles around the commercial pedestrian street, which can not only meet the travel needs of surrounding residents, but also ensure the transportation convenience of daily consumers.

  The block should be equipped with a public transport system with convenient ride, strong accessibility and diverse choices. There are subway stations or bus stops within 500 meters of the block to expand the coverage of public transportation. Promote the combination of various public transport stations and commercial facilities to reduce the impact of commercial passenger flow on surrounding traffic. There are taxi parking spots and non-motor vehicle parking spots within 100 meters of the block. Integrate the parking lot resources within the block. In principle, there should be no less than one supporting parking space per 100 square meters of commercial building area. Create a safe, convenient, comfortable and high-quality slow-moving system to enhance the "walking friendliness".

  (D) beautify the neighborhood environment

  Each district should prepare the planning of outdoor advertising facilities and guidelines for setting plaque signs in commercial pedestrian street blocks according to law, highlight cultural characteristics and local characteristics, reflect the vitality of commercial blocks, provide creative space for operators to independently design plaque signs, and avoid homogenization of styles, colors and fonts. Historical and cultural blocks should protect the existing courtyards and continue the tradition. The building facade, materials and colors should be coordinated with the whole block style to create a characteristic block with a unique humanistic and historical atmosphere.

  Each district should combine the theme orientation of the block with its own resource endowment, tailor-made characteristic signs, strengthen the impression of the block, create street interactive experience sketches and online celebrity punching points, add new landscape sketches and new node elements to traditional historical buildings, and interpret historical and cultural values in a modern form. Enrich the greening level and enhance the greening landscape. The lighting of the night scene of the block should focus on highlighting the characteristics of the block and showing the local cultural atmosphere, which should be coordinated with the commercial format and architectural style of the block. During holidays, lighting elements can be added. According to the needs of major activities, festival publicity and landscape environment layout, on the basis of implementing the concept of energy conservation and environmental protection, combined with regional features, light shows and other programs can be appropriately organized.

  (5) Improve public facilities.

  All districts should study and formulate management guidelines for using commercial pedestrian streets to carry out characteristic business activities, rationally plan business areas, clarify business hours and categories, and encourage enterprises that have settled in and obtained business licenses to carry out characteristic business activities within the scope of reasonable planning of their own land (land red line) by the district government.

  The guide system should be designed and formulated in a unified way, and the guide system should be marked in at least two languages, and the logo should be eye-catching, clear and beautiful. At least one public rest facility shall be set every 50 meters in the block. The appearance of leisure facilities should be coordinated with the overall style of the block, integrated with the cultural elements of the block, reflecting the unique cultural characteristics of the block, and creating a pleasant and comfortable outdoor recreation and leisure space. At least one classified garbage bin or mobile cleaning vehicle shall be set up every 50 meters in the block. A complete blind road system and barrier-free service facilities should be built in the block. There should be public security alarm points, riot prevention facilities and emergency shelters in the block.

  (6) Accelerate the construction of smart blocks.

  Strengthen infrastructure construction to achieve full coverage of 5G networks and wireless networks. Encourage the construction of a big data platform for smart blocks, dynamically monitor the passenger flow, brand, format and business operation data of commercial pedestrian streets, timely and accurately grasp the commercial stock and operating efficiency of blocks, and provide accurate services for consumers, commercial enterprises, operating institutions and government management.

  Encourage blocks to build smart business streets and smart shops, explore the use of AR/VR and other technologies, promote the popularization and application of new consumption formats, new models and new scenarios, and create smart consumption ecosystems such as navigation guide, digital landscape display, marketing service push, immersive experience, smart payment and smart parking. Use applets, apps, live broadcast platforms, multimedia interactive screens, etc., and introduce digital virtual elements to create smart consumption scenarios. Reasonably develop smart terminals such as unmanned supermarkets, unmanned shops and unmanned restaurants to realize self-help and contactless convenience consumption experience.

  (VII) Innovative operation governance model.

  Study and establish a co-governance mechanism and market-oriented operation mode with multi-participation of "government guidance, industry self-discipline, owner autonomy, social supervision and mass appraisal". Explore the scene of integrated comprehensive supervision, compact the responsibility of market entities, implement differentiated and accurate comprehensive supervision, implement credit supervision for commercial entities with strong management and service capabilities, and give full play to their self-management role. Encourage the establishment of commercial pedestrian street governance committees, chambers of commerce, alliances and other organizations to achieve standardized management, efficient operation and normal supervision.

  Third, safeguard measures

  (A) to strengthen organizational leadership

  Establish a "five-level linkage" working mechanism with unified guidance of the city, overall responsibility of the district, specific management of the street, self-discipline of the social industry and standardized operation of the store. The Municipal Bureau of Commerce is responsible for coordinating and promoting the work. Municipal commerce, finance, self-regulation, transportation, urban management, market supervision, cultural tourism, fire protection, cultural relics, landscaping and other departments, establish communication and coordination mechanisms, strengthen policy innovation, regularly communicate relevant information, study and solve the difficulties and problems encountered in the development of commercial pedestrian streets, and support the construction of various districts. All districts should strengthen the implementation of responsibilities, prepare implementation plans, organize planning and construction, foster development, supervision and management.

  (2) Strengthening policy support

  Relevant departments at the municipal level should focus on the difficult and painful problems that restrict the development of commercial pedestrian streets, and increase policy support for transformation and upgrading and business upgrading on the premise of conforming to market rules and not breaking through the planning bottom line. Coordinate the two levels of financial funds in urban areas to support the construction of commercial pedestrian streets. The Municipal Bureau of Commerce focuses on supporting projects such as the transformation and upgrading of commercial entities, digital construction, introduction of first stores and consumption promotion activities in commercial pedestrian streets in various districts. All districts should give support to municipal supporting projects such as traffic optimization, street reconstruction, environmental beautification and landscaping of commercial pedestrian streets.

  (3) Strengthen monitoring and evaluation

  The Municipal Bureau of Commerce is responsible for improving the evaluation standard system of commercial pedestrian streets in the city, and jointly with relevant departments and districts, regularly carries out evaluation through self-evaluation and expert review in each district, so as to promote the construction by evaluation and realize the double promotion of economic and social benefits.

  (4) Strengthen publicity and guidance.

  Through the combination of traditional media and new media, policy interpretation and case analysis, we will carry out publicity from all directions, angles and channels, respond to social concerns in time, and create a good atmosphere for promoting the construction of commercial pedestrian streets.

Evaluation Index System for High-quality Development of Commercial Pedestrian Street in Beijing (Trial))

Evaluation Index System for High-quality Development of Commercial Pedestrian Street in Beijing (Trial))

Evaluation Index System for High-quality Development of Commercial Pedestrian Street in Beijing (Trial))

通过admin

Japan and South Korea hold bilateral trade consultations again on the 19th. Japanese media: It is difficult to reach a consensus.

  BEIJING, Nov. 19 (Xinhua) According to Japanese media reports, on the 19th, Japan and South Korea will hold the second bilateral consultation in Switzerland on strengthening Japan’s export management to South Korea.

  South Korea filed a lawsuit against the WTO in September this year in view of Japan’s strengthening the export management of three commodities, including semiconductor raw materials. According to the relevant provisions of the WTO, as the first step of trade litigation, the parties to the dispute need to hold bilateral consultations. To this end, Japan and South Korea held their first bilateral consultation in October, but failed to reach an agreement.

  The representatives of the second consultation between the two sides were Junichiro Kuroda, Minister of Trade Organization of the Ministry of Economy, Trade and Industry of Japan, and Ding Haiguan, Cooperation Officer of New Trade Order of the Ministry of Industry, Trade and Resources of Korea.

  At present, the two sides still hold different views on Japan’s export management to South Korea. The Japanese side pointed out that the purpose of this move is to better manage goods that may be used for military purposes, while the South Korean side retorted that the Japanese side violated WTO principles and demanded that it be revoked.

  Japan Broadcasting Association (NHK) reported that, in view of this, it seems difficult for the two sides to reach a consensus in the second consultation. If this consultation fails, the relevant agencies of the WTO will start hearing this lawsuit.

  Since July, the dispute between Japan and South Korea caused by the "labor compensation case" has intensified after several confrontations, such as the mutual deletion of the "white list" of trade between the two sides, the abolition of the military agreement between the two countries by the ROK, and the prosecution of Japan by the ROK in the WTO. The relationship between the two countries has fallen into a freezing point.

通过admin

How long is the course of influenza? What if you have a fever? Fourteen questions about influenza are answered authoritatively by Beijing Children’s Hospital.

There are many respiratory diseases in children in winter, among which influenza virus is one of the common pathogens. On the questions that parents and friends are concerned about, the National Children’s Medical Center Beijing Children’s Hospital answered authoritatively.

1. What are the typical symptoms of influenza?

Children infected with influenza virus can show fever, chills, headache, myalgia and general malaise, often accompanied by respiratory diseases such as cough, sore throat and runny nose. The degree of fever in young children may be heavier, and some children may also have febrile convulsions; In addition, they will have more gastrointestinal symptoms, such as nausea, vomiting, diarrhea and poor appetite. Very few children infected with influenza may develop into severe influenza, causing laryngitis, pneumonia, encephalopathy, myocarditis and so on.

2. How does the flu spread and how long is the incubation period?

Influenza virus can spread from person to person through respiratory droplets (such as sneezing, coughing and talking) or after polluting the surface of objects. Influenza viruses can also spread through small air particles released by influenza patients when they breathe. Influenza patients are the main source of infection. The incubation period of influenza is generally 1-7 days, and most of them are 2-4 days.

3. How long is the general course of influenza and what is the change of the course?

For children without basic diseases, the course of influenza virus infection is acute and self-limited, and most symptoms disappear in about 2-3 days after onset. Some children’s fever lasts for 5 days, and most patients recover within 1 week, but cough may last for a long time, and fatigue and fatigue of a few elderly children (over seven or eight years old) may last for several weeks.

4. How to distinguish the flu from the common cold?

The full name of the flu is called "influenza", and you may think it is similar to the common cold, but the flu and the common cold cannot be confused.

The common cold can be caused by many pathogens, among which viruses are the most common, including rhinovirus, adenovirus, metapneumovirus, bocavirus, etc. Bacteria and mycoplasma can also cause the common cold. The symptoms of the common cold are mild, usually low-to-moderate fever, which lasts for 1-2 days, and may be accompanied by other catarrhal symptoms such as sneezing, runny nose, stuffy nose and slight cough, while the systemic symptoms such as chills, headache and joint muscle pain are very mild. Generally, there are no serious complications.

Influenza is mainly caused by influenza A and B virus infection, with high fever, severe systemic symptoms such as chills, headache and joint muscle pain. A few influenza patients may have complications such as rhabdomyolysis, pneumonia, encephalitis and encephalopathy.

In the flu season, children with flu-like symptoms, especially those with a history of contact with influenza patients, should first consider influenza virus infection, which can be diagnosed by influenza virus antigen detection or influenza virus nucleic acid detection.

5. How is the flu generally treated?

After being infected with influenza virus, the treatment measures include antiviral and symptomatic treatment.

Anti-influenza drugs: At present, the oral antiviral drugs for influenza virus are mainly neuraminidase inhibitors, commonly used drugs include oseltamivir and mabaloxavir, and intravenous drugs include paramivir. Once you have the flu, the sooner you use anti-influenza drugs, the better, especially within 48 hours of onset. However, even if the course of the disease exceeds 48 hours, once the flu is confirmed, you should actively use drugs.

Symptomatic treatment measures: mainly to reduce fever and relieve discomfort. You can choose antipyretics scientifically, and you can also use some drugs to relieve symptoms such as cough and stuffy nose. It should be noted that the pharmaceutical ingredients of some compound preparations may overlap with other therapeutic drugs, and the combined use may cause an excessive amount of one ingredient and cause adverse reactions in children.

6. Is there any specific medicine for influenza and can it be prevented by drugs?

Oseltamivir is an antiviral drug specifically for influenza virus, which can shorten the duration of clinical symptoms. However, it is not recommended that children take anti-influenza drugs as soon as they have a fever, because there are many respiratory pathogens that cause fever, and oseltamivir is only effective for influenza.

The best way to prevent influenza virus is to actively vaccinate. If there is no contraindication, people over 6 months are advised to actively vaccinate against influenza. For children with high risk of severe influenza or influenza complications, who are contraindicated by influenza vaccine or have not been vaccinated (or within 2 weeks after vaccination), drug prevention should be considered. Drug prevention can reduce but not eliminate the risk of influenza, and the susceptibility to influenza will be restored after drug withdrawal. Therefore, routine drug prevention for children is not recommended.

7. Are azithromycin and other antibacterial drugs useful for influenza?

Antibacterials, including azithromycin, are ineffective against viral infection. However, if there is a mixed infection of influenza virus and bacteria or mycoplasma, doctors will also consider the use of anti-influenza drugs combined with antibacterial drugs.

8. Fever is one of the typical symptoms of children. What misunderstandings should be avoided in home care?

The main purpose of taking antipyretics for children is not to reduce the body temperature to normal, but to increase the comfort of children and let them spend the fever period comfortably and safely.

First of all, you can’t take two antipyretics at the same time, which will increase the burden on your child’s liver and kidney and cause adverse reactions; It is also not recommended to use the two antipyretics alternately, because it can not increase the antipyretic effect, but may mistake the time and even lead to overdose.

Secondly, when parents choose antipyretics for their children, they should not only choose drugs suitable for their age, but also read the instructions carefully, and give them to their children in strict accordance with the instructions, paying attention to the dosage and time interval. Remember not to increase the dosage or frequency at will because the child’s body temperature has not dropped to normal.

Finally, if you give your child a compound cold preparation at the same time, you must read the drug ingredient list to avoid duplication with other drugs being used, such as antipyretics. If there is duplication, please use it with caution to avoid overdose.

In daily life, children should be kept in a regular routine to ensure adequate sleep; In terms of diet, we should pay attention to nutrition, have a balanced diet, eat more fruits and vegetables and drink more water. At the same time, avoid the family environment being too dry and ensure the humidity, which is conducive to the recovery of children. Parents should also pay attention to the fact that children should neither cover up their fever nor let them catch cold again. Parents should maintain a peaceful attitude, pay attention to their children’s fever, and don’t be overly anxious, carefully observe their children’s situation and help them recover as soon as possible.

9. I am particularly worried about my child’s febrile convulsion. What should I do if there is febrile convulsion?

If the child has a febrile convulsion, parents must keep calm and don’t panic: (1) Let the child lie on his side or tilt his head to one side, and clean up things with sharp corners around him to ensure that the child will not be hurt when the convulsion occurs. (2) When convulsions occur, don’t stuff anything into the child’s mouth, and don’t feed anything, and don’t try to stop twitching by pressing the limbs. (3) Record the duration and seizure characteristics of convulsions. If the duration of convulsions exceeds 5 minutes or the status quo of convulsions has occurred in the past, call an ambulance. In most cases, febrile convulsions will stop within 5 minutes.

10. What happens that requires timely medical treatment?

Most children with influenza are mild patients, so they can take care of them at home. However, if the following situations occur, they should seek medical attention in time: children who have been diagnosed with influenza have high fever or fever for more than three days, poor mental health or even consciousness disorder, shortness of breath/dyspnea, chest pain, blue skin on the lips, frequent vomiting or diarrhea, convulsions, refusal to eat, scanty urine or urine turning red, and obvious muscle pain; Or if the symptoms are repeated, such as fever again after the flu symptoms are relieved, you need to seek medical advice in time to avoid aggravation and even danger.

11. Which children are at high risk of severe influenza?

High-risk children with severe influenza include: children under 5 years old, especially children under 2 years old; There are basic diseases, such as asthma, tumor, kidney disease, immunodeficiency, taking immunosuppressive drugs, etc.; Obese children are also high-risk groups. When high-risk people have fever during the influenza epidemic season, they should attach great importance to it and seek medical treatment as soon as possible. Once influenza virus infection is considered, antiviral treatment should be started as soon as possible. If there are no contraindications, people at high risk of severe influenza should be actively vaccinated before the flu season begins.

12. Will you get the flu if you are infected with mycoplasma pneumonia recently?

I will. Because the body’s resistance will decrease when it is infected, it may be easy to be infected with other pathogens. Measures to prevent cross-infection include paying attention to self-protection, trying not to take children to crowded places, especially places with poor air circulation, during the high incidence season of respiratory diseases; Pay attention to open the window regularly for ventilation indoors, and isolate it from the sick family if possible; Pay attention to hand hygiene and remind children not to touch their eyes, nose and mouth with unclean hands.

13. Will children have sequelae after the flu?

Most children will not leave sequelae after being infected with the flu. However, after the flu temperature is normal, cough and runny nose may last for a week or even longer. The treatment is mainly symptomatic, keeping the air moist and promoting airway recovery. If cough seriously affects rest, you can take some antitussive drugs under the guidance of a doctor. Some children may have chronic cough due to airway hyperresponsiveness, especially those with eczema and wheezing history, and can be given medication under the guidance of a doctor.

14. How to prevent the spread of influenza in schools and families?

Schools should organize and mobilize students and faculty to get flu vaccine before the flu season begins; It is necessary to strengthen health education for students and their families, help and urge students to develop good hygiene habits, such as washing hands frequently and maintaining environmental hygiene; The classroom should be ventilated regularly; The school monitors students’ body temperature to find sick children in time; Once students are infected with influenza virus, they should rest at home and not go to school with illness; Attach importance to students’ physical exercise and enhance their physique and disease resistance.

Children suffering from influenza should ensure adequate rest, balanced nutrition, drink plenty of water and eat easily digestible food at home; Family members should maintain good hygienic living habits, pay attention to environmental hygiene and cough etiquette. If possible, we should try our best to isolate ourselves from sick family members; If you can’t isolate, you should wear a mask for protection. In addition, the indoor window should be ventilated regularly, but we should pay attention to keep warm in winter to avoid catching cold.

Authors: Zhao Guangyuan, the attending physician of emergency medicine in Beijing Children’s Hospital.

Audit: Wang Quan, Director of Department of Critical Care Medicine, Beijing Children’s Hospital

通过admin

Beijing property market regulates the full moon: the transaction cools down, and the official force purchases rents simultaneously.

  BEIJING, Beijing, April 17 (Zhongqing) After the introduction of the "3.17" overweight control policy in Beijing’s property market, Beijing has made more than ten moves in succession in the past month, blocking the loopholes in real estate speculation in an all-round way, and at the same time, focusing on building a housing system with both purchase and rent based on the fundamental demand of "living and living"; At the same time, strictly investigate the school district housing speculation, aisle rooms, garage, etc. that do not meet the actual living conditions, are not allowed as admission qualifications.

  Punch 12 times a month

  According to the incomplete statistics of Zhongxin. com, within one month from March 17 to April 16, Beijing issued 12 highly targeted property market regulation policies, all of which were "zero transition" on the same day or the next day. The determination to regulate is self-evident.

  In addition to opening the mode of "recognizing houses and loans", Beijing’s regulatory heavy punches also include reducing the first home loan discount, modifying the tax standard for non-Beijing-born houses, making it clear that the houses in the corridor school district are not registered, restricting the purchase of commercial projects, and piloting public rental housing with "New Beijingers". The industry believes that this has blocked any possibility of real estate speculation in Beijing.

  Now, what changes have taken place in the Beijing property market? Data from the Central Plains Real Estate Research Center show that from March 18th to April 10th, all properties in Beijing signed 5,817 contracts, which was 19% lower than that before the chain regulation. From the data point of view, due to the lag of online signing data, the actual market transaction or cooling is more obvious.

  A number of real estate agents also told the reporter of Zhongxin. com that "there are obviously fewer customers who come to see the house, and those who have the willingness to buy a house before have turned to wait and see." Recently, the reporter found in a number of chain intermediary stores in Fangshan District, Beijing that there were very few customers in the store, and the staff either chatted or looked at their computers.

  "It is estimated that in the second half of April, the transaction volume of second-hand houses may decline by about 50%." Zhang Dawei, chief analyst of Zhongyuan Real Estate, said that a few months ago, the second-hand housing prices in Beijing increased significantly faster than those of new houses. Therefore, the second-hand housing market was the most affected after the regulation and overweight.

  Commercial market cooling

  On the evening of March 26th, commercial houses in Beijing were officially restricted. When individuals can’t buy houses that are not built, under construction or under sale, they also need to meet two "harsh" conditions when buying second-hand commercial houses. At the same time, commercial banks suspend personal housing loans for individuals to buy commercial projects.

  Restricted purchases, stopped loans, and strictly investigated illegal sales, and the commercial market cooled down overnight.

  According to the data of Zhongyuan Real Estate, from March 27 to April 10, in half a month, the total number of commercial contracts in Beijing was 303, which was more than 90% lower than the previous transaction volume. Not only that, the contracted projects are concentrated in Tongzhou area, such as Tongzhou Everbright New Beijing Center and World Overseas Chinese Business Center, which have been restricted before. From a certain perspective, the commercial market is close to freezing.

  According to the reporter’s investigation, many buyers who are stuck in the purchase restriction policy and have not completed the online signing are eager to repent. "I am afraid of hitting my hands in the future" is what they are most worried about.

  Strictly check the corridor school district

  As the vanguard of the property market, the school district housing has also become the focus of Beijing’s crackdown on speculation. On March 23, the Beijing Municipal Education Commission, the Municipal Planning and Land Commission, the Municipal Public Security Bureau and other departments joined hands to refuse to register, settle down or enroll in schools nearby.

  The next day, 10 intermediary stores of Chain Home, I Love My Family and Zhongyuan Intermediary Company near four communities, such as Fenghuiyuan in Xicheng District, were ordered to suspend business for one month for rectification due to illegal acts such as tax payment, illegal agency, and bid up housing prices.

  In response to the speculation of the Beijing school district, the Beijing Municipal Education Commission has also repeatedly shot. First, it is clearly stated that "the corridor school district room" cannot be used as a qualification condition for admission; Then, in the opinions on enrollment in the compulsory education stage in 2017 released on April 16th, it is proposed to explore the enrollment mode of combining single-school scribing with multi-school scribing.

  In Zhang Dawei’s view, the above policies are real, whether in real estate regulation or in education coordination. The policy is very strong, and the structural adjustment of the school district is still steady and progressive.

  Make great efforts to purchase and rent at the same time

  If you want to "have a place to live", it is not the only way to buy a house. A multi-level, market-oriented, equal and orderly rental market can also solve this problem.

  It is precisely based on the "big goal" of paying equal attention to both rent and purchase that the Beijing Municipal Commission of Housing and Urban-Rural Development officially launched a pilot project of special allocation for new Beijingers (non-Beijing families with stable employment) in public rental housing and self-occupied housing this month. On April 12th, the first batch of 120 sets of public rental housing participating in the pilot project has been registered. According to the introduction of the Beijing Municipal Commission of Housing and Urban-Rural Development, about 1,000 suites of two public rental housing projects, namely, Changyang Lingfeng Four Seasons Garden and Yancun Lehuo Yayuan, will be taken out later, and special rent allocation will be piloted again.

  On the other hand, Beijing also actively expands the multi-level development of the leasing market, and encourages housing enterprises to use self-sustaining houses as rental houses through the land transfer method of "controlling land prices and limiting house prices". On April 14, the Beijing Municipal Commission of Housing and Urban-Rural Development issued the Notice on Relevant Issues Concerning the Management of Self-sustaining Commercial Housing Leases of Enterprises in this Municipality, prohibiting the housing enterprises that have obtained the held rental land from selling in disguised form through grey channels; At the same time, it provides a guarantee for enterprises and individuals to rent self-sustaining commercial houses of developers.

  With decoration, long lease period and negotiable rent, isn’t it great to rent a first-hand house directly with the developer? According to the regulations, the tenant is not limited to a specific enterprise or individual; The rental price shall be determined by both parties through consultation according to the market level; Before renting a self-sustaining commodity house, the house should be fully renovated; The term of the lease contract shall not exceed 10 years. (End)

通过admin

Affordable and healthy anti-cancer vegetables with two parity

  Some studies have found that cruciferous vegetables have certain benefits in preventing lung cancer, breast cancer, gastric cancer and intestinal cancer.

  Which vegetables belong to Cruciferae?

  In addition to the familiar purple cabbage, cabbage, broccoli and cauliflower, in fact, many green leafy vegetables belong to Cruciferae, even including Chinese cabbage, Chinese cabbage, white radish, Chinese kale, rape, water bamboo and so on.

  Today, I recommend two cheap anti-cancer dishes to my friends, purple cabbage and Chinese cabbage. They are cheap, especially Chinese cabbage. When they are on the market in large quantities, one yuan can buy several kilograms. Buy these two kinds of vegetables, 5 yuan can fill the vegetable basket, which is very affordable.

  First, purple cabbage

  Among all kinds of substances that play an anti-cancer role, there is a very important component called isothiocyanate.

  Purple cabbage itself does not contain isothiocyanate, but it contains glucose isothiocyanate. When eating purple cabbage, you should chew. In the process of chewing, glucose isothiocyanate is released and becomes isothiocyanate after human metabolism.

  In the whole metabolic process, isothiocyanate produces indole and thioglycoside. In vitro experiments showed that indole and glucosinolates had certain inhibitory effects on some cancer cells.

  In addition, purple cabbage is rich in flavonoids because of its purple color. Flavonoids are a very powerful group of antioxidants, and their antioxidant effects are better than those of β -Carotene, vitamin C and vitamin E should all be high.

  Second, Chinese cabbage

  Chinese cabbage is sweet and fragrant, crisp and juicy. Although the price is cheap, it definitely does not lose other vegetables in nutrition.

  Chinese cabbage is low in calories and suitable for people who want to lose weight. Chinese cabbage also contains dietary fiber, vitamin C, B vitamins, potassium, calcium, magnesium and other nutrients, which have the effects of relaxing bowels and resisting aging. In addition, the stewed cabbage is helpful for digestion and is also very suitable for people with low gastrointestinal function.

  Some researchers have found that the incidence of breast cancer in women who eat a lot of cabbage has decreased.

  However, when the components we detected in Chinese cabbage were extracted and made into medicines for people to take, the same effect did not appear. Increasing the dose, or taking several ingredients at the same time, has no effect.

  This has greatly inspired people, and it is more scientific and reasonable to ingest nutrients in the form of whole food than to ingest purified substances alone.

  In terms of the total amount of vegetables, the average adult can basically meet the demand by eating vegetables weighing about a catty every day.

  In fact, there are not many vegetables that weigh a catty. According to the amount after cooking, it is a plate at noon and a plate at night. The "Jin" mentioned here includes all kinds of vegetables. You can eat cruciferous vegetables 3-4 times a week, and you should also eat some other vegetables interspersed.

  For people with thyroid-related diseases, whether they can eat cruciferous vegetables depends on the specific situation, including whether they smoke, whether they take too much iodine or lack iodine, and the current treatment. It is recommended to follow the doctor’s advice.

  Text/Yu Kang (Professor of Clinical Nutrition, Peking Union Medical College Hospital)

通过admin

Kang Zhensheng: Determined to make China’s agricultural scientific research achievements "go abroad" after more than 30 years of wheat disease research.

CCTV News:In Yangling, Shaanxi, the birthplace of Chinese farming civilization, there is such a scientific researcher: he has been rooted in the northwest for more than 30 years and stuck to the yellow land. He is not a farmer, but better than a farmer.

He carried out research on the occurrence law and comprehensive control of wheat stripe rust, revealed the pathogenic variation path and mechanism of wheat stripe rust, made clear the causes of the prone areas of wheat stripe rust in summer in China, improved the understanding of the epidemic system of wheat stripe rust, and provided theoretical basis for comprehensive control of wheat stripe rust in China. The comprehensive control technology system of stripe rust in the prone areas in summer in China was constructed, and remarkable results were achieved through demonstration and application promotion, which effectively controlled stripe rust in China. The infection route and pathogenic mechanism of wheat scab were revealed, and the key period of disease prevention and control was determined, which provided theoretical basis and technical support for the prevention and control of wheat scab.

(Academician Kang Zhensheng introduced wheat stripe rust and its prevention to reporters. CCTV reporter Di Chenchen/photo)

(Academician Kang Zhensheng introduced wheat stripe rust and its prevention to reporters. CCTV reporter Di Chenchen/photo)

"Wheat stripe rust and scab are major biological disasters that affect China’s food security and food safety. I came out of a wheat field, and my career is in a wheat field. " He is Kang Zhensheng, an academician of China Academy of Engineering, distinguished professor, a Changjiang scholar of the Ministry of Education, a doctoral supervisor, and the director of the State Key Laboratory of Crop Stress Biology in Arid Areas. In the research building of Northwest A&F University, CCTV reporter met Professor Kang Zhensheng and listened to him tell his own research story.

Germinate the long-cherished wish of "relying on science to help agriculture increase production and income"

Kang Zhensheng was born in Anyue, Sichuan in 1957. He was a famous "good student" from primary school to high school. In 1981, Kang Zhensheng became the first graduate student of the school after the reform of the enrollment system with excellent results and the first place in the graduation thesis grade. Kang Zhensheng, who was born in a farmer’s family, witnessed the huge losses caused by stripe rust to wheat production. His character of not being afraid of difficulties and being brave in exploration also made Kang Zhensheng sprout his long-cherished wish of relying on science to help agriculture increase production and income in the vast fields.

He began his research career under the guidance of Professor Li Zhenqi, a famous plant pathologist in China. Under the leadership of Li Zhenqi, Kang Zhensheng visited the key areas where wheat stripe rust occurred in Longnan, Longdong and Guanzhong of Shaanxi Province for many times.

(Northwest A&F University Artificial Climate Room CCTV reporter Di Chenchen/photo)

(Northwest A&F University Artificial Climate Room CCTV reporter Di Chenchen/photo)

Through intensive investigation and repeated demonstration, they first discovered a new pathogenic strain of stripe rust, which seriously harmed the main wheat varieties in China, from thousands of analysis materials and infected wheat plants through a large number of analysis experiments and field inoculation, and made an accurate prediction on the development trend and harm of this strain. The prevention and control strategies and solutions put forward were adopted by agricultural production departments, which played an important guiding role in preventing and reducing the harm of wheat stripe rust. This achievement won the third prize of scientific and technological progress in Shaanxi Province in 1987.

Become a conqueror of "wheat cancer"

Wheat stripe rust, known as "wheat cancer", is a low-temperature fungal disease spread through the air, and it is one of the main public enemies of wheat production in the world, which often reduces wheat production by 10% to 30%, and even leads to wheat failure in serious cases.

For many years, Kang Zhensheng led the team to focus on the interaction between pathogenic fungi and host wheat, and to find out what caused the frequent changes of wheat stripe rust from the aspects of histology, cytology, molecular cytology and molecular biology.

(Wheat stripe rust in Academician Kang Zhensheng's office and its parasitic Berberis CCTV reporter Di Chenchen/photo)

(Wheat stripe rust in Academician Kang Zhensheng’s office and its parasitic Berberis CCTV reporter Di Chenchen/photo)

In order to find out the species of Berberis in the over-summer area of wheat stripe rust, Kang Zhensheng led his team members to travel all over the ravines of Gansu, Shaanxi, Sichuan and Yunnan provinces, and insisted on investigating the occurrence of wheat stripe rust. After a lot of field follow-up research, he sought the evidence that wheat stripe rust camped on Berberis in natural conditions and carried out experiments by using advanced scientific and technological means, and finally obtained a major discovery: sexual reproduction is the main pathogenic variation of wheat stripe rust in China. Wheat stripe rust is widely distributed in shrub leaves in northwest mountainous areas — — "Having children" on wild Berberis makes a new generation of germs become the "killer" of wheat varieties. On August 26, 2017, the research results were published in the top international academic journal Annual Review of Plant Pathology, which attracted wide attention at home and abroad.

Kang Zhensheng’s team established a technical system for forecasting wheat stripe rust in different places, and the accuracy of disease prediction was over 90%. The control technology system of "over-summer variable area" was established by taking measures such as crop structure adjustment, distribution of disease-resistant varieties, seed dressing with chemicals, winter spore isolation and Berberis treatment, which reduced the initial bacterial source of "over-summer variable area" by 40%, reduced the frequency of new races by 50% and extended the service life of disease-resistant varieties by 3-5 years, which played a key role in the effective control of stripe rust in China.

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

The research results benefit many countries and regions in the Belt and Road Initiative.

Wheat stripe rust is a serious biological disaster that affects the global wheat production safety for a long time. As the main academic leader of plant pathology in China, Kang Zhensheng led his team to make outstanding contributions to the research on the occurrence regularity, pathogenic mechanism and control technology of major diseases such as wheat stripe rust and scab. Kang Zhensheng promoted the establishment of "China Wheat Stripe Rust Germ Base Comprehensive Control Technology System", which was applied in 12 provinces, autonomous regions and municipalities in China, reducing the occurrence area of stripe rust by 50%, recovering more than 2 billion kilograms of grain losses every year, and increasing income and reducing expenditure by 4 billion yuan annually.

(Academician Kang Zhensheng explains agricultural research in the laboratory. CCTV reporter Di Chenchen/photo)

(Northwest A&F University Wheat-Stripe Rust Interaction Room CCTV reporter Di Chenchen/photo)

Since the "Belt and Road Initiative" was put forward, Kang Zhensheng’s team has successively cooperated with more than 10 countries and regions, including Kazakstan, Turkish and Ethiopian, collected and studied more than 1,300 standard samples of wheat stripe rust pathogens, and made China’s agricultural scientific research achievements with high quality and high yield of wheat "go abroad".

Today, Kang Zhensheng is still busy, but what he considers most now is to train young people, let them stand on their shoulders and grow up as soon as possible. "The work of revealing the genetic and molecular mechanism of virulence variation of Puccinia striiformis has just begun. In the future, while engaging in scientific research, we should train the young people behind us so that our agricultural science and technology can really run from the past to the leading stage." (Part of the data comes from Northwest A&F University)

通过admin

Is the "Today’s Headline" brought to court "Today’s Fried Bread" an infringement? Lawyer’s detailed explanation

  With today’s headlines, can there be "today’s fried dough sticks" and "today’s noodles"? Recently, this issue has caused netizens to watch. Today’s fried dough sticks company in Henan has designed a storefront that is highly similar to today’s headline LOGO and its APP interface, and a slogan similar to today’s headline "You care about the headline": "You care about you is a good fried dough sticks", and the business looks good.

  However, the announcement of Guangzhou Intellectual Property Court recently showed that Beijing ByteDance Technology Co., Ltd., to which today’s headline belongs, took "Today’s fried dough sticks" to court.

  Does today’s fried dough sticks constitute infringement? What is trademark infringement? What punishment will "today’s fried dough sticks" face once they are convicted of infringement? Please see the lawyer for a detailed explanation.

  Can "Today’s Headline" Trademark be Cross-protected?

  According to the enterprise survey data, today’s fried dough sticks catering management Co., Ltd. was established on May 13 this year with a registered capital of 1 million yuan. In addition to the "Today’s fried dough sticks" signboard, today’s fried dough sticks company applied for 16 trademarks such as today’s noodles, many cakes, instant cakes and tomorrow’s fried dough sticks in the categories of food, catering accommodation and convenience food. However, the above trademark applications are in a state of "waiting for substantive examination" and have not been successfully registered at present.

  China’s trademark law stipulates that using a trademark similar to its registered trademark on the same commodity or using a trademark identical to or similar to its registered trademark on similar commodities without the permission of the trademark registrant is likely to lead to confusion, which is an infringement of the exclusive right to use a registered trademark.

  The reporter noted that although ByteDance Company also registered the "Today’s Headline" trademark in the international classification "Class 43", the sub-item is "Day Nursery (babysitting); Animal foster care; Blankets for rent. " The trademark "Today’s Headline" registered in such sub-projects as "restaurants, teahouses and cafes" has passed the preliminary examination under the name of "Xia Rong (Shanghai) Catering Management Co., Ltd.". Therefore, "Today’s Headline" does not actually have the prior right of the trademark of the restaurant category, and whether the "Today’s Headline" trademark of the information technology category can be protected to the catering category will become the key.

  Huang Hui, an intellectual property partner of Wanhuida, believes that now is the era of attention economy, and today’s deep-fried dough-strips company is still applying for quick cakes and lots of cakes. In fact, they all want to take a shortcut and hitchhike and should not be encouraged. "This is obviously a free ride by taking advantage of other people’s market reputation." Huang Hui believes that the word "today’s headline" itself is relatively weak, because "today" and "headline" are the daily language of news media, but combined with the special graphic expression, according to the judicial interpretation of protecting well-known trademarks in China, today’s headlines may still be protected by well-known trademarks.

  Wu Xinhua, a senior partner of Beijing Weiheng Law Firm and director of the intellectual property department, also said that "Today’s Headline" itself is a word combination with weak distinctiveness, but it has gained high popularity and is well known by the relevant public after being widely used and publicized by ByteDance Company in recent years. However, whether it can be protected as a well-known trademark depends on the trial of Guangzhou Intellectual Property Court.

  Main identification elements of trademark infringement

  The cross-border imitation of "today’s fried dough sticks" is not unusual. Around well-known enterprises, "trademark imitation show" is often staged. Then, in judicial practice, how to identify trademark infringement? As long as the names are close, is it infringement?

  The reporter noticed that there is a ready-made case that is very close to today’s fried dough sticks, which can be used to illustrate.

  Pinduoduo, a well-known e-commerce platform, has been ridiculed by many people as "fighting for the evening". In November 2017, Shanghai Shita Information Technology Co., Ltd. registered the trademark "Pinxixi", and launched the website "Pinxixi Mall", WeChat WeChat official account and the mobile phone software "Pinxixi". On the "Pinxi Shopping Mall", there are also columns such as time-limited spike, quality fruit, half-day arrival, spelling love, 9 yuan and 9 special sales, and even imitating Pinduoduo’s advertising slogan: "Shopping APP that 100 million people are fighting for".

  In 2018, Pinduoduo’s Shanghai Dream Search Technology Co., Ltd. sued Shanghai Shita Information Technology Co., Ltd. to the court on the grounds of trademark infringement and unfair competition.

  The court’s first-instance judgment clearly stated that the central part of the two trademarks is Chinese "spelling". Observing the trademarks of the two brands with the general attention of the relevant public, the overall structure is similar, and it is easier for the relevant public to use Chinese "spelling" as the calling keyword when identifying the two brands. In addition, Pinduoduo’s trademarks are well-known and prominent. When the relevant public identifies the accused logo in isolation, it is easy to misunderstand the service source. Therefore, the court ruled that the two trademarks constitute similar trademarks, and the use of the accused logo by Shita Company infringed the exclusive right to use the trademark enjoyed by Dream Search Company.

  It can be seen from the court’s judgment that the key to trademark infringement lies in whether the main identification elements will cause misidentification.

  "Specific to this case, the design of the scarlet letter in today’s headline box is its unique logo, and its popularity is high. Today, the attempt to imitate the use of fritters is obvious." Huang Hui analyzed, "When the court identifies a well-known trademark, it should combine the specific pattern to identify it."

  In other words, whether today’s fried dough sticks or today’s noodles are suspected of hitchhiking on today’s headlines, as for today’s fried dough sticks, highlighting the word "fried dough sticks" in the form of oblique red frame and white background in the trademark, highly imitating the trademark and propaganda slogan of today’s headlines, and the intention of creating associations is very obvious, which is likely to infringe on the exclusive right to use trademarks enjoyed by ByteDance.

  "China’s trademark law stipulates that applying for trademark registration shall not damage the existing prior rights of others, nor shall it preemptively register trademarks that others have used and have certain influence by unfair means. In addition, for well-known trademarks registered by others, the trademark law gives cross-class protection under certain conditions. " Wu Xinhua said, "ByteDance can object to the trademark of today’s fried dough sticks in accordance with the law during the announcement period of preliminary examination. If it is a registered trademark, you can file an application for invalidation. "

  "Bangda Brand" can be fined up to 5 million yuan.

  Regarding his trademark registration, the person in charge of today’s fried dough sticks company explained: "I brush today’s headline APP every day, and I am a loyal user, ‘ Next to the big name ’ Just for fun. " The company also issued an "open letter", saying that it should take headlines as an example and be a favorite breakfast brand for ordinary people.

  "If the report is true, the words of the person in charge of today’s fried dough sticks company just show his subjective intention, which will be unfavorable to the enterprise in determining the facts of the case." Wu Xinhua believes.

  According to the trademark law, the infringer usually has to bear the responsibility of stopping the infringement, and the perpetrator who knows or should know that it is an infringement also has to bear the responsibility of compensation. If the circumstances are serious, they shall also bear criminal responsibility.

  In recent years, China’s protection of intellectual property rights, including trademarks, has been increasing. In April 2019, the National People’s Congress Standing Committee (NPCSC) revised the Trademark Law to increase the punishment for infringement of the exclusive right to use a trademark. The revised terms increased the amount of compensation for malicious infringement of the exclusive right to use a trademark from more than one time to less than three times to more than one time to less than five times, and raised the upper limit of legal compensation from 3 million yuan to 5 million yuan. The revised terms came into effect on November 1, 2019.

  "Operators must enhance their awareness of intellectual property rights and respect the prior trademark rights and interests of others, ‘ Next to the big name ’ It’ s cool for a while, and there are two lines of tears after the calculation. Malicious infringement of the exclusive right to use registered trademarks of others will be severely punished by law. " Wu Xinhua reminded, "In addition, the Anti-Unfair Competition Law stipulates that it is forbidden to use the same or similar marks such as commodity names, packaging and decoration that have certain influence on others without authorization. Today, the font pattern used by the fritters company on the storefront signboard is very similar to today’s headline trademark, and it is also suspected of violating the Anti-Unfair Competition Law. "

通过admin

Investigation and Research | Gene Mutation Must Be a Disaster?

Some problems that are difficult to explain in biology will only be recognized after more healthy people have sequenced their genomes. For example, despite carrying some catastrophic mutations that can lead to chronic failure diseases such as cystic fibrosis and Fanconi anemia, there are still a few extremely lucky people who can avoid being shot to stay healthy and show good resilience to diseases. How did this happen?

The research team led by professors Brenda Andrews, Charles Boone and Frederick Roth of Donnelly Research Center and Department of Molecular Genetics of the University of Toronto, in cooperation with Professor Chad Myers of the University of Minnesota Twin Cities, compiled the first comprehensive intracellular inhibitory mutation spectrum so far, and related research was published in the recent journal Science. Four professors are also members of the genetic network research project group of the Canadian Institute of Advanced Studies (CIFAR). Their findings are helpful to explain how the inhibitory gene mutation can combine with the pathogenic mutation to neutralize the attack of the disease and even protect the individual from the disease damage completely.

Harm.

What is gene suppression?

Chad Myers and others published this research in Science, entitled "Exploring genetic suppression interactions on a global scale". It is generally believed that when an organism has a genetic mutation, it is a genetic error. But not all mutations are harmful. At this time, another gene mutation can be used to save the phenotypic defect caused by this mutation. This process is called "gene suppression" (or "genetic repression") by scientists.

"In fact, we don’t know why some people with destructive mutations are sick and others are not. Part of the reason can be attributed to environmental factors, but it is more likely that other mutations have inhibited the previous mutations, "said Roth, a senior researcher from Lunenfeld-Tanenbaum Institute of Sinai Health System.

Imagine that you are locked in a room with a broken thermostat, and the room begins to get very hot. To cool down, you can choose to fix the thermostat-or you can just break a window. This is how gene suppression keeps cells healthy in the presence of destructive mutations. This provides a new way of thinking for understanding and even treating hereditary diseases.

Yeast substitution experiment

"If we know which genes have inhibitory mutations, then we can figure out the relationship between them and the pathogenic genes, which will help guide the development of drugs in the future," said Dr. Jolanda van Leeuwen, a postdoctoral researcher in Boone Laboratory and one of the leading scientists in this research.

But finding these mutations is not easy. In the human body, this job is like looking for a needle in a haystack. Theoretically, an inhibitory mutation may be any one of thousands of DNA coding errors, scattered among about 20,000 human genes and making each genome unique. Therefore, it is unrealistic to detect all the inhibitory mutations.

"Similar research has not been carried out at the genome-wide level. Considering that it is difficult to carry out such a laboratory with human cells, we use yeast as a model organism, in which we can clearly know how mutations affect the health of cells, "said Van Leeuwen. With only 6,000 genes, yeast cells can be regarded as "simplified versions" of human cells, but both of them follow some similar basic genetic laws. Moreover, it is much easier to remove any gene from yeast cells when studying serious mutation cases in which all gene functions are missing.

Narrow the search scope of mutant genes

The research team adopted a two-pronged strategy. On the one hand, they analyzed the known mutual inhibition relationship in published yeast genes. Despite the huge amount of information, these results are inevitably biased towards some of the most common genes, which have been fully studied by scientists. Therefore, Van Leeuwen and his colleagues conducted an unbiased analysis by evaluating the growth state of yeast cells with destructive mutations and their combination with other mutations. Because harmful mutations will slow down the growth rate of cells, any increase in cell growth rate can be attributed to an inhibitory mutation in another gene. These experiments revealed hundreds of inhibitory mutations corresponding to some known harmful mutations.

Importantly, the experimental data of different methods all point to the same conclusion. In the process of searching for suppressor genes, we usually don’t need to stay away from harmful gene mutations-these genes tend to play a similar role in cells, or because their coding proteins are located in the same position, or because they play a role in the same molecular pathway.

"We revealed the basic principle of gene suppression and found that harmful mutations and their inhibitory mutations are often located in genes with similar functions. When searching for the inhibitory mutation corresponding to human hereditary diseases, we can now narrow the scope of attention instead of looking for a needle in a haystack. We narrowed the search range of genes from 20,000 to hundreds, or even dozens. That’s a great progress. " Boone said.

The Paper (www.thepaper.cn) interviewed Jolanda van Leeuwen, the first author of this research email. She is a postdoctoral researcher in the laboratory of Professor Charlie Boone and Brenda Andrews at Donnelly Center for Cell and Molecular Biology, University of Toronto, Canada. At present, the main work is to use functional genomics tools to study how the interaction of mutations leads to the occurrence of unexpected phenotypes and how this determines the severity of genetic traits, including human diseases.

The Paper:People who carry harmful mutations can still stay healthy and not get sick. How to understand the significance of sequencing and analyzing the genome of such people? How to accurately correlate huge amounts of data with rare genetic diseases?

Jolanda:At present, we can sequence the genome of healthy people with disease-related mutations. Through this genome sequencing, we can find thousands of gene mutations, but we still don’t know how to identify which mutations are involved in the suppression of disease phenotype from these mutations. To make the situation more complicated, only a few individuals showing the "resilience" of the disease have been sequenced, and these data are obviously not enough for the identification of inhibitory mutations.

The Paper:At present, the experimental research is based on yeast. How can similar research guide the research in human cells? Considering that there are many genes in the human body, and the functions of most genes are unknown.

Jolanda:Theoretically, similar research can be carried out in human cells, and we are currently engaged in this research. This kind of research is indeed more complicated, because the number of inhibitory mutations is rare, and researchers need more cells to be able to identify them. Compared with yeast, human cells have more genes and the proliferation rate is much slower, so it will be difficult to screen out spontaneous inhibitory mutations. At present, we are increasing the incidence of inhibitory mutation events by inducing mutation, and we hope to reveal the mechanism of human cell inhibitory genes based on these data.

The Paper:What reference does it have for screening, diagnosis, pathogenesis research or treatment of genetic diseases? Can you give an example?

Jolanda:We have identified and quantified the mechanism of gene suppression. We found that inhibitory mutations often occur in genes that have significant functional correlation with their suppressed genes. Understanding how the inhibitory effect occurs will hopefully narrow the scope of research and help us identify the inhibitory mutations related to diseases from thousands of variations in the genomes of these resilient people. Knowing which genes the inhibitory mutation occurs in is helpful to the development of disease treatment methods.

The PaperWhat do you think is the most important significance of this research?

Jolanda:The identification and quantification of the inhibition mechanism described above is the most important discovery, because it has a significant potential correlation with human diseases. In addition, I am currently expanding the "inhibition network" in yeast and developing a screening method for this inhibition in human cell lines.

(Zhang Jiaojiao, Ph.D. student in food science of Zhejiang University, and Zhang Zhenyu, Ph.D. in gastrointestinal anorectal surgery of Dongfang Hospital affiliated to Tongji University also contributed to this article. News source: Science Daily, original title "Why bad genes are not necessarily bad news")